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BackgroundWith the shift in modern lifestyles, the relationship between physical activity (PA) and health has emerged as a significant concern in global public health. A sedentary lifestyle poses a substantial threat to cardiovascular health, particularly through the development of atherosclerosis, the primary pathological basis of cardiovascular disease (CVD) and a condition influenced by various lifestyle factors. The atherogenic index of plasma (AIP), a critical indicator for predicting cardiovascular disease risk, assesses an individual’s risk of atherosclerosis by reflecting the ratio of high-density lipoprotein cholesterol (HDL-C) to triglycerides (TG). Despite the recognized importance of PA, the impact of various physical activity patterns on AIP remains unclear.MethodsThis study utilized the National Health and Nutrition Examination Survey (NHANES) database from the United States. PA was assessed via a questionnaire, and participants were categorized into four groups: inactive, insufficiently active, weekend warriors (WW), and regularly active (RA). The AIP was calculated via the ratio of HDL-C to TG, with covariates such as age, sex, race, and body mass index controlled. Multivariate regression analysis served as the primary analytical method.ResultsThis study included a total of 24,504 participants. After adjusting for all potential covariates, RA (β=-0.044, P

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of clinical practice in China, and has accumulated a wealth of medical theories and treatment formulas, which has unique advantages in the prevention and treatment of malignant diseases. Traditional Chinese medicine may reduce the arrhythmic toxicity caused by chemotherapy without affecting the anti-cancer effect. This paper mainly discussed the types and pathogenesis of secondary chemotherapeutic drug-induced arrhythmia (CDIA), and summarized the studies on Chinese medicine compounds, Chinese medicine Combination Formula and Chinese medicine injection that may be beneficial in intervention with secondary CDIA including atrial fibrillation, ventricular arrhythmia and sinus bradycardia, in order to provide reference for clinical prevention and treatment of chemotherapy-induced arrhythmias.

BackgroundPancreatic cancer (PC) is one of the most lethal malignancies of the digestive system and is expected to be the second leading cause of cancer-related death in the United States by 2030. A growing body of evidence suggests that the gut microbiota (GM) is intimately involved in the clinical diagnosis, oncogenic mechanism and treatment of PC. However, no bibliometric analysis of PC and GM has been reported.MethodsThe literature on PC and GM was retrieved from the Web of Science Core Collection (WoSCC) database for the period from January 1, 2004 to April 25, 2023. Microsoft Excel 2021, CiteSpace, VOSviewer, Scimago Graphica, Graphpad Prism, Origin, the R package “bibliometrics” and the bibliometric online analysis program were used to visualize the publishing trends and hot spots in this field.ResultsA total of 1,449 articles were included, including 918 articles and 531 reviews. Publishing had grown rapidly since 2017, with the 2023 expected to publish 268 articles. Unsurprisingly, the United States ranked highest in terms of number of literatures, H index and average citations. The University of California System was the most active institution, but Harvard University tended to be cited the most on average. The three most influential researchers were Robert M. Hoffman, Zhao Minglei, and Zhang Yong. Cancers had published the most papers, while Nature was the most cited journal. Keyword analysis and theme analysis indicated that “tumor microenvironment,” “gemcitabine-resistance,” “ductal adenocarcinoma,” “gut microbiota” and “diagnosis” will be the hotspots and frontiers of research in the future.ConclusionIn summary, the field is receiving increasing attention. We found that future hotspots of PC/GM research may focus on the mechanism of oncogenesis, flora combination therapy and the exploitation of new predictive biomarkers, which provides effective suggestions and new insights for scholars.