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6. Remission of diabetes mellitus induced by prednisolone in combination with cyclosporine toxicity in a cat.

Author

Cha, Sijin, Koo, Yoonhoi, Choi, Yujin, Chae, Yeon, Lee, Dohee, Yun, Taesik, Yang, Mhan‐Pyo, Kang, Byeong‐Teck, and Kim, Hakhyun

Subjects
INFLAMMATORY bowel diseases, INTRAVENOUS therapy, DIABETIC acidosis, INSULIN therapy, SUBCUTANEOUS infusions
Abstract

A 6‐year‐old spayed female domestic short‐hair cat was presented for primary complaints of anorexia and lethargy. The cat was being treated with cyclosporine (25 mg/cat, PO q24h) and prednisolone (1 mg/kg, PO q12h) for feline hypersensitivity dermatitis and inflammatory bowel disease for 1 year, wherein prednisolone was withdrawn 2 weeks prior to presentation. At presentation, dehydration, hyperglycaemia, ketonaemia, increased fructosamine, glucosuria, ketonuria and metabolic acidosis were observed. The cat was diagnosed with diabetic ketoacidosis (DKA). Immediate treatments with insulin continuous‐rate infusion and intravenous fluid therapy were initiated. A serum cyclosporine concentration was >2100 ng/mL, indicating cyclosporine toxicity. Cyclosporine was discontinued immediately. The cat's acidosis and ketonaemia were resolved within a week, allowing a switch from insulin continuous‐rate infusion to subcutaneous glargine (1 IU/cat), which was eventually discontinued due to persistent normoglycaemia 12 days after initial presentation. Hyperglycaemia was not observed for 28 days thereafter without insulin, indicating remission of diabetes mellitus. This report suggests that using prednisolone, particularly immune suppressive doses, could be problematic in cats receiving long‐term cyclosporine therapy. Additionally, diabetic cats receiving immune‐suppressive agents can possibly achieve diabetic remission after surviving DKA through regular monitoring of blood glucose concentration, elimination of prednisolone and intensive blood glucose management. [ABSTRACT FROM AUTHOR]

Published
2024
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10. A single‐blind randomised study comparing the efficacy of fluconazole and itraconazole for the treatment of Malassezia dermatitis in client‐owned dogs.

Author

Lee, Hayoon, Koo, Yoonhoi, Yun, Taesik, Lee, Dohee, Chae, Yeon, Min, Kyung‐Duk, Kim, Hakhyun, Yang, Mhan‐Pyo, and Kang, Byeong‐Teck

Subjects
ITRACONAZOLE, FLEA control, MALASSEZIA, FLUCONAZOLE, SKIN inflammation, DOGS, VISUAL analog scale
Abstract

Copyright of Veterinary Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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20. The evaluation of power plant investments in the Korean electricity industry

Author

Yun, Taesik

Subjects
333
Abstract

The purpose of this thesis is to use real option methodologies to assess capital investment decisions of near future projects that will be made in Korea. I compare two base load plants burning different fuels such as coal and uranium within the CO2 allowance trading context to provide prominence to a nuclear power plant. Nuclear power plants have recently been rising to the surface as one of the leading alternatives to the generation plants using fossil fuels. To consider the flexibilities and uncertainties in a competitive market environment, I employed the real options approach, due to its superiority in dealing with uncertainties and incorporating management's flexibilities into the valuation process. Furthermore, I tried to evaluate the investment opportunity contingent on at least two underlying assets featuring different price evolution behaviours. As main pricing skeletons, I adopted the mean reversion model for the evolution of electricity prices and the gBm model for that of the COi allowance prices and construction costs of a nuclear power plant. In addition, I used the Monte Carlo simulation approach as the approximation tool to overcome a limitation of the analytic approach. Our findings confirmed that the real options approach uncovered hidden strategic value and provided critical insights to the investment decision making process. Keywords: Investment Analysis, Real Option Approach, Base Load Plant, CO2 Allowance, Electricity Price

Published
2010

26. Serratia marcescens‐associated subcutaneous abscess in a dog.

Author

Koo, Yoonhoi, Yun, Taesik, Chae, Yeon, Lee, Dohee, Yu, Hogeun, Cha, Sijin, Kim, Hakhyun, Yang, Mhan‐Pyo, and Kang, Byeong‐Teck

Subjects
*SERRATIA, *ABSCESSES, *DOGS, *DISEASE progression, *SERRATIA marcescens
Abstract

This report describes the clinical presentation and progression of a Serratia marcescens‐associated subcutaneous abscess in a dog with hypothyroidism, hyperadrenocorticism and diabetes mellitus. The S. marcescens isolate was resistant to several antibiotics. Treatment with antibiotics and topical antiseptics was not successful. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Recurrent Thyroid Carcinoma in a Dog - Diagnosis by 18F-Fluorodeoxyglucose Positron Emission Tomography

Author

Yu, Hogeun, Chae, Yeon, Yun, Taesik, Koo, Yoonhoi, Lee, Dohee, Kim, Hakhyun, Yang, Mhan-Pyo, and Kang, Byeong-Teck

Abstract

Background: Thyroid tumor is a common endocrine tumor that accounts for up to 3.8% of all tumors in dogs. Most of them are malignant and usually nonfunctional in dogs. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is an imaging modality that detects intracellular accumulation of radioactive deoxyglucose administered in the body and is used in combination with computed tomography to provide functional information with exact anatomical localization. It is used in human medicine to detect residual or recurrent head and neck neoplasm after treatments, such as surgical resection. This report describes the first case of diagnosing recurrent thyroid carcinoma (TC) through FDG-PET in a dog. Case: A 9-year-old castrated male Maltese dog presented with a palpable mobile mass in the right ventral cervical region. Radiography and ultrasonography (US) showed a radiopaque mass adjacent to the trachea, and the right thyroid gland was enlarged on computed tomography. The surgically excised mass was encapsulated and measured to be 2.3 × 1.0 × 3.4 cm (width x length x height) in size. Histopathologically, the mass was diagnosed as differentiated follicular TC, and gross and vascular invasions were observed. To prevent recurrence, postoperative carboplatin chemotherapy was performed for 5 months. Two months after completion of chemotherapy, a nodule of approximately 7 mm in diameter was detected in the thyroidectomy bed by US. FDG-PET scanning was performed as an effective means of evaluating the malignancy, local recurrence, and metastasis of differentiated follicular TC. The nodule had the dimensions of 2.8 × 5.9 × 8.6 mm, a maximum standardized uptake value (SUV) of 8.49, and a mean SUV of 5.6. The results of FDG-PET suggested the recurrence of TC; therefore, the second chemotherapy protocol using toceranib was applied for 16 months. After initiation of the second chemotherapy, follow-up examinations were conducted approximately every 4 months. On the 134th day, although the nodule was not palpated, its size was observed to have increased to 5.0 × 3.8 × 13.6 mm on cervical US on the 232nd day, showing heterogeneous and hypoechoic parenchyma. On the 405th day, the tumor was enlarged to a size of 13.4 × 12.9 × 22 mm and identified as a lobular, amorphous shape, and its heterogeneity was increased. Moreover, two pulmonary nodules with well-defined margins were found on radiography in the left caudal lung lobe (9 × 10 mm and 12 × 12 mm [width × length]); thus, lung metastasis was suspected. On the 536th day, anorexia and lethargy occurred, and the dog was lost to follow-up. Discussion: In the present case, local recurrence of TC was suspected based on cervical US. Although US was useful as a screening tool, additional examinations were necessary for evaluating local invasiveness, malignancy, and nodal/distant metastasis. FDG-PET can detect recurrence at an early stage because it can sense increased tumor metabolism through physiologic absorption of FDG, even before the beginning of anatomic change in the lesion. Therefore, FDG-PET can assist in treatment planning and provide better prognosis. In humans, focal FDG uptake and a high maximum SUV in the thyroid gland on FDG-PET were associated with a higher risk of cancer. Because there was no evidence of neoplasia except the thyroid lesion during the FDG-PET examination, the tumor showed an increasingly malignant pattern of the thyroid gland on US during the follow-up period, and the metastatic pulmonary nodules were identified on the 650th day after the thyroidectomy. Therefore, the present case was diagnosed as recurrent TC. This report describes the use of FDG-PET for diagnosing local recurrence of TC, pointing to FDG-PET as a potential strategy to evaluate loco-regional recurrence and distant metastasis of TC. Keywords: canine, FDG-PET, follicular thyroid carcinoma, metastasis, tumor, cancer.

Published
2023

31. Steroid-Responsive Myelitis in Dogs - Comparison with Steroid-Responsive Meningitis-Arteritis

Author

Koo, Yoonhoi, Yun, Taesik, Chae, Yeon, Lee, Dohee, kim, Hakhyun, Yang, Mhan-Pyo, and Kang, Byeong-Teck

Abstract

Background: Myelitis is the inflammation of the spinal cord parenchyma alone, whereas meningitis is the inflammation of the meninges. Steroid-responsive meningitis-arteritis (SRMA) is a meningomyelitis in which the major lesions involve the meninges, not the spinal cord parenchyma, and respond well to glucocorticoid treatment. However, myelitis in dogs has rarely been reported, and myelitis with a good response to glucocorticoid treatment without relapse has not been reported. This report describes 5 cases of steroid-responsive myelitis (SRM) in dogs.Cases: Case 1. A 8-year-old intact female Cocker Spaniel presented with progressive nonambulatory paraplegia. Whole spinal parenchymal lesions were identified using magnetic resonance imaging (MRI) scan. Mononuclear pleocytosis with increased total protein levels was the only abnormal finding on cerebrospinal fluid (CSF) analysis. Prednisolone (PDS) was administered followed by dose tapering according to therapeutic response. Cyclosporine was administered until the termination of PDS. Since then, no recurrence of neurological symptoms has been observed. Follow-up MRI and CSF analysis revealed resolution of previously observed abnormal findings. Case 2. A 2-year-old intact female Maltese presented with non-progressive paraparesis. A spinal parenchymal lesion in the lumbosacral region was observed on MRI. PDS was administered and slowly tapered at approximately 3-week intervals. No recurrence of neurological symptoms was observed after the treatment. Case 3. A 6-year-old intact female Miniature Pinscher presented with neck pain, along with leukocytosis and neutrophilia. Cervical spinal parenchyma lesions were revealed through MRI. Increased total protein concentration with mixed cell pleocytosis was observed on CSF analysis. Immunomodulatory therapy, similar to that in case 2, was initiated. A second MRI and CSF analysis revealed an improvement in the previously observed abnormalities. Case 4. A 2-year-old, intact female Toy Poodle presented with acute paraplegia and back pain. Lesions were observed in the spinal parenchyma at the T12-L3 levels on MRI. The treatment was conducted as in case 2. During treatment, neurological symptoms, including paraplegia and back pain, were not observed. Follow-up MRI revealed improvement in the spinal lesion. Case 5. A 6-month-old, castrated male Standard Poodle presented with progressive paraparesis. On MRI, lesions were observed in the T11-T13 regions. Immunomodulation therapy, similar to that in case 2, was initiated. No recurrence of neurological symptoms was observed after treatment initiation. Discussion: SRM is similar to SRMA in terms of good steroid-responsiveness and noninfectious inflammation etiology; however, it does not exactly satisfy the diagnostic criteria for SRMA, nor does it progress similarly. The characteristics of SRM that do not satisfy the diagnostic criteria of SRMA include the absence of fever, C-reactive protein elevation, hyperglobulinemia, and relapse, and the presence of spinal parenchymal lesions without parenchymal or meningeal enhancement on MRI. It is also a seemingly different from spinal cord-only meningoencephalomyelitis of unknown origin due to its better treatment response and prognosis. However, the dogs in the present report with SRM satisfied the diagnostic criteria for transverse myelitis in human patients. Therefore, SRM, including good steroid responsiveness and good prognosis without relapse, may represent a novel type of meningomyelitis. Keywords: canine, inflammatory spinal cord disease, myelitis, spinal cord, steroid.

Published
2023

32. 18F‐fluorodeoxyglucose positron emission tomography findings of peripheral nerve sheath tumour of the nasal cavity in a dog

Author

Lee, Dohee, primary, Yun, Hyejin, additional, Yun, Taesik, additional, Koo, Yoonhoi, additional, Chae, Yeon, additional, Nam, Hyeyeon, additional, Kang, Seonggweon, additional, Lee, Hayoon, additional, Chang, Dongwoo, additional, Yang, Mhan‐Pyo, additional, Kang, Byeong‐Teck, additional, and Kim, Hakhyun, additional

Published
2023
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35. A 192-Gb 12-High 896-GB/s HBM3 DRAM With a TSV Auto-Calibration Scheme and Machine-Learning-Based Layout Optimization

Author

Park, Myeong-Jae, primary, Lee, Jinhyung, additional, Cho, Kyungjun, additional, Park, Jihwan, additional, Moon, Junil, additional, Lee, Sung-Hak, additional, Kim, Tae-Kyun, additional, Oh, Sanghoon, additional, Choi, Seokwoo, additional, Choi, Yongsuk, additional, Cho, Ho Sung, additional, Yun, Taesik, additional, Koo, Young Jun, additional, Lee, Jae-Seung, additional, Yoon, Byung-Kuk, additional, Park, Young-Jun, additional, Oh, Sangmuk, additional, Lee, Chang Kwon, additional, Lee, Seong-Hee, additional, Kim, Hyun-Woo, additional, Ju, Yucheon, additional, Lim, Seung-Kyun, additional, Lee, Kyo Yun, additional, Lee, Sang-Hoon, additional, We, Woo Sung, additional, Kim, Seungchan, additional, Yang, Seung Min, additional, Lee, Keonho, additional, Kim, In-Keun, additional, Jeon, Younghyun, additional, Park, Jae-Hyung, additional, Yun, Jong Chan, additional, Kim, Seonyeol, additional, Lee, Dong-Yeol, additional, Oh, Su-Hyun, additional, Shin, Jung-Hyun, additional, Lee, Yeonho, additional, Jang, Jieun, additional, and Cho, Joohwan, additional

Published
2023
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38. Neuronal ceroid lipofuscinosis in a Border Collie: a case report

Author

Seo, Minsu, primary, Koo, Yoonhoi, additional, Choi, Dongjoon, additional, Kim, Sanggu, additional, Yun, Taesik, additional, Chae, Yeon, additional, Lee, Dohee, additional, Kim, Hakhyun, additional, Yang, Mhan-Pyo, additional, Kim, Soochong, additional, and Kang, Byeong-Teck, additional

Published
2022
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48. Use of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose positron emission tomography/computed tomography for staging thyroid carcinoma in a cat.

Author

Kang, Seonggweon, Koo, Yoonhoi, Yun, Taesik, Chae, Yeon, Lee, Dohee, Kim, Hakhyun, Yang, Mhan‐Pyo, and Kang, Byeong‐Teck

Subjects
THYROID cancer, POSITRON emission tomography, COMPUTED tomography, VETERINARY medicine, LYMPHATIC metastasis, THYROID nodules
Abstract

Thyroid nodules are common in older cats and are mostly benign; however, carcinomas may occur infrequently. In cats, thyroid carcinomas tend to be highly metastatic. The role of 18F‐2‐deoxy‐2‐fluoro‐D‐glucose (FDG) positron emission tomography (PET)/computed tomography (CT) in human thyroid carcinoma has been well established. However, guidelines have not yet been established for veterinary medicine. Metastasis assessment has typically been performed using CT in veterinary medicine; however, it is poorly sensitive in detecting regional lymph nodes or distant metastases if these lesions are not abnormally contrast‐enhanced, enlarged or cause overt mass effects. This case suggested that FDG PET/CT may be used for staging feline thyroid carcinoma, and the results contributed to treatment recommendations. [ABSTRACT FROM AUTHOR]

Published
2023
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