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24 results on '"Yue, Yale"'

7. Self‐Oxygenated Biomimetic Nanozyme for Tumor Catalytic Immunotherapy.

Author

Zhang, Baohua, Yuan, Ye, Xin, Qi, Wang, Shuyu, Feng, Yiming, Yan, Xiyun, Fan, Tianli, Jiang, Bing, and Yue, Yale

Subjects
GLUCOSE oxidase, BIOMIMETICS, BACTERIAL cell walls, SYNTHETIC enzymes, TUMOR growth
Abstract

The treatment of solid tumors remains a significant challenge due to the complex, immunosuppressive tumor microenvironment (TME). This manuscript introduces the self‐oxygenated biomimetic nanozyme system, SS‐MSN@Au‐BOM, which innovatively combines catalytic therapy with immunotherapy to modulate the TME for enhanced therapeutic efficacy. Employing mesoporous silicon nanoparticles doped with disulfide bonds, the system integrates gold nanozymes that exhibit glucose oxidase (GOx)‐like and peroxidase (POD)‐like activities, along with a catalase (CAT) function derived from bacterial outer membrane (BOM) coatings. SS‐MSN@Au‐BOM significantly disrupted tumor growth by catalyzing endogenous hydrogen peroxide to generate cytotoxic ROS and essential oxygen, enhancing intratumoral ROS levels while alleviating hypoxia. This catalytic action facilitates immunogenic cell death, enhances dendritic cell maturation, and T‐cell activation. Notably, the system shows excellent biocompatibility, effective tumor targeting, and prolonged systemic circulation. SS‐MSN@Au‐BOM offers a dual‐functional approach that effectively disrupts the TME and promotes robust antitumor immunity. This study paves the way for further clinical investigation and the development of enzyme‐based therapeutics, potentially transforming the landscape of cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2025
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10. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity

Author

Liu, Guangna, primary, Ma, Nana, additional, Cheng, Keman, additional, Feng, Qingqing, additional, Ma, Xiaotu, additional, Yue, Yale, additional, Li, Yao, additional, Zhang, Tianjiao, additional, Gao, Xiaoyu, additional, Liang, Jie, additional, Zhang, Lizhuo, additional, Wang, Xinwei, additional, Ren, Zhenhua, additional, Fu, Yang-Xin, additional, Zhao, Xiao, additional, and Nie, Guangjun, additional

Published
2023
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12. Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis (Adv. Mater. 17/2023)

Author

Li, Fenfen, primary, Zhao, Ying, additional, Cheng, Zhaoxia, additional, Wang, Yazhou, additional, Yue, Yale, additional, Cheng, Xiaoyu, additional, Sun, Jingyi, additional, Atabakhshi‐Kashi, Mona, additional, Yao, Jundong, additional, Dou, Jianping, additional, Yu, Jie, additional, Zhang, Xiuping, additional, Qi, Yingqiu, additional, Li, Xiaotian, additional, Qi, Xiaolong, additional, and Nie, Guangjun, additional

Published
2023
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13. Normalizing the Immune Macroenvironment via Debulking Surgery to Strengthen Tumor Nanovaccine Efficacy and Eliminate Metastasis

Author

Ma, Nana, primary, Chen, Zhiqiang, additional, Liu, Guangna, additional, Yue, Yale, additional, Li, Yao, additional, Cheng, Keman, additional, Ma, Xiaotu, additional, Feng, Qingqing, additional, Liang, Jie, additional, Zhang, Tianjiao, additional, Gao, Xiaoyu, additional, Wang, Xinwei, additional, Guo, Xinjing, additional, Zhu, Fei, additional, Nie, Guangjun, additional, and Zhao, Xiao, additional

Published
2022
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14. Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy

Author

Feng, Qingqing, primary, Ma, Xiaotu, additional, Cheng, Keman, additional, Liu, Guangna, additional, Li, Yao, additional, Yue, Yale, additional, Liang, Jie, additional, Zhang, Lizhuo, additional, Zhang, Tianjiao, additional, Wang, Xinwei, additional, Gao, Xiaoyu, additional, Nie, Guangjun, additional, and Zhao, Xiao, additional

Published
2022
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16. Rapid Surface Display of mRNA Antigens by Bacteria‐Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine

Author

Li, Yao, primary, Ma, Xiaotu, additional, Yue, Yale, additional, Zhang, Kaiyue, additional, Cheng, Keman, additional, Feng, Qingqing, additional, Ma, Nana, additional, Liang, Jie, additional, Zhang, Tianjiao, additional, Zhang, Lizhuo, additional, Chen, Zhiqiang, additional, Wang, Xinwei, additional, Ren, Lei, additional, Zhao, Xiao, additional, and Nie, Guangjun, additional

Published
2022
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18. Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post‐Photothermal Therapy

Author

Li, Yao, primary, Zhang, Kaiyue, additional, Wu, Yao, additional, Yue, Yale, additional, Cheng, Keman, additional, Feng, Qingqing, additional, Ma, Xiaotu, additional, Liang, Jie, additional, Ma, Nana, additional, Liu, Guangna, additional, Nie, Guangjun, additional, Ren, Lei, additional, and Zhao, Xiao, additional

Published
2022
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24. Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells

Author

Liang, Jie, Cheng, Keman, Li, Yao, Xu, Jiaqi, Chen, Yiwei, Ma, Nana, Feng, Qingqing, Zhu, Fei, Ma, Xiaotu, Zhang, Tianjiao, Yue, Yale, Liu, Guangna, Guo, Xinjing, Chen, Zhiqiang, Wang, Xinwei, Zhao, Ruifang, Zhao, Ying, Shi, Jian, Zhao, Xiao, and Nie, Guangjun

Abstract

Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen, thus efficiently facilitating antitumor adaptive immunity. Bacteria-derived outer membrane vesicles (OMVs) are an excellent candidate due to their abundance of pathogen associated molecular patterns. However, during the uptake of OMVs by dendritic cells (DCs), the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage, a phenomenon we refer to as “maturation-induced uptake obstruction” (MUO). Herein we decorated OMV with the DC-targeting αDEC205 antibody (OMV-DEC), which endowed the nanovaccine with an uptake mechanism termed as “not restricted to maturation via antibody modifying” (Normandy), thereby overcoming the MUO phenomenon. We also proved the applicability of this nanovaccine in identifying the human tumor neoantigens through rapid antigen display. In summary, this engineered OMV represents a powerful nanocarrier for personalized cancer vaccines, and this antibody modification strategy provides a reference to remodel the DC uptake pattern in nanocarrier design.

Published
2021
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