31 results on '"Yuji Kumakura"'
Search Results
2. New Eddy Current Probe for Vibration Signal Suppression
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Yuji Kumakura, Daigo Kosaka, Fumio Kojima, and Hiroyuki Yamasaki
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Materials science ,Acoustics ,Phase (waves) ,Signal ,Displacement (vector) ,Electronic, Optical and Magnetic Materials ,law.invention ,Vibration ,Amplitude ,Electromagnetic coil ,law ,Eddy-current testing ,Eddy current ,Electrical and Electronic Engineering - Abstract
This paper proposes a new probe for suppressing the vibration component from the detection signal in eddy current testing. The work is motivated by the desire to develop a new inspection method that can suppress the effects of vibration generated in the manufacturing process of metal parts such as tubes, rods and wires in order to make the current manufacturing process faster. The novelty of the probe lies in its simultaneous use of self and mutual inductions. The proposed probe uses the different effects of the self and mutual inductions to suppress the vibration component. This paper simplifies the discussion by limiting the dynamic vibration of the test specimen to static displacement. The coil distance between the excitation and detection coils should be adjusted for each test specimen for the most effective suppression of the displacement signal. The simulation and measurement results show that the coil distance in the mutual induction probe can control the phase of the displacement signal. It was confirmed that the amplitude of displacement signals measured by the proposed probe was under 6 % of the amplitude measured by the self-induction probe when the optimal coil distance was used. The results obtained suggest that the proposed probe can suppress the vibration component.
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- 2022
3. Postoperative hemodynamic changes for predicting anastomotic leakage after esophagectomy in patients with esophageal cancer using the FloTrac system
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Keigo Hara, Hideyuki Saito, Hiroaki Honjyo, Makoto Sohda, Yuji Kumakura, Masaru Tobe, Shigeru Saito, Hiroyuki Kuwano, Makoto Sakai, Masafumi Kanemoto, Tatsuya Miyazaki, and Hiroshi Hinohara
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Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Esophageal cancer ,FloTrac system ,Cardiac index ,Hemodynamics ,Anastomotic Leak ,General Biochemistry, Genetics and Molecular Biology ,Sepsis ,Postoperative Complications ,medicine ,Humans ,Aged ,Retrospective Studies ,business.industry ,General Medicine ,Stroke volume ,Middle Aged ,medicine.disease ,Surgery ,Esophagectomy ,Anastomotic leakage ,Prediction of anastomotic leakage ,Female ,business ,Complication - Abstract
Background : Anastomotic leakage after esophagectomy is significantly associated with more severe complications, such as sepsis and mortality. Early prediction for anastomotic leakage is usually difficult and needs to be treated rapidly. In the current study, we investigated the correlation between hemodynamic and several complications after esophagectomy in patients with esophageal cancer, using the FloTrac system. Materials and Methods : Between April 2013 and December 2014, 39 patients with a mean age of 66.6 ± 8.9 years underwent postoperative supervision using the FloTrac sensor / Vigileo monitoring system after curative surgery for esophageal cancer. We retrospectively evaluated the association between the number of aberrant cardiac index (CI) along with stroke volume variability (SVV) values and clinicopathological parameters of postoperative complications in this report. Results : There were significant positive correlations between the number of aberrant values of CI along with SVV and depth of invasion during pathological stage. Concerning major postoperative complications, there was a significant positive correlation between the number of aberrant values of CI and anastomotic leakage. Discussion: The hemodynamic change by employing the FloTrac system could predicts the complication of anastomotic leakage after esophagectomy. Adequate management of hemodynamic stability by utilizing it will reduce the complications of anastomotic leakage. J. Med. Invest. 67 : 240-245, August, 2020.
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- 2020
4. Pathophysiology of Vomiting and Esophageal Perforation in Boerhaave’s Syndrome
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Yuji Kumakura, Hiroshi Saeki, Kengo Kuriyama, Makoto Sohda, Ken Shirabe, Kyoichi Ogata, Takehiko Yokobori, Tomonori Yoshida, Hiroyuki Kuwano, Tatsuya Miyazaki, and Makoto Sakai
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Male ,medicine.medical_specialty ,Muscularis mucosae ,Vomiting ,Physiology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Mediastinal Diseases ,medicine ,Humans ,Abdominal Esophagus ,Retching ,Esophagus ,Aged ,Retrospective Studies ,Aged, 80 and over ,Esophageal Perforation ,Thoracic cavity ,business.industry ,Gastroenterology ,Middle Aged ,Hepatology ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Tears ,Female ,030211 gastroenterology & hepatology ,Esophagoscopy ,medicine.symptom ,business - Abstract
Boerhaave’s syndrome, involving esophagus rupture, is considered a pathological response to vomiting that may occur just before perforation. However, the mechanism of vomiting and occurrence of this disease have not been clearly demonstrated. We identified patients with esophageal perforation between 1995 and 2017 and reviewed endoscopic findings at retching during upper gastrointestinal endoscopy. Finally, we proposed a theory for the underlying pathological mechanism. We retrospectively investigated 10 patients with esophageal perforation between 1995 and 2017. All patients presented after vomiting associated with large volumes of food and alcohol intake. Nine were treated by primary closure of the perforation and drainage of the thoracic cavity, and one was conservatively treated. In all cases, the perforations were longitudinal tears (1–4 cm) and located in the left of the esophagus, just above the gastric cardia. We hypothesize that vomiting occurred by retrograde propagation of gastrointestinal motor contraction from the jejunum to the gastric antrum, followed by prolapse of the gastric fornix mucosal into the esophagus. Subsequent esophageal perforation probably resulted from excessive prolapse due to strong contraction and destruction of the muscularis mucosa of the left side of abdominal esophagus, with longitudinal stretching of the whole left esophageal wall due to traction. We also propose that Boerhaave’s syndrome is defined as “post-emetic esophageal perforation” to ensure broader recognition and more expedient diagnosis and treatment. Remaining conditions without any definite causes may be labeled “idiopathic” or “spontaneous” rupture of the esophagus.
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- 2020
5. Real-world treatment patterns and outcomes in Japanese patients with cervical esophageal cancer
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Kazuchika Ohno, Motomi Nasu, Hidetoshi Matsui, Yoshifumi Baba, Takushi Yasuda, Jun Sakuma, Kenichiro Ikeda, Takashi Maruo, Takumi Okuda, Norihiko Narita, Hisayuki Kato, Taiji Kawasaki, Hiroshi Sato, Kunihiko Tokashiki, Naoki Akisada, Hajime Ishinaga, Ken Akashi, Kenji Okami, Kosuke Murayama, Soichiro Yamamoto, Yuji Kumakura, Kenro Kawada, Akihiro Shiotani, and Takahiro Asakage
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Esophageal Neoplasms ,Japan ,Gastroenterology ,Humans ,Chemoradiotherapy ,Induction Chemotherapy ,Larynx - Abstract
Cervical esophageal cancer (CEC) carries a poor prognosis; however, due to its low incidence, optimal treatment for CEC remains to be established. The purpose of this study was to clarify the current status of treatment of CEC in Japan and obtain evidence for establishing the appropriate treatment method.We asked specialist training facilities accredited by the Japanese Broncho-Esophageal Society to register data on CEC cases that received curative treatment from January 2009 to December 2014, and conducted a retrospective review of the clinical data of 302 cases registered from 27 facilities.In regard to the initial therapy, of the 302 patients, 33 had undergone endoscopic resection, 41 had undergone surgery, 67 had received induction chemotherapy (IC), and 143 had received chemoradiotherapy (CRT). There were no significant differences in the 5-year overall survival rates among the patient groups that had received surgery, IC or CRT as the initial treatment; advanced stage and recurrent nerve invasion were identified as independent poor prognostic factors. Among the patients who had received IC or CRT as laryngeal-preserving surgery was not indicated at the time of the initial diagnosis, the functional laryngeal preservation rate at the end of the observation period was 34.8%.Even in patients with advanced CEC, there is the possibility of preserving the larynx by adopting IC or CRT. However, if the laryngeal function cannot be preserved, there is a risk of complications from aspiration pneumonia, so that the choice of treatment should be made carefully.
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- 2021
6. Multidisciplinary Therapy for Locally Advanced Oesophageal Cancer With Special Reference to Surgical Conversion and Salvage
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Keigo Hara, Hiroaki Honjyo, Makoto Sohda, Makoto Sakai, Naritaka Tanaka, Yuji Kumakura, Tatsuya Miyazaki, Ken Shirabe, and Takehiko Yokobori
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Male ,Cancer Research ,Prognostic factor ,medicine.medical_specialty ,Poor prognosis ,Time Factors ,Multivariate analysis ,Esophageal Neoplasms ,Clinical Decision-Making ,Locally advanced ,Time-to-Treatment ,Risk Factors ,medicine ,Humans ,Neoplasm Invasiveness ,Patient treatment ,Aged ,Neoplasm Staging ,Retrospective Studies ,Salvage Therapy ,business.industry ,Patient Selection ,General surgery ,Cancer ,Chemoradiotherapy, Adjuvant ,General Medicine ,Definitive chemoradiotherapy ,Middle Aged ,medicine.disease ,Neoadjuvant Therapy ,Esophagectomy ,Treatment Outcome ,Oncology ,Female ,Esophageal Squamous Cell Carcinoma ,business ,Chemoradiotherapy - Abstract
Background/aim Unresectable oesophageal cancer with surrounding invasion carries a particularly poor prognosis. The chemoradiotherapy treatment for locally-unresectable oesophageal cancer aims to initially control local invasion before proceeding to the next treatment, and is ideally used with curative intent. The aim of this study was to investigate patient treatment course and survival to determine the best treatment and evaluate surgical intervention for these advanced cancers. Patients and methods A total of 147 patients who were diagnosed with clinical T4b oesophageal cancer were included in this study. Results Forty-three patients had undergone curative resection of the tumour and surrounding invasion at midterm evaluation, 104 patients continued with definitive chemoradiotherapy, and salvage surgery was performed in 21 patients. Multivariate analysis of disease-specific survival showed that response at the midterm evaluation and surgical intervention (conversion surgery + salvage surgery) were significant prognostic factors. Conclusion Surgical intervention was an independent prognostic factor, and operation should be performed in eligible patients after considering the risks and proper timing.
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- 2019
7. Docetaxel, cisplatin, and 5-fluorouracil combination chemoradiotherapy for patients with cervical esophageal cancer: a single-center retrospective study
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Keigo Hara, Makoto Sakai, Ken Shirabe, Hideyuki Saito, Tomonori Yoshida, Shin-ei Noda, Makoto Sohda, Takashi Nakano, Yuji Kumakura, Tatsuya Miyazaki, Kengo Kuriyama, Kazutoshi Murata, Takehiko Yokobori, and Hiroyuki Kuwano
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Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Docetaxel ,Neutropenia ,Toxicology ,Single Center ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Mucositis ,Humans ,Pharmacology (medical) ,Aged ,Retrospective Studies ,Pharmacology ,Chemotherapy ,business.industry ,Chemoradiotherapy ,Middle Aged ,Esophageal cancer ,medicine.disease ,Progression-Free Survival ,Survival Rate ,030104 developmental biology ,Oncology ,Fluorouracil ,030220 oncology & carcinogenesis ,Female ,Radiotherapy, Intensity-Modulated ,Cisplatin ,business ,Follow-Up Studies ,medicine.drug - Abstract
To evaluate the efficacy of docetaxel, cisplatin, and 5-fluorouracil as combination chemoradiotherapy (DCF-RT) for cervical esophageal cancer (CEC), we performed a retrospective analysis of CEC patients treated by DCF-RT at a single institution. We conducted a single-center retrospective study. Twenty-one patients with CEC who underwent DCF-RT between 1999 and 2017 at our institute were included in this study. Chemotherapy consisted of intravenous docetaxel at 50 mg/m2 on day 1, intravenous CDDP at 60 mg/m2 on day 1, and intravenous 5-FU at 600 mg/m2 on days 1–4, repeated every 4 weeks for two cycles. Among the 21 patients, six were irradiated using three-dimensional conformal RT (3D- conformal RT) and 15 were treated using intensity-modulated RT (IMRT) consisting of 60 Gy in 30 fractions. The median follow-up period was 49.6 months (range 4.6–97.6). The overall complete response (CR) and local CR rates were 61.9% and 81.0% for all patients, and 76.9% and 84.6% for patients without hypopharyngeal and/or thoracic esophageal invasion, respectively. The 3-year overall survival (OS), progression-free survival (PFS), and local failure-free survival (LFFS) rates were 79.6, 52.4, and 74.7%, respectively. Grade 3–4 leucopenia developed in 12 patients (70.6%), neutropenia developed in 13 patients (81.2%), and mucositis developed in 2 patients (9.5%). There were no treatment-related deaths. The 3-year OS and LFFS of patients who underwent DCF-RT were higher than those in the previous studies. Although the high rate of myelosuppression requires careful management, DCF-RT is a safe and effective modality for CEC.
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- 2019
8. Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients
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Minoru Fukuchi, Makoto Sakai, Keigo Hara, Yuji Kumakura, Tomonori Yoshida, Hiroyuki Kuwano, Daigo Ozawa, Kengo Kuriyama, Naritaka Tanaka, Shigemasa Suzuki, Tatsuya Miyazaki, Hiroaki Honjyo, Makoto Sohda, and Hideyuki Saito
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Male ,Cancer Research ,medicine.medical_specialty ,Esophageal Neoplasms ,Adjuvant chemotherapy ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Gastroenterology ,Disease-Free Survival ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Carcinoma ,Advanced esophageal cancer ,Humans ,Lymph node ,Aged ,Neoplasm Staging ,Pharmacology ,business.industry ,Esophageal cancer ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Esophagectomy ,medicine.anatomical_structure ,Lymphatic system ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,Esophageal Squamous Cell Carcinoma ,Fluorouracil ,Lymph ,Cisplatin ,Neoplasm Recurrence, Local ,business ,Research Article - Abstract
BACKGROUND/AIM Postoperative chemotherapy is an absolutely imperative treatment for advanced esophageal cancer patients, while preoperative chemotherapy is the standard therapy for clinical stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. The aim of this study was to report the effect of postoperative chemotherapy on survival after esophagectomy due to thoracic esophageal squamous cell carcinoma. PATIENTS AND METHODS One hundred thirteen consecutive patients with esophageal carcinoma who underwent esophagectomy were included. Several regiments were performed at various times. RESULTS Adjuvant chemotherapy brought a significantly superior overall survival (p=0.002), although there was no significant difference in cancer-specific survival (p=0.054) for clinical stage II or stage III esophageal cancer patients. Depth of invasion (p=0.003), number of lymph node metastases (p=0.048), and venous invasion (p
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- 2019
9. Evaluation of Surgical Procedures that Affect the Hemodynamics Using the FloTrac System in Esophageal Cancer Patients
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Masaru Tobe, Makoto Sakai, Masafumi Kanemoto, Yuji Kumakura, Shigeru Saito, Tatsuya Miyazaki, Tomonori Yoshida, Hiroshi Hinohara, Kengo Kuriyama, Hiroaki Honjyo, Makoto Sohda, and Hiroyuki Kuwano
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Male ,Cancer Research ,Esophageal Neoplasms ,medicine.medical_treatment ,Cardiac index ,Hemodynamics ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Humans ,Medicine ,Aged ,Aged, 80 and over ,Postoperative Care ,Pharmacology ,business.industry ,Hemodynamic Monitoring ,Disease Management ,Stroke Volume ,Perioperative ,Stroke volume ,Middle Aged ,Esophageal cancer ,medicine.disease ,Esophagectomy ,030220 oncology & carcinogenesis ,Anesthesia ,Heart Function Tests ,Female ,Lymphadenectomy ,business ,Complication ,Research Article - Abstract
Background/aim Esophagectomy is more invasive compared to other gastrointestinal surgery types. Perioperative circulatory management is important to avoid postoperative heart complications. The FloTrac sensor along with the Vigileo monitor is a minimally invasive haemodynamic monitoring device. Here, we examined different surgical procedures affecting hemodynamics using the FloTrac system in esophageal cancer patients following esophagectomy. Patients and methods Thirty-one patients undergoing postoperative monitoring with the FloTrac sensor/Vigileo monitor system following esophagectomy were included. Evaluation of cardiac index (CI) and stroke volume variation (SVV) measurements were performed by analyzing the number of aberrant values. We evaluated the correlation between the number of aberrant values of CI, SVV and surgical methods of esophagectomy and perioperative factors. Results There was no significant correlation between the number of aberrant values of CI, SVV and operative approach or fields of lymphadenectomy. Regarding the reconstruction route following esophagectomy, there was a significant correlation between the number of aberrant values of CI, SVV and retrosternal route compared with other routes. There was a significant correlation between the number of aberrant values of SVV and preoperative heart complication. Conclusion Hemodynamic stability management using FloTrac/Vigileo system following esophagectomy is useful for safe performance of postoperative management of esophageal cancer patients.
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- 2019
10. Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
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Makoto Sohda, Masaya Miyazaki, Tatsuya Miyazaki, Tomonori Yoshida, Makoto Sakai, Toshiyuki Okumura, Hideyuki Sakurai, Junko Hirato, Hitoshi Ishikawa, Yuji Kumakura, Takehiko Yokobori, Hiroyuki Kuwano, and Kengo Kuriyama
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Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Cryotherapy ,Multimodality Therapy ,Adenocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Proton Therapy ,Internal Medicine ,Carcinoma ,medicine ,Humans ,Combined Modality Therapy ,Esophagus ,Lymph node ,business.industry ,Liver Neoplasms ,General Medicine ,Middle Aged ,Esophageal cancer ,medicine.disease ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,alpha-Fetoproteins ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing alpha-fetoprotein (AFP) with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy. A complete response has been maintained for 16 months and the overall survival time is 4 years and 2 months. Proton beam therapy for primary esophageal cancer and metastatic lesions was thus found to be an effective therapeutic option for such cases.
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- 2018
11. Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study
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Shigemasa Suzuki, Tatsuya Miyazaki, Hiroyuki Kuwano, Masahiko Nishiyama, Makoto Sohda, Tomonori Yoshida, Makoto Sakai, Yuji Kumakura, Navchaa Gombodorj, Takehiko Yokobori, Seded Baatar, Kengo Kuriyama, Naritaka Tanaka, and Ken Shirabe
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Male ,0301 basic medicine ,Oncology ,F-Box-WD Repeat-Containing Protein 7 ,Esophageal Neoplasms ,Organoplatinum Compounds ,genetic structures ,Biopsy ,medicine.medical_treatment ,Docetaxel ,chemistry.chemical_compound ,0302 clinical medicine ,Radiation sensitivity ,Antineoplastic Combined Chemotherapy Protocols ,Neoadjuvant therapy ,medicine.diagnostic_test ,General Medicine ,Middle Aged ,Esophageal cancer ,Immunohistochemistry ,Neoadjuvant Therapy ,Fluorouracil ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,Taxoids ,Esophageal Squamous Cell Carcinoma ,therapeutics ,medicine.drug ,medicine.medical_specialty ,03 medical and health sciences ,Cell Line, Tumor ,Internal medicine ,medicine ,Humans ,Nedaplatin ,neoplasms ,Aged ,Retrospective Studies ,Cell Nucleus ,business.industry ,Chemoradiotherapy, Adjuvant ,medicine.disease ,digestive system diseases ,030104 developmental biology ,chemistry ,Cancer cell ,Myeloid Cell Leukemia Sequence 1 Protein ,Surgery ,business - Abstract
BACKGROUND AND OBJECTIVES Esophageal squamous cell carcinoma (ESCC) exhibits good reactivity to chemoradiation therapy (CRT). The dysregulation of F-Box and WD Repeat Domain Containing 7 (FBXW7) is associated with therapeutic resistance in cancer cells. However, the correlation between FBXW7 expression and CRT sensitivity in patients with clinical ESCC has been investigated only in few studies. Therefore, this study aimed to elucidate the significance of FBXW7 expression in pretreatment biopsy specimens from patients with ESCC receiving CRT. METHODS We investigated the relationship between FBXW7 expression and CRT sensitivity in 30 pretreatment biopsy specimens with histological grades of post-CRT surgically resected tumors. Furthermore, we evaluated the effects of high FBXW7 expression on the sensitivity to cytotoxic agents, including docetaxel and nedaplatin, and radiation in ESCC cells in vitro. RESULTS High FBXW7 expression before CRT correlated with a good pathological CRT response in patients with advanced ESCC (P
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- 2018
12. Elucidation of the Anatomical Mechanism of Nodal Skip Metastasis in Superficial Thoracic Esophageal Squamous Cell Carcinoma
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Takehiko Yokobori, Hiroyuki Kuwano, Makoto Sohda, Tetsunari Oyama, Tadashi Handa, Tomonori Yoshida, Hideaki Yokoo, Yuji Kumakura, Makoto Sakai, Hiroshi Yorifuji, Keigo Hara, and Tatsuya Miyazaki
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Adult ,Male ,Thorax ,Pathology ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,03 medical and health sciences ,Esophagus ,0302 clinical medicine ,Cadaver ,medicine ,Lymphatic vessel ,Humans ,Lymph node ,Aged ,Lymphatic Vessels ,Aged, 80 and over ,Gastrointestinal Oncology ,business.industry ,Stomach ,Mediastinum ,Muscle, Smooth ,Middle Aged ,Esophagectomy ,Lymphatic system ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Lymph Node Excision ,Female ,030211 gastroenterology & hepatology ,Surgery ,Lymphadenectomy ,Esophageal Squamous Cell Carcinoma ,Lymph Nodes ,business - Abstract
Background Lymph node metastasis (LNM) is a standard mechanism of cancer progression in esophageal squamous cell carcinoma (ESCC). We aimed to clarify the anatomical mechanism of skip nodal metastasis to mediastinal zones by analyzing the relationship between LNM to sentinel zones and lymphatic vessel counts in the muscle layer adjacent to the outer esophagus. Methods We examined the surgical records of 287 patients with ESCC who underwent potentially curative surgery (three-field lymphadenectomy) and whole esophagi, including pharynges and stomachs from 10 cadavers, to determine the number of lymphatic vessels in the intra-outer longitudinal muscle layer adjacent to the outer esophagus of the cervical (Ce), upper thoracic, middle thoracic (Mt), lower thoracic (Lt), and abdominal esophagi (Ae). Results The frequency of LNM to the middle mediastinal and supraclavicular zones, including the Mt and Ce, respectively, was lower than to the upper and lower mediastinal and abdominal zone in patients with superficial and advanced thoracic ESCC. In cadavers, the lymphatic vessel counts of the intra-outer longitudinal muscle layer in the Mt and Ce were significantly lower than those of the Lt and Ae, suggesting that lymphatic flow toward the outside of the Mt and Ce was not more abundant than to other sites. Conclusion Our anatomical data suggested that the absence of intra-muscle lymphatic vessels in the middle mediastinal and supraclavicular zones causes skip LNM in patients with thoracic ESCC. Thus, standard esophagectomy with lymph node dissection, including distant zones, may be appropriate for treating patients with superficial thoracic ESCC. Electronic supplementary material The online version of this article (10.1245/s10434-018-6390-0) contains supplementary material, which is available to authorized users.
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- 2018
13. High expression of carcinoembryonic antigen and telomerase reverse transcriptase in circulating tumor cells is associated with poor clinical response to the immune checkpoint inhibitor nivolumab
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Toshitaka Maeno, Kyoichi Ogata, Ken Shirabe, Tetsunari Oyama, Hiroaki Honjo, Tatsuya Miyazaki, Halin Bao, Pinjie Bao, Munenori Ide, Kimihiro Shimizu, Bolag Altan, Koji Takata, Minoru Fukuchi, Takeshi Hisada, Tuya Bai, Makoto Sakai, Takashi Ohnaga, Makoto Sohda, Tadashi Handa, Tomonori Yoshida, Yuji Kumakura, Takayuki Asao, Kyoichi Kaira, Takehiko Yokobori, Hiroyuki Kuwano, and Akira Mogi
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0301 basic medicine ,Cancer Research ,immune checkpoint inhibitor ,circulating tumor cells ,size sorting ,03 medical and health sciences ,0302 clinical medicine ,Carcinoembryonic antigen ,Circulating tumor cell ,medicine ,Telomerase reverse transcriptase ,Lung cancer ,neoplasms ,biology ,business.industry ,Large cell ,Cancer ,Articles ,Cell cycle ,medicine.disease ,digestive system diseases ,030104 developmental biology ,CTC chip ,Oncology ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,Nivolumab ,business - Abstract
The present study aimed to enrich circulating tumor cells (CTCs) from blood samples using a new size-sorting CTC chip. The present study also set out to identify a blood sensitivity marker for the immune checkpoint inhibitor nivolumab in patients with advanced, pre-treatment lung cancer. The CTC sorting efficacy of the chip was investigated and the large cell fraction of blood samples from 15 patients with pre-treatment lung cancer who were later administered nivolumab were purified. The expression levels of carcinoembryonic antigen (CEA), human Telomerase Reverse Transcriptase (hTERT), cytokeratin19 (CK19), and programmed death ligand-1 (PD-L1) were investigated to clarify the association between these CTC markers and the clinical response to nivolumab. The CTC chip effectively enriched cells from lung cancer cell line PC-9. The large cell fraction had a high expression of CEA and hTERT, with the former being significantly associated with the clinical response to nivolumab. The expression of CEA and hTERT in CTCs derived from the blood of a patient with lung cancer were also validated. The evaluation of CEA and possibly hTERT in CTCs collected by the CTC chip may represent a promising predictive blood marker for sensitivity to nivolumab. To the best of our knowledge this is the first report to describe the predictive CTC marker for nivolumab in pre-treatment patients.
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- 2017
14. Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma
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Makoto Sohda, Tomonori Yoshida, Takehiko Yokobori, Hiroyuki Kuwano, Yuji Kumakura, Makoto Sakai, Masahiko Nishiyama, Tatsuya Miyazaki, Bolag Altan, Halin Bao, Susumu Rokudai, and Misaki Iijima
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0301 basic medicine ,Oncology ,squamous cell carcinoma ,Male ,Cancer Research ,Esophageal Neoplasms ,Carcinogenesis ,medicine.medical_treatment ,medicine.disease_cause ,Esophageal squamous cell carcinoma ,0302 clinical medicine ,esophageal cancer ,Aged, 80 and over ,General Medicine ,Esophageal cancer ,Middle Aged ,University hospital ,Prognosis ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Original Article ,Female ,Esophageal Squamous Cell Carcinoma ,TP63 ,medicine.medical_specialty ,Disease-Free Survival ,03 medical and health sciences ,Internal medicine ,Cell Line, Tumor ,ΔNp63/p40 ,medicine ,Biomarkers, Tumor ,Humans ,neoplasms ,Aged ,Neoplasm Staging ,Chemotherapy ,business.industry ,Tumor Suppressor Proteins ,Diagnostic marker ,Original Articles ,medicine.disease ,digestive system diseases ,030104 developmental biology ,business ,Transcription Factors - Abstract
This study aims to explore the expression level of ΔNp63 in esophageal squamous cell carcinoma (ESCC). To investigate the association between ΔNp63 (p40) expression and ESCC biology, we compared the levels of ΔNp63 expression in normal and tumor tissues, with a specific focus on the diagnostic value of ΔNp63 in ESCC. We analyzed 160 consecutive patients with ESCC who underwent surgical resection without neoadjuvant chemotherapy at Gunma University Hospital (Maebashi, Japan) between September 2000 and January 2010. The clinicopathological characteristics and survival of patients were subclassified based on the expression of ΔNp63 as determined by immunohistochemistry, indicating that ΔNp63 was highly expressed in 75.6% (121/160) of ESCC patients. Clinicopathological analysis of ΔNp63 expression showed that ΔNp63-positive tumors significantly correlated with two important clinical parameters: T factor (P = 0.0316) and venous invasion (P = 0.0195). The 5-year overall survival rates of advanced ESCC patients with positive and negative expression of ΔNp63 were 35.6% and 71.7%, respectively. Multivariate analysis revealed that the expression of ΔNp63 was identified as an independent prognostic factor (P = 0.0049) in advanced ESCC. In line with this, ΔNp63α-transduced ESCC cell lines increased tumor growth in a soft agar colony formation assay. We report here for the first time that ΔNp63 expression increases the oncogenic potential of ESCC and is an independent marker for predicting poor outcome in advanced ESCC. Our findings suggest that ΔNp63 could serve as a new diagnostic marker for ESCC and might be a relevant therapeutic target for the treatment of patients with this disease.
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- 2017
15. TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma
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Keigo Hara, Daigo Ozawa, Tatsuya Miyazaki, Hiroyuki Kuwano, Yuji Kumakura, Makoto Sakai, Yuni Elsa Hadisaputri, Takehiko Yokobori, Hiroaki Honjo, and Makoto Sohda
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Adult ,Male ,0301 basic medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,Esophageal Neoplasms ,Cell ,Biology ,medicine.disease_cause ,TNFAIP3 ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Cell Line, Tumor ,Carcinoma ,medicine ,Humans ,Neoplasm Invasiveness ,RNA, Small Interfering ,skin and connective tissue diseases ,Tumor Necrosis Factor alpha-Induced Protein 3 ,Aged ,Cell Proliferation ,Aged, 80 and over ,Oncogene ,Cell growth ,NF-kappa B ,Cancer ,Middle Aged ,Cell cycle ,Prognosis ,medicine.disease ,Immunohistochemistry ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Cancer research ,Female ,RNA Interference ,Esophageal Squamous Cell Carcinoma ,Carcinogenesis - Abstract
Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal squamous cell carcinoma (ESCC) has not yet been reported. We examined 149 ESCC tissue specimens to determine the clinical significance of TNFAIP3 by immunohistochemistry. Western blot analyses were used to detect TNFAIP3 expression in TE-1, TE-8, TE-15 and KYSE-70 ESCC cells and in Het-1A, a non-cancerous esophageal cell line. TNFAIP3 protein knockdown was conducted using small-interfering RNA to investigate its impact on cell proliferation, migration and invasion. Significant correlations between TNFAIP3 expression and differentiation (P=0.04) among clinicopathological characteristics of ESCC patients were demonstrated, and high TNFAIP3 expression was associated with poor survival (P=0.02). Moreover, multivariate analysis result showed that high TNFAIP3 expression was an independent factor for poor survival (P=0.04). In vitro analysis showed high expression of TNFAIP3 protein in TE-15 cells and low expression in Het-1A cells. Furthermore, the proliferation, migration and invasion of TE-15 cells after TNFAIP3 suppression by siRNA were significantly reduced. These findings suggest that TNFAIP3 protein may be an independent prognostic marker for poor survival, and a promising target for ESCC therapy.
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- 2017
16. Impact of the Level of Anastomosis on Reflux Esophagitis Following Esophagectomy with Gastric Tube Reconstruction
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Makoto Sakai, Tatsuya Miyazaki, Makoto Sohda, Hiroaki Honjo, Yuji Kumakura, Hiroyuki Kuwano, Takehiko Yokobori, Tomonori Yoshida, and Keigo Hara
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Adult ,Male ,Thorax ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Anastomosis ,03 medical and health sciences ,Stomach surgery ,Esophagus ,0302 clinical medicine ,medicine ,Humans ,Reflux esophagitis ,Esophagitis, Peptic ,Aged ,business.industry ,Anastomosis, Surgical ,Stomach ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Surgery ,Cardiac surgery ,Esophagectomy ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,business ,Esophagitis ,Neck ,Abdominal surgery - Abstract
Among patients who undergo gastric tube reconstruction after esophagectomy, it is generally accepted that the incidence of reflux esophagitis (RE) is significantly lower in patients with neck anastomosis than in those with intrathoracic anastomosis. However, the true impact of the level of anastomosis on RE currently remains unclear.We examined 53 patients with thoracic esophageal cancer underwent radical esophagectomy with gastric tube reconstruction and neck anastomosis. The level of anastomosis was assessed by measuring the distance from the sternal notch to the stapled ring by computed tomography. The relative level of anastomosis was calculated by the distance from the sternal notch to the most caudal side of the stapled ring (mm)/height (cm).The relative level of anastomosis in 30 (56.6%) patients showed0, which indicated that anastomosis in these patients was located at a lower level than the sternal notch. The mean relative level of anastomosis was significantly lower in patients with RE (grade A to D) than in those without RE (grade N) (-0.062 vs. -0.012 mm/cm, respectively; p = 0.043). RE was more severe with a lower relative level of anastomosis (p for trends = 0.044).The level of anastomosis in patients with gastric tube reconstruction following esophagectomy was associated with the incidence of RE. The displacement of anastomosis into the thoracic cavity was detected in approximately half of the patients with neck anastomosis. RE was more severe with a lower level of anastomosis, even in patients with neck anastomosis.
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- 2016
17. [High-resolution Manometry for Esophageal Motility Disorders]
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Makoto, Sakai, Hideyuki, Saito, Kengo, Kuriyama, Tomonori, Yoshida, Yuji, Kumakura, Keigo, Hara, Makoto, Sohda, Hiroyuki, Kuwano, and Ken, Shirabe
- Subjects
Esophageal Achalasia ,Manometry ,Humans ,Esophageal Motility Disorders ,Esophagogastric Junction ,Deglutition - Abstract
High-resolution manometry (HRM) has significant contribution in the field of esophageal motility disorders recently. The development of HRM has categorized various esophageal motility disorders focusing on patterns of esophageal motor function. Additionally, the Chicago classification criteria are widely used for manometric diagnosis. HRM provides functional imaging of the esophagus. HRM has closely spaced pressure sensors and displays pressure variations as pressure topography plots. In the analysis of HRM according to the Chicago classification, a hierarchical categorization of motility disorders is made after evaluation of the individual swallow patterns. First the lower esophageal sphincter (LES) function, and subsequently the esophageal pressure patterns are used to make a diagnosis. The hierarchical flow-chart has 4 groups; (1) incomplete LES relaxation( achalasia or esophagogastric junction outflow obstruction), (2) major motility disorders, (3) minor motility disorders, (4) normal esophageal motility. HRM is the gold standard for diagnosis of esophageal motility disorders.
- Published
- 2018
18. Comparable Data Between Double Endoscopic Intraluminal Operation and Conventional Endoscopic Submucosal Dissection for Esophageal Cancer
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Hiroyuki Kuwano, Tomonori Yoshida, Tatsuya Miyazaki, Makoto Sakai, Makoto Sohda, Hiroaki Honjo, Kengo Kuriyama, and Yuji Kumakura
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Male ,medicine.medical_specialty ,Endoscopic Mucosal Resection ,Esophageal Neoplasms ,Endoscopic surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Significant difference ,Gastroenterology ,En bloc resection ,Endoscopic submucosal dissection ,Esophageal cancer ,medicine.disease ,University hospital ,Treatment Outcome ,030220 oncology & carcinogenesis ,Mediastinal Emphysema ,Carcinoma, Squamous Cell ,030211 gastroenterology & hepatology ,Surgery ,Female ,Radiology ,business ,Complication - Abstract
Endoscopic submucosal dissection (ESD) of superficial esophageal cancer has been used increasingly as an alternative to surgery because it is minimally invasive and has a high rate of en bloc resection. We previously reported that the double endoscopic intraluminal operation (DEILO) is a useful technique for ESD of early esophageal cancers. In the current study, we showed comparable short-term data between DEILO and conventional ESD groups to demonstrate the further advanced use of DEILO. We studied 111 esophageal cancer patients with 111 lesions treated using endoscopic surgery between January 2010 and June 2016 at Gunma University Hospital. Of the patients, 51 underwent DEILO (DEILO group) and 60 underwent conventional ESD (ESD group). We compared the operable performance, complications, and pathological outcome between the ESD and DEILO groups. There was no significant difference in operable performance. However, the DEILO group showed a significantly lower rate of mediastinal emphysema compared to the ESD group (p = 0.025). Overall, the DEILO group showed a lower complication rate compared to the ESD group, although there was no apparent significance. To our knowledge, this is the first report comparing DEILO and conventional ESD for esophageal cancer. The results showed that DEILO is not inferior to conventional ESD. DEILO is an excellent endoscopic surgical method, although it has some limitations compared to conventional ESD.
- Published
- 2018
19. Association of Preoperative Nutritional Status with Prognosis in Patients with Esophageal Cancer Undergoing Salvage Esophagectomy
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Makoto Sohda, Hiroaki Honjo, Tatsuya Miyazaki, Keigo Hara, Daigo Ozawa, Makoto Sakai, Takehiko Yokobori, Tomonori Yoshida, Shigemasa Suzuki, Hiroyuki Kuwano, Naritaka Tanaka, and Yuji Kumakura
- Subjects
Male ,Cancer Research ,Poor prognosis ,medicine.medical_specialty ,Multivariate analysis ,Esophageal Neoplasms ,Nutritional Status ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Preoperative Care ,medicine ,Humans ,In patient ,Aged ,Retrospective Studies ,Salvage Therapy ,Univariate analysis ,business.industry ,Malnutrition ,Retrospective cohort study ,Nutritional status ,General Medicine ,Esophageal cancer ,Prognosis ,medicine.disease ,Salvage esophagectomy ,Esophagectomy ,Survival Rate ,Nutrition Assessment ,Oncology ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,030211 gastroenterology & hepatology ,business ,Follow-Up Studies - Abstract
BACKGROUND To investigate whether malnutrition is associated with poor prognosis of patients who undergo salvage esophagectomy. We examined the association between the preoperative prognostic nutritional index (PNI) and prognosis of patients who undergo salvage esophagectomy. PATIENTS AND METHODS We conducted a single-center retrospective study and reviewed hospital patient records for tumor characteristics and patient outcomes. Univariate and multivariate survival analyses were carried out using the Cox proportional hazards regression model. RESULTS Thirty-two patients with esophageal squamous cell carcinoma (ESCC) who underwent salvage esophagectomy between 1998 and 2015 at our Institute were included in this study. Univariate analysis revealed that clinical response (p=0.045), preoperative PNI (p
- Published
- 2018
20. ASO Author Reflections: Nodal Skip Metastasis in Esophageal Squamous Cell Carcinoma
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Makoto Sohda, Ken Shirabe, Hiroyuki Kuwano, Takehiko Yokobori, and Yuji Kumakura
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Skip metastasis ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,MEDLINE ,Esophageal squamous cell carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Surgical oncology ,Esophagectomy ,030220 oncology & carcinogenesis ,medicine ,030211 gastroenterology & hepatology ,Surgery ,Radiology ,NODAL ,business - Published
- 2018
21. Nuclear PROX1 is Associated with Hypoxia-Inducible Factor 1α Expression and Cancer Progression in Esophageal Squamous Cell Carcinoma
- Author
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Hiroyuki Kuwano, Munenori Ide, Makoto Sohda, Minoru Fukuchi, Tatsuya Miyazaki, Keigo Hara, Bolag Altan, Takehiko Yokobori, Pinjie Bao, Hiroaki Honjo, Masahiko Nishiyama, Tetsunari Oyama, Yuji Kumakura, Susumu Rokudai, Daigo Ozawa, Tuya Bai, and Makoto Sakai
- Subjects
Adult ,Male ,Small interfering RNA ,Esophageal Neoplasms ,Blotting, Western ,Bioinformatics ,Metastasis ,Immunoenzyme Techniques ,Downregulation and upregulation ,Cell Movement ,Biomarkers, Tumor ,Tumor Cells, Cultured ,medicine ,Humans ,Neoplasm Invasiveness ,RNA, Small Interfering ,Lymph node ,Aged ,Cell Proliferation ,Neoplasm Staging ,Aged, 80 and over ,Cell Nucleus ,Homeodomain Proteins ,business.industry ,Tumor Suppressor Proteins ,Cancer ,Middle Aged ,Hypoxia-Inducible Factor 1, alpha Subunit ,Prognosis ,medicine.disease ,Lymphangiogenesis ,Gene Expression Regulation, Neoplastic ,Survival Rate ,medicine.anatomical_structure ,Oncology ,Hypoxia-inducible factors ,Carcinoma, Squamous Cell ,Cancer research ,Immunohistochemistry ,Female ,Surgery ,business ,Follow-Up Studies - Abstract
Transcription factor prospero homeobox 1 (PROX1) has been identified as a master regulator of lymphangiogenesis associated with metastasis. Although PROX1 expression has been investigated in several cancers, its clinical significance remains controversial and needs further validation. In this study, we investigated the clinical and functional significance of PROX1 and PROX1 regulator hypoxia-inducible factor 1α (HIF1α) in esophageal squamous cell carcinoma (ESCC). A total of 117 samples from ESCC patients were analyzed for PROX1, HIF1α, and E-cadherin expression by immunohistochemistry; correlation with clinicopathological characteristics was determined. PROX1 function was evaluated in PROX1 small interfering RNA (siRNA)-transfected human ESCC cells in vitro by assessing cell proliferation and migration. PROX1 expression was higher in ESCC than in normal tissues. Patients with higher PROX1 expression (n = 26) had increased nuclear accumulation of HIF1α (p = 0.004) and more advanced metastasis, both lymph node (N factor; p = 0.09) and hematogenous (M factor; p = 0.04), than those with lower PROX1 expression (n = 91). In addition, high PROX1 and HIF1α expression correlated with low levels of E-cadherin, an epithelial cell marker. Analysis of overall and cancer-specific survival indicated that elevated PROX1 expression was significantly correlated with poor prognosis (p = 0.0064). PROX1 downregulation in ESCC cells inhibited cellular proliferation and migration (p
- Published
- 2015
22. Clinical Significance of Salvage Esophagectomy for Patients with Esophageal Cancer and Factors of Influencing Long-term Survival
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Shigemasa Suzuki, Tomonori Yoshida, Keigo Hara, Tatsuya Miyazaki, Hideyuki Saito, Hiroaki Honjyo, Makoto Sohda, Hiroyuki Kuwano, Makoto Sakai, Daigo Ozawa, Kengo Kuriyama, Minoru Fukuchi, Naritaka Tanaka, and Yuji Kumakura
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Neoplasm, Residual ,Esophageal Neoplasms ,medicine.medical_treatment ,Kaplan-Meier Estimate ,030230 surgery ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Clinical significance ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Salvage Therapy ,Univariate analysis ,Proportional hazards model ,business.industry ,Chylothorax ,General Medicine ,Middle Aged ,Esophageal cancer ,medicine.disease ,Surgery ,Esophagectomy ,Pneumonia ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Background/aim Definitive chemoradiotherapy (CRT) without planned surgery has been recently widely used as a therapeutic option for locally advanced esophageal cancer. Salvage esophagectomy can offer the chance of prolonged survival for patients who have locoregional failure after definitive CRT, but many clinicians oppose the use of surgery due to the associated excessive morbidity and mortality. The aim of this study was to identify patients who are good candidates for salvage surgery by investigating factors influencing long-term survival. Patients and methods A total of 40 patients underwent concurrent CRT or RT followed by esophagectomy for residual tumor or locoregional recurrence of esophageal squamous cell carcinoma without distant organ metastasis at the Department of General Surgical Science, Gunma University, Gunma, Japan, and were included in this study. As short-term outcomes after salvage esophagectomy, pulmonary and cardiovascular complications, anastomotic leakage, and chylothorax, and the length of postoperative stay were evaluated. Survival rates were calculated using the Kaplan-Meier method, and the Cox proportional hazards model was used for univariate and multivariate analyses of disease-specific survival. Results Postoperative complications were noted in 20 patients (50%), and pulmonary complications were the most common (25%), followed by anastomotic leakage (20%). There was also one case of in-hospital death, caused by multiple organ failure due to chylothorax. Univariate analysis revealed that sex, clinical residual tumor, CRT response, pathological tumor depth, and pathological residual tumor were significant factors affecting disease-specific survival (p=0.034, p=0.009, p=0.014, p=0.020, and p=0.026, respectively). Moreover, multivariate analysis demonstrated that clinical residual tumor was the only independent factor influencing disease-specific survival (p=0.036). Thirteen patients (32.5%) died from other illnesses after salvage surgery, 53.8% patients from pneumonia. Conclusion Based on long-term survival, recurrence rather than residual tumor after definitive CRT was a favorable indicator for salvage esophagectomy. Not only management of postoperative morbidity and curative operation but, also long-term rigorous outpatient management, including respiratory rehabilitation to reduce pneumonia, is necessary.
- Published
- 2017
23. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma
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Tatsuya Miyazaki, Tomonori Yoshida, Hiroaki Honjyo, Yuji Kumakura, Makoto Sohda, Minoru Fukuchi, Makoto Sakai, Hiroyuki Kuwano, Takehiko Yokobori, and Keigo Hara
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Cancer Research ,Poor prognosis ,Pathology ,medicine.medical_specialty ,Esophageal Neoplasms ,Down-Regulation ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,microRNA ,TaqMan ,medicine ,Biomarkers, Tumor ,Humans ,Basal cell ,neoplasms ,Cell Proliferation ,Reverse Transcriptase Polymerase Chain Reaction ,Gene Expression Profiling ,In vitro toxicology ,General Medicine ,Prognosis ,MicroRNA 7 ,digestive system diseases ,Reverse transcription polymerase chain reaction ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Cancer research ,Carcinoma, Squamous Cell ,030211 gastroenterology & hepatology ,Esophageal Squamous Cell Carcinoma ,Function (biology) - Abstract
Background/aim We detected microRNA-7 (miR-7) as being specific for oesophageal squamous cell carcinoma (ESCC) by using database analysis. However, the significance of miR-7 in clinical ESCC remains unexplored. This study aimed to clarify the clinicopathological significance of miR-7 in ESCC, and investigate miR-7 function. Materials and methods Quantitative TaqMan reverse transcription polymerase chain reaction was used to evaluate miR-7 expression in 85 ESCC samples to determine the clinicopathological significance of miR-7 expression. The regulation of proliferation by miR-7 was examined with miR-7 precursor-transfected cells. Results The expression of miR-7 in ESCC was higher than that in normal tissues. Low expression levels of miR-7 were associated with poor prognosis. Multivariate analysis indicated that low miR-7 expression was an independent prognostic factor for poor survival. In vitro assays showed miR-7 precursor treatment suppressed the proliferation of ESCC cells. Conclusion miR-7 might be a promising prognostic marker and therapeutic target in ESCC.
- Published
- 2017
24. Surgical management for achalasia after coronary artery bypass graft using the right gastroepiploic artery: a case report
- Author
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Hideyuki Saito, Tomonori Yoshida, Hiroaki Honjyo, Ryo Muranushi, Makoto Sohda, Makoto Sakai, Tatsuya Miyazaki, Hiroyuki Kuwano, Takehiko Yokobori, Yuji Kumakura, and Kengo Kuriyama
- Subjects
medicine.medical_specialty ,Right gastroepiploic artery ,Myocardial ischemia ,Bypass grafting ,medicine.medical_treatment ,Achalasia ,Case Report ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Laparotomy ,Internal medicine ,Coronary artery bypass graft ,medicine ,business.industry ,Perioperative ,medicine.disease ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Balloon dilation ,Cardiology ,030211 gastroenterology & hepatology ,business ,Artery - Abstract
Background The right gastroepiploic artery is commonly used in coronary artery bypass grafting. Appropriate strategies are required when performing upper abdominal surgeries after the right gastroepiploic artery has been used in coronary artery bypass grafting because compressing or injuring the graft may cause myocardial ischemia and fatal arrhythmias. To our knowledge, this is the first reported case of surgery for achalasia performed after coronary artery bypass grafting using the right gastroepiploic artery. We have discussed the surgical procedure and particular intraoperative considerations. Case presentation A 62-year-old man who had undergone coronary artery bypass grafting using the right gastroepiploic artery presented with achalasia. Because medication and balloon dilation had been ineffective and he was having difficulty ingesting food, we performed a Heller–Dor procedure via laparotomy. The right gastroepiploic artery was not damaged during this surgery, and there were no perioperative cardiovascular complications. Adequate control of symptoms was achieved. Conclusions When performing upper abdominal surgeries after coronary artery bypass grafting with the right gastroepiploic artery, it is necessary to investigate the patient carefully preoperatively and adapt the intraoperative procedure to minimize risk of injury to the graft and consequent cardiovascular complications.
- Published
- 2016
25. Postoperative hemodynamic changes for predicting anastomotic leakage after esophagectomy in patients with esophageal cancer using the FloTrac system.
- Author
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Makoto Sohda, Hideyuki Saito, Yuji Kumakura, Hiroaki Honjyo, Keigo Hara, Makoto Sakai, Tatsuya Miyazaki, Masafumi Kanemoto, Masaru Tobe, Hiroshi Hinohara, Shigeru Saito, and Hiroyuki Kuwano
- Subjects
HEMODYNAMICS ,SURGICAL anastomosis ,ESOPHAGECTOMY ,ESOPHAGEAL cancer ,SURGICAL complications - Abstract
Background: Anastomotic leakage after esophagectomy is significantly associated with more severe complications, such as sepsis and mortality. Early prediction for anastomotic leakage is usually difficult and needs to be treated rapidly. In the current study, we investigated the correlation between hemodynamic and several complications after esophagectomy in patients with esophageal cancer, using the FloTrac system. Materials and Methods: Between April 2013 and December 2014, 39 patients with a mean age of 66.6 ± 8.9 years underwent postoperative supervision using the FloTrac sensor / Vigileo monitoring system after curative surgery for esophageal cancer. We retrospectively evaluated the association between the number of aberrant cardiac index (CI) along with stroke volume variability (SVV) values and clinicopathological parameters of postoperative complications in this report. Results: There were significant positive correlations between the number of aberrant values of CI along with SVV and depth of invasion during pathological stage. Concerning major postoperative complications, there was a significant positive correlation between the number of aberrant values of CI and anastomotic leakage. Discussion: The hemodynamic change by employing the FloTrac system could predicts the complication of anastomotic leakage after esophagectomy. Adequate management of hemodynamic stability by utilizing it will reduce the complications of anastomotic leakage. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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26. Utility of double endoscopic intraluminal operation for esophageal cancer
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Hiroyuki Kuwano, Daigo Ozawa, Tatsuya Miyazaki, Keigo Hara, Makoto Sakai, Naritaka Tanaka, Hiroaki Honjyo, Hideyuki Saito, Makoto Sohda, Minoru Fukuchi, Shigemasa Suzuki, Yuji Kumakura, and Tomonori Yoshida
- Subjects
Male ,medicine.medical_specialty ,Endoscopic Mucosal Resection ,Esophageal Neoplasms ,Perforation (oil well) ,Adenocarcinoma ,Postoperative Hemorrhage ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Carcinoma ,Humans ,Aged ,business.industry ,Cancer ,Endoscopy ,Perioperative ,Esophageal cancer ,Length of Stay ,medicine.disease ,Surgery ,Treatment Outcome ,Pneumothorax ,030220 oncology & carcinogenesis ,Mediastinal Emphysema ,Carcinoma, Squamous Cell ,030211 gastroenterology & hepatology ,Female ,business ,Abdominal surgery - Abstract
Endoscopic submucosal dissection (ESD) is a more difficult technique for esophageal cancer than for gastric cancer because the working space for esophageal ESD is small. Further, the difficulty level gradually increases depending on the size of the carcinoma. To overcome these difficulties, double endoscopic intraluminal operation (DEILO), which enables the resection of mucosal lesions using two fine endoscopes and monopolar shears, was reported previously. Here, we report the utility of DEILO for esophageal cancer. A total of 26 esophageal cancer patients (19 men and seven women) with 26 lesions treated using DEILO between 2011 and 2014 at Gunma University Hospital were included. We evaluated the utility and safety of DEILO for early esophageal cancer. For all patients (100%), the DEILO procedure was performed successfully, and en bloc resection was achieved. The median operation time, postoperative hospital stay, and the longitudinal dimension of resected specimens were 123 min (range 45–236 min), 5 days, and 32 mm, respectively. Perioperative perforation, pneumothorax, and mediastinal emphysema were not recognized. Only one patient was diagnosed with a postoperative hemorrhage, but the bleeding was successfully treated by bleeding vessel coagulation. DEILO has good utility as a technique of ESD for early esophageal cancers. Additional improvement and advancement of the procedure will increase the indication of DEILO.
- Published
- 2016
27. Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint’s triad
- Author
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Keigo Hara, Takehiko Yokobori, Takahiro Yamanaka, Hiroyuki Kuwano, Makoto Sakai, Yuji Kumakura, Makoto Sohda, Hiroaki Honjo, and Tatsuya Miyazaki
- Subjects
Saint’s triad ,medicine.medical_specialty ,Pregnancy ,business.industry ,Umbilical hernia ,education ,Female sex ,SAINT ,Case Report ,medicine.disease ,digestive system diseases ,Surgery ,Hiatal hernia ,Triad (sociology) ,stomatognathic diseases ,surgical procedures, operative ,Cholelithiasis ,medicine ,Risk factor ,business ,Body mass index - Abstract
We experienced two cases involving the simultaneous presence of cholelithiasis, hiatal hernia, and umbilical hernia. Both patients were female and overweight (body mass index of 25.0-29.9 kg/m(2)) and had a history of pregnancy and surgical treatment of cholelithiasis. Additionally, both patients had two of the three conditions of Saint's triad. Based on analysis of the pathogenesis of these two cases, we consider that these four diseases (Saint's triad and umbilical hernia) are associated with one another. Obesity is a common risk factor for both umbilical hernia and Saint's triad. Female sex, older age, and a history of pregnancy are common risk factors for umbilical hernia and two of the three conditions of Saint's triad. Thus, umbilical hernia may readily develop with Saint's triad. Knowledge of this coincidence is important in the clinical setting. The concomitant occurrence of Saint's triad and umbilical hernia may be another clinical "tetralogy."
- Published
- 2015
28. Gastrojejunostomy for pyloric stenosis after acute gastric dilatation due to overeating
- Author
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Akiharu Kimura, Norihiro Haga, Tomokazu Ito, Yuji Kumakura, Hiroyuki Kuwano, Hiroyuki Kato, Norihiro Masuda, Jyunko Takita, Kichirou Otsuka, and Hitoshi Satomura
- Subjects
Adult ,medicine.medical_specialty ,Time Factors ,Gastric Dilatation ,medicine.medical_treatment ,Perforation (oil well) ,Gastric Bypass ,Case Report ,Nasogastric Decompression ,Endoscopy, Gastrointestinal ,Pyloric Stenosis ,Pyloric stenosis ,Predictive Value of Tests ,Risk Factors ,medicine ,Humans ,Intubation ,Bulimia ,Mechanical ventilation ,Upper gastrointestinal series ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,General Medicine ,medicine.disease ,Surgery ,Endoscopy ,Treatment Outcome ,Acute Disease ,Female ,Tomography, X-Ray Computed ,business - Abstract
A 34-year-old woman presented at our hospital with abdominal distention due to overeating. Acute gastric dilatation was diagnosed. The patient was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed pyloric stenosis; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The patient was discharged from the hospital with no postoperative complications. Gastric necrosis and perforation due to overeating-induced gastric dilatation are life-threatening conditions. Surgical intervention may be required if delayed pyloric stenosis occurs after conservative treatment. We report a case of pyloric stenosis due to overeating-induced gastric dilatation treated by gastrojejunostomy 18 mo after the initial presentation.
- Published
- 2015
29. TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma.
- Author
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HADISAPUTRI, YUNI ELSA, TATSUYA MIYAZAKI, TAKEHIKO YOKOBORI, MAKOTO SOHDA, MAKOTO SAKAI, DAIGO OZAWA, KEIGO HARA, HIROAKI HONJO, YUJI KUMAKURA, and HIROYUKI KUWANO
- Published
- 2017
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30. Resection of an esophageal schwannoma with thoracoscopic surgery: a case report
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Takayoshi Watanabe, Hiroaki Honjyo, Makoto Sohda, Tatsuya Miyazaki, Takehiko Yokobori, Yuji Kumakura, Tomonori Yoshida, Hiroyuki Kuwano, Makoto Sakai, and Hideyuki Saito
- Subjects
medicine.medical_specialty ,business.industry ,Esophageal schwannoma ,Case Report ,Schwannoma ,medicine.disease ,nervous system diseases ,Resection ,Surgery ,Thoracoscopic surgery ,03 medical and health sciences ,0302 clinical medicine ,Esophageal tumors ,030220 oncology & carcinogenesis ,EUS-FNA ,otorhinolaryngologic diseases ,Medicine ,030211 gastroenterology & hepatology ,Fdg pet ct ,Radiology ,S-100 ,business ,neoplasms ,FDG-PET CT - Abstract
Background Esophageal schwannomas are rare primary submucosal esophageal tumors. We herein report a case of an esophageal schwannoma that was difficult to diagnose. Case presentation A 39-year-old woman presented with chief complaints of difficulty swallowing and epigastric pain. Enhanced computed tomography of her chest revealed a tumor mass at the upper thoracic esophagus with internal heterogeneity. 18-Fluorodeoxyglucose positron emission tomography/computed tomography showed a hypermetabolic appearance matching the tumor mass; the accumulation had a maximum standardized uptake value of 5.5. We performed endoscopic ultrasound-guided fine-needle aspiration biopsy under general anesthesia, but the small specimens obtained prevented a definitive diagnosis. Thoracoscopic esophagectomy was performed due to the large size of the tumor, suspicion of its malignant potential, and the patient’s symptoms. Histopathological examination revealed spindle-shaped cells in a fasciculated and disarrayed architecture in the proper muscle layer. Immunohistochemical studies showed S100 protein positivity and the absence of CD34 and c-kit. We diagnosed the tumor as a benign schwannoma. Conclusions We herein report a relatively rare case of schwannoma of the esophagus that was diagnosed with difficulty.
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31. Gastrojejunostomy for pyloric stenosis after acute gastric dilatation due to overeating.
- Author
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Kimura A, Masuda N, Haga N, Ito T, Otsuka K, Takita J, Satomura H, Kumakura Y, Kato H, and Kuwano H
- Subjects
- Acute Disease, Adult, Endoscopy, Gastrointestinal, Female, Gastric Dilatation diagnosis, Gastric Dilatation therapy, Humans, Predictive Value of Tests, Pyloric Stenosis diagnosis, Pyloric Stenosis etiology, Risk Factors, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Bulimia complications, Gastric Bypass, Gastric Dilatation etiology, Pyloric Stenosis surgery
- Abstract
A 34-year-old woman presented at our hospital with abdominal distention due to overeating. Acute gastric dilatation was diagnosed. The patient was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed pyloric stenosis; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The patient was discharged from the hospital with no postoperative complications. Gastric necrosis and perforation due to overeating-induced gastric dilatation are life-threatening conditions. Surgical intervention may be required if delayed pyloric stenosis occurs after conservative treatment. We report a case of pyloric stenosis due to overeating-induced gastric dilatation treated by gastrojejunostomy 18 mo after the initial presentation.
- Published
- 2015
- Full Text
- View/download PDF
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