Search

Prostate cancer is the most common genitourinary cancer in men. Population-based serum prostate-specific antigen (PSA) testing is used to screen men for the early detection of asymptomatic prostate cancer. The present study compared the features of patients with prostate cancer in Kusatsu City, the only municipality in Shiga Prefecture of Japan to implement organized PSA screening, with those in other municipalities. The target population for organized PSA screening by mail invitation was men ≥50 years. Patients were pathologically diagnosed via prostate biopsy because of elevated serum PSA. This multicenter observational study was subsequently conducted in 14 hospitals. The following information was extracted from patient records: age, reason for PSA testing, initial PSA level, Gleason score, clinical stage, and place of residence. Risk classification was defined as low, intermediate, high, and advanced. Each patient was stratified according to their city/town. A total of 984 patients diagnosed with prostate cancer in Shiga in 2012 and 2017 were analyzed, of which 955 (97%) were opportunistically tested, with the remaining 29 (3%) assessed by organized screening. In Kusatsu, 93 patients were diagnosed, of whom 26 (28%) were detected by organized screening. By contrast, only three of 891 patients (0.3%) were detected by organized screening in other municipalities. Of patients in Kusatsu, cases identified by opportunistic testing had a higher initial PSA value (P=0.010) than those identified by organized screening. However, patients detected through opportunistic testing in Kusatsu City were younger (P=0.034), had a lower PSA value (P=0.001), and improved risk classification (P

Previous studies have categorized depression into three major symptoms (depressed mood, somatic complaints, and anhedonia); thus, it becomes necessary to examine each symptom separately rather than depression as a syndrome. The behavioral theory of depression suggests that it is exacerbated by reduced environmental rewards caused due to avoidance. However, the relationship between the three symptoms and avoidance, as mediated by environmental rewards has not been sufficiently examined. The purpose of this study was to use the three-symptom classification of depression and clarify how avoidance and reduced environmental rewards worsen these symptoms using a mediation analysis. The participants were 101 clinical patients diagnosed with major depressive disorder in Japanese adults, who completed a questionnaire to measure their depressive symptoms, avoidance, and environmental rewards. The mediation analysis showed that somatic complaints were significantly associated with the direct effect of avoidance and the indirect effect of environmental rewards, and anhedonia was significantly associated with the indirect effect of environmental rewards, whereas depressed mood was not associated with avoidance and environmental rewards. Therefore, the present study revealed that the relationship between avoidance, environmental rewards, and symptoms of depression differed depending on the individual symptom type.

Presenteeism is the loss of productivity due to a worker's health problems, despite the worker being present at the workplace. Although the association between presenteeism and insomnia complaints is well known, few studies have examined the association between insomnia severity and presenteeism. This study aimed to explore the association between insomnia severity and presenteeism. This study included 1925 participants (1543 males, 379 females, and three of other genders) in total. The mean age of the participants was 49.94 ± 9.82 years. The inclusion criteria were full-time employment, working 8 hr per day and 5 days per week, and having no night shifts. The insomnia severity was classified based on the Insomnia Severity Index and Athens Insomnia Scale criteria. Logistic regression analysis showed that moderate and severe insomnia severity were associated to a greater magnitude with presenteeism than mild insomnia severity. Severe insomnia severity was associated to a greater magnitude with presenteeism than moderate insomnia severity. In summary, logistic regression analysis showed that increased insomnia severity based on Insomnia Severity Index classification was associated with increased odds of presenteeism, but increased insomnia severity based on Athens Insomnia Scale classification was not fully consistent with increased odds of presenteeism. Because increased insomnia severity is associated with worsening of presenteeism, early detection of and early intervention against insomnia complaints are important for reducing presenteeism. This study was the first to examine the associations between presenteeism and insomnia severity classification of no insomnia, mild, moderate, and severe insomnia severity.

Background:This study evaluated the efficacy of a single instillation of pirarubicin with a short retention time for preventing intravesical recurrence of low-risk non-muscle-invasive bladder cancer., Patients and methods:We analyzed 165 patients with low-risk non-muscle-invasive bladder cancer who underwent transurethral surgery. Single instillation of pirarubicin with 15-min retention time immediate after surgery was performed in 47 (28%) patients. The other patients (118, 72%) were treated without instillation therapy. The primary endpoint was recurrence-free survival., Results:Median overall follow-up was 50 (range=6-134) months. Recurrence-free survival at 1 and 5 years was 91% and 72%, and 79% and 54% in the group treated with pirarubicin, and that treated with surgery alone, respectively (p=0.031). Cox's hazard analysis revealed lack of instillation and larger tumor size (>10 mm) as significant factors for risk of recurrence. No adverse events regarding intravesical chemotherapy were observed., Conclusion:Pirarubicin instillation with 15-min retention time can prevent intravesical recurrence of low-risk bladder tumors.

Substance abusers’ family members tend to have a unique dysfunctional cognition, which may affect mental health. Objectives: This study investigated dysfunctional cognition’s effects on mental heal...

Background Sleep problems interfere with work performance. Decreased work productivity due to health problems is defined as presenteeism. Although empirical data on the improvement of presenteeism by sleep interventions have been published, a systematic review elucidating whether there is a difference in the improvement of presenteeism across various types of sleep interventions has not yet been published. This systematic review of studies aimed to clarify which sleep interventions are more likely to be effective in improving presenteeism. Methods The electronic databases PubMed, PsycINFO, and MEDLINE were used to perform a literature search (the start and end search dates were October 20, 2019, and March 11, 2020, respectively). A combination of terms such as “employee*,” “sleep,” “insomnia,” and “presenteeism” was used for the search. Both randomized and non-randomized control trials were included in this systematic review. Results Six types of sleep interventions were identified, including cognitive behavioral therapy for insomnia (CBT-I), sleep hygiene education, yoga, mindfulness, weight loss program, and changing the color temperature of fluorescent lights in the workplace. Only CBT-I improved both sleep problems and presenteeism compared with a control group. The results of this review also show that there is heterogeneity in the measurement of presenteeism. Conclusions The results of this systematic review suggested that CBT-I could be adapted for workers with sleep problems and presenteeism. We discussed whether CBT-I improved both sleep problems and presenteeism compared with other interventions. In addition, methods for measuring presenteeism in future research are proposed.

Background In all the prefectures of Japan, with the exception of Shiga Prefecture, more than half of local governments have an organized prostate-specific antigen (PSA) screening system in place. However, in the Shiga Prefecture, only a single city performed PSA screening over the time period of this survey. The purpose of the present study was to determine the clinical, pathological, and therapeutic features of newly diagnosed prostate cancer in localities where a formally organized screening system was almost entirely absent. Methods A multicenter observational study was conducted in the Shiga Prefecture, which has the lowest rate of population-based PSA-screening in Japan. Patients' age, initial PSA, reasons for PSA testing, Gleason score, clinical stage, and primary treatments were surveyed. We stratified patients according to the reasons for PSA measurement, and compared the differences between groups subject to organized versus opportunistic screening. Results In the 2 years 2012 and 2017, 984 newly diagnosed prostate cancer patients were analyzed. Of these, 954 (97%) were opportunistically tested (i.e., not as part of an organized screening system), with the remaining 29 (3%) measured as part of an organized screening program. Patients in the former group exhibited a higher initial PSA value than in the organized screening group (median: 11.49 vs. 5.67 ng/ml). They also had worse clinical features, including higher Gleason score and TNM stage. More patients in the organized screening group were treated curatively than in the nonorganized screening group in terms of the primary treatment. The results were similar in a subanalysis of the patients of age 50-69 years. Conclusions Organized PSA screening contributes to increasing the number of patients diagnosed with early-stage cancer who can be treated curatively.

Depression can be explained by certain behavioural patterns, especially low levels of environmental rewards; it is generally accompanied by infrequent goal-directed behaviour, increased depressed mood, and anhedonia. However, no research has statistically examined the mediating effect of environmental rewards on the relation between goal-directed behaviour and the symptoms of depressed mood or anhedonia. This study sought to determine whether such a mediating effect of environmental rewards is present in cross-sectional study. The participants included 101 patients diagnosed with major depressive disorders. Data were collected through three questionnaires measuring depression and behavioural patterns that maintain depression: the Center for Epidemiologic Studies Depression Scale (CES-D), the Environmental Reward Observation Scale (EROS), and the Behavioral Activation for Depression Scale—Short Form (BADS-SF). Mediation analysis was conducted using depressed mood and anhedonia as dependent variables, environmental rewards as the mediating variable, and goal-directed behaviour as the independent variable. Environmental rewards significantly mediated the relationship between goal-directed behaviour and anhedonia but not that between goal-directed behaviour and depressed mood. No significant relationships were found among depressed mood, goal-directed behaviour and environmental rewards. From these results, we conclude that low levels of environmental rewards accompanied by infrequent goal-directed behaviour can lead to increased anhedonia but not depressed mood.

Highlights • We report the first case of a paraurethral mixed Müllerian cystadenoma. • The cystic lesion was lined by a mixture of three different types of epithelium. • All epithelial cells were positive for estrogen receptor and PAX8.

BackgroundThere are many different skill components used in cognitive behavioural therapy (CBT). However, there is currently no comprehensive way of measuring these skills in patients.ObjectiveTo develop a comprehensive and brief measure of five main CBT skills: self-monitoring, behavioural activation, cognitive restructuring, assertiveness training and problem-solving.MethodsUniversity students (N=847) who participated in a fully factorial randomised controlled trial of smartphone CBT were assessed with the CBT Skills Scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalised Anxiety Disorder-7 (GAD-7) and the short form of the Japanese Big Five Scale. Structural validity was estimated with exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and internal consistency evaluated with Cronbach’s α coefficients. Construct validity was evaluated with the correlations between each factor of the CBT Skills Scale, the PHQ-9, the GAD-7 and the Big Five Scale.FindingsThe EFA supported a five-factor solution based on the original instruments assessing each CBT skill component. The CFA showed sufficient goodness-of-fit indices for the five-factor structure. The Cronbach’s α of each factor was 0.75–0.81. Each CBT skills factor was specifically correlated to the PHQ-9, GAD-7, and the Big Five Scale.ConclusionsThe CBT Skills Scale has a stable structural validity and internal consistency with a five-factor solution and appropriate content validity concerning the relationship with depression, anxiety and personality.Clinical implicationsThe CBT Skills Scale will be potential predictor and effect modifier in studying the optimisation of CBT interventions.Trial registrationCTR-000031307.

Background: There are many different skill components used in cognitive-behavioral therapy (CBT). However, there is currently no comprehensive way of measuring these skills in patients. Assessing pretreatment CBT skills will contribute to prediction of treatment responses in the context of CBT for depression.Methods: We developed the CBT Skills Scale from five pre-existing instruments measuring major CBT components: self-monitoring, behavioral activation, cognitive restructuring, assertiveness training, and problem-solving. University students (N = 847) who participated in a fully factorial randomized controlled trial of smartphone CBT were assessed with the CBT Skills Scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7 (GAD-7), and the short form of the Japanese Big Five Scale. Structural validity was estimated with exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and internal consistency evaluated with Cronbach’s α coefficients. Construct validity was evaluated with the correlations between each factor of the CBT Skills Scale, the PHQ-9, the GAD-7, and the Big Five Scale.Results: The EFA supported a five-factor solution based on the original instruments assessing each CBT skill component. The CFA showed sufficient goodness-of-fit indices for the five-factor structure. The Cronbach’s α of each factor was 0.75-0.81. Each CBT skills factor was specifically correlated to the PHQ-9, GAD-7, and the Big Five Scale.Conclusions: The CBT Skills Scale has a stable structural validity and internal consistency with a five-factor solution and appropriate content validity concerning the relationship with depression, anxiety, and personality. Trial registration: UMIN, CTR-000031307. Retrospectively registered on February 14, 2018.

Although previous studies reported a relationship between cognitive dysfunction and depressive symptoms, whether context processing relates to symptoms of depression remains unclear. Hence, the question of whether context processing in depressed individuals is negatively specific or a general deficit also remains unanswered. The purpose of our study was to investigate whether mildly depressed individuals would evince a context processing deficit in response to negative emotional stimuli interference. We employed Emotional AX-CPT (AX version Continuous Performance Task), in which negative distractors were presented in the interval between cue and probe stimuli. ANOVAs revealed that when negative distractors were presented, the depressed group made more BX errors than the non-depressed group, and that the depressed group made more BX errors in response to negative distractors than to neutral distractors. Our results suggest that mildly depressed individuals show a context processing deficit when negatively charged stimuli interfere with retaining contextual information.

This study examined self-efficacy (confidence to exercise), pros (exercise’s advantages), and cons (exercise’s disadvantages) as variables associated across the transtheoretical model’s six stages of change in 403 Japanese college students. A series of logistic regression analyses were conducted. Results showed that higher pros and lower cons were associated with being in contemplation compared to precontemplation. Lower cons were associated with being in preparation compared to contemplation. Higher self-efficacy was associated with being in action compared to preparation as well as being in maintenance compared to action. Lower cons were associated with being in termination compared to maintenance.

Behavioral activation is a validated intervention for depression, which helps depressed people re-engage overt behaviors to facilitate contacts with reinforcing environmental contingencies and subsequent reductions in depression. Moreover, behavioral activation deals with values that are based on acceptance and commitment therapy. However, there is no empirical study that examines the role of behavior in line with values in behavioral activation. This study examined the role of behavior in line with values in behavioral activation by examining the association between behavior in line with values and variables of behavioral activation intervention targets, as well as the mediating effect of behavioral commitment. Japanese versions of the Personal Values Questionnaire II, the Behavioral Activation for Depression Scale, the Environmental Reward Observation Scale, and the Center for Epidemiological Studies Depression were completed by 292 Japanese undergraduate students ( M age = 19.2 yr., SD = 1.7; 65 men, 226 women, 1 unknown). Results indicated that behavior in line with values was associated with focused, goal-directed activation and completion of scheduled activities, which were mediated by behavioral commitment to values.

Aim The present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). Methods We examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI), the Cognitive Appraisal Rating Scale (CARS; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA and AG. The Mini International Neuropsychiatric Interview was used to diagnose AG and PD. Results After excluding individuals with possible organic gastrointestinal diseases by using ‘red flag items,’ valid data were obtained from 174 participants, including 110 PD patients without IBS (PD/IBS[–]) and 64 with IBS (PD/IBS[+]). The PD/IBS[+] group had higher AA and higher comorbidity with AG than the PD/IBS[–] group. In the PD/IBS[+] group, the controllability score of CARS was significantly correlated with AA and ASI. Multiple regression analysis showed a significant effect of ASI but not of controllability on AA in PD/IBS[+] subjects. Conclusion This study suggested that the presence of IBS may be related to agoraphobia and anticipatory anxiety in PD patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD patients with IBS with anxiety sensitivity mediating this correlation.

Many studies have reported that behavioral activation is an effective intervention for depression. The behavioral activation model is based on several formulations. For example, depressive mood leads to avoidant behaviors, avoidance negatively affects social contacts, decreased socialization lessens opportunities for positive reinforcement, and a decrease in positive reinforcement results in more depressive mood. The purpose of this study was to examine relationships among avoidant behavior, social contact, frequency of positive reinforcement, and depressive mood by using structural equation modeling to assess support for aspects of this behavioral activation model. Participants were 630 Japanese undergraduate students and vocational school students. Results provided preliminary support for the model. Treating both avoidance and activating behavior might contribute to decreased impairment.

Previous studies from western countries have reported that happy individuals report lower levels of negative mood during and/or following mental stress testing; this finding has not been examined in Japan. This study examined the relationship between happiness, measured using the Subjective Happiness Scale (Lyubomirsky & Lepper, 1999), and negative moods (i.e., tension and anxiety) during and after mental stress testing in Japanese college students. Based on the findings of previous literature and inverse correlations between positive and negative moods, we hypothesized that participants with higher levels of happiness (the higher happiness group, or HG) show significantly lower levels of negative moods and higher levels of positive moods following mental stress testing, compared to participants with lower levels of happiness (the lower happiness group, or LG). Of a total of 392 Japanese undergraduates who participated in a screening survey, those whose scores were one standard deviation higher or lower than the average score were invited to participate in the experiment. Eight HG and nine LG students agreed to participate. A five-minute computerized mental arithmetic task was used to induce stress. The session comprised a five minute pre-task period, a five minute task, and a five minute post-task period. The levels of positive and negative moods during each period were measured retrospectively following each period. Heart rate was measured during the session. Participant heart rate levels and negative moods increased significantly from the pre-task to the task periods, and subsequently decreased during the post-task period. Levels of positive mood decreased from the pre-task to the task period. Negative moods were significantly lower in HGs than in LGs during the post-task period. These results partially supported the hypothesis whereby subjective happiness buffered the impact of stressors on negative moods by influencing post-stress negative mood levels.

The main aims of the present study were to compare the frequency of social phobia and taijin kyofusho symptoms among young adults in Japan and in England and to examine the role of family environment in the development of these two conditions. A total of 927 young adults (462 in England and 465 in Japan) between the ages of 19 and 24 were investigated. They completed a set of questionnaires that were used to measure social phobia and taijin kyofusho symptoms, as well as family background. Results showed that young adults in Japan reported significantly higher levels of taijin kyofusho and social phobia symptoms than young adults in England. Family sociability had a consistent effect on both social phobia and taijin kyofusho symptoms across the two cultures, but parental rearing attitudes showed distinct patterns between the two countries. This finding suggests that cross-cultural models need to consider familial factors that may be predictive across cultures and others that may be more culturally specific.

This study investigated whether high socially anxious individuals interpret other people’s ambiguous behavior in a more negative or threatening manner in comparison to low socially anxious individuals, after controlling for the effects of depression. High and low socially anxious participants (N = 31) gave a speech. During the speech, a confederate performed ambiguous behaviors. After the speech, participants were asked to answer questions about their interpretation of the confederate’s behaviors using open-ended questions and rating scales. The results showed that the high socially anxious participants interpreted the confederate’s ambiguous behavior in a more negative and threatening manner as measured by the rating scales, and in a less neutral manner as measured by the open-ended responses in comparison to the low socially anxious participants. After controlling for the effects of depression, the effects of social anxiety on the threat rating score remained significant. These results suggest that social anxiety is partially related to threatening interpretations of other’s ambiguous behaviors.

The relationship between negative interpretation of bodily sensations and social anxiety was investigated, and hypothesized cognitive models were tested using structural equation modeling in performance and social interactive situations. The following interpretations of bodily sensations were examined: (1) the overestimation of the visibility of bodily sensations and (2) the fear of negative evaluation of bodily sensations by others. Undergraduate students (N = 293) responded to a set of measures including the Social Phobia Scale and the Social Interaction Anxiety Scale. Correlation analyses indicated that the two interpretations were positively correlated with each other, as well as with social anxiety. Results of structural equation modeling indicated different structures for models of performance and social interactive situations. In both situations, the fear of negative evaluation of bodily sensations by others mediated the relationship between overestimating the visibility of bodily sensations and so...

Background: Safety behaviour plays an important role in the maintenance of social anxiety disorder (SAD). SAD patients engage in various safety behaviours in social situations in order to decrease the risk of negative evaluations from others. Aims: The present study examined the effect of safety behaviour on the maintenance of anxiety and negative belief in SAD by using Structural Equation Modelling (SEM). Methods: Participants were a healthy group (442) and a SAD group (46) who met the SAD criteria for DSM-IV and who had high scores of SAD symptoms. In the assumed maintenance model, independence variables were safety and avoidance behaviour and dependence variables were anxiety and negative belief. Results: This result showed that the SAD group significantly has more high scores than the healthy group in all scales of anxiety, negative belief and avoidance behaviour, expect for safety behaviour. The result of the multiple-group procedure indicated that safety behaviour contributes more strongly to anxiety and negative belief in the SAD group than in the healthy group. Conclusions: It is speculated that the SAD group have a stronger link between safety behaviour and negative belief than the healthy group, whereas frequency of the use of safety behaviour is equivalent between two groups. These results support the findings of previous studies.

本研究では, 現代において男性社会にも広がっていると考えられる痩身願望の存在に注目し, 体型への損得意識を媒介に痩身願望が規定される心理的メカニズムのモデルを検討した。体型の損得意識においては, 自己肯定感のような自己の視点からみたメリット感と対人関係のように他者の視点からみたメリット感があるのではないかと仮定した。青年期男子224名を対象に質問紙調査を実施し, 体型への損得意識に影響を及ぼすと考えられる個人特性と痩身願望との関連について検討した。現在の体型よりも痩せることが魅力的だとする男子学生131名について分析した結果, 「賞賛獲得欲求」「拒否回避欲求」「身体満足度」などが痩身願望と関連のあることが示された。これらの関連を検討したところ, 痩せれば自分に自信がもてるといった「自己視点からの痩身のメリット感」が痩身願望に直接影響し, それ以外の変数はこの「自己視点のメリット感」を媒介として痩身願望に影響することが明らかにされた。痩身願望に至るルートとして, 第1に自己顕示欲求から発する痩身願望, 第2に自己不満感や不安感から発する痩身願望, 第3に自分の意識する肥満度から発するルートが見出せた。

We conducted a meta-analysis using 20 randomised controlled studies of cognitive behavioural therapy (CBT) for anxiety disorders in children and adolescents. The mean pre-post effect size was d = 0.94, which was maintained at follow-up. The mean effect size when comparing the CBT and control group was d = 0.61. Within the CBT group, the mean effect size of university clinics (d = 0.77) was larger than that of other clinics (d = 0.37). The difference in effect sizes was hardly noticeable when comparing CBT with family or parents and CBT with child only (d = 0.03). Further studies are required to examine the effectiveness of family CBT versus child CBT.

Self-focused attention is considered to be a cognitive characteristic of depression. However, some articles report that self-focused attention is also related to anxiety. This study examines the differential relationships of self-focused attention to depression and anxiety. The Preoccupation Scale, Self-rating Depression Scale, and State-Trait Anxiety Inventory T-Form were administered to 454 undergraduate students. The results showed a partial correlation between self-focused attention and anxiety that was significant while controlling for depression, but the partial correlation between self-focused attention and depression was not significant while controlling for anxiety. In addition, the results of an analysis of covariance structure revealed that self-focused attention was related to anxiety, and the relationship between self-focused attention and depression was due to the mediating effect of anxiety. Therefore, it was suggested that self-focused attention appears to be a significant component of cognitive operations for anxiety, but not for depression.

To understand patients' preferences regarding the disclosure of bad news is important in the clinical oncology setting. The aim of this study was to clarify descriptively the preferences of cancer patients. Five hundred and twenty-nine Japanese cancer outpatients were surveyed regarding their preferences regarding the disclosure of bad news, and several psychosocial and medical demographic variables were analyzed. In a descriptive analysis, more than 90% of the patients strongly preferred to discuss their current medical condition and treatment options with their physician and to have their physicians take the feelings of their family into consideration as well. While half of the patients preferred to receive information regarding their life expectancy, 30% preferred not to receive it. Multiple regression analyses indicated the preferences showing interindividual variations were associated with the level of education and the mental adjustment to cancer scores. A factor analysis revealed four preferences factors: method of disclosure of the bad news, provision of emotional support, provision of additional information, and setting. These four factors had good internal consistency reliability (Cronbach's alpha = 0.93-0.77). Providing emotional support, including the desire for the physician to show consideration for the patient's family, and understanding an individual's communication preferences may be useful for promoting patient-physician communication.

This study explores the psychological effects that Japanese people experience when consuming their "Shikohin", such as alcohol, tea, coffee, and tobacco. We'conducted a cross-sectional study among 542 people, from 20-to 69-year-old; who regularly consumed any one of "Shikohin" in Tokyo, Kanagawa, Saitama, and Chiba. The participants responded to an anonymous questionnaire concerning the consumption patterns of their "Shikohin" and the psychological effects that they experienced in taking in their "Shikohin". Results obtained using the K-J methods showed three common psychological effects in each "Shikohin". These effects included an increase in relaxation response, the promotion of social relationships, and an increase in positive mood. Our findings suggest that Japanese people may get some common effects through consumption of different "Shikohin".

Background Several studies have reported an increased tendency towards anger in patients with panic disorder (PD). If this propensity for anger arises from the pathological process of PD, it may be associated with the duration of the illness. The present study therefore examined the relationship between duration of PD and the personality tendency to experience anger in PD patients. Methods Participants were 413 patients (132 men and 281 women; age = 38.7 years) with PD. Diagnoses were confirmed using the Mini-International Neuropsychiatric Interview. Illness duration ranged from less than a year to 51 years. After participants completed the Revised NEO Personality Inventory, we examined the association between illness duration and the Angry Hostility and Impulsiveness subscale scores. In the analysis, participants were divided into two groups by duration of illness (long group, n = 186 and short group, n = 200) using the median value (9 years) as a cut-off because of the skewed distribution of the duration. Patients with an illness duration of 9 years (n = 27) were excluded from the comparison. Results The duration of illness was significantly correlated with the Angry Hostility score (p = 0.002) after controlling for age. Scores were significantly higher in the long group than in the short group (p = 0.04). No significant association was observed between Impulsiveness scores and duration of illness. Conclusion The present study suggests that longer PD duration is related to a stronger tendency to experience anger.