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Objective. Numerus studies present that remnant cholesterol (RC) as a risk factor participates in the progression of multiple diseases. The aim of this study was to assess the relationship between cholesterol and periodontitis in the US population to find a reliable lipid predictor for periodontitis. Materials and Methods. Clinical data was retrieved from the National Health and Nutrition Examination Survey (NHANES) database between 2009 and 2014. The logistic regression was conducted to examine the corelationship between RC and various clinical features. Meanwhile, the dose-response relationship was measured through restricted cubic spline analysis. And the propensity score matching (PSM) was established to further investigate the potential relationship between RC and periodontitis. Results. A number of 4,829 eligible participants were included in this study. It was found that the increased RC is associated with the higher risk of periodontitis after adjusting the potential confounding factors with the adjusted odds ratios (aOR) of 1.403 (95% confidence intervals (CI): 1.171-1.681, P < 0.001 , univariate analysis) and 1.341 (95% CI: 1.105-1.629, P = 0.003 , multivariate analysis) in the highest grade. There were significant differences in the relationship between RC and various clinical features including age, gender, body mass index (BMI), race, hypertension, and diabetes mellitus (all P < 0.001 ). Besides, the calculated thresholds for predicting periodontitis were 19.99 (before propensity score matching (PSM)) and 20.91 (after PSM) mg/dL. Conclusions. In this study, RC was identified to be positively associated with the occurrence of periodontitis, which suggests that RC can be considered as a predictor for periodontitis.

As one typical giant permittivity material in the last 20 years, CaCu3Ti4O12 is need of a clarification between structures and the permittivity in the development of industrialization. Besides, it presents other electrical, antiferromagnetic, and photo-related properties. One model for all phenomena, all doubt for one model. We highlight the importance of intrinsic structures, by identifying the insulating anisotropy of grain boundaries, the undesirable loss effect of twinning boundaries and the dielectric insensitivity of A-site atomic Ca/Cu disorders. Based on both B-site specific titanium ions and A-site copper ions' polaron-like 3d electrons, we have established a comprehensive and self-consistent model of binary dielectric polarizing species, mainly with the Hamiltonian in the Ising model analysis of dielectric polarization. The review points to a new way of applying quantum physics to deepen dielectric researches in transitional metal oxides, by exploiting strong ionic and electronic correlations beyond classical dielectric physics.

Bronchiolitis obliterans (BO), is a chronic rejection phenotype characterized by chronic small airway fibrous obliteration, hinders the patients who suffer from lung transplanting for surviving longer. Cell‐based therapies using dendritic cells (DCs) and T regulatory cells (Tregs) have been developed to regulate allograft rejection, and to induce and maintain immune tolerance. In the present study, the effects of mir‐27a‐3p on regulating DCs as well as resulting effects on BO attenuation have been investigated. According to our reporter assays, the potential targets of mir‐27a‐3p were Smad2, sprouty2, and Smad4, respectively. Furthermore, sprouty2 inhibition by mir‐27‐3p indirectly activated extracellular regulated protein kinases (ERK) and increased IL‐10 production in DCs. This led to a positive feedback loop that maintained the immature state of DCs via IL‐10/JAK/STAT3 pathway, and caused an increase in Foxp3+CD4+ T cells amount as well as TGF‐β level. Furthermore, mir‐27a‐3p regulated TGF‐β function, inhibited TGF‐β/Smad pathway, and suppressed myofibroblast differentiation through influencing the function of Smad2 and Smad4. In short, the study indicated the effect of mir‐27a‐3p on suppressing DC maturation, which implicated the potential clinical application in treating postlung transplant BO., 1.Our study confirms the regulatory role of mir‐27a‐3p on DCs and suggests its potential clinical application to treat postlung transplant BO.2.Mir‐27a‐3p regulates DC maturation by targeting sprouty2 that indirectly activates ERK and promotes IL‐10 through the IL‐10/JAK1/STAT3 protein signaling.3.Mir‐27a‐3p also regulated TGF‐β function, inhibited the TGF‐β/Smad pathway, and suppressed myofibroblast differentiation by targeting Smad2 and Smad4.4.We confirmed the regulatory role of mir‐27a‐3p in DCs, providing a feasible clinically applicable strategy for BO treatment after lung transplantation.

Obstructive sleep apnea syndrome (OSAS) is a common health problem that is associated with abnormality in craniofacial morphology. The growth hormone receptor (GHR) belongs to the cytokine receptor superfamily and mediates the majority of growth hormone signaling, which, among other functions, determines mandibular growth and development. The aim of this study was to determine if correlations exist between single nucleotide polymorphisms (SNPs) in the GHR gene and OSAS in the Han or Hani ethnic groups in China. A total of 274 Han subjects (106 with OSAS and 168 without OSAS) and a total of 270 Hani subjects (64 with OSAS and 206 without OSAS) were enrolled in our study. Genomic DNA was extracted from peripheral blood obtained from all subjects. Genotyping was undertaken for eight SNPs in the GHR gene (rs3756416, rs7727047, rs2910875, rs12153009, rs2972781, rs12518414, rs4410646, and rs6451620) using PCR amplification and Sanger sequencing. The genotype frequency of rs12518414 was associated with OSAS in both the Han and Hani groups, and the A allele frequency was remarkably lower in Hani OSAS patients compared with Hani controls (16.7 vs 29.9%). In addition, the G allele frequency of the rs3756416 SNP was significantly lower in OSAS patients compared with normal controls in the Hani ethnic group (12.5 vs 24.6%). In a comparison between ethnic groups, genotype frequencies of four SNPs (rs2972781, rs6451620, rs12518414, and rs7727047) differed between Han and Hani OSAS patients, with the A allele frequency of the rs12518414 and G allele frequency of the rs7727047 were significantly higher in the Han OSAS patients. In conclusion, significant associations were detected between some SNPs in the GHR gene and OSAS occurrence while others appeared to be ethnicity-dependent.

Energy reforms advance development of human civilizations. As environmental problems go increasingly severe, hydrogen energy which is featured by zero carbon emissions, high efficiency, easy storage and other advantages has won attention from researchers from around the world. China has rich hydrogen energy, and in the next energy reform, hydrogen will play an important role. This paper will introduce the application of hydrogen energy in industries, fuel-driven and electric cars, hydrogen storage and heat-power joint production in hybrid energy systems as well as the current development conditions. Typical study cases from different countries have been analyzed and interpreted. On that basis, the problems and bottlenecks for development of hydrogen energy in China are concluded.

It is an important way to solve the problem of energy environment to use the new energy to run the multi-type energy coupling integrated energy system.Firstly, the mathematical model of power-to-gas (P2G) and electric-to-gas (P2HSS) energy storage system is established in this paper, and then the comprehensive energy system model of power-to-gas is established by using the modeling method of general energy hub. With the goal of reducing costs, reducing emissions, increasing new energy output and increasing P2G and P2H conversion benefits, optimization dispatch analysis was conducted. The numerical example shows that the consumption of new energy in the system is good. At the same time, P2HSS system has a significant effect on peak cutting and valley filling to ensure the economic and stable operation of the system.

Litter decomposition is an important process of C and N cycling in the soil. Variation in the response of litter decomposition to nitrogen (N) addition (positive, negative or neutral) has been observed in many field studies. However, mechanism about variability in individual fungal species response to N addition has not yet been well demonstrated in the literature. Therefore, the objective of this study was to investigate the effects of N addition and litter chemistry properties on litter decomposition and enzyme activities of individual fungi. Three fungal species (Penicillium, Aspergillus, and Trichoderma) were isolated from a subtropical mixed forest soil. An incubation experiment was conducted using the individual fungi with two types of litter (leaf of Pinus massoniana and needle of Cryptocarya chinensis) and different N addition levels (0, 50 and 100 for N-deficient treatments, and 500 and 1000 μg N for N-excessive treatments). Cumulative CO2-C, enzyme activities, and lignin and cellulose loss were measured during the incubation period of 60 days. Litter decomposition and enzyme activities significantly varied with the fungal species, while the N addition and litter types greatly affected fungal enzyme activities. The N treatments significantly increased lignin-rich needle decomposition by lignocellulose decomposers (Penicillium and Aspergillus) but did not affect their leaf decomposition. On the contrary, The N treatments stimulated leaf decomposition by cellulolytic species (Trichoderma) but did not affect its needle decomposition. Correlation analysis showed that lignin in the litter was the key component to affect litter decomposition. Activities of N-acetyl-β-glucosaminidase and phenol oxidase were both positively correlated to litter decomposition. The fungi (Penicillium and Aspergillus) with higher production of N-acetyl-β-glucosaminidase showed higher litter decomposition ability. The low N addition levels stimulated Penicillium and Aspergillus litter decomposition, but they still required more N source (e.g., litter N source) to support decomposition. Depressed fungal litter N uptake (lower N-acetyl-β-glucosaminidase activities) only occurred at the highest N addition level. Litter decomposition of Trichoderma depended more on external N and its litter decomposition capability was the lowest among the three species.