340 results on '"Yubing, Wang"'
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2. Automatic Train Operation System Based on Vehicle Deep Integration
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Yubing WANG and Tian GAO
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urban rail transit ,ato system ,vehicle system ,integration design ,Transportation engineering ,TA1001-1280 - Abstract
Objective Conventional ATO (automatic train operation) systems lack a direct, real-time, and bidirectional data exchange with the vehicle traction/braking systems. In the vehicle control process, information on the vehicle traction/braking status and capabilities is not available, which can lead to issues such as control commands from the ATO system not aligning with actual vehicle capabilities, long control cycles, and low parking precision, calling for a need to achieve deep integration between ATO and vehicle systems. Method The working principle and limitations of conventional ATO systems are discussed. The ATO system based on deep vehicle integration (hereinafter referred to as Integrated ATO) is introduced. The integration optimization measures of the Integrated ATO system in terms of system architecture, information transfer, vehicle interfaces, and system functionality are elucidated. A comparative analysis is conducted between conventional and Integrated ATO systems to highlight the advantages of the latter. Result & Conclusion The Integrated ATO system cancels the interlink between ATO and vehicle traction/braking systems, reduces communication links to enhance richness and transparency of information transfer between them. The Integrated ATO system leverages the characteristics and advantages of both the vehicle and signaling systems, enhancing the coordination between ATO system and traction/braking systems, thereby improving overall control effectiveness.
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- 2024
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3. An ecological resilience model for adolescents with type 1 diabetes: a cross-sectional study
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Dan Luo, Xue Cai, Hong Wang, Jingjing Xu, Yubing Wang, and Mingzi Li
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Diabetes type 1 ,Adolescents ,Resilience ,Ecological determinants ,Psychiatry ,RC435-571 - Abstract
Abstract Background Highly resilient adolescents with type 1 diabetes have been proved to achieve within-target glycemic outcomes and experience high quality of life. The ecological resilience model for adolescents with type 1 diabetes was developed in this study. It aims to increase our understanding of how resilience is both positively and negatively affected by internal and environmental ecological factors. Methods This cross-sectional study surveyed 460 adolescents with type 1 diabetes from 36 cities in 11 provinces, China. Participants completed self-report questionnaires on resilience, family functioning, peer support, peer stress, coping style, and demographics. Standard glycated hemoglobin tests were performed on the adolescents. Structural equation modeling was applied to analyze the data. Results The ecological resilience model for adolescents with type 1 diabetes was a good model with a high level of variance in resilience (62%). Family functioning was the most important predictor of resilience, followed by peer support, positive coping, and peer stress. Moreover, positive coping was the mediator of the relationship between family functioning and resilience. Positive coping and peer stress co-mediated the association between peer support and resilience. Conclusions Family functioning, peer relationships, and positive coping are interrelated, which may jointly influence resilience. The findings provide a theoretical basis for developing resilience-promotion interventions for adolescents with type 1 diabetes, which may lead to health improvements during a vulnerable developmental period.
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- 2024
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4. The role of peer social relationships in psychological distress and quality of life among adolescents with type 1 diabetes mellitus: a longitudinal study
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Dan Luo, Xue Cai, Hong Wang, Yubing Wang, and Jingjing Xu
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Coping ,Diabetes distress ,Pediatric diabetes ,Peer ,Quality of life ,Psychiatry ,RC435-571 - Abstract
Abstract Background Adolescents with type 1 diabetes mellitus suffer from diabetes distress and poor health-related quality of life (HRQOL) since living with the condition that differentiates them from their peers. The present study investigated the effects of peer support and stress on diabetes distress and HRQOL and whether positive coping mediated the effects. Methods We used a prospective study design. A total of 201 adolescents with type 1 diabetes mellitus from 20 cities in 4 provinces were recruited.Participants complete two separate surveys at approximately 18-month intervals. The scales employed at both Time 1 and Time 2 included the Diabetes-Specific Peer Support Measure, Diabetes Stress Questionnaire for Youths, Simplified Coping Style Questionnaire, 5-item Problem Areas in Diabetes Scale, and the Diabetes Quality of Life for Youth scale. Results Baseline peer stress directly predicted diabetes distress and HRQOL at 18 months, even controlling for age, gender, and peer support. However, the direct effect of baseline peer support on 18-month diabetes distress and HRQOL was insignificant. Baseline peer support indirectly affected diabetes distress and HRQOL at 18 months through positive coping, indicating that positive coping plays a mediating role. Conclusion The findings suggest that peer social relationships, especially peer stress, and positive coping are promising intervention targets for adolescents facing challenges in psychosocial adaptation.
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- 2024
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5. A Global Earthquake Prediction Model Based on Spherical Convolutional LSTM.
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Zhongchang Zhang and Yubing Wang
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- 2024
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6. Blood pressure response to clonidine in children with short stature is correlated with postural characteristics: a retrospective cross-sectional study
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Wentao Yang, Shanshan Wang, Wei Gu, Francis Manyori Bigambo, Yubing Wang, and Xu Wang
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Clonidine ,Hypotension ,Passive leg raising ,Posture ,Short stature ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Clonidine stimulation test has been widely used in the diagnosis of growth hormone deficiency in children with short stature with a high level of reliability. However, it may cause hypotension, which usually appears as headache, dizziness, bradycardia, and even syncope. It is well known that elevating the beds to make patients’ feet above their cardiac level might relieve this discomfort. However, the real efficiency of this method remains to be proved while the best angle for the elevated bed is still unclear. Methods A total of 1200 children with short stature were enrolled in this retrospective cross-sectional study. Age, gender, weight, and basic systolic and diastolic blood pressure were collected. Blood pressure at 1, 2, 3, and 4 h after stimulation tests were recorded. The participants were divided into 3 groups based on the angles of the elevated foot of their beds named 0°, 20°, and 40° groups. Results At one hour after the commencement of the tests, participants lying on the elevated beds showed a higher mean increase on the change of pulse pressure. The difference in the angles of the elevated beds did not show statistical significance compared with those who did not elevate their beds (0.13 vs. 2.83, P = 0.001; 0.13 vs. 2.18, P = 0.005; 2.83 vs. 2.18, P = 0.369). When it came to 4 h after the tests began, participants whose beds were elevated at an angle around 20° had a significantly higher mean increase in the change of pulse pressure values compared with those whose beds were elevated at an angle around 40° (1.46 vs. -0.05, P = 0.042). Conclusion Elevating the foot of the beds of the patients who are undergoing clonidine stimulation tests at an angle of 20°might be a good choice to alleviate the hypotension caused by the tests.
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- 2024
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7. Investigation of the flow boiling performance in mini channel with micro pin fin
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Yubing, Wang, Li, Jie, Zhang, Dalin, Chen, Weijian, and Zhu, Guangya
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- 2023
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8. Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
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Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang, and Andrew M. Chan
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YKL-40 ,Astrocyte ,Amyloid-beta ,Alzheimer’s disease ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic biomarker of Alzheimer’s disease. High levels of YKL-40 are associated with either advanced Alzheimer’s disease or the normal aging process. However, the functional role of YKL-40 in Alzheimer’s disease development has not been firmly established. In a 5xFAD mouse model of Alzheimer’s disease, we observed increased YKL-40 expression in the cerebrospinal fluid of 7-month-old mice and was correlated with activated astrocytes. In primary astrocytes, Aβ1-42 upregulated YKL-40 in a dose-dependent manner and was correlated with PI3-K signaling pathway activation. Furthermore, primary neurons treated with YKL-40 and/or Aβ1-42 resulted in significant synaptic degeneration, reduced dendritic complexity, and impaired electrical parameters. More importantly, astrocyte-specific knockout of YKL-40 over a period of 7 days in symptomatic 5xFAD mice could effectively reduce amyloid plaque deposition in multiple brain regions. This was also associated with attenuated glial activation, reduced neuronal attrition, and restored memory function. These biological phenotypes could be explained by enhanced uptake of Aβ1-42 peptides, increased rate of Aβ1-42 degradation and acidification of lysosomal compartment in YKL-40 knockout astrocytes. Our results provide new insights into the role of YKL-40 in Alzheimer’s disease pathogenesis and demonstrate the potential of targeting this soluble biomarker to alleviate cognitive defects in symptomatic Alzheimer’s disease patients.
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- 2023
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9. Encoder-Decoder Framework for Interactive Free Verses with Generation with Controllable High-Quality Rhyming.
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Tommaso Pasini, Alejo López-ávila, Husam Quteineh, Gerasimos Lampouras, Jinhua Du, Yubing Wang, Ze Li, and Yusen Sun
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- 2024
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10. Duodenal–Jejunal Bypass Restores Sweet Taste Receptor-Mediated Glucose Sensing and Absorption in Diabetic Rats
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Sipeng Sun, Anping Wang, Rongguan Kou, Hantao Xue, Xiangyu Zhao, Ben Yang, Mengqi Shi, Yubing Wang, Qingtao Yan, Meihua Qu, Yi Wang, and Zhiqin Gao
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Conclusion: DJB ameliorates glycemic control probably by restoring STR-mediated glucose sensing and absorption with the responses of GLP-1 and GLP-2 to carbohydrate.
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- 2024
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11. Hyperspectral Image Classification Using 3D Attention Mechanism in Collaboration with Transformer.
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Yubing Wang, Ye Zhang, and Kaifeng Duan
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- 2023
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12. Low-Polarization, Broad-Spectrum Semiconductor Optical Amplifiers
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Meng Zhang, Tianyi Zhang, Hui Tang, Lei Liang, Yongyi Chen, Li Qin, Yue Song, Yuxin Lei, Peng Jia, Yubing Wang, Cheng Qiu, Yuntao Cao, Yongqiang Ning, and Lijun Wang
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semiconductor optical amplifier ,gain sensitivity ,polarization sensitivity ,gain bandwidth ,quaternary compound ,Chemistry ,QD1-999 - Abstract
Polarization-insensitive semiconductor optical amplifiers (SOAs) in all-optical networks can improve the signal-light quality and transmission rate. Herein, to reduce the gain sensitivity to polarization, a multi-quantum-well SOA in the 1550 nm band is designed, simulated, and developed. The active region mainly comprises the quaternary compound InGaAlAs, as differences in the potential barriers and wells of the components cause lattice mismatch. Consequently, a strained quantum well is generated, providing the SOA with gain insensitivity to the polarization state of light. In simulations, the SOA with ridge widths of 4 µm, 5 µm, and 6 µm is investigated. A 3 dB gain bandwidth of >140 nm is achieved with a 4 µm ridge width, whereas a 6 µm ridge width provides more output power and gain. The saturated output power is 150 mW (21.76 dB gain) at an input power of 0 dBm but increases to 233 mW (13.67 dB gain) at an input power of 10 dBm. The polarization sensitivity is
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- 2024
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13. Semiconductor Optical Amplifiers with Wide Gain Bandwidth and Enhanced Polarization Insensitivity Based on Tensile-Strained Quantum Wells
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Hui Tang, Meng Zhang, Changjin Yang, Lei Liang, Li Qin, Yuxin Lei, Peng Jia, Yongyi Chen, Yubing Wang, Yue Song, Cheng Qiu, Yuntao Cao, Dabing Li, and Lijun Wang
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semiconductor optical amplifier ,wide gain bandwidth ,low polarization ,low noise ,optical communication ,Chemical technology ,TP1-1185 - Abstract
The paper presents a wide-bandwidth, low-polarization semiconductor optical amplifier (SOA) based on strained quantum wells. By enhancing the material gain of quantum wells for TM modes, we have extended the gain bandwidth of the SOA while reducing its polarization sensitivity. Through a combination of tilted waveguide design and cavity surface optical thin film design, we have effectively reduced the cavity surface reflectance of the SOA, thus decreasing device transmission losses and noise figure. At a wavelength of 1550 nm and a drive current of 1.4 A, the output power can reach 188 mW, with a small signal gain of 36.4 dB and a 3 dB gain bandwidth of 128 nm. The linewidth broadening is only 1.032 times. The polarization-dependent gain of the SOA is below 1.4 dB, and the noise figure is below 5.5 dB. The device employs only I-line lithography technology, offering simple fabrication processes and low costs yet delivering outstanding and stable performance. The designed SOA achieves wide gain bandwidth, high gain, low polarization sensitivity, low linewidth broadening, and low noise, promising significant applications in the wide-bandwidth optical communication field across the S + C + L bands.
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- 2024
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14. Adjoint Algorithm Design of Selective Mode Reflecting Metastructure for BAL Applications
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Zean Li, Xunyu Zhang, Cheng Qiu, Yingshuai Xu, Zhipeng Zhou, Ziyuan Wei, Yiman Qiao, Yongyi Chen, Yubing Wang, Lei Liang, Yuxin Lei, Yue Song, Peng Jia, Yugang Zeng, Li Qin, Yongqiang Ning, and Lijun Wang
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broad-area laser ,large scale ,mode selection ,adjoint algorithm ,inverse design ,Chemistry ,QD1-999 - Abstract
Broad-area lasers (BALs) have found applications in a variety of crucial fields on account of their high output power and high energy transfer efficiency. However, they suffer from poor spatial beam quality due to multi-mode behavior along the waveguide transverse direction. In this paper, we propose a novel metasurface waveguide structure acting as a transverse mode selective back-reflector for BALs. In order to effectively inverse design such a structure, a digital adjoint algorithm is introduced to adapt the considerably large design area and the high degree of freedom. As a proof of the concept, a device structure with a design area of 40 × 20 μm2 is investigated. The simulation results exhibit high fundamental mode reflection (above 90%), while higher-order transverse mode reflections are suppressed below 0.2%. This is, to our knowledge, the largest device structure designed based on the inverse method. We exploited such a device and the method and further investigated the device’s robustness and feasibility of the inverse method. The results are elaborately discussed.
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- 2024
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15. Marker Density and Models to Improve the Accuracy of Genomic Selection for Growth and Slaughter Traits in Meat Rabbits
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Wenjie Li, Wenqiang Li, Zichen Song, Zihao Gao, Kerui Xie, Yubing Wang, Bo Wang, Jiaqing Hu, Qin Zhang, Chao Ning, Dan Wang, and Xinzhong Fan
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genomic selection ,marker density ,GBLUP models ,low-coverage whole-genome sequencing ,meat rabbits ,Genetics ,QH426-470 - Abstract
The selection and breeding of good meat rabbit breeds are fundamental to their industrial development, and genomic selection (GS) can employ genomic information to make up for the shortcomings of traditional phenotype-based breeding methods. For the practical implementation of GS in meat rabbit breeding, it is necessary to assess different marker densities and GS models. Here, we obtained low-coverage whole-genome sequencing (lcWGS) data from 1515 meat rabbits (including parent herd and half-sibling offspring). The specific objectives were (1) to derive a baseline for heritability estimates and genomic predictions based on randomly selected marker densities and (2) to assess the accuracy of genomic predictions for single- and multiple-trait linear mixed models. We found that a marker density of 50 K can be used as a baseline for heritability estimation and genomic prediction. For GS, the multi-trait genomic best linear unbiased prediction (GBLUP) model results in more accurate predictions for virtually all traits compared to the single-trait model, with improvements greater than 15% for all of them, which may be attributed to the use of information on genetically related traits. In addition, we discovered a positive correlation between the performance of the multi-trait GBLUP and the genetic correlation between the traits. We anticipate that this approach will provide solutions for GS, as well as optimize breeding programs, in meat rabbits.
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- 2024
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16. The effect of environmental factors on precocious puberty in children: a case–control study
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Francis Manyori Bigambo, Dandan Wang, Qing Niu, Mingzhi Zhang, Sabitina Mrisho Mzava, Yubing Wang, and Xu Wang
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Precocious puberty ,Cesarean section ,Secondhand smoke ,Child BMI ,Adequate sleep ,Children ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Recently the prevalence of precocious puberty development is increasing among Chinese children. Proper understanding of the risk factors for precocious puberty in children is pivotal as could help to improve children's health. This study aims to evaluate the effect of environmental factors on precocious puberty in children. Methods We matched the cases and controls by age at the ratio of 1:1 (201 cases and 201 controls) for girls and 1:4 (24 cases and 96 controls) for boys. We used conditional logistic regression to explore the effect of environmental factors on precocious puberty, and a random forest model to identify the most important risk factor. Results In the multivariate regression, cesarean section (OR = 1.99, 95% CI: 1.05, 3.76), child body mass index [BMI] (OR = 1.25, 95% CI: 1.10, 1.43), maternal BMI (OR = 1.13, 95%CI: 1.01, 1.26), and exposure to secondhand smoke several times a month but less than once a week (OR = 4.09, 95%CI: 1.79,9.35), and almost every day (OR = 6.48, 95% CI: 2.14, 19.56) were risk factors for precocious puberty in girls. While maternal height (OR = 0.82, 95% CI: 0.75, 0.88), paternal height (OR = 0.91, 95% CI: 0.85, 0.98), bedtime at night (OR = 0.30, 95% CI: 0.17, 0.51), and night sleep (OR = 0.43, 95% CI: 0.21, 0.86) were protective factors. In boys, only exposure to secondhand smoke several times a month but less than once a week (OR = 7.94, 95% CI: 1.25, 50.33) was a risk factor for precocious puberty. In the random forest model, Child BMI was the most important risk factor for precocious puberty in girls. Conclusions Our findings suggest that environmental factors were associated with precocious puberty in children, particularly in girls.
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- 2023
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17. Option pricing under sub-mixed fractional Brownian motion based on time-varying implied volatility using intelligent algorithms.
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Jingjun Guo, Weiyi Kang, and Yubing Wang
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- 2023
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18. A Spatiotemporal Model for Global Earthquake Prediction Based on Convolutional LSTM.
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Zhongchang Zhang and Yubing Wang
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- 2023
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19. Deep Neural Network-Based Phase-Modulated Continuous-Wave LiDAR.
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Hao Zhang, Yubing Wang, Mingshi Zhang, Yue Song, Cheng Qiu, Yuxin Lei, Peng Jia, Lei Liang, Jianwei Zhang, Li Qin, Yongqiang Ning, and Lijun Wang
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- 2024
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20. Advances in Semiconductor Lasers Based on Parity–Time Symmetry
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Hongbo Sha, Yue Song, Yongyi Chen, Jishun Liu, Mengjie Shi, Zibo Wu, Hao Zhang, Li Qin, Lei Liang, Peng Jia, Cheng Qiu, Yuxin Lei, Yubing Wang, Yongqiang Ning, Guoqing Miao, Jinlong Zhang, and Lijun Wang
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semiconductor lasers ,parity–time (PT) symmetry ,quantum mechanics ,longitudinal modulation in PT-symmetric structures ,transverse modulation ,distributed-feedback laser ,Chemistry ,QD1-999 - Abstract
Semiconductor lasers, characterized by their high efficiency, small size, low weight, rich wavelength options, and direct electrical drive, have found widespread application in many fields, including military defense, medical aesthetics, industrial processing, and aerospace. The mode characteristics of lasers directly affect their output performance, including output power, beam quality, and spectral linewidth. Therefore, semiconductor lasers with high output power and beam quality are at the forefront of international research in semiconductor laser science. The novel parity–time (PT) symmetry mode-control method provides the ability to selectively modulate longitudinal modes to improve the spectral characteristics of lasers. Recently, it has gathered much attention for transverse modulation, enabling the output of fundamental transverse modes and improving the beam quality of lasers. This study begins with the basic principles of PT symmetry and provides a detailed introduction to the technical solutions and recent developments in single-mode semiconductor lasers based on PT symmetry. We categorize the different modulation methods, analyze their structures, and highlight their performance characteristics. Finally, this paper summarizes the research progress in PT-symmetric lasers and provides prospects for future development.
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- 2024
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21. Feasibility of challenging treadmill speed-dependent gait and perturbation-induced balance training in chronic stroke patients with low ambulation ability: a randomized controlled trial
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Jia Hu, Lingjing Jin, Yubing Wang, and Xia Shen
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stroke ,gait ,balance ,perturbation ,treadmill ,velocity ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundTreadmill training shows advantages in the specificity, amount, and intensity of gait and balance practice for the rehabilitation of stroke patients.ObjectiveTo investigate the feasibility and effectiveness of challenging treadmill speed-dependent gait and perturbation-induced balance training in chronic stroke patients with low ambulation ability.MethodsFor this randomized controlled trial (Chinese Clinical Trials.gov registration number ChiCTR-IOR-16009536) with blinded testers, we recruited 33 ambulatory stroke participants with restricted community ambulation capacity and randomly assigned them into two groups: the experimental group with 2 week treadmill speed-dependent gait training combined with 2 week treadmill perturbation-induced balance training (EXP) or the control group with traditional gait and balance training (CON). Various variables were recorded during EXP training, including the rating of perceived exertion, heart rate, causes of pauses, treadmill speed, and perturbation intensity. Outcome measures were examined before training and at 2 and 4 weeks after training. They included gait velocity during five-meter walk test at comfortable and fast speed and reactive balance ability in the compensatory stepping test as primary outcome measures, as well as dynamic balance ability (timed up-and-go test and 5 times sit-to-stand test) and balance confidence as secondary outcome measures.ResultsAll participants completed the study. The treadmill speed and perturbation intensity significantly increased across training sessions in the EXP group, and no adverse effects occurred. The normal and fast gait velocities showed significant time and group interaction effects. They significantly increased after 2 and 4 weeks of training in the EXP group (p 0.05). Likewise, dynamic balance ability measured using the timed up-and-go test at a fast speed significantly improved after 2 and 4 weeks of training in the EXP group (p 0.05), although without a significant time and group interaction effect. Surprisingly, the reactive balance ability did not show improvement after treatment in the EXP group (p > 0.05).ConclusionChallenging treadmill speed-dependent gait and treadmill perturbation-induced balance training is feasible and effective to improve ambulation function in chronic stroke patients with low ambulation ability.
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- 2023
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22. A Design of High-Efficiency: Vertical Accumulation Modulators Based on Silicon Photonics
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Zhipeng Zhou, Zean Li, Cheng Qiu, Yongyi Chen, Yingshuai Xu, Xunyu Zhang, Yiman Qiao, Yubing Wang, Lei Liang, Yuxin Lei, Yue Song, Peng Jia, Yugang Zeng, Li Qin, Yongqiang Ning, and Lijun Wang
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silicon photonics ,plasma dispersion effect ,optical modulator ,modulation efficiency ,loss-efficiency product ,Chemistry ,QD1-999 - Abstract
On-chip optical modulators, which are capable of converting electrical signals into optical signals, constitute the foundational components of photonic devices. Photonics modulators exhibiting high modulation efficiency and low insertion loss are highly sought after in numerous critical applications, such as optical phase steering, optical coherent imaging, and optical computing. This paper introduces a novel accumulation-type vertical modulator structure based on a silicon photonics platform. By incorporating a high-K dielectric layer of ZrO2, we have observed an increase in modulation efficiency while maintaining relatively low levels of modulation loss. Through meticulous study and optimization, the simulation results of the final device structure demonstrate a modulation efficiency of 0.16 V·cm, with a mere efficiency–loss product of 8.24 dB·V.
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- 2023
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23. 184QPS/W 64Mb/mm23D Logic-to-DRAM Hybrid Bonding with Process-Near-Memory Engine for Recommendation System.
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Dimin Niu, Shuangchen Li, Yuhao Wang 0002, Wei Han, Zhe Zhang 0006, Yijin Guan, Tianchan Guan, Fei Sun, Fei Xue, Lide Duan, Yuanwei Fang, Hongzhong Zheng, Xiping Jiang, Song Wang, Fengguo Zuo, Yubing Wang, Bing Yu, Qiwei Ren, and Yuan Xie 0001
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- 2022
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24. Advances in wide-tuning and narrow-linewidth external-cavity diode lasers.
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Qiang Cui, Yu Xin Lei, Yong Yi Chen, Cheng Qiu, Ye Wang, Dexiao Zhang, Lutai Fan, Yue Song, Peng Jia, Lei Liang, Yubing Wang, Li Qin, Yongqiang Ning, and Li Jun Wang
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- 2022
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25. Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease
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Linghong Song, Yubing Wang, Yufei Feng, Hao Peng, Chengyan Wang, Juncang Duan, Kejian Liu, Xihua Shen, Wenyi Gu, Yan Qi, Shan Jin, and Lijuan Pang
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Genetics ,QH426-470 - Abstract
Background. Calcific aortic valve disease (CAVD) is the most common native valve disease. Valvular interstitial cell (VIC) osteogenic differentiation and valvular endothelial cell (VEC) dysfunction are key steps in CAVD progression. Circular RNA (circRNAs) is involved in regulating osteogenic differentiation with mesenchymal cells and is associated with multiple disease progression, but the function of circRNAs in CAVD remains unknown. Here, we aimed to investigate the effect and potential significance of circRNA-miRNA-mRNA networks in CAVD. Methods. Two mRNA datasets, one miRNA dataset, and one circRNA dataset of CAVD downloaded from GEO were used to identify DE-circRNAs, DE-miRNAs, and DE-mRNAs. Based on the online website prediction function, the common mRNAs (FmRNAs) for constructing circRNA-miRNA-mRNA networks were identified. GO and KEGG enrichment analyses were performed on FmRNAs. In addition, hub genes were identified by PPI networks. Based on the expression of each data set, the circRNA-miRNA-hub gene network was constructed by Cytoscape (version 3.6.1). Results. 32 DE-circRNAs, 206 DE-miRNAs, and 2170 DE-mRNAs were identified. Fifty-nine FmRNAs were obtained by intersection. The KEGG pathway analysis of FmRNAs was enriched in pathways in cancer, JAK-STAT signaling pathway, cell cycle, and MAPK signaling pathway. Meanwhile, transcription, nucleolus, and protein homodimerization activity were significantly enriched in GO analysis. Eight hub genes were identified based on the PPI network. Three possible regulatory networks in CAVD disease were obtained based on the biological functions of circRNAs including: hsa_circ_0026817-hsa-miR-211-5p-CACNA1C, hsa_circ_0007215-hsa-miR-1252-5p-MECP2, and hsa_circ_0007215-hsa-miR-1343-3p- RBL1. Conclusion. The present bionformatics analysis suggests the functional effect for the circRNA-miRNA-mRNA network in CAVD pathogenesis and provides new targets for therapeutics.
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- 2023
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26. Optimal Consumption and Investment Problem under 4/2-CIR Stochastic Hybrid Model
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Aiqin Ma, Cuiyun Zhang, and Yubing Wang
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4/2 stochastic volatility ,CIR interest rate ,optimal strategy ,CRRA utility ,HJB equation ,Mathematics ,QA1-939 - Abstract
In this paper, we investigate the optimal consumption and investment problem under the expected utility maximization criterion. It is supposed that the financial market consists of a risky asset and a risk-free asset, and the risky asset prices follow the 4/2 Cox–Ingersoll–Ross (CIR) stochastic hybrid model. The investment objective is to obtain an optimal consumption–investment strategy by maximizing the objective function. The closed-form expression of the optimal consumption–investment strategy is obtained by using optimal control theory and the corresponding Hamilton–Jacobi–Bellman (HJB) equation under the power utility function. In addition, we present a numerical example to illustrate the influence of model parameters on the optimal consumption–investment strategy.
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- 2023
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27. A Review of High-Power Semiconductor Optical Amplifiers in the 1550 nm Band
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Hui Tang, Changjin Yang, Li Qin, Lei Liang, Yuxin Lei, Peng Jia, Yongyi Chen, Yubing Wang, Yue Song, Cheng Qiu, Chuantao Zheng, Xin Li, Dabing Li, and Lijun Wang
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semiconductor optical amplifier ,high power ,low noise ,polarization insensitive ,master oscillator power amplifier ,LiDAR ,Chemical technology ,TP1-1185 - Abstract
The 1550 nm band semiconductor optical amplifier (SOA) has great potential for applications such as optical communication. Its wide-gain bandwidth is helpful in expanding the bandwidth resources of optical communication, thereby increasing total capacity transmitted over the fiber. Its relatively low cost and ease of integration also make it a high-performance amplifier of choice for LiDAR applications. In recent years, with the rapid development of quantum-well (QW) material systems, SOAs have gradually overcome the shortcomings of polarization sensitivity and high noise. The research on quantum-dot (QD) materials has further improved the noise characteristics and transmission loss of SOAs. The design of special waveguide structures—such as plate-coupled optical waveguide amplifiers and tapered amplifiers—has also increased the saturation output power of SOAs. The maximum gain of the SOA has been reported to be more than 21 dB. The maximum saturation output power has been reported to be more than 34.7 dBm. The maximum 3 dB gain bandwidth has been reported to be more than 120 nm, the lowest noise figure has been reported to be less than 4 dB, and the lowest polarization-dependent gain has been reported to be 0.1 dB. This study focuses on the improvement and enhancement of the main performance parameters of high-power SOAs in the 1550 nm band and introduces the performance parameters, the research progress of high-power SOAs in the 1550 nm band, and the development and application status of SOAs. Finally, the development trends and prospects of high-power SOAs in the 1550 nm band are summarized.
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- 2023
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28. Predicting Organic Matter Content, Total Nitrogen and pH Value of Lime Concretion Black Soil Based on Visible and Near Infrared Spectroscopy
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Yubing Wang, Huang, He, and Chen, Xiangyu
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- 2021
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29. Functional analysis of the short splicing variant encoded by CHI3L1/YKL-40 in glioblastoma
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Mengqi Shi, Qianyun Ge, Xinrong Wang, Wenbin Diao, Ben Yang, Sipeng Sun, Guohui Wang, Tian Liu, Andrew Man-Lok Chan, Zhiqin Gao, Yi Wang, and Yubing Wang
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YKL-40 ,splicing variant ,glioblastoma ,transcriptomes ,protein secretion ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The glycoprotein YKL-40 has been well studied as a serum biomarker of prognosis and disease status in glioblastoma. YKL-40 is a chitinase-like protein with defective chitinase activity that plays an important role in promoting cell proliferation, migration, and metastasis in glioblastoma multiforme (GBM). The short variant (SV) of YKL-40, generated by an alternative splicing event that splices out exon 8, was reported in the early developing human musculoskeletal system, although its role in GBM is still unknown. Our results showed that individual glioblastoma cell lines displayed increased expression of the short variant of YKL-40 after low serum treatment. In addition, unlike the full-length (FL) version, which was localized to all cell compartments, the short isoform could not be secreted and was localized only to the cytoplasm. Functionally, FL YKL-40 promoted cell proliferation and migration, whereas SV YKL-40 suppressed them. Transcriptome analysis revealed that these opposing roles of the two isoforms may be modulated by differentially regulating several oncogenic-related pathways, including p53, the G2/M checkpoint, and MYC-related signaling. This study may provide new ideas for the development of targeted anti-YKL-40 therapy in GBM treatment.
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- 2022
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30. Tumour‐derived substrate‐adherent cells promote neuroblastoma survival through secreted trophic factors
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Jing Li, Yubing Wang, Lisha Li, Penelope M.‐Y. Or, Chi Wai Wong, Tian Liu, Wayne L.H. Ho, and Andrew M. Chan
- Subjects
ALK ,neuroblastoma ,STAT3 ,substrate‐adherent cells ,tumour microenvironment ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Neuroblastoma (NB) is the most common extracranial solid tumour in children. NB is highly heterogeneous and is comprised of a mixture of neuroblastic cancer cells and stromal cells. We previously reported that N‐type cells (neuroblastic cells) and S‐type cells (substrate‐adherent cells) in the SK‐N‐SH cell line shared almost identical genetic backgrounds. Sublines of N‐ and S‐type cells were isolated from an early passage (P35) of SK‐N‐SH. Sequencing analysis revealed that all sublines harboured the anaplastic lymphoma kinase (ALK) F1174L mutation, indicating that they were tumour derived. Surprisingly, over 74% resembled S‐type cells. In coculture experiments, S‐type cells protected N‐type cells from apoptosis induced by the oncogenic ALK inhibitor TAE684. Western blotting analyses showed that ALK, protein kinase A (AKT) and STAT3 signalling were stimulated in the cocultures. Furthermore, the conditioned medium from S‐type cells activated these downstream signalling molecules in the N‐type cells. The activation of STAT3 in the N‐type cells was ALK‐independent, while AKT was regulated by the ALK activation status. To identify the responsible soluble factors, we used a combination of transcriptomic and proteomic analysis and found that plasminogen activator inhibitor 1, secreted protein acidic and cysteine rich, periostin and galectin‐1 were potential mediators of STAT3 signalling. The addition of recombinant proteins to the tumour cells treated with the ALK inhibitor partially enhanced cell viability. Overall, the tumour‐derived S‐type cells prevented apoptosis in the N‐type cells via ALK‐independent STAT3 activation triggered by secreted factors. The inhibition of these factors in combination with ALK inhibition could provide a new direction for targeted therapies to treat high‐risk NB.
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- 2021
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31. A 1596GB/s 48Gb Embedded DRAM 384-Core SoC with Hybrid Bonding Integration.
- Author
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Xiping Jiang, Fengguo Zuo, Song Wang, Xiaofeng Zhou, Bing Yu, Yubing Wang, Qi Liu, Ming Liu, Yi Kang, and Qiwei Ren
- Published
- 2021
- Full Text
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32. Research Progress of Horizontal Cavity Surface-Emitting Laser
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Jishun Liu, Yue Song, Yongyi Chen, Li Qin, Lei Liang, Shen Niu, Ye Wang, Peng Jia, Cheng Qiu, Yuxin Lei, Yubing Wang, Yongqiang Ning, and Lijun Wang
- Subjects
surface emission laser ,SE-DFB laser ,photonic crystal ,second order diffraction ,high power semiconductor laser ,Chemical technology ,TP1-1185 - Abstract
The horizontal cavity surface emitting laser (HCSEL) boasts excellent properties, including high power, high beam quality, and ease of packaging and integration. It fundamentally resolves the problem of the large divergence angle in traditional edge-emitting semiconductor lasers, making it a feasible scheme for realizing high-power, small-divergence-angle, and high-beam-quality semiconductor lasers. Here, we introduce the technical scheme and review the development status of HCSELs. Firstly, we thoroughly analyze the structure, working principles, and performance characteristics of HCSELs according to different structures, such as the structural characteristics and key technologies. Additionally, we describe their optical properties. Finally, we analyze and discuss potential development prospects and challenges for HCSELs.
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- 2023
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33. Phase-Modulated Continuous-Wave Coherent Ranging Method and Anti-Interference Evaluation
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Mingshi Zhang, Yubing Wang, Qian Hu, Shuhua Zhao, Lei Liang, Yongyi Chen, Yuxin Lei, Cheng Qiu, Peng Jia, Yue Song, Li Qin, and Lijun Wang
- Subjects
LiDAR ,PhMCW ,anti-interference capability ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Light detection and ranging (LiDAR) has been applied in many areas because of its excellent performance. An easily achievable, cost-effective, and high-performance ranging method is a major challenge of LiDAR. Meanwhile, with the increasing applications of LiDAR, numerous LiDARs can be made to operate simultaneously, and potential interference is inevitable. Therefore, immunity against interference is paramount in LiDAR systems. In this paper, we demonstrated a ranging method referred to as phase-modulated continuous-wave (PhMCW). A detection range of 50 m and a ranging error of 2.2 cm are achieved. A one-dimensional scanning LiDAR system that is capable of detecting targets at 28 m is built, demonstrating the validation of the PhMCW method. Moreover, we propose a quantitative method for evaluating the anti-interference capability of lidar systems. The p-values of the Ljung–Box test were 0.0589 and 0.6327 for ToF and coherent LiDAR interferences, respectively, indicating that the PhMCW system is immune to interference. The proposed method can be applied to all types of LiDAR systems, regardless of the ranging method or beam-steering technique used.
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- 2023
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34. Adaptive output feedback control for a class of non-affine nonlinear systems.
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Yubing Wang, Peng Bai, Xiaolong Liang, and Jiaqiang Zhang
- Published
- 2021
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35. Anomaly information detection and fault tolerance control method for CAN-FD bus network.
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Aoran Wang, Jie Fang, Yinan Xu 0002, Yihu Xu, Yubing Wang, Yujing Wu, and Jin-Gyun Chung
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- 2022
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36. PNA-Modified Liposomes Improve the Delivery Efficacy of CAPIRI for the Synergistic Treatment of Colorectal Cancer
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Wenbin Diao, Ben Yang, Sipeng Sun, Anping Wang, Rongguan Kou, Qianyun Ge, Mengqi Shi, Bo Lian, Tongyi Sun, Jingliang Wu, Jingkun Bai, Meihua Qu, Yubing Wang, Wenjing Yu, and Zhiqin Gao
- Subjects
colorectal cancer ,liposomes ,peanut agglutinin ,combination therapy ,irinotecan ,capecitabine ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Tumor-associated antigen mucin 1 (MUC1) is highly expressed in colorectal cancer and is positively correlated with advanced stage at diagnosis and poor patient outcomes. The combination of irinotecan and capecitabine is standard chemotherapy for metastatic colorectal cancer and is known as XELIRI or CAPIRI, which significantly prolongs the progression-free survival and overall survival of colorectal cancer patients compared to a single drug alone. We previously reported that peanut agglutinin (PNA)-conjugated liposomes showed enhanced drug delivery efficiency to MUC1-positive liver cancer cells. In this study, we prepared irinotecan hydrochloride (IRI) and capecitabine (CAP)-coloaded liposomes modified by peanut agglutinin (IRI/CAP-PNA-Lips) to target MUC1-positive colorectal cancer. The results showed that IRI/CAP-PNA-Lips showed an enhanced ability to target MUC1-positive colorectal cancer cells compared to unmodified liposomes. Treatment with IRI/CAP-PNA-Lips also increased the proportion of apoptotic cells and inhibited the proliferation of colorectal cancer cells. The targeting specificity for tumor cells and the antitumor effects of PNA-modified liposomes were significantly increased in tumor-bearing mice with no severe cytotoxicity to normal tissues. These results suggest that PNA-modified liposomes could provide a new delivery strategy for the synergistic treatment of colorectal cancer with clinical chemotherapeutic agents.
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- 2022
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37. Resilience Among Parents of Adolescents With Type 1 Diabetes: Associated With Fewer Parental Depressive Symptoms and Better Pediatric Glycemic Control
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Dan Luo, Yubing Wang, Xue Cai, Ruxue Li, Mingzi Li, Haiyan Liu, and Jingjing Xu
- Subjects
resilience ,depressive symptoms ,diabetes distress ,parents ,diabetes mellitus Type 1 ,Psychiatry ,RC435-571 - Abstract
BackgroundAlthough pediatric resilience plays a significant role in resisting negative moods and improving glycaemic control, little research exists regarding resilience among the parents of adolescents with Type 1 diabetes.ObjectiveTo investigate parental resilience's correlations with parental depressive symptoms, parental diabetes distress, and pediatric glycaemic control.MethodsThis cross-sectional study recruited adolescents with Type 1 diabetes and their parents from two hospitals. The parents completed questionnaires. The 10-item Connor-Davidson Resilience Scale measured resilience; the Problem Areas in Diabetes Survey-Parent Revised version measured diabetes distress; the Patient Health Questionnaire-9 measured depressive symptoms. Standard glycated hemoglobin tests were performed on the adolescents.ResultsData from 224 parents (77.2% female, Mage = 39.88 [SD = 5.02], age range = 30–56 years) of adolescents (50.9% boys, Mage = 13.54 years [SD = 2.48], age range = 10–19 years) were available. More than half (52.7%) of parents exceeded the criterion score for high resilience. Parental resilience was significantly negatively associated with parental depressive symptoms and diabetes distress. Parents from the high-resilience group reported fewer depressive symptoms than those from the low-resilience group. In multivariate regressions, greater parental resilience is consistently related to better pediatric glycaemic control beyond parental psychological risk factors.ConclusionsThis study highlights the importance of parental resilience for parental mental health and glycaemic control among adolescents with Type 1 diabetes. The appropriate resilience support programme might be developed for parents, especially for those existing depressive symptoms and diabetes distress.
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- 2022
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38. Study on Benzylamine(BZA) and Aminoethylpiperazine(AEP) Mixed Absorbent on Ship-Based Carbon Capture
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Xudong Mao, Hao Chen, Yubing Wang, Xinbo Zhu, and Guohua Yang
- Subjects
ship ,carbon capture ,absorbent ,benzylamine ,aminoethylpiperazine ,Organic chemistry ,QD241-441 - Abstract
To find suitable absorbents for ship-based carbon capture, the absorption and desorption properties of four mixed aqueous amines based on BZA were investigated, and the results indicated that BZA-AEP had the best absorption and desorption performance. Then, the absorption and desorption properties of different mole ratios of BZA-AEP were tested. The results showed that the average CO2 absorption rate had the highest value at the mole ratio of BZA to AEP of three. The average CO2 desorption rate had the maximum value at the mole ratio of BZA to AEP of one. Three fitted models of the absorption and desorption performance of BZA-AEP based on the test data were obtained. The p-values of all three models were less than 0.0001. Considering the performance and material cost, the BZA-AEP mole ratio of 1.5 is more appropriate for ship carbon capture. Compared with MEA, the average CO2 absorption rate increased by 48%, the CO2 desorption capacity increased by 120%, and the average CO2 desorption rate increased by 161%.
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- 2023
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- View/download PDF
39. Research Progress of Monolithic Integrated DFB Laser Arrays for Optical Communication
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Shen Niu, Yue Song, Ligong Zhang, Yongyi Chen, Lei Liang, Ye Wang, Li Qin, Peng Jia, Cheng Qiu, Yuxin Lei, Yubing Wang, Yongqiang Ning, and Lijun Wang
- Subjects
DFB laser array ,multi-wavelength ,series and parallel ,optical communication ,photonic integrated circuits ,Crystallography ,QD901-999 - Abstract
Photonic integrated circuits (PICs) play a leading role in modern information and communications technology. Among the core devices in PICs is the distributed feedback (DFB) multi-wavelength semiconductor laser array. Multi-wavelength semiconductor laser arrays can be integrated on a single chip and have the advantages of high stability, good single-mode performance, and narrow line width. The wavelength tuning range has been expanded through the design of the DFB laser array, which is an ideal light source for wavelength-division multiplexing systems. The preparation of DFB laser arrays with a large number of channels, ease of mass production, and accurate emission wavelengths has become an important field of research. The connection methods of lasers in DFB laser arrays are introduced systematically and the current methods of manufacturing multi-wavelength DFB laser arrays covering the perspective of technical principles, technical advantages and disadvantages, main research progress, and research status are summarized.
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- 2022
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- View/download PDF
40. Optimal Configuration Analysis of AOA Localization and Optimal Heading Angles Generation Method for UAV Swarms.
- Author
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Weijia Wang 0004, Peng Bai, Yu Zhou, Xiaolong Liang, and Yubing Wang
- Published
- 2019
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41. Reconnaissance Mission Conducted by UAV Swarms Based on Distributed PSO Path Planning Algorithms.
- Author
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Yubing Wang, Peng Bai, Xiaolong Liang, Weijia Wang 0004, Jiaqiang Zhang, and Qixi Fu
- Published
- 2019
- Full Text
- View/download PDF
42. Optimal Sensor Deployment and Velocity Configuration With Hybrid TDOA and FDOA Measurements.
- Author
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Weijia Wang 0004, Peng Bai, Yubing Wang, Xiaolong Liang, and Jiaqiang Zhang
- Published
- 2019
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43. Advances in narrow linewidth diode lasers.
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Xingkai Lang, Peng Jia, Yongyi Chen, Li Qin, Lei Liang, Chao Chen, Yubing Wang, Xiaonan Shan, Yongqiang Ning, and Lijun Wang
- Published
- 2019
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44. Modulation Characteristics of High-Speed Transistor Lasers
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Lutai Fan, Peng Jia, Yuxin Lei, Qiang Cui, Yongyi Chen, Li Qin, Lei Liang, Cheng Qiu, Yue Song, Yubing Wang, Yongqiang Ning, and Lijun Wang
- Subjects
transistor laser ,bandwidth ,modulation characteristics ,intracavity photon-assisted tunneling ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The spontaneous emission recombination lifetime of carriers in the active region of transistor lasers (TLs) is significantly reduced due to the accelerated carrier transport in the base region under the collector bias. Thus, it has the potential for use as a high-speed optical fiber communication light source. The unique three-electrode structure of TL notably enriches the modulation methods of the light source. As an important parameter to measure the data transfer rate, the modulation bandwidth of TL has been studied extensively. This paper briefly analyzes the inherent characteristics and advantages of TL and then discusses the progress in the research on TL modulation characteristics. Currently, the common methods to increase the modulation rate include optimizing the device structure, intracavity photon-assisted tunneling, and adding external auxiliary circuits. Through these techniques, single quantum well GaAs- based TL can achieve error-free transmission of 22 Gb/s, and simulation data show that for InP- based TL, this can reach 40 Gb/s. Finally, the challenges faced by TL in the area of optical fiber communication are elucidated.
- Published
- 2022
- Full Text
- View/download PDF
45. Development of a High-Power Surface Grating Tunable Distributed-Feedback Bragg Semiconductor Laser Based on Gain-Coupling Effect
- Author
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Xin Li, Lei Liang, Li Qin, Yuxin Lei, Peng Jia, Hui Tang, Changjin Yang, Yongyi Chen, Yubing Wang, Yu Song, Cheng Qiu, Chuantao Zheng, and Lijun Wang
- Subjects
1550 nm ,tunable DFB semiconductor laser ,gain-coupled ,surface grating ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Lasers used for space communication, lidar, and laser detection in space-air-ground integration applications typically use a traditional 1550 nm band tunable distributed-feedback Bragg (DFB) semiconductor laser. This has low output power, complex fabrication process, and high fabrication cost. In this paper, we present a gain-coupled surface grating-based 1550 nm DFB semiconductor laser that can be fabricated without the use of secondary epitaxial growth techniques or high-precision lithography. The periodic electrical injection is used to achieve a gain coupling effect. A tapered waveguide is added to achieve a high output power, and the use of AlGaInAs multiple quantum wells in the active region reduces the linewidth of the laser. A continuous-wave (CW)output power of 401.5 mW is achieved at 20 °C, the maximum side mode rejection ratio exceeds 55 dB, the measured 3 dB linewidth is 18.86 MHz, and the stable single-mode output with a quasi-continuous tuning range of 6.156 nm near 1550 nm from 10 °C to 50 °C. This simple preparation method, low cost, excellent performance, and stable tunable laser have extremely high commercial value in applications such as space communication, lidar, and laser detection.
- Published
- 2022
- Full Text
- View/download PDF
46. Advances in silicon-based, integrated tunable semiconductor lasers
- Author
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Changjin Yang, Lei Liang, Li Qin, Hui Tang, Yuxin Lei, Peng Jia, Yongyi Chen, Yubing Wang, Yu Song, Cheng Qiu, Chuantao Zheng, Huan Zhao, Xin Li, Dabing Li, and Lijun Wang
- Subjects
Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Biotechnology - Abstract
Tunable semiconductor lasers have many important applications such as wavelength division multiplexing, light detection and ranging, and gas detection. The increased interest in silicon photonics has led to the rapid development of miniaturized on-chip tunable semiconductor lasers. However, silicon has poor light-emitting properties. Therefore, realizing high-performance tunable semiconductor lasers requires the integration of light sources with silicon. In this study, we review silicon-based light source integration methods and the development of silicon-based integrated tunable semiconductor lasers. Considering that narrow-linewidth performance greatly expands the applications of tunable semiconductor lasers, methods for reducing the linewidth of tunable lasers are summarized. Finally, the development trends and prospects for silicon-based integrated light sources and silicon-based integrated tunable lasers are analyzed and discussed.
- Published
- 2023
47. Advances in the Applications of Mucin 1 in Cancer Therapy
- Author
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Ben Yang, Hanyue Li, Fei Wang, Changjun Zuo, Yicheng Qi, Tiantian Song, Sipeng Sun, Rongguan Kou, Anping Wang, Hui Wang, Mengqi Shi, Wenjing Yu, Yubing Wang, and Zhiqin Gao
- Subjects
Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,General Materials Science ,Bioengineering - Abstract
Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation. Mucin 1 is weakly O-glycosylated in tumor cells, the core site is exposed, and it is widely distributed on the surface of tumor cells, making it an important tumor marker. Mucin 1 has a wide range of applications in tumor diagnosis, tumor drug targeted delivery, and immunodeficiency therapy. Animal studies and clinical studies suggest that mucin 1 can be used as a target in tumor-targeted therapy. This review covers our current summary of the structure and function of mucin 1, reveals its expression in human tumors, focuses on mucin 1-based targeted therapy regimens, and summarizes the research progress of mucin 1 in targeted tumor therapy.
- Published
- 2023
48. Soil Organic Carbon Prediction Using Vis-NIR Spectroscopy with a Large Dataset.
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Yang Shi, Rujing Wang, and Yubing Wang
- Published
- 2017
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49. Neural Adaptive Dynamic Surface Control of Nonlinear Systems with Partially Constrained Tracking Errors and Input Saturation.
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Hairong Dong 0001, Xiaoyu Wang, Shigen Gao, and Yubing Wang
- Published
- 2017
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50. Enhanced targeted delivery of adenine to hepatocellular carcinoma using glycyrrhetinic acid-functionalized nanoparticles in vivo and in vitro
- Author
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Fei Wu, Hantao Xue, Xiaocheng Li, Wenbin Diao, Bin Jiang, Weiyu Wang, Wenjing Yu, Jingkun Bai, Yi Wang, Bo Lian, Weiguo Feng, Tongyi Sun, Meihua Qu, Chunling Zhao, Yubing Wang, Jingliang Wu, and Zhiqin Gao
- Subjects
Hepatocellular carcinoma ,Nanoparticles ,Targeted delivery ,Glycyrrhetinic acid ,Adenine ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection and liver transplantation, with chemotherapy as a significant synergistic option. Adenine (Ade), a nucleobase, exhibits antitumor effects by blocking human hepatic carcinoma cells in S phase and inhibiting tumor cell proliferation. However, its use is limited owing to its low solubility, poor targeting ability, and nephrotoxicity. Therefore, liver-targeting drug delivery systems have attracted considerable attention for the treatment of HCC. In this study, we explored the liver-targeting efficacy and antitumor effect of adenine-loaded glycyrrhetinic acid-modified hyaluronic acid (Ade/GA-HA) nanoparticles in vitro and in vivo. The GA-HA nanoparticles possessed obvious targeting specificity toward liver cancer cells, which was mainly achieved by the specific binding of the GA ligand to the GA receptor that was highly expressed on the liver cell membrane. In vitro and in vivo results showed that Ade/GA-HA nanoparticles could inhibit liver cancer cell proliferation and migration, promote apoptosis, and significantly inhibit the growth of tumor tissues. Altogether, this study is the first to successfully demonstrate that the targeting activity and antitumor effect of Ade against HCC are enhanced by using GA-HA nanoparticles in vitro and in vivo.
- Published
- 2020
- Full Text
- View/download PDF
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