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326 results on '"Yuan, Kefei"'

6. Supplementary Fig. S3 from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Author

Liao, Haotian, primary, Chen, Xing, primary, Wang, Haichuan, primary, Lin, Youpei, primary, Chen, Lu, primary, Yuan, Kefei, primary, Liao, Mingheng, primary, Jiang, Hanyu, primary, Peng, Jiajie, primary, Wu, Zhenru, primary, Huang, Jiwei, primary, Li, Jiaxin, primary, and Zeng, Yong, primary

Published
2024
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7. Supplementary Methods from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Author

Liao, Haotian, primary, Chen, Xing, primary, Wang, Haichuan, primary, Lin, Youpei, primary, Chen, Lu, primary, Yuan, Kefei, primary, Liao, Mingheng, primary, Jiang, Hanyu, primary, Peng, Jiajie, primary, Wu, Zhenru, primary, Huang, Jiwei, primary, Li, Jiaxin, primary, and Zeng, Yong, primary

Published
2024
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9. Supplementary Tables from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Author

Liao, Haotian, primary, Chen, Xing, primary, Wang, Haichuan, primary, Lin, Youpei, primary, Chen, Lu, primary, Yuan, Kefei, primary, Liao, Mingheng, primary, Jiang, Hanyu, primary, Peng, Jiajie, primary, Wu, Zhenru, primary, Huang, Jiwei, primary, Li, Jiaxin, primary, and Zeng, Yong, primary

Published
2024
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15. Whole-genome DNA methylation profiling of intrahepatic cholangiocarcinoma reveals prognostic subtypes with distinct biological drivers

Author

Liao, Haotian, primary, Chen, Xing, additional, Wang, Haichuan, additional, Lin, Youpei, additional, Chen, Lu, additional, Yuan, Kefei, additional, Liao, Mingheng, additional, Jiang, Hanyu, additional, Peng, Jiajie, additional, Wu, Zhenru, additional, Huang, Jiwei, additional, Li, Jiaxin, additional, and Zeng, Yong, additional

Published
2024
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24. Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma.

Author

Zhou, Xinyi, Huang, Tengda, Pan, Hongyuan, Du, Ao, Wu, Tian, Lan, Jiang, Song, Yujia, Lv, Yue, He, Fang, and Yuan, Kefei

Subjects
SARS-CoV-2, COVID-19, SYSTEMS biology, CHOLANGIOCARCINOMA
Abstract

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals worldwide, which poses a severe threat to human health. COVID-19 is a systemic ailment affecting various tissues and organs, including the lungs and liver. Intrahepatic cholangiocarcinoma (ICC) is one of the most common liver cancer, and cancer patients are particularly at high risk of SARS-CoV-2 infection. Nonetheless, few studies have investigated the impact of COVID-19 on ICC patients. Methods: With the methods of systems biology and bioinformatics, this study explored the link between COVID-19 and ICC, and searched for potential therapeutic drugs. Results: This study identified a total of 70 common differentially expressed genes (DEGs) shared by both diseases, shedding light on their shared functionalities. Enrichment analysis pinpointed metabolism and immunity as the primary areas influenced by these common genes. Subsequently, through protein-protein interaction (PPI) network analysis, we identified SCD, ACSL5, ACAT2, HSD17B4, ALDOA, ACSS1, ACADSB, CYP51A1, PSAT1, and HKDC1 as hub genes. Additionally, 44 transcription factors (TFs) and 112 microRNAs (miRNAs) were forecasted to regulate the hub genes. Most importantly, several drug candidates (Periodate-oxidized adenosine, Desipramine, Quercetin, Perfluoroheptanoic acid, Tetrandrine, Pentadecafluorooctanoic acid, Benzo[a]pyrene, SARIN, Dorzolamide, 8-Bromo-cAMP) may prove effective in treating ICC and COVID-19. Conclusion: This study is expected to provide valuable references and potential drugs for future research and treatment of COVID-19 and ICC. [ABSTRACT FROM AUTHOR]

Published
2024
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28. A classification based on tumor budding and immune score for patients with hepatocellular carcinoma

Author

Li Wei, Zhang Delin, Yuan Kefei, Wu Hong, Huang Jiwei, and Zhang Yange

Subjects
hepatocellular carcinoma, tumor budding, immune score, prognosis, whole exome sequencing, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: The role of immune profiling and tumor budding in hepatocellular carcinoma (HCC) remains largely unknown. This study evaluated the association between tumor budding and lymphocytic infiltration in HCC. Meanwhile, HCC patients were stratified based on tumor budding grade and immune score. Patients and methods: A total of 423 HCC patients were divided into training (n = 212) and validation (n = 211) cohort. Tumor slides from resected HCC samples were used for tumor budding assessment. A prognosis-relevant immune score was developed based on five types of immune cells out of eleven immune markers. A classification based on tumor budding grade and immune type was established (IS-TB type). To explore the association of IS-TB type and molecular alterations of HCC, 100 HCC samples and adjacent non-tumor tissues from 100 patients were investigated by whole-exome sequencing. Results: Tumor budding was an independent adverse prognostic factor for OS and DFS in both of the training and validation cohorts (all P values

Published
2020
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32. The effect of diet and nutrition on T cell function in cancer.

Author

Zhou, Xinyi, Wang, Zhen, and Yuan, Kefei

Subjects
CELL physiology, T cells, CANCER cells, NUTRITION, T-cell exhaustion
Abstract

Cancer can be considered one of the most threatening diseases to human health, and immunotherapy, especially T‐cell immunotherapy, is the most promising treatment for cancers. Diet therapy is widely concerned in cancer because of its safety and fewer side effects. Many studies have shown that both the function of T cells and the progression of cancer can be affected by nutrients in the diet. In fact, it is challenging for T cells to infiltrate and eliminate cancer cells in tumor microenvironment, because of the harsh metabolic condition. The intake of different nutrients has a great influence on the proliferation, activation, differentiation and exhaustion of T cells. In this review, we summarize the effects of typical amino acids, lipids, carbohydrates and other nutritional factors on T cell functions and provide future perspectives for dietary treatment of cancer based on modifications of T cell functions. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Supplementary Figure S1-2 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Author

Dou, Qianhui, primary, Chen, Hai-Ning, primary, Wang, Kui, primary, Yuan, Kefei, primary, Lei, Yunlong, primary, Li, Kai, primary, Lan, Jiang, primary, Chen, Yan, primary, Huang, Zhao, primary, Xie, Na, primary, Zhang, Lu, primary, Xiang, Rong, primary, Nice, Edouard C., primary, Wei, Yuquan, primary, and Huang, Canhua, primary

Published
2023
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36. Supplementary Materials and Methods from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Author

Dou, Qianhui, primary, Chen, Hai-Ning, primary, Wang, Kui, primary, Yuan, Kefei, primary, Lei, Yunlong, primary, Li, Kai, primary, Lan, Jiang, primary, Chen, Yan, primary, Huang, Zhao, primary, Xie, Na, primary, Zhang, Lu, primary, Xiang, Rong, primary, Nice, Edouard C., primary, Wei, Yuquan, primary, and Huang, Canhua, primary

Published
2023
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42. Supplementary Figure Legends from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Author

Dou, Qianhui, primary, Chen, Hai-Ning, primary, Wang, Kui, primary, Yuan, Kefei, primary, Lei, Yunlong, primary, Li, Kai, primary, Lan, Jiang, primary, Chen, Yan, primary, Huang, Zhao, primary, Xie, Na, primary, Zhang, Lu, primary, Xiang, Rong, primary, Nice, Edouard C., primary, Wei, Yuquan, primary, and Huang, Canhua, primary

Published
2023
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43. Supplementary Figure S3-6 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Author

Dou, Qianhui, primary, Chen, Hai-Ning, primary, Wang, Kui, primary, Yuan, Kefei, primary, Lei, Yunlong, primary, Li, Kai, primary, Lan, Jiang, primary, Chen, Yan, primary, Huang, Zhao, primary, Xie, Na, primary, Zhang, Lu, primary, Xiang, Rong, primary, Nice, Edouard C., primary, Wei, Yuquan, primary, and Huang, Canhua, primary

Published
2023
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49. Supplementary Figure S7-9 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Author

Dou, Qianhui, primary, Chen, Hai-Ning, primary, Wang, Kui, primary, Yuan, Kefei, primary, Lei, Yunlong, primary, Li, Kai, primary, Lan, Jiang, primary, Chen, Yan, primary, Huang, Zhao, primary, Xie, Na, primary, Zhang, Lu, primary, Xiang, Rong, primary, Nice, Edouard C., primary, Wei, Yuquan, primary, and Huang, Canhua, primary

Published
2023
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