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Your search keyword '"Yves Delmarcelle"' showing total 3 results
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3 results on '"Yves Delmarcelle"'

1. STAT3 signaling induces the differentiation of human ICOS(+) CD4 T cells helping B lymphocytes.

Author

Laure Ysebrant de Lendonck, Fouad Eddahri, Yves Delmarcelle, Muriel Nguyen, Oberdan Leo, Stanislas Goriely, and Arnaud Marchant

Subjects
Medicine, Science
Abstract

The generation of high-affinity antibodies and the development of B cell memory are dependent on the help provided by CD4 T cells. Mouse studies indicate that STAT3 signaling in CD4 T cells promotes the acquisition of the B cell help function. However, the role of STAT3 in humans has been controversial. In this study, we show that IL-6 and other STAT3 activating cytokines (IL-21 and IL-27) induce the differentiation of CD4 T cells promoting antibody production by B cells. The acquisition of B cell stimulating properties by naive cord blood CD4 T cells required the STAT3-dependent expression of ICOS and IL-21. Gene reporter and ChIP experiments unambiguously demonstrated that upon IL-6 stimulation, STAT3 induces the transcription of the ICOS gene through direct recruitment to the proximal promoter region indicating that STAT3 acts in part through the direct activation of the ICOS gene.

Published
2013
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2. Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection

Author

Martin Larsen, Véronique Olislagers, Marie Tackoen, Yves Delmarcelle, Corinne Liesnard, Wivine Burny, Catherine Donner, Michel Van Rysselberge, Arnaud Marchant, Ariane Huygens, Victor Appay, and Sandra Lecomte

Subjects
Adult, CD4-Positive T-Lymphocytes, medicine.medical_treatment, Congenital cytomegalovirus infection, Cytomegalovirus, Biology, CD8-Positive T-Lymphocytes, Cohort Studies, Pregnancy, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, Pregnancy Complications, Infectious, Receptor, Antigens, Viral, Effector, Infant, Newborn, T lymphocyte, medicine.disease, Fetal Blood, Chronic infection, Infectious Diseases, Cytokine, Immunology, Cytomegalovirus Infections, Cytokines, Female, CD8
Abstract

Background Cytomegalovirus (CMV) infection during fetal life causes severe symptoms and is associated with prolonged viral excretion. Previous studies reported low CD4(+) T-cell responses to CMV infection in early life, contrasting with large responses of effector CD8(+) T cells. The mechanisms underlying the defective CD4(+) T-cell responses and the possible dissociation with CD8(+) T-cell responses have not been clarified. Methods The magnitude and the quality of the fetal CD8(+) and CD4(+) T-cell responses to CMV infection were compared to those of adults with primary or chronic infection. Results In utero CMV infection induced oligoclonal expansions of fetal CD4(+) and CD8(+) T lymphocytes expressing a T-helper type 1 or Tc1 effector phenotype similar to that of adult CMV-specific cells. However, the effector cytokine responses and the polyfunctionality of newborn CD4(+) and CD8(+) T cells were markedly lower than those of adult cells. This reduced functionality was associated with a higher expression of the programmed death 1 inhibitory receptor, and blockade of this receptor increased newborn T-cell responses. Conclusions Functional exhaustion limits effector CD4(+) and CD8(+) T-lymphocyte responses to CMV during fetal life.

Published
2014

3. Pathogenesis of intraocular hypertension in cases of arteriovenous aneurysm

Author

Roger Weekers and Yves Delmarcelle

Subjects
medicine.medical_specialty, Fistula, business.industry, Arteriovenous fistula, Glaucoma, medicine.disease, Surgery, Lesion, Ophthalmology, Skull, Aneurysm, medicine.anatomical_structure, medicine.artery, Cavernous sinus, Arteriovenous Fistula, Hypertension, medicine, Humans, medicine.symptom, Internal carotid artery, business, Depression (differential diagnoses)
Abstract

INTRAOCULAR hypertension is a fairly constant symptom in patients with aneurysm of the cavernous sinus and the internal carotid artery. We have found it in each of five patients recently examined. Three times it was unilateral and affected only the eye on the same side as the lesion ; twice it was bilateral. The present work is the report of a new case of arteriovenous aneurysm complicated by intraocular hypertension. The use of recent techniques—measurement of the episcleral venous pressure, measurement of the resistance to the aqueous flow, and calculation of the volume of this flow—has thrown some light on the mechanism of intraocular hypertension. REPORT OF A CASE M. J., aged 17 years, was wounded in June, 1950, in a road accident. He sustained a fracture of the skull, with depression of the right frontotemporal region. His condition steadily improved in the weeks following the accident. Recovery seemed complete, but

Published
1952

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