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Your search keyword '"Yuka Ishizaka"' showing total 5 results
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5 results on '"Yuka Ishizaka"'

1. ChemInform Abstract: One-Pot Catalysis Using a Chiral Iridium Complex/Broensted Base: Catalytic Asymmetric Synthesis of Catalponol

Author

Takeyuki Suzuki, Yuka Ishizaka, Da-Yang Zhou, Takeyuki Ismiyarto, Hiroaki Sasai, and Kaori Asano

Subjects
Tandem, Chemistry, Enantioselective synthesis, Catalponol, chemistry.chemical_element, Aldol condensation, General Medicine, Iridium, Base (exponentiation), Combinatorial chemistry, Catalysis
Abstract

Based on a tandem oxidation/aldol condensation reaction meso-1,4-tetralinediol is efficiently converted according to the title reaction.

Published
2016

2. One-Pot Catalysis Using a Chiral Iridium Complex/Brønsted Base: Catalytic Asymmetric Synthesis of Catalponol

Author

Kaori Asano, Da-Yang Zhou, Ismiyarto, Hiroaki Sasai, Takeyuki Suzuki, and Yuka Ishizaka

Subjects
Tandem, Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, Biochemistry, Combinatorial chemistry, Catalysis, Hydroboration, chemistry, Stereoselectivity, Aldol condensation, Iridium, Physical and Theoretical Chemistry, Brønsted–Lowry acid–base theory
Abstract

Tandem asymmetric hydrogen transfer oxidation/aldol condensation under relay catalysis of a chiral iridium complex/achiral Bronsted base binary system is described for the synthesis of α-benzylidene-γ-hydroxytetralones with high ee’s. A two-step synthesis of catalponol was achieved using this sequential methodology together with regio- and stereoselective hydroboration.

Published
2015

3. Enantioselective Multicatalytic Synthesis of α-Benzyl-β-hydroxyindan-1-ones

Author

Hiroaki Sasai, Da-Yang Zhou, Kazem Ghozati, Kaori Asano, Takeyuki Suzuki, and Yuka Ishizaka

Subjects
inorganic chemicals, chemistry.chemical_classification, Ketone, organic chemicals, Organic Chemistry, Enantioselective synthesis, Medicinal chemistry, Aldehyde, Desymmetrization, Catalysis, chemistry.chemical_compound, chemistry, Cascade reaction, Aldol reaction, polycyclic compounds, heterocyclic compounds, Aldol condensation, Enone
Abstract

Asymmetric tandem coupling of meso-diols with aldehydes was achieved by using a chiral iridium catalyst. This tandem reaction consists of oxidative desymmetrization of the meso-diol, aldol condensation with an aldehyde, and reduction of the enone intermediate. A one-pot method using an excess of a hydrogen donor gave α-benzyl-β-hydroxyindan-1-ones in up to 94% ee and 88% yield. An asymmetric hydrogen autotransfer method in the absence of an additional hydrogen donor gave the desired benzyl ketone in 92% ee.

Published
2013

4. ChemInform Abstract: Enantioselective Multicatalytic Synthesis of α-Benzyl-β-hydroxyindan-1-ones

Author

Da-Yang Zhou, Hiroaki Sasai, Kazem Ghozati, Yuka Ishizaka, Kaori Asano, and Takeyuki Suzuki

Subjects
inorganic chemicals, Coupling (electronics), Tandem, Chemistry, organic chemicals, fungi, polycyclic compounds, Enantioselective synthesis, heterocyclic compounds, General Medicine, Combinatorial chemistry
Abstract

Asymmetric tandem coupling of meso-diols (I) with aldehydes is achieved using a chiral Ir-catalyst.

Published
2013

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