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2. Association of Guideline-Recommended COPD Inhaler Regimens With Mortality, Respiratory Exacerbations, and Quality of Life A Secondary Analysis of the Long-Term Oxygen Treatment Trial

Author

Keller, Thomas, Spece, Laura J, Donovan, Lucas M, Udris, Edmunds, Coggeshall, Scott S, Griffith, Matthew, Bryant, Alexander D, Casaburi, Richard, Cooper, J Allen, Criner, Gerard J, Diaz, Philip T, Fuhlbrigge, Anne L, Gay, Steven E, Kanner, Richard E, Martinez, Fernando J, Panos, Ralph J, Shade, David, Sternberg, Alice, Stibolt, Thomas, Stoller, James K, Tonascia, James, Wise, Robert, Yusen, Roger D, Au, David H, and Feemster, Laura C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Comparative Effectiveness Research, Lung, Chronic Obstructive Pulmonary Disease, Clinical Trials and Supportive Activities, Clinical Research, Respiratory, Good Health and Well Being, Administration, Inhalation, Adrenal Cortex Hormones, Adrenergic beta-2 Receptor Agonists, Aged, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Muscarinic Antagonists, Nebulizers and Vaporizers, Oxygen Inhalation Therapy, Practice Guidelines as Topic, Pulmonary Disease, Chronic Obstructive, Quality of Life, COPD, guidelines, inhaled corticosteroids, pharmacotherapy, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundAlthough inhaled therapy reduces exacerbations among patients with COPD, the effectiveness of providing inhaled treatment per risk stratification models remains unclear.Research questionAre inhaled regimens that align with the 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy associated with clinically important outcomes?Study design and methodsWe conducted secondary analyses of Long-term Oxygen Treatment Trial (LOTT) data. The trial enrolled patients with COPD with moderate resting or exertional hypoxemia between 2009 and 2015. Our exposure was the patient-reported inhaled regimen at enrollment, categorized as either aligning with, undertreating, or potentially overtreating per the 2017 GOLD strategy. Our primary composite outcome was time to death or first hospitalization for COPD. Additional outcomes included individual components of the composite outcome and time to first exacerbation. We generated multivariable Cox proportional hazard models across strata of GOLD-predicted exacerbation risk (high vs low) to estimate between-group hazard ratios for time to event outcomes. We adjusted models a priori for potential confounders, clustered by site.ResultsThe trial enrolled 738 patients (73.4% men; mean age, 68.8 years). Of the patients, 571 (77.4%) were low risk for future exacerbations. Of the patients, 233 (31.6%) reported regimens aligning with GOLD recommendations; most regimens (54.1%) potentially overtreated. During a 2.3-year median follow-up, 332 patients (44.9%) experienced the composite outcome. We found no difference in time to composite outcome or death among patients reporting regimens aligning with recommendations compared with undertreated patients. Among patients at low risk, potential overtreatment was associated with higher exacerbation risk (hazard ratio, 1.42; 95% CI, 1.09-1.87), whereas inhaled corticosteroid treatment was associated with 64% higher risk of pneumonia (incidence rate ratio, 1.64; 95% CI, 1.01-2.66).InterpretationAmong patients with COPD with moderate hypoxemia, we found no difference in clinical outcomes between inhaled regimens aligning with the 2017 GOLD strategy compared with those that were undertreated. These findings suggest the need to reevaluate the effectiveness of risk stratification model-based inhaled treatment strategies.

Published
2020

4. Characteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial

Author

Moy, Marilyn L, Harrington, Kathleen F, Sternberg, Alice L, Krishnan, Jerry A, Albert, Richard K, Au, David H, Casaburi, Richard, Criner, Gerard J, Diaz, Philip, Kanner, Richard E, Panos, Ralph J, Stibolt, Thomas, Stoller, James K, Tonascia, James, Yusen, Roger D, Tan, Ai-Yui M, Fuhlbrigge, Anne L, and Group, for the LOTT Research

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Research, Clinical Trials and Supportive Activities, HIV/AIDS, Respiratory, Aftercare, Aged, Disease Progression, Early Intervention, Educational, Female, Humans, Hypoxia, Male, Middle Aged, Outcome Assessment, Health Care, Oxygen Inhalation Therapy, Perception, Pulmonary Disease, Chronic Obstructive, Self Concept, Self Efficacy, Time, Treatment Adherence and Compliance, LTOT, COPD, Adherence, Self-efficacy, Readiness, Confidence, LOTT Research Group, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology
Abstract

RationaleCharacteristics associated with adherence to long-term oxygen therapy (LTOT) in COPD remain unclear.ObjectivesTo identify patient characteristics at the time of oxygen initiation associated with its adherence.MethodsWe conducted a secondary analysis of data from 359 COPD participants assigned to oxygen in the Long-term Oxygen Treatment Trial. Participants were prescribed continuous (n = 214) or intermittent (n = 145) oxygen based on desaturation patterns at study entry. At the time of initial prescription, participants rated their perceived readiness, confidence, and importance to use oxygen on a 0-10 scale (0 = not at all, 10 = very much). During follow-up, they self-reported average hours per day of use (adherence). Adherence was averaged over short-term (0-30 days), medium-term (months 9-12), and long-term (month 13 to last follow-up) intervals. Multivariable logistic regression models explored characteristics associated with high adherence (≥16 h/day [continuous] or ≥8 h/day [intermittent]) during each time interval.ResultsParticipant readiness, confidence, and importance at the time of oxygen initiation were associated with high short- and medium-term adherence. For each unit increase in baseline readiness, the odds of high short-term adherence increased by 21% (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.05-1.40) and 94% (OR 1.94, 95% CI 1.45-2.59) in the continuous and intermittent groups, respectively. In both groups, high adherence in the medium-term was associated with high adherence in the long-term (continuous, OR 12.49, 95% CI 4.90-31.79; intermittent, OR 38.08, 95% CI 6.96-208.20).ConclusionsReadiness, confidence, and importance to use LTOT at initiation, and early high adherence, are significantly associated with long-term oxygen adherence.

Published
2019

5. Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study

Author

Hachem, Ramsey R, Kamoun, Malek, Budev, Marie M, Askar, Medhat, Ahya, Vivek N, Lee, James C, Levine, Deborah J, Pollack, Marilyn S, Dhillon, Gundeep S, Weill, David, Schechtman, Kenneth B, Leard, Lorriana E, Golden, Jeffrey A, Baxter-Lowe, LeeAnn, Mohanakumar, Thalachallour, Tyan, Dolly B, and Yusen, Roger D

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Transplantation, Prevention, Lung, Organ Transplantation, Adult, Aged, Female, Follow-Up Studies, Graft Rejection, Graft Survival, HLA Antigens, Histocompatibility Testing, Humans, Isoantibodies, Lung Transplantation, Male, Middle Aged, Postoperative Complications, Prognosis, Prospective Studies, Risk Factors, Survival Rate, Tissue Donors, clinical research, practice, histocompatibility, lung transplantation, pulmonology, major histocompatibility complex, monitoring: immune, rejection: antibody-mediated, rejection: T cell mediated, clinical research/practice, lung transplantation/pulmonology, Medical and Health Sciences, Surgery, Clinical sciences
Abstract

Donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) are associated with worse outcomes after lung transplantation. To determine the incidence and characteristics of DSA early after lung transplantation, we conducted a prospective multicenter observational study that used standardized treatment and testing protocols. Among 119 transplant recipients, 43 (36%) developed DSA: 6 (14%) developed DSA only to class I HLA, 23 (53%) developed DSA only to class II HLA, and 14 (33%) developed DSA to both class I and class II HLA. The median DSA mean fluorescence intensity (MFI) was 3197. We identified a significant association between the Lung Allocation Score and the development of DSA (HR = 1.02, 95% CI: 1.001-1.03, P = .047) and a significant association between DSA with an MFI ≥ 3000 and acute cellular rejection (ACR) grade ≥ A2 (HR = 2.11, 95% CI: 1.04-4.27, P = .039). However, we did not detect an association between DSA and survival. We conclude that DSA occur frequently early after lung transplantation, and most target class II HLA. DSA with an MFI ≥ 3000 have a significant association with ACR. Extended follow-up is necessary to determine the impact of DSA on other important outcomes.

Published
2018

6. Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease

Author

Baker, Anna M, Holbrook, Janet T, Yohannes, Abebaw M, Eakin, Michelle N, Sugar, Elizabeth A, Henderson, Robert J, Casper, Anne S, Kaminsky, David A, Rea, Alexis L, Mathews, Anne M, Que, Loretta G, Ramsdell, Joe W, Gerald, Lynn B, Wise, Robert A, Hanania, Nicola A, Hanania, Nicola, Sockrider, Marianna, Bertrand, Laura, Atik, Mustafa, Lopez, Blanca A, Reibman, Joan, DiMango, Emily, Rogers, Linda, Carapetyan, Karen, Rivera, Kristina, Scheuerman, Melissa, Fiorino, Elizabeth, Bryce-Robinson, Newel, Green, Deanna, Noveck, Robert, Foss, Catherine, Ghidorzi, Jessica, Wang, Zongyao, Pangborn, Elise, Robertson, V Susan, Eberlein, Nicholas, Stiles, Jane, Land, Michael, Vickery, Brian, Wu, Eveline, Jaggers, Denise, Allen, Stephanie, Mervin-Blake, Sabrena, Smith, Lewis, Kalhan, Ravi, Moy, James, Naureckas, Edward, Hixon, Jenny, Gonsalves, Zenobia, Zagaja, Virginia, Kustwin, Jennifer, Xu, Ben, Matthews, Thomas, Robinson, Lucius, Singh, Noopur, Happel, Kyle, Sandi, Marie C, Graham, Jennifer M, Sullivan, Katelyn, Poretta, Elizabeth, Katial, Rohit, Hoyte, Flavia, Rojas, Maria, Castro, Mario, Bacharier, Leonard B, Sumino, Kaharu, Yusen, Roger D, Tarsi, Jaime J, Patterson, Brenda, Montgomery, Terri, Busk, Michael, Weiss, Debra, Sundblad, Kimberly, Irvin, Charles, Dixon, Anne E, Teneback, Charlotte, Kanagalingam, Jothi, Burns, Stephanie M, Dwinell, Kathleen, Goodwin, James L, Brown, Mark A, Carr, Tara F, Berry, Cristine E, Bime, Christian, Goforth, Mark A, Ryan, Elizabeth A, Wences, Jesus A, Lopez, Silvia L, Priefert, Janette C, Provencio-Dean, Natalie S, Ogas, Destinee R, Bloss, Valerie R, Wasserman, Stephen I, Soler, Xavier T, Kinninger, Katie H, and Martineau, Amber J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Mental Health, Brain Disorders, Chronic Obstructive Pulmonary Disease, Clinical Research, Mental health, Respiratory, Good Health and Well Being, test anxiety scale, chronic obstructive pulmonary disease, anxiety, psychometric properties, American Lung Association Airways Clinical Research Centers, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires: the Generalized Anxiety Disorder 7-Item Scale (GAD-7), the Hospital Anxiety and Depression Scale Anxiety subscale (HADS-A), and the Anxiety Inventory for Respiratory Disease (AIR).Objectives: To evaluate and compare the test performance characteristics of three anxiety screening questionnaires, using the Mini-International Neuropsychiatric Interview (MINI), version 7.0, as the "gold standard."Methods: Individuals with COPD were recruited at 16 centers. The MINI and questionnaires were administered by trained research coordinators at an in-person visit and readministered by telephone 2-4 weeks later. A composite score for the presence of any Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) anxiety disorder was computed, based on the MINI as the gold standard, compared with a participant screening positive on self-report measures for these analyses.Results: Two hundred and twenty eligible individuals with COPD were enrolled; 219 completed the study. Eleven percent were identified as having a DSM-V anxiety disorder, based on the MINI. Elevated anxiety symptoms based on questionnaires were 38% for the AIR, 30% for the GAD-7, and 20% for the HADS-A. Area under the receiver operating characteristic curve (AUC) was highest for the GAD-7 (0.78; 95% confidence interval [CI], 0.69-0.87), followed by the HADS-A (0.74; 95% CI, 0.64-0.84) and the AIR (0.66; 95% CI, 0.56-0.76). The AUC for the GAD-7 was significantly greater than for the AIR (P = 0.014). Sensitivity was not statistically different among the questionnaires: 77% for the GAD-7, 63% for the HADS-A, and 66% for the AIR. The HADS-A had the highest specificity, 85%, which was significantly higher than that of the GAD-7 (77%; P

Published
2018

7. The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned

Author

Yusen, Roger D, Criner, Gerard J, Sternberg, Alice L, Au, David H, Fuhlbrigge, Anne L, Albert, Richard K, Casaburi, Richard, Stoller, James K, Harrington, Kathleen F, Cooper, J Allen D, Diaz, Philip, Gay, Steven, Kanner, Richard, MacIntyre, Neil, Martinez, Fernando J, Piantadosi, Steven, Sciurba, Frank, Shade, David, Stibolt, Thomas, Tonascia, James, Wise, Robert, Bailey, William C, Sampong, Ernestina, Sloan, Karin, Wagner, Ashley, Anderson, Susan, Moy, Marilyn, Okunbor, Osarenoma, Marlow, Scott, Meli, Yvonne, Rice, Richard, Aboussouan, Loutfi S, Castele, Robert, Parambil, Joseph, Khatri, Sumita, Pande, Aman, Zein, Joe, Olbrych, Thomas, Alkins, Stephan, Jocko, Christine, Rahaghi, Franck, Barton, Jean, Underwood, Jennifer, Make, Barry, Davies, John, Mularski, Richard, Naleway, Allison, Vertrees, Sarah, Porszasz, Janos, Walker, Peggy, Indelicato, Renee, Specht, Lennard, Ellstrom, Kathleen, Portillo, Jamie, Horak, David, Tiep, Brian, Barnett, Mary, Drake, Janice, Rittinger, Mahasti, Compton, Rachael, Miller, Scott, Panos, Ralph J, Lach, Laura A, Criner, Gerard, Grabianowski, Carla, Cordova, Francis, Desai, Parag, Krachman, Samuel, Mamary, James, Marchetti, Nathaniel, Satti, Aditi, Mumm, Eileen, Vega-Olivo, Michelle, Hua, Jenny, Tauch, Vanna, Criner, Lii-Yoong, Jacobs, Michael, Rising, Peter, Simonelli, Paul, Mitchell, Michele, Lammi, Matthew, Romaine, Connie, Lee, Howard, Ianacone, Mary, Scharf, Steven, Bell-Farrell, Wanda, Mador, M Jeffery, Rahman, Ayesha, Zaman, Mumtaz, Hill, Lisa, and Platt, Alec

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Prevention, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Aged, 80 and over, Female, Geography, Humans, Long-Term Care, Male, Middle Aged, Multicenter Studies as Topic, Oxygen, Oxygen Inhalation Therapy, Patient Admission, Pulmonary Disease, Chronic Obstructive, Quality of Life, Randomized Controlled Trials as Topic, Time Factors, United States, chronic obstructive pulmonary disease, hypoxemia, oxygen, randomized controlled trial, survival, LOTT Research Group *, LOTT Research Group, Cardiovascular medicine and haematology, Clinical sciences
Abstract

The Long-Term Oxygen Treatment Trial demonstrated that long-term supplemental oxygen did not reduce time to hospital admission or death for patients who have stable chronic obstructive pulmonary disease and resting and/or exercise-induced moderate oxyhemoglobin desaturation, nor did it provide benefit for any other outcome measured in the trial. Nine months after initiation of patient screening, after randomization of 34 patients to treatment, a trial design amendment broadened the eligible population, expanded the primary outcome, and reduced the goal sample size. Within a few years, the protocol underwent minor modifications, and a second trial design amendment lowered the required sample size because of lower than expected treatment group crossover rates. After 5.5 years of recruitment, the trial met its amended sample size goal, and 1 year later, it achieved its follow-up goal. The process of publishing the trial results brought renewed scrutiny of the study design and the amendments. This article expands on the previously published design and methods information, provides the rationale for the amendments, and gives insight into the investigators' decisions about trial conduct. The story of the Long-Term Oxygen Treatment Trial may assist investigators in future trials, especially those that seek to assess the efficacy and safety of long-term oxygen therapy. Clinical trial registered with clinicaltrials.gov (NCT00692198).

Published
2018

9. High-Sensitivity vs Conventional Troponin Cutoffs for Risk Stratification in Patients With Acute Pulmonary Embolism

Author

Bikdeli, Behnood, primary, Muriel, Alfonso, additional, Rodríguez, Carmen, additional, González, Sara, additional, Briceño, Winnifer, additional, Mehdipoor, Ghazaleh, additional, Piazza, Gregory, additional, Ballaz, Aitor, additional, Lippi, Giuseppe, additional, Yusen, Roger D., additional, Otero, Remedios, additional, and Jiménez, David, additional

Published
2023
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10. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

Author

Albert, Richard K, Au, David H, Blackford, Amanda L, Casaburi, Richard, Cooper, J Allen, Criner, Gerard J, Diaz, Philip, Fuhlbrigge, Anne L, Gay, Steven E, Kanner, Richard E, MacIntyre, Neil, Martinez, Fernando J, Panos, Ralph J, Piantadosi, Steven, Sciurba, Frank, Shade, David, Stibolt, Thomas, Stoller, James K, Wise, Robert, Yusen, Roger D, Tonascia, James, Sternberg, Alice L, and Bailey, William

Subjects
Rehabilitation, Lung, Clinical Trials and Supportive Activities, Chronic Obstructive Pulmonary Disease, Clinical Research, 6.7 Physical, Evaluation of treatments and therapeutic interventions, Respiratory, Aged, Exercise, Exercise Tolerance, Female, Follow-Up Studies, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Oxygen, Oxygen Inhalation Therapy, Patient Compliance, Pulmonary Disease, Chronic Obstructive, Quality of Life, Time Factors, Treatment Failure, Long-Term Oxygen Treatment Trial Research Group, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundLong-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation.MethodsWe originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%). After 7 months and the randomization of 34 patients, the trial was redesigned to also include patients who had stable COPD with moderate exercise-induced desaturation (during the 6-minute walk test, Spo2 ≥80% for ≥5 minutes and

Published
2016

11. Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysis

Author

Leitao Filho, Fernando Sergio, Mattman, Andre, Schellenberg, Robert, Criner, Gerard J., Woodruff, Prescott, Lazarus, Stephen C., Albert, Richard K., Connett, John, Han, Meilan K., Gay, Steven E., Martinez, Fernando J., Fuhlbrigge, Anne L., Stoller, James K., MacIntyre, Neil R., Casaburi, Richard, Diaz, Philip, Panos, Ralph J., Cooper, J. Allen, Jr., Bailey, William C., LaFon, David C., Sciurba, Frank C., Kanner, Richard E., Yusen, Roger D., Au, David H., Pike, Kenneth C., Fan, Vincent S., Leung, Janice M., Man, Shu-Fan Paul, Aaron, Shawn D., Reed, Robert M., and Sin, Don D.

Published
2020
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14. Donation after circulatory death in lung transplantation—five-year follow-up from ISHLT Registry

Author

Van Raemdonck, Dirk, Keshavjee, Shaf, Levvey, Bronwyn, Cherikh, Wida S., Snell, Greg, Erasmus, Michiel, Simon, André, Glanville, Allan R., Clark, Stephen, D'Ovidio, Frank, Catarino, Pedro, McCurry, Kenneth, Hertz, Marshall I., Venkateswaran, Rajamiyer, Hopkins, Peter, Inci, Ilhan, Walia, Rajat, Kreisel, Daniel, Mascaro, Jorge, Dilling, Daniel F., Camp, Philip, Mason, David, Musk, Michael, Burch, Michael, Fisher, Andrew, Yusen, Roger D., Stehlik, Josef, and Cypel, Marcelo

Published
2019
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15. Chest computed tomography imaging improves potential lung donor assessment

Author

Gauthier, Jason M., Bierhals, Andrew J., Liu, Jingxia, Balsara, Keki R., Frederiksen, Christine, Gremminger, Emily, Hachem, Ramsey R., Witt, Chad A., Trulock, Elbert P., Byers, Derek E., Yusen, Roger D., Aguilar, Patrick R., Marklin, Gary, Nava, Ruben G., Kozower, Benjamin D., Pasque, Michael K., Meyers, Bryan F., Patterson, G. Alexander, Kreisel, Daniel, and Puri, Varun

Published
2019
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17. Characteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial

Author

Moy, Marilyn L., Harrington, Kathleen F., Sternberg, Alice L., Krishnan, Jerry A., Albert, Richard K., Au, David H., Casaburi, Richard, Criner, Gerard J., Diaz, Philip, Kanner, Richard E., Panos, Ralph J., Stibolt, Thomas, Stoller, James K., Tonascia, James, Yusen, Roger D., Tan, Ai-Yui M., and Fuhlbrigge, Anne L.

Published
2019
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19. Bronchiolitis obliterans syndrome–free survival after lung transplantation: An International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis

Author

Kulkarni, Hrishikesh S., Cherikh, Wida S., Chambers, Daniel C., Garcia, Victoria C., Hachem, Ramsey R., Kreisel, Daniel, Puri, Varun, Kozower, Benjamin D., Byers, Derek E., Witt, Chad A., Alexander-Brett, Jennifer, Aguilar, Patrick R., Tague, Laneshia K., Furuya, Yuka, Patterson, G. Alec, Trulock, Elbert P., III, and Yusen, Roger D.

Published
2019
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21. The 2018 ISHLT/APM/AST/ICCAC/STSW Recommendations for the Psychosocial Evaluation of Adult Cardiothoracic Transplant Candidates and Candidates for Long-term Mechanical Circulatory Support

Author

Dew, Mary Amanda, DiMartini, Andrea F., Dobbels, Fabienne, Grady, Kathleen L., Jowsey-Gregoire, Sheila G., Kaan, Annemarie, Kendall, Kay, Young, Quincy-Robyn, Abbey, Susan E., Butt, Zeeshan, Crone, Catherine C., De Geest, Sabina, Doligalski, Christina T., Kugler, Christiane, McDonald, Laurie, Ohler, Linda, Painter, Liz, Petty, Michael G., Robson, Desiree, Schlöglhofer, Thomas, Schneekloth, Terry D., Singer, Jonathan P., Smith, Patrick J., Spaderna, Heike, Teuteberg, Jeffrey J., Yusen, Roger D., and Zimbrean, Paula C.

Published
2018
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24. Treatment of Right Heart Thrombi Associated with Acute Pulmonary Embolism

Author

Monreal, Manuel, Decousus, Hervè, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Verhamme, Peter, Adarraga, M.D., Aibar, M.A., Alfonso, M., Arcelus, J.I., Azcarate-Agüero, P.M., Ballaz, A., Barba, R., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Blanco-Molina, A., Cañada, G., Cañas, I., Casado, I., Chic, N., del Pozo, R., del Toro, J., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Falgá, C., Fernández-Aracil, C., Fernández-Capitán, C., Fidalgo, M.A., Font, C., Font, L., Gallego, P., García, M.A., García-Bragado, F., García-Brotons, P., Gavín, O., Gómez, C., Gómez, V., González, J., Grau, E., Grimón, A., Guirado, L., Gutiérrez, J., Hernández-Comes, G., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jiménez, J., Joya, M.D., Llamas, P., Lobo, J.L., López, P., López-Jiménez, L., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Luque, J.M., Marchena, P.J., Martínez, C., Martín-Martos, F., Monreal, M., Nieto, J.A., Nieto, S., Núñez, A., Núñez, M.J., Otalora, S., Otero, R., Pedrajas, J.M., Pérez, G., Pérez-Ductor, C., Peris, M.L., Pons, I., Porras, J.A., Reig, O., Riera-Mestre, A., Riesco, D., Rivas, A., Rodríguez, M., Rodríguez-Dávila, M.A., Rosa, V., Sahuquillo, J.C., Sala-Sainz, M.C., Sampériz, A., Sánchez-Martínez, R., Sanz, O., Soler, S., Sopeña, B., Suriñach, J.M., Tolosa, C., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valero, B., Valle, R., Vela, J., Vidal, G., Vilar, C., Xifre, B., Vanassche, T., Verhamme, P., Yoo, H.H.B., Wells, P., Hirmerova, J., Malý, R., Salgado, E., Bertoletti, L., Bura-Riviere, A., Farge-Bancel, D., Hij, A., Mahé, I., Merah, A., Moustafa, F., Braester, A., Brenner, B., Tzoran, I., Antonucci, G., Barillari, G., Bilora, F., Bonanome, A., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Ciantis, P., Dentali, F., Di Micco, P., Duce, R., Giorgi-Pierfranceschi, M., Grandone, E., Imbalzano, E., Lessiani, G., Maida, R., Mastroiacovo, D., Pace, F., Parisi, R., Pesavento, R., Pinelli, M., Poggio, R., Prandoni, P., Quintavalla, R., Rocci, A., Tiraferri, E., Tonello, D., Tufano, A., Venturelli, U., Visonà, A., Gibietis, V., Skride, A., Vitola, B., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Barrios, Deisy, Chavant, Jeremy, Jiménez, David, Rosa-Salazar, Vladimir, Muriel, Alfonso, Viallon, Alain, Fernández-Capitán, Carmen, and Yusen, Roger D.

Published
2017
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25. National Early Warning Score-2 for Identification of Patients with Intermediate-High-Risk Pulmonary Embolism.

Author

Rodríguez, Carmen, Muriel, Alfonso, Carrasco, Luis, González, Sara, Briceño, Winnifer, Durán, Diego, Retegui, Ana, Yusen, Roger D., Bikdeli, Behnood, and Jiménez, David

Subjects
PULMONARY embolism, EARLY warning score
Abstract

Consensus statements have proposed the use of the National Early Warning Score 2 (NEWS2) to identify stable patients with acute pulmonary embolism (PE) and an intermediate-high risk of adverse outcomes. We aimed to externally validate NEWS2 and compare it to another predictive score (Bova). Using NEWS2 (cutoff ≥5 and ≥7) and the Bova score (cutoff >4), we classified patients as intermediate-high risk (vs. non-intermediate-high risk), and we compared the test characteristics of these risk classification tools for a complicated course within 30 days after PE diagnosis. We also assessed the validity of NEWS2 for predicting a complicated course by adding the results of echocardiography and troponin testing to the model. Of the 848 enrolled patients, the NEWS2 score ≥5 classified 471 (55.5%) and the Bova score classified 37 (4.4%) as intermediate-high risk. NEWS2 had a significantly lower specificity for a 30-day complicated course than Bova (45.4 vs. 96.3%, respectively; p < 0.001). Using the higher score threshold (≥7), the NEWS2 classified 99 (11.7%) as intermediate-high risk, and the specificity was 88.9% (difference with Bova, 7.4%; p < 0.001). The proportion of patients with intermediate-high risk PE was 2.4% for the combination of a positive troponin testing and echocardiographic right ventricle dysfunction and a positive NEWS2 (score ≥7), while the specificity was 97.8% (difference with Bova, 1.5%; p = 0.07). Bova outperforms NEWS2 for predicting a complicated course among stable patients with PE. Addition of troponin testing and echocardiography improved the specificity of NEWS2, although it was not superior to Bova. ClinicalTrials.gov number : NCT02238639. [ABSTRACT FROM AUTHOR]

Published
2023
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27. DVT Management and Outcome Trends, 2001 to 2014

Author

Monreal, Manuel, Decousus, Hervè, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Papadakis, Manolis, Agudo, P., Aibar, M.A., Akasbi, M., Alcalde-Manero, M., Andújar, V., Arcelus, J.I., Ballaz, A., Barba, R., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Blanco-Molina, A., Cañas, I., Casado, I., de Miguel, J., del Toro, J., Díaz, S., Díaz-Peromingo, J.A., Falgá, C., Fernández-Capitán, C., Font, C., Font, L., Gallego, P., García-Bragado, F., García-Rodenas, M., Gómez, V., González, C.J., Grau, E., Guirado, L., Gutiérrez, J., Hernández, G., Hernández-Blasco, L., Isern, V., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Lobo, J.L., López-Jiménez, L., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín, M., Martín-Antorán, J.M., Martín-Martos, F., Monreal, M., Morales, M.V., Nauffal, D., Nieto, J.A., Nieto, S., Núñez, M.J., Orbegoso, C., Otalora, S., Otero, R., Pagán, B., Pedrajas, J.M., Pérez, C., Pérez, G., Peris, M.L., Pons, I., Porras, J.A., Reig, O., Riera-Mestre, A., Rivas, A., Rodríguez, C., Rodríguez-Dávila, M.A., Rosa, V., Rosa-Murillo, A.S., Ruiz-Giménez, N., Sahuquillo, J.C., Sala, M.C., Sampériz, A., Sánchez, R., Sanz, O., Soler, S., Suriñach, J.M., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Vela, J., Vidal, G., Vilar, C., Villalta, J., Xifre, B., Vanassche, T., Verhamme, P., Wells, P., Hirmerova, J., Malý, R., Tomko, T., Celis, G., Salgado, E., Sánchez, G.T., Bertoletti, L., Bura-Riviere, A., Farge-Bancel, D., Hij, A., Mahé, I., Merah, A., Quere, I., Papadakis, M., Braester, A., Brenner, B., Tzoran, I., Apollonio, A., Barillari, G., Bertone, A., Bilora, F., Bucherini, E., Ciammaichella, M., De Ciantis, P., Dentali, F., Di Micco, P., Duce, R., Ferrazzi, P., Grandone, E., Lessiani, G., Lodigiani, C., Mastroiacovo, D., Pace, F., Pesavento, R., Pinelli, M., Poggio, R., Prandoni, P., Rosa, M., Rota, L., Tiraferri, E., Tonello, D., Tufano, A., Venturelli, U., Visonà, A., Zalunardo, B., Drucka, E., Kigitovica, D., Skride, A., Mafalda, A., Ribeiro, J.L., Sousa, M.S., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Morillo, Raquel, Jiménez, David, Aibar, Miguel Ángel, Mastroiacovo, Daniela, Wells, Philip S., Sampériz, Ángel, Saraiva de Sousa, Marta, Muriel, Alfonso, and Yusen, Roger D.

Published
2016
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44. Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism

Author

Jiménez, David, primary, Rodríguez, Carmen, additional, León, Francisco, additional, Jara-Palomares, Luis, additional, López-Reyes, Raquel, additional, Ruiz-Artacho, Pedro, additional, Elías, Teresa, additional, Otero, Remedios, additional, García-Ortega, Alberto, additional, Rivas-Guerrero, Agustina, additional, Abelaira, Jaime, additional, Jiménez, Sonia, additional, Muriel, Alfonso, additional, Morillo, Raquel, additional, Barrios, Deisy, additional, Le Mao, Raphael, additional, Yusen, Roger D., additional, Bikdeli, Behnood, additional, Monreal, Manuel, additional, and Lobo, José Luis, additional

Published
2021
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45. Prognostic significance of multidetector CT in normotensive patients with pulmonary embolism: results of the protect study

Author

Jiménez, David, Lobo, José Luis, Monreal, Manuel, Moores, Lisa, Oribe, Mikel, Barrón, Manuel, Otero, Remedios, Nauffal, Dolores, Rabuñal, Ramón, Valle, Reina, Navarro, Carmen, Rodríguez-Matute, Consolación, Álvarez, Celso, Conget, Francisco, Uresandi, Fernando, Aujesky, Drahomir A, Yusen, Roger D, Álvarez, Celso, Abaitúa, Jose María, Abraira, Víctor, Alonso, Ángel, Alonso, Luis Javier, Ballaz, Aitor, Ballester, Marta, Barrón, Manuel, Briongos, Sem, Castañer, Eva, Castro, Olalla, Conget, Francisco, Cuesta, José María, Elías, Teresa, Gómez, Vicente, Gallego, Ignacio, González, Mariano, Gorospe, Luis, Guillaumet, Eva, Iglesias, Concepción, Jiménez, David, López, Francisco, López, Mónica, Lladó, María, Lobo, José Luis, Lucio, Pilar, Marín, Jesús, Martín, María, Monreal, Manuel, Muriel, Alfonso, Nauffal, Dolores, Navarro, Carmen, Oribe, Mikel, Osa, Ana, Otero, Remedios, Pamies, José, Piret, María Victoria, Pozo, Delfina, Prieto, Amador, Rabuñal, Ramón, Rodríguez, Consolación, Rodríguez, Nuria, Rodrigo, Carmen, Santolaria, Miguel Ángel, Serrano, Pilar, Testa, Ana, Uresandi, Fernando, Valle, Reina, Velasco, Sonia, Vicente, Agustina, Vivancos, Jorge, Yusen, Roger D., Zamora, Javier, Zorrilla, Vanesa, de Benito, José Luis, and del Rey, José Manuel

Published
2014
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47. Computerised clinical decision support for suspected PE

Author

Jiménez, David, Resano, Santiago, Otero, Remedios, Jurkojc, Carolina, Portillo, Ana Karina, Ruiz-Artacho, Pedro, Corres, Jesús, Vicente, Agustina, den Exter, Paul L, Huisman, Menno V, Moores, Lisa, Yusen, Roger D, Arrieta, P, Barrios, D, Castillo, H, Castro, P, Gómez, V, Gotera, C, Ibáñez, D, Jurkok, C, Kopecna, D, Lazo, P, Lietor, A, Mirambeaux, R, Moreno, C, Muriel, A, Navas, JJ, Nieto, R, Del, Rey JM, Sueiro, A, and Vicente, A

Published
2015
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