5 results on '"Yukako Makutani"'
Search Results
2. Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism
- Author
-
Naru Babaya, Yukako Makutani, Shinsuke Noso, Yoshihisa Hiromine, Hiroyuki Ito, Yasunori Taketomo, Kazuki Ueda, Hokuto Ushijima, Yoshifumi Komoike, Yuto Yamazaki, Hironobu Sasano, Yumiko Kawabata, and Hiroshi Ikegami
- Subjects
Hyperaldosteronism ,Incidentaloma ,Paradoxical hyperplasia ,Micronodular hyperplasia ,Aldosterone-producing cell clusters ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed. Case presentation A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 × 5.2 cm) by abdominal computed tomography. His laboratory data showed that his plasma aldosterone concentration (PAC) was within the normal range, but his plasma renin activity (PRA) was reduced, resulting in an increased aldosterone/renin ratio (ARR). Load tests of captopril or furosemide in the standing position demonstrated autonomous aldosterone secretion and renin suppression. Adrenal venous sampling (AVS) with ACTH stimulation indicated bilateral hypersecretion of aldosterone. A left supra-renal tumor was resected because of the possibility of malignancy and was found to be a benign schwannoma arising from the juxta-adrenal region together with an adrenal gland. The dissected left adrenal gland was morphologically hyperplastic in the zona glomerulosa, but was immunohistochemically negative for CYP11B2 (aldosterone synthase). Multiple CYP11B2-positive adrenocortical micronodules were detected in the adrenal gland, indicating micronodular hyperplasia. Although bilateral aldosteronism was indicated by AVS before the operation, the PRA, PAC and ARR values were within their respective reference ranges after resection of the unilateral tumor, suggesting that the slight increase in hormone secretion from the remaining right-sided lesion could not be detected after resection. Conclusion A clinical and morphologic diagnosis of juxta-adrenal schwannoma is difficult, particularly in a case of hyperaldosteronism, as shown in this case. These data suggest the complexity and difficulty diagnosing adrenal incidentaloma.
- Published
- 2017
- Full Text
- View/download PDF
3. Associations between genetic loci related to lean mass and body composition in type <scp>2</scp> diabetes
- Author
-
Sawa Yoshida, Fumimaru Niwano, Hiroshi Ikegami, Naru Babaya, Shinsuke Noso, Yasunori Taketomo, Tatsuro Minohara, Shuzo Imamura, Sara Yasutake, Yukako Makutani, and Yoshihisa Hiromine
- Subjects
Male ,Oncology ,Sarcopenia ,medicine.medical_specialty ,17-Hydroxysteroid Dehydrogenases ,Alpha-Ketoglutarate-Dependent Dioxygenase FTO ,Type 2 diabetes ,Independent predictor ,Body Mass Index ,Fat mass ,ADAMTS Proteins ,Absorptiometry, Photon ,Versicans ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Muscle, Skeletal ,Genotyping ,Genetic association ,Extracellular Matrix Proteins ,business.industry ,medicine.disease ,Aldehyde Oxidoreductases ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Genetic Loci ,Body Composition ,Insulin Receptor Substrate Proteins ,Lean body mass ,Female ,business ,Genome-Wide Association Study - Abstract
Aim Several genetic loci related to lean mass have been identified in healthy individuals by genome-wide association studies; however, the contribution of these loci to body composition in type 2 diabetes remains to be investigated. Here, we aimed to clarify the genetic determinants of body composition in individuals with type 2 diabetes. Methods A total of 176 Japanese outpatients (70 women and 106 men) with type 2 diabetes were studied using a cross-sectional design. Body composition was measured using bioimpedance analysis with a commercially available device (InBody770). Single-nucleotide polymorphisms in IRS1 (rs2943656), HSD17B11 (rs9991501), VCAN (rs2287926), ADAMTSL3 (rs4842924) and FTO (rs9936385) were evaluated by genotyping. The contributions of single-nucleotide polymorphisms to body composition were examined, considering known clinical determinants. Results Sex, body composition and age were identified as clinical predictors. IRS1 rs2934656 was identified as an independent predictor of skeletal muscle mass (β = 0.11, P = 0.026), and ADAMTSL3 rs4842924 was an independent predictor of body fat mass (β = 0.15, P = 0.0095) and appendicular lean mass (β = -0.13, P = 0.017). Conclusions The findings clarified the contribution of genetic factors - IRS1 and ADAMTSL3 - to interindividual variation in body composition, independent of clinical factors, in type 2 diabetes patients. These data will contribute to the establishment of effective methods for the prediction, prevention, and intervention of sarcopenia and frailty in diabetes patients. Geriatr Gerontol Int 2021; ••: ••-••.
- Published
- 2021
- Full Text
- View/download PDF
4. Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus
- Author
-
Tadao Tsuboyama, Kazunori Ikebe, Haruhiko Osawa, Eri Kiyoshige, Fumihiko Matsuda, Hiroshi Ikegami, Katsuhiko Kohara, Hiroshi Onuma, Yasuyuki Gondo, Yukako Makutani, Yasunori Takata, Tome Ikezoe, Mai Kabayama, Noriaki Ichihashi, Tomohiro Katsuya, Yoshihisa Hiromine, Kei Kamide, Masahiro Fukuda, Ken Sugimoto, Yasuharu Tabara, and Hiromi Rakugi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Sarcopenia ,Endocrinology, Diabetes and Metabolism ,Population ,Type 2 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,Body Mass Index ,chemistry.chemical_compound ,Skeletal muscle mass ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Mass index ,education ,Glycemic ,Aged ,Aged, 80 and over ,Glycated Hemoglobin ,education.field_of_study ,business.industry ,Incidence ,General Medicine ,Odds ratio ,Articles ,Middle Aged ,medicine.disease ,RC648-665 ,Prognosis ,Clinical Science and Care ,Cross-Sectional Studies ,chemistry ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,Body Composition ,Original Article ,Female ,Glycated hemoglobin ,business ,Biomarkers ,Follow-Up Studies - Abstract
Aims/Introduction Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes. Materials and Methods Study participants consisted of patients with type 2 diabetes (n = 746, the average age was 69.9 years) and an older general population (n = 2,067, the average age was 68.2 years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index. Results Among patients with type 2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c
- Published
- 2019
5. Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism
- Author
-
Yasunori Taketomo, Yoshifumi Komoike, Shinsuke Noso, Hironobu Sasano, Naru Babaya, Yuto Yamazaki, Kazuki Ueda, Hiroshi Ikegami, Yoshihisa Hiromine, Yumiko Kawabata, Hokuto Ushijima, Yukako Makutani, and Hiroyuki Ito
- Subjects
Aldosterone synthase ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Urology ,Case Report ,Schwannoma ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Plasma renin activity ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Adrenal Glands ,Hyperaldosteronism ,Medicine ,Humans ,030212 general & internal medicine ,Aged ,Incidentaloma ,Micronodular hyperplasia ,lcsh:RC648-665 ,Aldosterone ,biology ,business.industry ,Adrenal gland ,Adrenalectomy ,General Medicine ,medicine.disease ,Prognosis ,medicine.anatomical_structure ,chemistry ,Zona glomerulosa ,030220 oncology & carcinogenesis ,Paradoxical hyperplasia ,biology.protein ,Aldosterone-producing cell clusters ,business ,Neurilemmoma - Abstract
Background We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed. Case presentation A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 × 5.2 cm) by abdominal computed tomography. His laboratory data showed that his plasma aldosterone concentration (PAC) was within the normal range, but his plasma renin activity (PRA) was reduced, resulting in an increased aldosterone/renin ratio (ARR). Load tests of captopril or furosemide in the standing position demonstrated autonomous aldosterone secretion and renin suppression. Adrenal venous sampling (AVS) with ACTH stimulation indicated bilateral hypersecretion of aldosterone. A left supra-renal tumor was resected because of the possibility of malignancy and was found to be a benign schwannoma arising from the juxta-adrenal region together with an adrenal gland. The dissected left adrenal gland was morphologically hyperplastic in the zona glomerulosa, but was immunohistochemically negative for CYP11B2 (aldosterone synthase). Multiple CYP11B2-positive adrenocortical micronodules were detected in the adrenal gland, indicating micronodular hyperplasia. Although bilateral aldosteronism was indicated by AVS before the operation, the PRA, PAC and ARR values were within their respective reference ranges after resection of the unilateral tumor, suggesting that the slight increase in hormone secretion from the remaining right-sided lesion could not be detected after resection. Conclusion A clinical and morphologic diagnosis of juxta-adrenal schwannoma is difficult, particularly in a case of hyperaldosteronism, as shown in this case. These data suggest the complexity and difficulty diagnosing adrenal incidentaloma.
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.