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Purpose: The wide-spread use of organophosphorus pesticides (OPP) and their substantial toxicity determine the high frequency of poisoning with them. Despite the modern treatment methods, the acute exogenous intoxications (AEI) continue to exhibit high lethality and are the source of one of the most serious problems in the clinical toxicology. A number of not commonly accepted criteria have been suggested to estimate the gravity of the organophosphorous intoxication. Until now no system of clinical criteria exists that would forecast the outcome of this type of acute poisoning. The aim of this study is to develop an outcome forecast of AEI with OPP with the help of basic clinical criteria. Materials/Methods: The subjects of the study are 160 patients. We explore the significance of five of the most typical clinical indicators of the acute poisoning with OPP for the outcome of the intoxication and the need of artificial pulmonary ventilation, with the aid of discriminatory statistical analysis. The selected indicators form a discriminatory model with automatically built discrimination function. Results: The obtained classification coefficients allow us to construct a forecast matrix containing score estimates designed for practical applications.

Purpose: Several criteria have been suggested to estimate the intoxication severity, yet so far no system of clinical criteria has been developed to determine the duration of hospitalisation. The forecast is linked to the influence of the extended corrected QT interval and GCS (Glasgow Coma Scale) on the frequency of the developing acute pulmonary insufficiency and lethality. The average duration of hospital treatment is also crucial. First of all, it is determined by the intoxication severity and lasts from 3 to 26 days. The aim of this study is to develop an individual forecast about the duration of hospitalisation for patients suffering from acute exogenous intoxication with organophosphorus pesticides (OPP). Materials/Methods: The subjects are 160 patients. We use statistical regression analysis to study the significance of 5 of the most typical clinical indicators of organophosphorus intoxication on the duration of hospitalisation: type of conscience, presence of spasms, pulmonary oedema, shock and multi-organ insufficiency syndrome (MOIS). To forecast the treatment length, we obtain simplified mathematical expressions in the form of score estimates. Results: The significance of the clinical indicators “MOIS”, “conscience” and “spasm” has been confirmed. A forecast matrix that gives the opportunity to forecast the personal duration of hospital treatment for each patient has been built.

Purpose: Poisoning with drugs occupies a leading position among the causes of acute intoxications. Etiological distribution of medicated poisoning in different countries, even if they are adjacent, is different. In the most studies it was reported that the highest incidence of poisoning is with benzodiazepines or other psychoactive drugs. A retrospective analysis of acute poisoning with benzodiazepines and other hypnotic drugs in the Varna region for 25 years period – from 1991 to 2015 was carried out. Material and Methods: The number of patients who received hospital treatment after poisoning with benzodiazepines is 1741, and those with other hypnotics is 293, representing respectively 26.37% and 4.44% of all drug intoxications. Results: The share of poisoning with benzodiazepines and hypnotics compared to all acute intoxications is 11.66%. They are more common in women – 1566 (77%). Men are 468 (23%), the ratio of men to women was 3.34:1. The largest number of intoxications is in the age group up to 24 years - 1123 (55.2%), and only 4.1% of patients over 60 years. Intentional suicide attempts are 1896 (93.2%). Death is registered in 8 (0.4%) patients.

Purpose: Poisoning with drugs is a serious medical and social problem worldwide. Retrospective analysis of acute poisoning with narcotic drugs had been performed in Varna region for 25 years (1991-2015). Material and Methods: The number of patients received hospital treatment after poisonings with narcotic substances was 677, which represented 3.9% of all acute exogenous intoxications. Results: Narcotic poisonings were more common in men – 546 (80.6%), than in women – 131 (19.4 %). The ratio male/ female was 4.17:1. The largest number of intoxications were in the age group up to 24 years – 1123 (66%), and only 2.65% of patients were over 45 years. Death was registered in 6 (0.9%) patients.