353 results on '"Yue, Wyatt W."'
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2. Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
3. Architecture and regulation of filamentous human cystathionine beta-synthase
4. Novel homozygous variants in PRORP expand the genotypic spectrum of combined oxidative phosphorylation deficiency 54
5. Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors
6. Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase
7. Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
8. Snapshots of actin and tubulin folding inside the TRiC chaperonin
9. The complex machinery of human cobalamin metabolism
10. The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency
11. Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency
12. Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency
13. Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum
14. Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
15. Contributors
16. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases
17. Nbeal2 interacts with Dock7, Sec16a, and Vac14
18. Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
19. Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release
20. Architecture and regulation of filamentous human cystathionine beta-synthase
21. The Role of Protein Structural Analysis in the Next Generation Sequencing Era
22. Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation
23. Novel homozygous variants in PRORPexpand the genotypic spectrum of combined oxidative phosphorylation deficiency 54
24. 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
25. Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
26. Arginine does not rescue p.Q188R mutation deleterious effect in classic galactosemia
27. NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
28. Carnosine metabolism in diabetes is altered by reactive metabolites
29. Expanding the HPSE2 Genotypic Spectrum in Urofacial Syndrome, A Disease Featuring a Peripheral Neuropathy of the Urinary Bladder
30. FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in Drosophila S2 Cells
31. Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening
32. NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy.
33. Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis
34. Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
35. Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations
36. Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk
37. Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
38. A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency
39. Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design
40. Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies
41. Leri’s pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis
42. Functional Characterization and Categorization of Missense Mutations that Cause Methylmalonyl-CoA Mutase (MUT) Deficiency
43. Structure and activation mechanism of the human liver-type glutaminase GLS2
44. Structural biochemistry coming of age in the study of genetic metabolic disorders
45. Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase
46. Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain
47. Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease
48. A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks
49. Structural basis of fumarate hydratase deficiency
50. High-throughput structural biology of metabolic enzymes and its impact on human diseases
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