1. Novel insight into the genetic signatures of altitude adaptation related body composition in Tibetans
- Author
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Xuguang Li, Shilin Xu, Xuemei Li, Yuhe Wang, Yemeng Sheng, Hengxun Zhang, Wei Yang, Dongya Yuan, Tianbo Jin, and Xue He
- Subjects
GWAS ,high altitude adaptation ,body compositions ,Tibetan college students ,EPAS1 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe Tibetan population residing in high-altitude (HA) regions has adapted to extreme hypoxic environments. However, there is limited understanding of the genetic basis of body compositions in Tibetan population adapted to HA.MethodsWe performed a genome-wide association study (GWAS) to identify genetic variants associated with HA and HA-related body composition traits. A total of 755,731 single nucleotide polymorphisms (SNPs) were genotyped using the precision medicine diversity array from 996 Tibetan college students. T-tests and Pearson correlation analysis were used to estimate the association between body compositions and altitude. The mixed linear regression identified the SNPs significantly associated with HA and HA-related body compositions. LASSO regression was used to screen for important SNPs in HA and body compositions.ResultsSignificant differences were observed in lean body mass (LBW), muscle mass (MM), total body water (TBW), standard weight (SBW), basal metabolic rate (BMR), total protein (TP), and total inorganic salt (Is) in different altitudes stratification. We identified three SNPs in EPAS1 (rs1562453, rs7589621 and rs7583392) that were significantly associated with HA (p
- Published
- 2024
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