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The effective construction of electron transport channels has essential significance for electron-transfer rate enhancement in REDOX processes during peroxymonosulfate (PMS) activation. This study focuses on the establishment of Cu-involved covalent bonds due to the unique electron configuration of Cu ions. The strategy was achieved by anchoring Cu atoms to an O-doped g-C3N4 (Cu–O–CN) matrix. The C–O–Cu linkage was successfully constructed, derived from the precise incorporation of oxygen. From XAFS, H2-TPR, and solid-ESR characteristic observations, the desired REDOX performance was verified. The constructed C–O–Cu linkages were treated as electron transport channels for electron transfer while reacting with PMS, effectively accelerating the REDOX circulation of the Cu(II)/Cu(I) redox couple and promoting the consecutive generation of active species. Consequently, nearly 100% bisphenol A (BPA) was degraded in the Cu–O–CN/PMS reaction system within 30 min. This demonstrates the effectiveness of Cu–O–CN for PMS activation. The prepared Cu–O–CN exhibited definite stability and potential reusability. This research not only highlights the tailored design of heterogeneous catalysts for PMS activation but also broadens its application in water purification.

The visibility in a foggy environment has a significant impact on driver behavior and traffic flow status, especially for whole closed highways with long distances between entrances and exits. Foggy days are very likely to cause congestion and even secondary traffic accidents, which seriously affect the reliability of freeway operation. In order to explore the influence of a fog environment on freeway traffic jams, firstly, this paper was based on the analysis of the impact of visibility on foggy days. Light fog, medium fog and heavy fog were classified as one scenario, while dense foggy weather was set separately as an extreme scenario without considering lane change. Furthermore, it used the SIR model of infectious disease for reference, and combined with the cellular automata (CA) model, the car-following model and lane-changing rules in different scenarios were set based on safe driving distance and speed for two scenarios. Finally, the key parameters of CA-SIR were calibrated, such as congestion propagation, recovery probability, vehicle braking, and lane-changing probability. The simulation analysis showed that with the decrease in visibility and vehicle speed, the phenomenon of congestion propagation was more prominent, but the causes of queuing phenomenon were different. A low speed limit was the main reason for traffic jams in the light fog condition. In the medium fog condition, the frequency of traffic jams was related to the random braking probability of the visibility. In heavy fog conditions, the congestion area gradually moved upstream with the passage of time. Moreover, in the dense fog condition, the congested area gradually moved upstream with the passage of time; however, vehicles were more likely to accompany each other, and the congested area traveled downstream synchronously with the passage of time and did not dissipate easily. Therefore, in a foggy environment, the best speed limit should be better established under different visibilities, the flow of highway traffic should be strictly controlled if necessary, and in worse situations than high-density traffic in low visibility, to avoid the spread of congestion, the intermittent release of different lanes is suggested to be implemented.

Compared with generally reported Mo

Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. Thus, GLCC1 is mechanistically, functionally, and clinically oncogenic in colorectal cancer. Targeting GLCC1 and its pathway may be meaningful for treating patients with colorectal cancer., lncRNA and cellular metabolism are frequently dysregulated in cancer. In this study, the authors discover the lncGLCC1 is increased in colorectal cancer cells under glucose starvation conditions and correlates with poor prognosis in this cancer.

Compared with generally reported Mo4+/Mo6+ redox cycle, the exposed Mo2+ active sites of Mo-based materials may have a superior potential to effectively activate PMS. However, Mo2+-involved materials as efficient catalysts in sulfate radical-based advanced oxidation processes (SR-AOPs) has rarely been researched. In this work, a spherical Mo2C-loaded carbon material, Mo2C/C, was prepared for the first time by hydrothermal-calcination method directly used as peroxymonosulfate (PMS) activator towards carbamazepine (CBZ) degradation. The results showed that the Mo2C/C could effectively remove nearly 100% CBZ (5 mg·L−1) in the presence of 0.75 mM PMS within 75 min under the optimal conditions. It was attributed to the reductive Mo2+, as active sites, benefits to absorb PMS on the surface to trigger electron transmission, and the defective carbon structures accelerate the activation of PMS. Consequently, the efficient Mo2+/Mo4+/Mo6+ electron transfer was achieved, resulting in excellent catalysis. A series of reactive species including SO4 −, OH and 1O2 species participated in CBZ oxidation degradation. Derived from the superior stability and reusability of Mo2C/C, the removal rate of CBZ still maintained above 80% even after five consecutive cycles, which is expected to be applied in the wastewater treatment including pharmaceuticals in the future.

Long noncoding RNAs (lncRNAs) contribute to many steps in carcinogenesis and often serve as biomarkers or therapeutic targets for tumor diagnosis and therapy. Although the role of lncRNAs in tumor formation is becoming clear, whether lncRNAs mediate gut microbiota-induced colorectal cancer (CRC) is largely unknown. Enterotoxigenic Bacteroides fragilis (ETBF) is a well-known tumor-inducing bacterium in the human gut; however, its tumorigenic effect remains to be explored. In the present study, we revealed the mechanism by which a lncRNA participates in gut bacteria-induced carcinogenesis: Bacteroides fragilis-associated lncRNA1 (BFAL1) in CRC tissues mediates ETBF carcinogenesis. BFAL1 was highly expressed in CRC tissues compared with that in adjacent normal tissues. In vitro, BFAL1 was upregulated in ETBF-treated CRC cells. Mechanistically, ETBF promoted tumor growth via BFAL1 by activating the Ras homolog, which is the MTORC1 binding/mammalian target of the rapamycin (RHEB/mTOR) pathway. Furthermore, BFAL1 regulated RHEB expression by competitively sponging microRNAs miR-155-5p and miR-200a-3p. Clinically, both high expression of BFAL1 and high abundance of ETBF in CRC tissues predicted poor outcomes for patients with CRC. Thus, BFAL1 is a mediator of ETBF-induced carcinogenesis and may be a potential therapeutic target for ETBF-induced CRC.

Gastric acidity-associated disorders such as peptic ulcer and reflux diseases are widespread, and the reported resistance and side effects of currently used medicines suggest an urgent requirement for alternative therapeutic approaches. Here we demonstrate a critical role of ASAP3 in regulating the microvilli structure of parietal cells in vivo, and reveal the feasibility of controlling gastric acidity by targeting ASAP3. Conditional knockout of ASAP3 in mice caused elongation and stacking of microvilli in parietal cells, and substantially decreased gastric acid secretion. These were associated with active assembly of F-actin caused by a higher level of GTP-bound Arf6 GTPase. Consistently, a small molecular compound QS11 inhibited ASAP3 function and significantly reduced gastric acidity in vivo. Of note, the expression of ASAP3 was positively correlated with gastric acid secretion in 90 human cases, and high expression of ASAP3 was associated with reflux disease and peptic ulcer. These results reveal for the first time that ASAP3 regulates the microvilli structures in parietal cells. Our data also suggest ASAP3 as a feasible and drugable therapeutic target for gastric acidity-associated diseases. A drug that blocks a protein found in the minute projections of acid-secreting cells of the stomach could help treat ulcers and reflux. A team led by Jing-Yuan Fang and Jie Xu from Shanghai Jiao Tong University, China, investigated the function of a protein called ASAP3 in regulating the tiny protrusions (called microvilli) of parietal cells, which secrete hydrochloric acid and other digestive juices in the stomach. In mice with depleted ASAP3 activity, the microvilli became elongated and produced far less gastric acid. Also, mice injected with a compound that blocks ASAP3 had reduced acid levels. Human patients suffering from reflux disease and peptic ulcer disease exhibited elevated ASAP3 activity, which further suggests that drugs directed at blocking ASAP3 could help people with acid-associated stomach conditions.

Consumer trust has been more and more recognized as an important factor for a successful e-commerce vendor. Based on the previous research, this paper developed an extended model for analyzing the main attributes of trust of the users in China. A survey regarding the trust of e-commerce users is conducted to empirically test the model. The result shows the perceived reputation and size; the level of multi-channel integration, the system assurance, consumers' propensity to trust and experienced-based familiarity are all positively related with consumers' trust in the vendor. The findings may provide the suggestions for the vendors to consider the trustworthy by the consumers.