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Objective Heparin resistance is often encountered during cardiopulmonary bypass. Heparin dose and activated clotting time target values for the initiation of cardiopulmonary bypass are not yet universally standardized; further no consensus exists on the management of heparin resistance. This study aimed to investigate the current real-world practice on heparin management and anticoagulant treatment for heparin resistance in Japan. Methods A questionnaire survey was conducted at medical institutions nationwide with which The Japanese Society of Extra-Corporeal Technology in Medicine members are affiliated, targeting surgical cases with cardiopulmonary bypass performed from January 2019 through December 2019. Results Among 69% (230/332) of the participating institutions, the criterion for heparin resistance was defined as “the target activated clotting time value not reached even with an additional dose of heparin administration”. Cases of heparin resistance were reported in 89.8% (202/225) of the responded institutions. Of note, 75% (106/141) of the responded institutions reported heparin resistance associated with antithrombin activity ≥ 80%. Antithrombin concentrate was used in 38.4% (238/619 responses) or third dose of heparin in 37.8% (234/619 responses) for advanced heparin resistance treatment. Antithrombin concentrate was found to be effective in resolving heparin resistance in patients having normal, as well as lower antithrombin activity. Conclusion Heparin resistance has occurred in many cardiovascular centers, even among patients with normal antithrombin activities. Interestingly, the administration of antithrombin concentrate resolved heparin resistance, regardless of the baseline antithrombin activity value.

The primordial He abundance $Y_\mathrm{P}$ is a powerful probe of cosmology. Currently, $Y_\mathrm{P}$ is best determined by observations of metal-poor galaxies, while there are only a few known local extremely metal-poor ($, Comment: 22 pages, 9 figures, accepted for publication in ApJ

Accurate clotting time assay results are vital, as the test is employed to indicate the amount of oral anticoagulant to be prescribed, while it is also used for screening the hemorrhagic and thrombotic diseases. The procedure chosen for preparation of a patient blood sample including centrifugation can contribute to significant differences in the results obtained. Thus, for the purpose of proposing a standardized method to appropriately prepare blood samples prior to assay, the Japanese Society of Laboratory Hematology organized the Working Group for Standardization of Sample Preparation for Clotting Time Assays (WG). Following reviews of previously announced guidelines and original experimental results, consensus was obtained by the WG, with the main findings as follows. (1) The recommended anticoagulant in the blood collection tube is sodium citrate solution at 0.105–0.109 M (3.13–3.2%). (2) Whole blood samples should be stored at room temperature (18–25 ˚C) within 1 h of collection from the patient. (3) For plasma preparation, centrifugation at 1500 × g should be performed for at least 15 min or at 2000 × g for at least 10 min at room temperature. (4) After the plasma sample is prepared, it should be stored at room temperature and assayed within 4 h.

We present a new observation of satellite galaxies around seven Milky Way (MW)-like galaxies located outside of the Local Group (LG) using Subaru/Hyper Suprime-Cam imaging data to statistically address the missing satellite problem. We select satellite galaxy candidates using magnitude, surface brightness, S\'{e}rsic index, axial ratio, full width half maximum, and surface brightness fluctuation cuts, followed by visual screening of false-positives such as optical ghosts of bright stars. We identify 51 secure dwarf satellite galaxies within the virial radius of nine host galaxies, two of which are drawn from the pilot observation presented in Paper I. We find that the average luminosity function of the satellite galaxies is consistent with that of the MW satellites, although the luminosity function of each host galaxy varies significantly. We observe an indication that more massive hosts tend to have a larger number of satellites. Physical properties of the satellites such as the size-luminosity relation is also consistent with the MW satellites. However, the spatial distribution is different; we find that the satellite galaxies outside of LG shows no sign of concentration or alignment, while that of the MW satellites is more concentrated around the host and exhibits a significant alignment. As we focus on relatively massive satellites with $M_V, Comment: 20 pages, 11 figures, accepted for publication in The Astrophysical Journal

We report fourteen and twenty-eight protocluster candidates at z = 5.7 and 6.6 over 14 and 19 deg2 areas, respectively, selected from 2,230 Lyα emitters (LAEs) photometrically identified with Subaru/Hyper Suprime-Cam (HSC) deep images. Six out of the 42 protocluster candidates include at least 1 spectroscopically confirmed LAEs at redshifts up to z = 6.574. By the comparisons with the cosmological Lyα radiative transfer (RT) model reproducing LAEs with the reionization effects, we find that more than a half of these protocluster candidates might be progenitors of the present-day clusters with a mass of ≳ 1014M⊙. We also investigate the correlation between LAE overdensity and Lya rest-frame equivalent width (EW), because the cosmological Lyα RT model suggests that a slope of EW-overdensity relation is steepened towards the epoch of cosmic reionization (EoR), due to the existence of the ionized bubbles around galaxy overdensities easing the escape of Lyα emission from the partly neutral intergalactic medium. The available HSC data suggest that the slope of the EW-overdensity correlation does not evolve from the post-reionization epoch z = 5.7 to the EoR z = 6.6 beyond the moderately large statistical errors.

The development of carbon dioxide fixation under mild conditions is a central theme in organic synthesis. Despite the tremendous progress in the field of organocatalysis in the past two decades, the coupling reactions of epoxides with carbon dioxide that proceed at atmospheric pressure at temperatures of less than 100 °C have remained challenging. In our aspirational studies of tetraarylphosphonium salts (TAPS) catalysis, we report here the bifunctional TAPS-catalyzed synthesis of five-membered cyclic carbonates by chemical fixation using 1 atm of carbon dioxide at 60 °C. Intriguing substituent effects of TAPS were observed, in which electron-donating groups enhanced their reactivity. In addition, the mechanism was thoroughly investigated by undertaking both experimental and theoretical studies, suggesting that the electronic properties of TAPS affect carbon dioxide insertion into halohydrin intermediates. The results provided fruitful information to understand the origin of the TAPS behavior, which would contribute to the design of novel catalysts for carbon dioxide capture.

We present the statistical redshift distribution of a large sample of low surface brightness (LSB) galaxies identified in the first 200 deg$^2$ of the Hyper Suprime-Cam Strategic Survey Program. Through cross-correlation with the NASA-SDSS Atlas, we find that the majority of objects lie within z 10^8$ M_sun) the LSB galaxies do not form a smooth extension of the mass-size relation of higher surface brightness galaxies, perhaps suggesting that the LSB galaxy population is distinct in its formation path., 15 pages, 6 figures, resubmitted to ApJ after review

We present the spectroscopic discovery of 69 quasars at 5.8 < z < 7.0, drawn from the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP) imaging survey data. This is the 16th publication from the Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) project, and completes identification of all but the faintest candidates (i.e., i-band dropouts with zAB < 24 and y-band detections, and z-band dropouts with yAB < 24) with Bayesian quasar probability Pq > 0.1 in the HSC-SSP third public data release (PDR3). The sample reported here also includes three quasars with Pq < 0.1 at z ~ 6.6, which we selected in an effort to completely cover the reddest point sources with simple color cuts. The number of high-z quasars discovered in SHELLQs has now grown to 162, including 23 type-II quasar candidates. This paper also presents identification of seven galaxies at 5.6 < z < 6.7, an [O III] emitter at z = 0.954, and 31 Galactic cool stars and brown dwarfs. High-z quasars and galaxies comprise 75 % and 16 % respectively of all the spectroscopic SHELLQs objects that pass our latest selection algorithm with the PDR3 photometry. That is, a total of 91 % of the objects lie at z > 5.6. This demonstrates that the algorithm has very high efficiency, even though we are probing an unprecedentedly low-luminosity population down to M1450 ~ -21 mag., Accepted for publication in The Astrophysical Journal Supplement Series

16 pages, 9 figures, 2 tables, MNRAS, in press, minor changes with abstract/conclusion the same; International audience; ABSTRACT Recent studies have highlighted the potential significance of intracluster medium (ICM) clumping and its important implications for cluster cosmology and baryon physics. Many of the ICM clumps can originate from infalling galaxies, as stripped interstellar medium (ISM) mixing into the hot ICM. However, a direct connection between ICM clumping and stripped ISM has not been unambiguously established before. Here, we present the discovery of the first and still the only known isolated cloud (or orphan cloud [OC]) detected in both X-rays and H α in the nearby cluster A1367. With an effective radius of 30 kpc, this cloud has an average X-ray temperature of 1.6 keV, a bolometric X-ray luminosity of ∼3.1 × 1041 erg s−1, and a hot gas mass of ∼1010 M⊙. From the Multi-Unit Spectroscopic Explorer (MUSE) data, the OC shows an interesting velocity gradient nearly along the east-west direction with a low level of velocity dispersion of ∼80 km s−1, which may suggest a low level of the ICM turbulence. The emission line diagnostics suggest little star formation in the main H α cloud and a low-ionization (nuclear) emission-line regions like spectrum, but the excitation mechanisms remain unclear. This example shows that stripped ISM, even long after the initial removal from the galaxy, can still induce ICM inhomogeneities. We suggest that the magnetic field can stabilize the OC by suppressing hydrodynamic instabilities and thermal conduction. This example also suggests that at least some ICM clumps are multiphase in nature and implies that the ICM clumps can also be traced in H α. Thus, future deep and wide-field H α surveys can be used to probe the ICM clumping and turbulence.

Characterizing high-z quasar environments is key to understanding the co-evolution of quasars and the surrounding galaxies. To restrict their global picture, we statistically examine the g-dropout galaxy overdensity distribution around 570 faint quasar candidates at z ~ 4, based on the Hyper Suprime-Cam Subaru Strategic Program survey. We compare the overdensity significances of g-dropout galaxies around the quasars with those around g-dropout galaxies, and find no significant difference between their distributions. A total of 4 (22) out of the 570 faint quasars, 0.7_{-0.4}^{+0.4} (3.9_{-0.8}^{+0.8}) %, are found to be associated with the > 4 sigma overdense regions within an angular separation of 1.8 (3.0) arcmin, which is the typical size of protoclusters at this epoch. This is similar to the fraction of g-dropout galaxies associated with the > 4 sigma overdense regions. This result is consistent with our previous work that 1.3_{-0.9}^{+0.9} % and 2.0_{-1.1}^{+1.1} % of luminous quasars detected in the Sloan Digital Sky Survey exist in the > 4 sigma overdense regions within 1.8 and 3.0 arcmin separations, respectively. Therefore, we suggest that the galaxy number densities around quasars are independent of their luminosity, and most quasars do not preferentially appear in the richest protocluster regions at z ~ 4. The lack of an apparent positive correlation between the quasars and the protoclusters implies that: i) the gas-rich major merger rate is relatively low in the protocluster regions, ii) most high-z quasars may appear through secular processes, or iii) some dust-obscured quasars exist in the protocluster regions., 12 pages, 4 figures

We study emission line profiles of 21 nearby low-mass ($M_*=10^4-10^7~M_\odot$) galaxies in deep medium-high resolution spectra taken with Magellan/MagE. These low-mass galaxies are actively star-forming systems with high specific star-formation rates of $\mathrm{sSFR}\sim100-1000~\mathrm{Gyr}^{-1}$ that are well above the star-formation main sequence and its extrapolation. We identify broad-line components of H$\alpha$ and [OIII]$\lambda 5007$ emission in 14 out of the 21 galaxies that cannot be explained by the MagE instrumental profile or the natural broadening of line emission. We conduct double Gaussian profile fitting to the emission of the 14 galaxies, and find that the broad-line components have line widths significantly larger than those of the narrow-line components, indicative of galactic outflows. The board-line components have moderately large line widths of $\sim 100$ km s$^{-1}$. We estimate the maximum outflow velocities $v_\mathrm{max}$ and obtain values of $\simeq 60-200$ km s$^{-1}$, which are found to be comparable to or slightly larger than the escape velocities. Positive correlations of $v_\mathrm{max}$ with star-formation rates, stellar masses, and circular velocities, extend down into this low-mass regime. Broad- to narrow-line flux ratios BNRs are generally found to be smaller than those of massive galaxies. The small $v_\mathrm{max}$ and BNRs suggest that the mass loading factors $\eta$ can be as small as 0.1 - 1 or below, in contrast to the large $\eta$ of energy-driven outflows predicted by numerical simulations., Comment: 22 pages, 11 figures, Accepted for publication by ApJ

We present new measurements of rest-UV luminosity functions and angular correlation functions from 4,100,221 galaxies at z~2-7 identified in the Subaru/Hyper Suprime-Cam survey and CFHT Large-Area U-band Survey. The obtained luminosity functions at z~4-7 cover a very wide UV luminosity range of ~0.002-2000L*uv combined with previous studies, revealing that the dropout luminosity function is a superposition of the AGN luminosity function dominant at Muv-22 mag, consistent with galaxy fractions based on 1037 spectroscopically-identified sources. Galaxy luminosity functions estimated from the spectroscopic galaxy fractions show the bright end excess beyond the Schechter function at >2sigma levels, which is possibly made by inefficient mass quenching, low dust obscuration, and/or hidden AGN activity. By analyzing the correlation functions at z~2-6 with halo occupation distribution models, we find a weak redshift evolution (within 0.3 dex) of the ratio of the star formation rate (SFR) to the dark matter accretion rate, SFR/(dMh/dt), indicating the almost constant star formation efficiency at z~2-6, as suggested by our earlier work at z~4-7. Meanwhile, the ratio gradually increases with decreasing redshift at z10 with $\propto10^{-0.5(1+z)}$, which will be directly tested with JWST., Comment: 53 pages, 26 figures, 10 tables, accepted for publication in ApJS. Dropout galaxy catalogs are available on our project webpage (http://cos.icrr.u-tokyo.ac.jp/rush.html)

Introduction Fibrin/fibrinogen degradation products (FDP) values reflect coagulation and fibrinolysis status, and FDP levels are helpful for diagnosis and classification of disseminated intravascular coagulation (DIC). FDP measurement has always played a key role in diagnosing DIC, a phenomenon that has recently gained renewed attention because of its occurrence in coronavirus disease 2019 (COVID-19) patients. Although the evaluation of FDP is crucial for the management of critical care, the variability among FDP reagents is unclear. In this study, we aimed to compare LIASAUTO P-FDP with three FDP reagents and investigate their characteristics. Methods In total, 172 plasmas samples were used in the correlation. The sample data were divided into three groups including negative, no and positive discrepancy based on the discrepancy percentages calculated from each correlation between LIASAUTO P-FDP and other three reagents. D-dimer, plasmin-α2 plasmin inhibitor complex (PIC), fibrin monomer complex (FMC), fibrinogen (Fbg) and Plasmin-α2 Plasmin Inhibitor (α2 PI) were measured and included in data analysis. Results The positive discrepancy groups showed higher D-dimer, PIC and FMC values than the negative discrepancy groups. The data indicated that LIASAUTO P-FDP had higher reactivity to D-dimer than other reagents and the values were elevated in the fibrinolysis-enhanced samples with various FDP fragments. Conclusion LIASAUTO P-FDP displayed the reactivity towards various fibrin/fibrinogen degradation products, and it might be useful for DIC diagnosis because the fibrinolytic status differed in the DIC types and stages.

We have conducted a comprehensive survey of emission-line galaxies at $z\lesssim1.6$ based on narrowband (NB) imaging data taken with Hyper Suprime-Cam (HSC) on the Subaru telescope. In this paper, we update the catalogs of H$\alpha$, [OIII], and [OII] emission-line galaxies using the data from the second Public Data Release (PDR2) of Subaru Strategic Program (SSP) of HSC and Cosmic HydrOgen Reionization Unveiled with Subaru (CHORUS) survey along with the spectroscopic redshifts for 2,019 emission-line galaxies selected with the PDR1 data. The wider effective coverage of NB816 and NB921, 16.3 deg$^2$ and 16.9 deg$^2$ respectively, are available in the Deep and UltraDeep layers of HSC-SSP from the PDR2. The CHORUS survey provides us with data with additional three NBs (NB527, NB718, and NB973) in the COSMOS field in the UltraDeep layer (1.37 deg$^2$). The five NB datasets allow us to investigate the star-forming galaxies presenting emission-lines at 14 specific redshifts ranging from $z\sim1.6$ down to $z\sim0.05$. We revisit the distribution of large-scale structures and luminosity functions (LFs) for the emission-line galaxies with the large samples of 75,377 emission-line galaxies selected. The redshift revolution of LFs shows that the star formation rate densities (SFRDs) decreases monotonically from $z\sim1.6$, which is consistent with the cosmic SFRD ever known. Our samples of emission-line galaxies covering a sufficiently large survey volume are useful to investigate the evolution of star-forming galaxies since the cosmic noon in a wide range of environments including galaxy clusters, filaments, and voids., Comment: 32 pages, 23 figures, 6 tables, accepted for publication in PASJ. The catalog of emission-line galaxies from HSC-SSP PDR2 data will be available soon at https://hsc-release.mtk.nao.ac.jp/, and the catalog from CHORUS data will be available after the CHORUS data are publicly released

We present the galaxy luminosity functions (LFs) of four Hickson Compact Groups using image data from the Subaru Hyper Suprime-Cam. A distinct dip appeared in the faint-ends of all the LFs at $M_g\sim-12$. A similar dip was observed in the LFs of the galaxy clusters Coma and Centaurus. However, LFs in the Virgo, Hydra, and the field had flatter slopes and no dips. As the relative velocities among galaxies are lower in compact groups than in clusters, the effect of galaxy-galaxy interactions would be more significant in compact groups. The $M_g\sim-12$ dip of compact groups may imply that frequent galaxy-galaxy interactions would affect the evolution of galaxies, and the dip in LF could become a boundary between different galaxy populations.

Accurate clotting time assay results are vital, as the test is employed to indicate the amount of oral anticoagulant to be prescribed, while it is also used for screening the hemorrhagic and thrombotic diseases. The procedure chosen for preparation of a patient blood sample including centrifugation can contribute to significant differences in the results obtained. Thus, for the purpose of proposing a standardized method to appropriately prepare blood samples prior to assay, the Japanese Society of Laboratory Hematology organized the Working Group for Standardization of Sample Preparation for Clotting Time Assays (WG). Following reviews of previously announced guidelines and original experimental results, consensus was obtained by the WG, with the main findings as follows. (1) The recommended anticoagulant in the blood collection tube is sodium citrate solution at 0.105-0.109 M (3.13-3.2%). (2) Whole blood samples should be stored at room temperature (18-25 ˚C) within 1 h of collection from the patient. (3) For plasma preparation, centrifugation at 1500 × g should be performed for at least 15 min or at 2000 × g for at least 10 min at room temperature. (4) After the plasma sample is prepared, it should be stored at room temperature and assayed within 4 h.

Green valley galaxies represent the population that is likely to transition from the star-forming to the quiescent phases. To investigate the role of the environment in quenching star formation, we use the wide-field data from the Hyper Suprime-Cam Strategic Subaru Proposal survey to quantify the frequency of green valley galaxies in different environments and their redshift evolution. We find that the green valley fraction, in general, is less than 20% in any redshift and environment. The green valley fraction, when normalized to the total population, is higher in the field than that in groups or clusters and decreases with a decreasing redshift and increasing mass. The lower fraction of transitional galaxies in denser environments could be a consequence of the lack of star-forming galaxies, which could be the progenitors of green valley galaxies. To assess the effect of the environment on star formation quenching, we define the effective green valley fraction as the ratio of the number of green valley galaxies to that of nonquiescent galaxies only. The effective green valley fraction for field galaxies is lower than that for group or cluster galaxies, which reveals a strong positive mass dependence and mild redshift evolution. Moreover, the specific star formation rate (sSFR) is reduced by 0.1-0.3 dex in groups or clusters. Our results thus imply that an ongoing slow quenching process has been acting in the dense environment since z~1., Comment: 18 pages, 6 figures, and 5 tables. Accepted by ApJ

We report the rest-frame ultraviolet luminosity function of $g$-dropout galaxies in 177 protocluster candidates (PC UVLF) at $z\sim4$ selected in the Hyper Suprime-Cam Subaru Strategic Program. Comparing with the UVLF of field galaxies at the same redshift, we find that the PC UVLF shows a significant excess towards the bright-end. This excess can not be explained by the contribution of only active galactic nuclei, and we also find that this is more significant in higher dense regions. Assuming that all protocluster members are located on the star formation main sequence, the PC UVLF can be converted into a stellar mass function. Consequently, our protocluster members are inferred to have a 2.8 times more massive characteristic stellar mass than that of the field Lyman break galaxies at the same redshift. This study, for the first time, clearly shows that the enhancement in star formation or stellar mass in overdense regions can generally be seen as early as at $z\sim4$. We also estimate the star formation rate density (SFRD) in protocluster regions as $\simeq 6-20\%$ of the cosmic SFRD, based on the measured PC UVLF after correcting for the selection incompleteness in our protocluster sample. This high value suggests that protoclusters make a non-negligible contribution to the cosmic SFRD at $z\sim4$, as previously suggested by simulations. Our results suggest that protoclusters are essential components for the galaxy evolution at $z\sim4$., Comment: 22 pages, 16 figures, Accepted for publication in ApJ

We present proper motion measurements for more than $0.55$ million main-sequence stars, by comparing astrometric positions of matched stars between the multi-band imaging datasets from the Hyper Suprime-Cam (HSC) Survey and the SDSS Stripe 82. In doing this we use $3$ million galaxies to recalibrate the astrometry and set up a common reference frame between the two catalogues. The exquisite depth and the nearly $12$ years of time baseline between HSC and SDSS enable high-precision measurements of statistical proper motions for stars down to $i\simeq 24$. A validation of our method is demonstrated by the agreement with the $Gaia$ proper motions, to the precision better than $0.1$ mas yr$^{-1}$. To retain the precision, we make a correction of the subtle effects due to the differential chromatic refraction in the SDSS images based on the comparison with the $Gaia$ proper motions against colour of stars, which is validated using the SDSS spectroscopic quasars. Combining with the photometric distance estimates for individual stars based on the precise HSC photometry, we show a significant detection of the net proper motions for stars in each bin of distance out to $100$ kpc. The two-component tangential velocities after subtracting the apparent motions due to our own motion display rich phase-space structures including a clear signature of the Sagittarius stream in the halo region of distance range $[10,\ 35]$ kpc. We also measure the tangential velocity dispersion in the distance range $5-20$ kpc and find that the data are consistent with a constant isotropic dispersion of $80\pm 10\ {\rm km/s}$. More distant stars appear to have random motions with respect to the Galactic centre on average., Comment: accepted by MNRAS, add more details

We utilize the Hyper Suprime-Cam (HSC) Wide Survey to explore the properties of galaxies located in the voids identified from the Baryon Oscillation Spectroscopic Survey (BOSS) up to z~0.7. The HSC reaches i~25, allowing us to characterize the void galaxies down to 10$^{9.2}$ solar mass. We find that the revised void galaxy densities, when including faint galaxies in voids defined by bright galaxies, are still underdense compared to the mean density from the entire field. In addition, we classify galaxies into star-forming, quiescent, and green valley populations, and find that void galaxies tend to have slightly higher fractions of star-forming galaxies under the mass and redshift control, although the significance of this result is only moderate (2$\sigma$). However, when we focus on the star-forming population, the distribution of the specific star formation rate (sSFR) of void galaxies shows little difference from that of the control galaxies. Similarly, the median sSFR of star-forming void galaxies is also in good agreement with that of the star-forming control galaxies. Moreover, the effective green valley fraction of void galaxies, defined as the number of green valley galaxies over the number of nonquiescent galaxies, is comparable to that of the control ones, supporting the suggestion that void and control galaxies evolve under similar physical processes and quenching frequencies. Our results thus favor a scenario of the galaxy assembly bias., Comment: 17 pages, 10 figures, 3 tables, ApJ accepted

We present Keck/LRIS follow-up spectroscopy for 13 photometric candidates of extremely metal-poor galaxies (EMPGs) selected by a machine-learning technique applied to the deep (∼26 AB mag) optical and wide-area (∼500 deg2) Subaru imaging data in the EMPRESS survey. Nine out of the 13 candidates are EMPGs with an oxygen abundance (O/H) less than ∼10% solar value (O/H)⊙, and four sources are contaminants of moderately metal-rich galaxies or no emission-line objects. Notably, two out of the nine EMPGs have extremely low stellar masses and oxygen abundances of 5 × 104–7 × 105 M ⊙ and 2%–3% (O/H)⊙, respectively. With a sample of five EMPGs with (Fe/O) measurements, two (three) of which are taken from this study (the literature), we confirm that two EMPGs with the lowest (O/H) ratios of ∼2% (O/H)⊙ show high (Fe/O) ratios of ∼0.1, close to the solar abundance ratio. Comparing galaxy chemical enrichment models, we find that the two EMPGs cannot be explained by a scenario of metal-poor gas accretion/episodic star formation history due to their low (N/O) ratios. We conclude that the two EMPGs can be reproduced by the inclusion of bright hypernovae and/or hypothetical pair-instability supernovae (SNe) preferentially produced in a metal-poor environment. This conclusion implies that primordial galaxies at z ∼ 10 could have a high abundance of Fe that did not originate from Type Ia SNe with delays and that Fe may not serve as a cosmic clock for primordial galaxies.

BACKGROUND Light transmission aggregometry (LTA) is the gold standard for platelet function assessment. The automated coagulation analyzer from Sysmex that performs LTA offers the advantage of being a walk-away technology. Recently, a new parameter "ADP-induced platelet aggregation level (APAL)" was developed to support the interpretation of results. APAL is calculated as a score from 0.0 to 10.0 based on platelet aggregation patterns with 1 and 10 µM adenosine diphosphate (ADP). Here, the basic performance of the newly developed APAL system and comparison with the maximum aggregation rate of ADP (ADP-MA) was evaluated. METHODS The within-run precision was calculated by conducting five replicate analyses of the platelet-rich plasma (PRP) from healthy volunteers and 0.05 µM of cangrelor-spiked PRP. Cangrelor is a P2Y12 inhibitor that does not require liver CYP activation. The reference interval was calculated from the results of 67 healthy volunteers. The effect of the antiplatelet P2Y12 agent was evaluated using several concentrations of cangrelor. A comparative study was performed using 103 PRP samples with different levels of aggregation. Each test was analyzed with both APAL and ADP-MA. RESULTS The percentage coefficient of variation in within-run precision was within 7% for APAL and 10 µM ADP-MA. Reference interval of APAL and 10 µM ADP-MA was 7.1 - 10.0 and 80.0 - 99.2%, respectively. APAL signifi-cantly decreased with the addition of 0.02 µM cangrelor, while 10 µM ADP-MA was barely affected. A significant correlation was observed between APAL and 10 µM ADP-MA (r = 0.94; p < 0.0001). CONCLUSIONS The newly developed APAL system exhibited an acceptable performance. APAL score showed a good correlation with ADP-MA and was adequate to detect the weak effect of P2Y12 inhibitors. APAL is a new platelet aggregation scoring system with the potential to monitor the effects of P2Y12 inhibitor over a wide range.

We present the morphology and stellar population of 27 extremely metal poor galaxies (EMPGs) at $z\sim0$ with metallicities of 0.01--0.1 Z$_{\odot}$. We conduct multi-component surface brightness (SB) profile fitting for the deep Subaru/HSC $i$-band images of the EMPGs with the {\sc Galfit} software, carefully removing the SB contributions of tails. We find that the EMPGs with a median stellar mass of $\log(M_{*}/{\rm M}_{\odot})=6.0$ have a median S{\'e}rsic index of $n=1.1$ and a median effective radius of $r_{\rm e}=200$ pc, suggesting that typical EMPGs have very compact disk. We compare the EMPGs with $z\sim6$ galaxies and local galaxies on the size-mass ($r_{\rm e}$-$M_*$) diagram, and identify that the majority of the EMPGs have a $r_{\rm e}$-$M_*$ relation similar to $z\sim0$ star-forming galaxies rather than $z\sim6$ galaxies. Not every EMPG is a local analog of high-$z$ young galaxies in the $r_{\rm e}$-$M_*$ relation. A spectrum of one pair of EMPG and tail, so far available, indicates that the tail is dynamically related to the EMPG with a median velocity difference of $\Delta V=101\pm32$ km s$^{-1}$. This moderately-large $\Delta V$ cannot be explained by the dynamics of the tail, but likely by the infall on the tail. For the first time, we may identify the metal-poor star-forming system just now infalling into the tail., Comment: ApJ in Press

Preparation of a range of oxazolidinones, including enantioenriched N-aryl-substituted oxazolidinones, in which tetraarylphosphonium salts (TAPS) catalyze the [3 + 2] coupling reaction of isocyanates and epoxides effectively, is described. The key finding is a Brønsted acid/halide ion bifunctional catalyst that can accelerate epoxide ring opening with high regioselectivity. Mechanistic studies disclosed that the ylide generated from TAPS, along with the formation of halohydrins, plays a crucial role in the reaction with isocyanates.

Although Type Ia supernova cosmology has now reached a mature state, it is important to develop as many independent methods as possible to understand the true nature of dark energy. Recent studies have shown that Type II supernovae (SNe II) offer such a path and could be used as alternative distance indicators. However, the majority of these studies were unable to extend the Hubble diagram above redshift z = 0.3 because of observational limitations. Here, we show that we are now ready to move beyond low redshifts and attempt high-redshift (z ≳ 0.3) SN II cosmology as a result of new-generation deep surveys such as the Subaru/Hyper Suprime-Cam survey. Applying the "standard candle method" to SN 2016jhj (z = 0.3398 ± 0.0002; discovered by HSC) together with a low-redshift sample, we are able to construct the highest-redshift SN II Hubble diagram to date with an observed dispersion of 0.27 mag (i.e. 12-13% in distance). This work demonstrates the bright future of SN II cosmology in the coming era of large, wide-field surveys like that of the Large Synoptic Survey Telescope., Facultad de Ciencias Astronómicas y Geofísicas, Instituto de Astrofísica de La Plata

Carbonyl-stabilized phosphonium ylides exhibit great utility in modern organic synthesis, and they are known as an ambident nucleophile at the carbonyl oxygen atom and at the α-carbon atom. However, they have found limited use as catalysts. We focused on the inherent nucleophilicity of the oxygen atom to develop an ionic nucleophilic catalysis, and the phosphonium ylide-catalyzed primary alcohol selective acylation of mixed diols with acid anhydrides has been demonstrated. Mechanistic studies revealed the behavior of a catalyst, which would contribute to the field of ylide chemistry.

We report on the discovery of a new Milky Way (MW) satellite in Bo\"otes based on data from the on-going Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP). This satellite, named Bo\"otes IV, is the third ultra-faint dwarf that we have discovered in the HSC-SSP. We have identified a statistically significant (32.3$\sigma$) overdensity of stars having characteristics of a metal-poor, old stellar population. The distance to this stellar system is $D_{\odot}=209^{+20}_{-18}$ kpc with a $V$-band absolute magnitude of $M_V=-4.53^{+0.23}_{-0.21}$ mag. Bo\"otes IV has a half-light radius of $r_h=462^{+98}_{-84}$ pc and an ellipticity of $0.64^{+0.05}_{-0.05}$, which clearly suggests that this is a dwarf satellite galaxy. We also found another overdensity that appears to be a faint globular cluster with $M_V=-0.20^{+0.59}_{-0.83}$ mag and $r_h=5.9^{+1.5}_{-1.3}$ pc located at $D_{\odot}=46^{+4}_{-4}$ kpc. Adopting the recent prediction for the total population of satellites in a MW-sized halo by Newton et al. (2018), which combined the characteristics of the observed satellites by SDSS and DES with the subhalos obtained in $\Lambda$CDM models, we estimate that there should be about two MW satellites at $M_V\le0$ in the $\sim676$ deg$^2$ covered by HSC-SSP, whereas that area includes six satellites. Thus, the observed number of satellites is larger than the theoretical prediction. On the face of it, we have a problem of too many satellites, instead of the well-known missing satellites problem whereby the $\Lambda$CDM theory overpredicts the number of satellites in a MW-sized halo. This may imply that the models need more refinements for the assignment of subhalos to satellites such as considering those found by the current deeper survey. [abridged], Comment: 13 pages, 11 figures, 2 tables, accepted for publication in PASJ

We present measurements of cosmic shear two-point correlation functions (TPCFs) from Hyper Suprime-Cam Subaru Strategic Program (HSC SSP) first-year data, and derived cosmological constraints based on a blind analysis. The HSC first-year shape catalog is divided into four tomographic redshift bins ranging from $z=0.3$ to 1.5 with equal widths of $\Delta z =0.3$. The unweighted galaxy number densities in each tomographic bin are 5.9, 5.9, 4.3, and 2.4 arcmin$^{-2}$ from lower to higher redshifts, respectively. We adopt the standard TPCF estimators, $\xi_\pm$, for our cosmological analysis, given that we find no evidence of the significant B-mode shear. The TPCFs are detected at high significance for all ten combinations of auto- and cross-tomographic bins over a wide angular range, yielding a total signal-to-noise ratio of 19 in the angular ranges adopted in the cosmological analysis, $7', Comment: Replaced with the bug-fixed version. The results presented in the original publication were found to be affected by bugs in the software used for the numerical computation. The erratum will be published in PASJ. In this version, revised results obtained from corrected computations are presented. Revised chains are available from http://th.nao.ac.jp/MEMBER/hamanatk/HSC16aCSTPCFbugfix/index.html