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17 results on '"Yuan, Defu"'

4. Dual Infection of Different Clusters of HIV in People Living with HIV Worldwide: A Meta-Analysis Based on Next-Generation Sequencing Studies.

Author

Yuan, Defu, Zhao, Fei, Liu, Shanshan, Liu, Yangyang, Yan, Hongxia, Liu, Lifeng, Su, Bin, and Wang, Bei

Subjects
*HIV prevention, *MEDICAL information storage & retrieval systems, *HEALTH literacy, *HIV, *RESEARCH funding, *ANTIRETROVIRAL agents, *HIV-positive persons, *HIV infections, *META-analysis, *DESCRIPTIVE statistics, *SYSTEMATIC reviews, *MEDLINE, *MEDICAL databases, *PUBLIC health, *ONLINE information services, *DATA analysis software, *CONFIDENCE intervals, *SUPERINFECTION, *NATURAL immunity, *HEALTH education, *MIXED infections, *SEQUENCE analysis
Abstract

To understand the global dual HIV infection (DI) profiles comprehensively, the databases Cochrane Library, Embase, PubMed, and Web of Science were the data sources up to March 31, 2024 (PROSPERO: CRD42023388328). Stata and R-language software were used to analyze the extracted data. Publication bias was assessed using Egger's test. Sensitivity analysis was conducted to evaluate the stability of the combined effect values. Data from 17 eligible studies across four continents (Africa, Asia, Europe, and North America) with 1,475 subjects were used. The combined dual infection rate (DIR) was 10.47% (95% CI: 7.11%−14.38%) without a time trend (p = 0.105). The DIRs of target population groups differed significantly, with FSWs having the highest DIR (15.14%), followed by general population (12.08%), MSM (11.84%), and DUs (9.76%). The subtype profiles of 122 patients with dual infection were extracted, and the results showed that intrasubtype infections were predominant in coinfection (16/22, 72.73%) and superinfection (68/100, 68.00%) groups, with the subtype pattern B and B accounts for the largest proportion. The global dual infection rate may be underestimated, even though the data fluctuated around 10% and showed no time trend. The occurrence of DI indicated that individuals still do not acquire sufficient resistance to HIV even after primary infection, which could potentially compromise the patient's treatment effect and lead to the emergence of new subtypes, posing a significant challenge to HIV prevention, control, and treatment, suggesting that behavioral counseling and health education for all HIV-infected individuals are still crucial during the antiviral therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Association of sleep duration and sleep quality with the risk of metabolic syndrome in adults: a systematic review and meta-analysis

Author

Hu, Jingyao, primary, Zhu, Xiaoyue, additional, Yuan, Defu, additional, Ji, Dakang, additional, Guo, Haijian, additional, Li, You, additional, He, Zhiliang, additional, Bai, Hexiang, additional, Zhu, Qiuqi, additional, Shen, Chenye, additional, Ma, Haonan, additional, Fu, Fangteng, additional, and Wang, Bei, additional

Published
2022
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13. The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China

Author

Guo Hongxiong, Xu Xiaoqin, Hu Haiyang, Lu Jing, Zhou Ying, Wang Bei, Fu Gengfeng, Yin Yueqi, Xuan Yan, Chen Jianshuang, Yuan Defu, and Cheng Hao

Subjects
Genetics, Phylogenetic tree, Maximum likelihood, Human immunodeficiency virus (HIV), Biology, medicine.disease_cause, Genome, Virus, Men who have sex with men, law.invention, Infectious Diseases, law, Virology, medicine, Recombinant DNA
Abstract

Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years. Objective: This study aimed to report on novel HIV-1 recombinants. Method: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1. Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world. Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.

Published
2021

16. Effect of Metabolic Health and Obesity Phenotype on Risk of Diabetes Mellitus: A Population-Based Longitudinal Study

Author

Zhu, Xiaoyue, primary, Hu, Jingyao, additional, Guo, Haijian, additional, Ji, Dakang, additional, Yuan, Defu, additional, Li, Mingma, additional, Yan, Tao, additional, Xue, Chenghao, additional, Ma, Haonan, additional, Zhou, Xu, additional, Liu, Yuxiang, additional, Li, You, additional, Sun, Kaicheng, additional, Liu, Yu, additional, Sun, Zilin, additional, and Wang, Bei, additional

Published
2021
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