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2. Is peritoneal dialysis suitable technique CKD patients over 65 years? A prospective multicenter study

Author

Tato, A., Molano, Bernal, Martín Cleary, C., Escribano, A., Vian, J., Sanz Ballesteros, S., Vega, A., Martínez, A., Campos, J., Bajo, M.A., Del Peso, G., Rodríguez Palomares, J.R., Carreño, A., Felipe, C., Perpén, A., Hernández, M.J., Moreno, F., Sánchez García, L., Rivera Gorrín, M., Burguera, A., Fernández-Reyes, M.J., Rodríguez, A., Hevia, C., Lorenzo, M., Paraíso, V., González Sanchidrián, S., Tornero, F., Hernández, E., Ortega, M., Campos Gutiérrez, B., Benito, J., Ortega, O., Herrero, J.C., Pizarro, M.S., Portolés, Jose, Vega, Almudena, Lacoba, Enrique, López-Sánchez, Paula, Botella, Mario, Yuste, Claudia, Martín Cleary, Catalina, Sanz Ballesteros, Sandra, González Sanchidrian, Silvia, Sánchez García, Luisa, Carreño, Agustín, Bajo, M. Auxiliadora, and Janeiro, Darío

Published
2021
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3. ¿Es adecuada la diálisis peritoneal para pacientes mayores de 65 años? Estudio multicéntrico prospectivo

Author

Tato, A., Molano, Bernal, Martín Cleary, C., Escribano, A., Vian, J., Sanz Ballesteros, S., Vega, A., Martínez, A., Campos, J., Bajo, M.A., Del Peso, G., Rodríguez Palomares, J.R., Carreño, A., Felipe, C., Perpén, A., Hernández, M.J., Moreno, F., Sánchez García, L., Rivera Gorrín, M., Burguera, A., Fernández-Reyes, M.J., Rodríguez, A., Hevia, C., Lorenzo, M., Paraíso, V., González Sanchidrián, S., Tornero, F., Hernández, E., Ortega, M., Campos Gutiérrez, B., Benito, J., Ortega, O., Herrero, J.C., Pizarro, M.S., Portolés, Jose, Vega, Almudena, Lacoba, Enrique, López-Sánchez, Paula, Botella, Mario, Yuste, Claudia, Martín Cleary, Catalina, Sanz Ballesteros, Sandra, González Sanchidrian, Silvia, Sánchez García, Luisa, Carreño, Agustín, Bajo, M. Auxiliadora, and Janeiro, Darío

Published
2021
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7. Hemodialysis-Associated Immune Dysregulation in SARS-CoV-2-Infected End-Stage Renal Disease Patients

Author

González-Cuadrado, Cecilia, primary, Caro-Espada, Paula Jara, additional, Chivite-Lacaba, Marta, additional, Utrero-Rico, Alberto, additional, Lozano-Yuste, Claudia, additional, Gutierrez-Solis, Elena, additional, Morales, Enrique, additional, Sandino-Pérez, Justo, additional, Gil-Etayo, Francisco Javier, additional, Allende-Martínez, Luis, additional, Laguna-Goya, Rocio, additional, and Paz-Artal, Estela, additional

Published
2023
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9. Podocytes are new cellular targets of haemoglobin‐mediated renal damage

Author

Rubio‐Navarro, Alfonso, Sanchez‐Niño, Maria Dolores, Guerrero‐Hue, Melania, García‐Caballero, Cristina, Gutiérrez, Eduardo, Yuste, Claudia, Sevillano, Ángel, Praga, Manuel, Egea, Javier, Román, Elena, Cannata, Pablo, Ortega, Rosa, Cortegano, Isabel, de Andrés, Belén, Gaspar, María Luisa, Cadenas, Susana, Ortiz, Alberto, Egido, Jesús, and Moreno, Juan Antonio

Published
2018
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10. Haematuria as a risk factor for chronic kidney disease progression in glomerular diseases: A review

Author

Moreno, Juan Antonio, Yuste, Claudia, Gutierrez, Eduardo, Sevillano, Ángel M., Rubio-Navarro, Alfonso, Amaro-Villalobos, Juan Manuel, Praga, Manuel, and Egido, Jesús

Subjects
Preventive medicine -- Research, Hematuria -- Research -- Development and progression -- Care and treatment -- Complications and side effects, Health
Abstract

Haematuria has long been considered to be a benign condition associated with glomerular diseases. However, new evidences suggest that haematuria has a pathogenic role in promoting kidney disease progression. An increased risk for end-stage renal disease has been reported in adolescents and young adults with persistent microscopic haematuria. A persistent impairment of renal function has been also reported following macroscopic haematuria-associated acute kidney injury in immunoglobulin A nephropathy. Haematuria-induced renal damage has been related to oxidant, cytotoxic and inflammatory effects induced by haemoglobin or haem released from red blood cells. The pathophysiological origin of haematuria may be due to a more fragile and easily ruptured glomerular filtration barrier, as reported in several glomerular diseases. In this review we describe a number of the key issues associated with the epidemiology and pathogenesis of haematuria-associated diseases, provide an update of recent knowledge on the role of haematuria on renal function outcome and discuss specific therapeutic approaches in this setting. Key summary points Glomerular haematuria is a common observation in a number of renal diseases that may lead to persistent renal injury. Haematuria in children differs from that in adults in specific aspects, particularly in the frequency of glomerular diseases and renal disease outcome. Regular follow-up of renal function in children with isolated microhaematuria may be recommended., Author(s): Juan Antonio Moreno[sup.1] , Claudia Yuste[sup.2] , Eduardo Gutierrez[sup.3] , Ángel M. Sevillano[sup.3] , Alfonso Rubio-Navarro[sup.1] , Juan Manuel Amaro-Villalobos[sup.1] , Manuel Praga[sup.3] , Jesús Egido[sup.1] [sup.4] Author Affiliations: [...]

Published
2016
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12. Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease

Author

Ceprian, Noemi, primary, Valera, Gemma, additional, Caro, Jara, additional, Yuste, Claudia, additional, Serroukh, Nadia, additional, González de Pablos, Ignacio, additional, Oliva, Carlos, additional, Figuer, Andrea, additional, Praga, Manuel, additional, Alique, Matilde, additional, Ramirez, Rafael, additional, Morales, Enrique, additional, and Carracedo, Julia, additional

Published
2021
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13. Is peritoneal dialysis suitable technique CKD patients over 65 years? A prospective multicenter study

Author

Portolés, Jose, primary, Vega, Almudena, additional, Lacoba, Enrique, additional, López-Sánchez, Paula, additional, Botella, Mario, additional, Yuste, Claudia, additional, Martín Cleary, Catalina, additional, Sanz Ballesteros, Sandra, additional, González Sanchidrian, Silvia, additional, Sánchez García, Luisa, additional, Carreño, Agustín, additional, Bajo, M. Auxiliadora, additional, Janeiro, Darío, additional, Tato, A., additional, Molano, Bernal, additional, Martín Cleary, C., additional, Escribano, A., additional, Vian, J., additional, Sanz Ballesteros, S., additional, Vega, A., additional, Martínez, A., additional, Campos, J., additional, Bajo, M.A., additional, Del Peso, G., additional, Rodríguez Palomares, J.R., additional, Carreño, A., additional, Felipe, C., additional, Perpén, A., additional, Hernández, M.J., additional, Moreno, F., additional, Sánchez García, L., additional, Rivera Gorrín, M., additional, Burguera, A., additional, Fernández-Reyes, M.J., additional, Rodríguez, A., additional, Hevia, C., additional, Lorenzo, M., additional, Paraíso, V., additional, González Sanchidrián, S., additional, Tornero, F., additional, Hernández, E., additional, Ortega, M., additional, Campos Gutiérrez, B., additional, Benito, J., additional, Ortega, O., additional, Herrero, J.C., additional, and Pizarro, M.S., additional

Published
2021
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20. MO912INMUNE STATUS ON HAEMODIALYSIS PATTIENTS AFFECTED WITH COVID19 INFECTION

Author

Sandino Pérez, Justo, primary, Utrero-Rico, Alberto, additional, Yuste, Claudia, additional, Gutierrez-Solis, Elena, additional, Morales, Enrique, additional, Mérida, Evangelina, additional, Gonzalez-Cuadrado, Cecilia, additional, Chivite-Lacaba, Marta, additional, Mancebo, Esther, additional, Paz-Artal, Estela, additional, and Caro Espada, Paula Jara, additional

Published
2021
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22. ¿Es adecuada la diálisis peritoneal para pacientes mayores de 65 años? Estudio multicéntrico prospectivo

Author

Portolés, Jose, primary, Vega, Almudena, additional, Lacoba, Enrique, additional, López-Sánchez, Paula, additional, Botella, Mario, additional, Yuste, Claudia, additional, Martín Cleary, Catalina, additional, Sanz Ballesteros, Sandra, additional, González Sanchidrian, Silvia, additional, Sánchez García, Luisa, additional, Carreño, Agustín, additional, Bajo, M. Auxiliadora, additional, Janeiro, Darío, additional, Tato, A., additional, Molano, Bernal, additional, Martín Cleary, C., additional, Escribano, A., additional, Vian, J., additional, Sanz Ballesteros, S., additional, Vega, A., additional, Martínez, A., additional, Campos, J., additional, Bajo, M.A., additional, Del Peso, G., additional, Rodríguez Palomares, J.R., additional, Carreño, A., additional, Felipe, C., additional, Perpén, A., additional, Hernández, M.J., additional, Moreno, F., additional, Sánchez García, L., additional, Rivera Gorrín, M., additional, Burguera, A., additional, Fernández-Reyes, M.J., additional, Rodríguez, A., additional, Hevia, C., additional, Lorenzo, M., additional, Paraíso, V., additional, González Sanchidrián, S., additional, Tornero, F., additional, Hernández, E., additional, Ortega, M., additional, Campos Gutiérrez, B., additional, Benito, J., additional, Ortega, O., additional, Herrero, J.C., additional, and Pizarro, M.S., additional

Published
2021
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27. Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

Author

Ministerio de Economía y Competitividad (España), Sociedad Española de Nefrología, Fundación Renal Íñigo Álvarez de Toledo, Comunidad de Madrid, La Caixa, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España), Rubio-Navarro, Alfonso, Vázquez-Carballo, Cristina, Guerrero-Hue, Melania, García-Caballero, Cristina, Herencia, Carmen, Gutiérrez, Eduardo, Yuste, Claudia, Sevillano, Ángel, Praga, Manuel, Egea, Javier, Cannata, Pablo, Cortegano, Isabel, Andrés, Belén de, Gaspar, María Luisa, Cadenas, Susana, Michalska, Patrycja, León, Rafael, Ortiz, Alberto, Egido, Jesús, Moreno, Juan Antonio, Ministerio de Economía y Competitividad (España), Sociedad Española de Nefrología, Fundación Renal Íñigo Álvarez de Toledo, Comunidad de Madrid, La Caixa, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España), Rubio-Navarro, Alfonso, Vázquez-Carballo, Cristina, Guerrero-Hue, Melania, García-Caballero, Cristina, Herencia, Carmen, Gutiérrez, Eduardo, Yuste, Claudia, Sevillano, Ángel, Praga, Manuel, Egea, Javier, Cannata, Pablo, Cortegano, Isabel, Andrés, Belén de, Gaspar, María Luisa, Cadenas, Susana, Michalska, Patrycja, León, Rafael, Ortiz, Alberto, Egido, Jesús, and Moreno, Juan Antonio

Abstract

Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We investigated the role of Nrf2 in intravascular hemolysis and whether Nrf2 activation protected against hemoglobin (Hb)/heme-mediated renal damage in vivo and in vitro. We observed renal Nrf2 activation in human hemolysis and in an experimental model of intravascular hemolysis promoted by phenylhydrazine intraperitoneal injection. In wild-type mice, Hb/heme released from intravascular hemolysis promoted AKI, resulting in decreased renal function, enhanced expression of tubular injury markers (KIM-1 and NGAL), oxidative and endoplasmic reticulum stress (ER), and cell death. These features were more severe in Nrf2-deficient mice, which showed decreased expression of Nrf2-related antioxidant enzymes, including heme oxygenase 1 (HO-1) and ferritin. Nrf2 activation with sulforaphane protected against Hb toxicity in mice and cultured tubular epithelial cells, ameliorating renal function and kidney injury and reducing cell stress and death. Nrf2 genotype or sulforaphane treatment did not influence the severity of hemolysis. In conclusion, our study identifies Nrf2 as a key molecule involved in protection against renal damage associated with hemolysis and opens novel therapeutic approaches to prevent renal damage in patients with severe hemolytic crisis. These findings provide new insights into novel aspects of Hb-mediated renal toxicity and may have important therapeutic implications for intravascular hemolysis-related diseases

Published
2019

32. Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

Author

Rubio-Navarro, Alfonso, primary, Vázquez-Carballo, Cristina, additional, Guerrero-Hue, Melania, additional, García-Caballero, Cristina, additional, Herencia, Carmen, additional, Gutiérrez, Eduardo, additional, Yuste, Claudia, additional, Sevillano, Ángel, additional, Praga, Manuel, additional, Egea, Javier, additional, Cannata, Pablo, additional, Cortegano, Isabel, additional, de Andrés, Belén, additional, Gaspar, María Luisa, additional, Cadenas, Susana, additional, Michalska, Patrycja, additional, León, Rafael, additional, Ortiz, Alberto, additional, Egido, Jesús, additional, and Moreno, Juan Antonio, additional

Published
2019
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35. FP272MASSIVE INTRAVASCULAR HEMOLYMASSIVE INTRAVASCULAR HEMOLYSIS INDUCES ACUTE KIDNEY INJURY IN A NRF2-DEPENDENT WAY

Author

Vázquez-Carballo, Cristina, primary, Guerrero-Hue, Melania, additional, García-Caballero, Cristina, additional, Rubio-Navarro, Alfonso, additional, Herencia, Carmen, additional, Gutiérrez, Eduardo, additional, Yuste, Claudia, additional, Sevillano, Angel, additional, Praga, Manuel, additional, Egea, Javier, additional, Cannata-Ortiz, Pablo, additional, Cortegano, Isabel, additional, De Andrés, Belén, additional, Gaspar, Maria Luisa, additional, Cadenas, Susana, additional, Michalska, Patricia, additional, León, Rafael, additional, Ortiz, Alberto, additional, Egido, Jesús, additional, and Moreno, Juan Antonio, additional

Published
2019
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36. SP490IS PD SUITABLE TECHNIQUE FOR OLDER CKD PATIENTS? : A RETROSPECTIVE HEALTH SYSTEM STUDY

Author

Portolés, Jose, primary, Lacoba, Enrique, additional, Botella, Mario, additional, Sanz, Sandra, additional, Dura-Gurpide, Beatriz, additional, Lopez-Sanchez, Paula, additional, Rodriguez Palomares, Jose Ramon, additional, Romero, Sara, additional, Yuste, Claudia, additional, Fernandez-Reyes, Maria Jose, additional, Bajo, M Auxiliadora, additional, and Group, Gcdp, additional

Published
2019
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37. SP526HOW LONG ARE PATIENTS HOSPITALIZED DURING THE FIRST YEAR IN PERITONEAL DIALYSIS?

Author

Lopez-Sanchez, Paula, primary, Portolés, Jose, additional, Martín-Rodriguez, Leyre, additional, Dura-Gurpide, Beatriz, additional, Yuste, Claudia, additional, Peso, Gloria, additional, Vega, Almudena, additional, Burguera Vion, Victor, additional, Paraiso, Vicente, additional, Ortiz, Alberto, additional, Tornero, Fernando, additional, and Group, Gcdp, additional

Published
2019
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38. Glomerular Hematuria: Cause or Consequence of Renal Inflammation?

Author

Moreno, Juan Antonio, primary, Sevillano, Ángel, additional, Gutiérrez, Eduardo, additional, Guerrero-Hue, Melania, additional, Vázquez-Carballo, Cristina, additional, Yuste, Claudia, additional, Herencia, Carmen, additional, García-Caballero, Cristina, additional, Praga, Manuel, additional, and Egido, Jesús, additional

Published
2019
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39. Is High-Volume Online Hemodiafiltration Associated With Malnutrition?

Author

Macías, Nicolás, primary, Vega, Almudena, additional, Abad, Soraya, additional, Santos, Alba, additional, Cedeño, Santiago, additional, Linares, Tania, additional, García-Prieto, Ana María, additional, Aragoncillo, Inés, additional, Yuste, Claudia, additional, and López-Gómez, Juan Manuel, additional

Published
2017
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40. MP241HAEMOGLOBIN INDUCES PODOCYTE INJURY IN MICE AND HUMAN WITH PATHOLOGIES ASSOCIATED WITH MASSIVE INTRAVASCULAR HEMOLYSIS

Author

Guerrero Hue, Melania, primary, Rubio Navarro, Alfonso, additional, Sanchez-Niño, Maria Dolores, additional, Palomino Antolín, Alejandra, additional, Gutierrez, Eduardo, additional, Yuste, Claudia, additional, Sevillano, Angel, additional, Praga, Manuel, additional, Egea, Javier, additional, Román, Elena, additional, Cannata, Pablo, additional, Ortega, Rosa, additional, Ortiz, Alberto, additional, Egido, Jesús, additional, and Moreno, Juan Antonio, additional

Published
2017
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42. Gastrointestinal complications induced by sevelamer crystals

Author

Yuste, Claudia, primary, Mérida, Evangelina, additional, Hernández, Eduardo, additional, García-Santiago, Ana, additional, Rodríguez, Yolanda, additional, Muñoz, Teresa, additional, Gómez, Gonzalo Jesús, additional, Sevillano, Ángel, additional, and Praga, Manuel, additional

Published
2017
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43. El síndrome metabólico se asocia con eventos cardiovasculares en hemodiálisis

Author

Pérez de José, Ana, Verdalles-Guzmán, Úrsula, Abad, Soraya, Vega, Almudena, Reque, Javier, Panizo, Nayara, Rincón, Abrahan, Yuste, Claudia, Arroyo, David, and López-Gómez, Juan M.

Subjects
Síndrome metabólico, Cardiovascular events, Bioimpedance, Eventos cardiovasculares, Índice de conicidad, Bioimpedancia, Conicity index, Índice de tejido graso, Metabolic syndrome, Fat tissue index
Abstract

Antecedentes: El síndrome metabólico (SM) es un factor de riesgo cardiovascular y de mortalidad en la población general y en pacientes con enfermedad renal crónica. Sin embargo, apenas se ha estudiado en pacientes en hemodiálisis (HD). Objetivos: El objetivo del estudio es analizar el efecto del SM sobre la aparición de eventos cardiovasculares en HD. El objetivo secundario es determinar la influencia del índice de tejido graso y del índice de conicidad en los eventos cardiovasculares. Métodos: Estudio prospectivo en el que se incluyeron 100 pacientes en HD. El tiempo de seguimiento es de 3 años. Se recogieron eventos cardiovasculares y mortalidad. Se definió SM según los criterios de ATPIII e IDF. Resultados: La prevalencia del SM definido por ATPIII es 32 % y por IDF 29 %. La concordancia entre las dos definiciones es elevada (índice kappa 0,79, intervalo de confianza 95 % 0,65-0,92). El riesgo de desarrollar un evento cardiovascular es mayor en pacientes con SM (log rank 6,185, p = 0,013), con índice de tejido graso mayor 11,5 kg/m² (log rank 10,220, p = 0,001) y con índice de conicidad mayor 1,2 (log rank 6,393, p = 0,011). En el análisis de Cox, ajustado a la edad y sexo, los pacientes con SM tienen el doble de riesgo de ingresar por un evento cardiovascular (odds ratio 1,93, 1,022-3,6, p = 0,043). La mortalidad fue 35 % en los 3 años de seguimiento sin diferencias entre los grupos con y sin SM. Conclusiones: El SM es una patología muy prevalente en pacientes en HD y su presencia duplica el riesgo de hospitalización por eventos cardiovasculares a corto plazo. Background: Metabolic syndrome (MS) is a cardiovascular risk factor and is associated with mortality in the general population and in patients with chronic kidney disease. However, few studies have been carried out in patients on haemodialysis (HD). Objectives: The objective of the study is to analyse the effect of MS on the occurrence of cardiovascular events in HD. The secondary objective is to determine the influence of the fat tissue index and conicity index on cardiovascular events. Methods: A prospective study including 100 patients on HD. The follow-up period was 3 years. Cardiovascular events and mortality were recorded. MS was defined in accordance with ATPIII and IDF criteria. Results: MS prevalence as defined by the ATPIII was 32%, and by the IDF, 29%. The concordance between the two definitions was high (kappa index 0.79, 95% confidence interval 0.65 to 0.92). The risk of cardiovascular events was higher in patients with MS (Log Rank 6.185, p = 0.013), with a fat tissue index greater than 11.5 kg/m² (log rank 10.220, p=.001) and a conicity index greater than 1.2 (log rank 6.393, p=.011). In the Cox analysis, adjusted for age and sex, patients with MS had twice the risk of being admitted due to a cardiovascular event (odds ratio 1.93, 1.022 to 3.6, p=.043). Mortality was 35% in the 3 year follow-up period with no differences between the groups with and without MS. Conclusions: MS is a very prevalent disease in HD patients and its presence doubles the risk of hospitalisation due to cardiovascular events in the short term.

Published
2014

44. El síndrome metabólico se asocia con eventos cardiovasculares en hemodiálisis

Author

Pérez de José,Ana, Verdalles-Guzmán,Úrsula, Abad,Soraya, Vega,Almudena, Reque,Javier, Panizo,Nayara, Rincón,Abrahan, Yuste,Claudia, Arroyo,David, and López-Gómez,Juan M.

Subjects
Síndrome metabólico, Eventos cardiovasculares, Índice de conicidad, Bioimpedancia, Índice de tejido graso
Abstract

Antecedentes: El síndrome metabólico (SM) es un factor de riesgo cardiovascular y de mortalidad en la población general y en pacientes con enfermedad renal crónica. Sin embargo, apenas se ha estudiado en pacientes en hemodiálisis (HD). Objetivos: El objetivo del estudio es analizar el efecto del SM sobre la aparición de eventos cardiovasculares en HD. El objetivo secundario es determinar la influencia del índice de tejido graso y del índice de conicidad en los eventos cardiovasculares. Métodos: Estudio prospectivo en el que se incluyeron 100 pacientes en HD. El tiempo de seguimiento es de 3 años. Se recogieron eventos cardiovasculares y mortalidad. Se definió SM según los criterios de ATPIII e IDF. Resultados: La prevalencia del SM definido por ATPIII es 32 % y por IDF 29 %. La concordancia entre las dos definiciones es elevada (índice kappa 0,79, intervalo de confianza 95 % 0,65-0,92). El riesgo de desarrollar un evento cardiovascular es mayor en pacientes con SM (log rank 6,185, p = 0,013), con índice de tejido graso mayor 11,5 kg/m² (log rank 10,220, p = 0,001) y con índice de conicidad mayor 1,2 (log rank 6,393, p = 0,011). En el análisis de Cox, ajustado a la edad y sexo, los pacientes con SM tienen el doble de riesgo de ingresar por un evento cardiovascular (odds ratio 1,93, 1,022-3,6, p = 0,043). La mortalidad fue 35 % en los 3 años de seguimiento sin diferencias entre los grupos con y sin SM. Conclusiones: El SM es una patología muy prevalente en pacientes en HD y su presencia duplica el riesgo de hospitalización por eventos cardiovasculares a corto plazo.

Published
2014

46. CD163-Macrophages Are Involved in Rhabdomyolysis-Induced Kidney Injury and May Be Detected by MRI with Targeted Gold-Coated Iron Oxide Nanoparticles

Author

Rubio-Navarro, Alfonso, primary, Carril, Mónica, additional, Padro, Daniel, additional, Guerrero-Hue, Melanie, additional, Tarín, Carlos, additional, Samaniego, Rafael, additional, Cannata, Pablo, additional, Cano, Ainhoa, additional, Villalobos, Juan Manuel Amaro, additional, Sevillano, Ángel Manuel, additional, Yuste, Claudia, additional, Gutiérrez, Eduardo, additional, Praga, Manuel, additional, Egido, Jesús, additional, and Moreno, Juan Antonio, additional

Published
2016
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47. Factors related with the progression of chronic kidney disease

Author

Yuste, Claudia, Barraca, Daniel, Aragoncillo-Sauco, Inés, Vega-Martínez, Almudena, Abad, Soraya, Verdalles-Guzmán, Úrsula, Ruiz-Caro, Caridad, Ampuero, Jara, and López-Gómez, Juan M.

Subjects
Proteinuria, Metabolismo óseo, Bone metabolism, Chronic kidne disease, Progression of renal insufficiency, Parathyroid hormone (PTH), Fosfato sérico, Hormona paratiroidea (PTH), Enfermedad renal crónica, Progresión de insuficiencia renal, Serum phosphate
Abstract

Background: Our aims were to determine the rate of progression of chronic kidney disease (CKD) and to identify predictors, with particular emphasis on bone and mineral metabolism. Methods: Retrospective and observational study including 300 patients with advanced CKD (61.2% males, 33.1% diabetics; age 65.6±14 years). Mean follow-up time was19.4±10.1 months. Baseline estimated glomerular filtration rate (eGFR) (MDRD-4) was 22.5±7.18mL/min. To calculate the rate of decline in eGFR, we used the slope of the regression line between all determinations of eGFR and follow-up time. We calculated the mean values for proteinuria and serum phosphate, calcium, uric acid, and PTH, as well as 24-hour urinary excretion of urea nitrogen over time for each patient. Follow-up was at least 6 months and included at least 4 measurements of eGFR. Results: The mean rate of decline eGFR (-1.64 mL/min/1.73m²/year) was inversely correlated with serum phosphate levels (4.3±2.1 mg/dL, p

Published
2013

48. Factors related with the progression of chronic kidney disease

Author

Yuste,Claudia, Barraca,Daniel, Aragoncillo-Sauco,Inés, Vega-Martínez,Almudena, Abad,Soraya, Verdalles-Guzmán,Úrsula, Ruiz-Caro,Caridad, Ampuero,Jara, and López-Gómez,Juan M.

Subjects
Proteinuria, Bone metabolism, Chronic kidne disease, Progression of renal insufficiency, Parathyroid hormone (PTH), Serum phosphate
Abstract

Background: Our aims were to determine the rate of progression of chronic kidney disease (CKD) and to identify predictors, with particular emphasis on bone and mineral metabolism. Methods: Retrospective and observational study including 300 patients with advanced CKD (61.2% males, 33.1% diabetics; age 65.6±14 years). Mean follow-up time was19.4±10.1 months. Baseline estimated glomerular filtration rate (eGFR) (MDRD-4) was 22.5±7.18mL/min. To calculate the rate of decline in eGFR, we used the slope of the regression line between all determinations of eGFR and follow-up time. We calculated the mean values for proteinuria and serum phosphate, calcium, uric acid, and PTH, as well as 24-hour urinary excretion of urea nitrogen over time for each patient. Follow-up was at least 6 months and included at least 4 measurements of eGFR. Results: The mean rate of decline eGFR (-1.64 mL/min/1.73m²/year) was inversely correlated with serum phosphate levels (4.3±2.1 mg/dL, p

Published
2013

49. Valoración del estado nutricional en pacientes en hemodiálisis

Author

Yuste,Claudia, Abad,Soraya, Vega,Almudena, Barraca,Daniel, Bucalo,Laura, Pérez-de José,Ana, and López-Gómez,Juan M.

Subjects
Hemodiálisis, Nutrición, Parámetros analíticos, Bioimpedancia espectroscópica
Abstract

La malnutrición es un problema frecuente y un factor de riesgo de mortalidad en pacientes en hemodiálisis. Sin embargo, no existe un consenso para evaluarla. Objetivo: Evaluar la relación entre el estado nutricional medido por bioimpedancia espectroscópica (BIS) y los parámetros analíticos nutricionales, así como la evolución nutricional, valorada como sus modificaciones, en un año. Métodos: Estudio prospectivo observacional de 124 pacientes en hemodiálisis (edad 61,2 [±15,8] años, varones 62,9 %, diabéticos 33,1 %). Los parámetros analíticos nutricionales y la BIS se realizaron basalmente y al año. Resultados: El índice de masa magra (IMM) basal (medio 13,3 ± 3,6 kg/m²) se correlaciona de forma directa con el sexo masculino (p =0,01) e inversamente con la edad (p = 0,006). Basalmente el índice de masa grasa (IMG) (medio 11,2 ± 6,1 kg/m²)se correlaciona de forma directa con el índice de masa corporal (p < 0,001) y el sexo femenino (p = 0,004). No encontramos asociación con la comorbilidad o los parámetros inflamatorios. No observamos correlación entre las modificaciones de masa magra o masa grasa con las modificaciones de parámetros nutricionales. Los pacientes con ganancia de IMM (> 0 kg/m²) presentan albúmina sérica basal más baja (p = 0,017), menor IMM basal (p < 0,001) y mayor IMG basal (p = 0,027). Los pacientes con pérdida de IMG (< 0 kg/m²) presentan menores cifras de tensión arterial sistólica(p = 0,04). Conclusión: La valoración del estado nutricional mediante parámetros analíticos no presenta una buena relación con los parámetros de composición corporal ni con sus modificaciones.

Published
2013

50. Valoración del estado nutricional en pacientes en hemodiálisis

Author

Yuste, Claudia, Abad, Soraya, Vega, Almudena, Barraca, Daniel, Bucalo, Laura, Pérez-de José, Ana, and López-Gómez, Juan M.

Subjects
Analytical data, Haemodialysis, Hemodiálisis, Bioimpedance spectroscopy, Nutrición, Parámetros analíticos, Bioimpedancia espectroscópica, Nutrition
Abstract

La malnutrición es un problema frecuente y un factor de riesgo de mortalidad en pacientes en hemodiálisis. Sin embargo, no existe un consenso para evaluarla. Objetivo: Evaluar la relación entre el estado nutricional medido por bioimpedancia espectroscópica (BIS) y los parámetros analíticos nutricionales, así como la evolución nutricional, valorada como sus modificaciones, en un año. Métodos: Estudio prospectivo observacional de 124 pacientes en hemodiálisis (edad 61,2 [±15,8] años, varones 62,9 %, diabéticos 33,1 %). Los parámetros analíticos nutricionales y la BIS se realizaron basalmente y al año. Resultados: El índice de masa magra (IMM) basal (medio 13,3 ± 3,6 kg/m²) se correlaciona de forma directa con el sexo masculino (p =0,01) e inversamente con la edad (p = 0,006). Basalmente el índice de masa grasa (IMG) (medio 11,2 ± 6,1 kg/m²)se correlaciona de forma directa con el índice de masa corporal (p < 0,001) y el sexo femenino (p = 0,004). No encontramos asociación con la comorbilidad o los parámetros inflamatorios. No observamos correlación entre las modificaciones de masa magra o masa grasa con las modificaciones de parámetros nutricionales. Los pacientes con ganancia de IMM (> 0 kg/m²) presentan albúmina sérica basal más baja (p = 0,017), menor IMM basal (p < 0,001) y mayor IMG basal (p = 0,027). Los pacientes con pérdida de IMG (< 0 kg/m²) presentan menores cifras de tensión arterial sistólica(p = 0,04). Conclusión: La valoración del estado nutricional mediante parámetros analíticos no presenta una buena relación con los parámetros de composición corporal ni con sus modificaciones. Malnutrition is a common problem and a risk factor of mortality in haemodialysis patients. However, there is no consensus for its assessment. Objective: To assess the relationship between nutritional status, measured by bioimpedance spectrometry (BIS), and laboratory markers of nutritional status, as well as nutritional evolution and its changes after 1 year. Methods: We performed an observational prospective study on 124 haemodialysis patients (aged 61.2 [±15.8] years, 2.9% were males, 33.1% were diabetic. Laboratory markers of nutritional status and BIS were implemented at baseline and after one year. Results: At baseline, lean mass index (LMI) (13.3 [±3.6] Kg/m²) was inversely correlated with age (P=.006), and directly with male gender (P=.01). At baseline, the fat mass index (FMI) (mean 11.2 ± 6.1kg/m²) correlates directly with the body mass index (P0kg/m²) have lower baseline serum albumin (P=.017), lower baseline LMI (P

Published
2013

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