Search

Your search keyword '"ZENG, X.-H."' showing total 235 results
Start Over Author "ZENG, X.-H."
235 results on '"ZENG, X.-H."'

1. Improved limits on solar axions and bosonic dark matter from the CDEX-1B experiment using the profile likelihood ratio method

Author

Wang, Y., Yue, Q., Liu, S. K., Kang, K. J., Li, Y. J., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Geng, X. P., Gong, H., Gu, P., Guo, X. Y., He, H. T., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, L. P., Li, H. B., Li, H., Li, M. X., Li, J. M., Li, J., Li, X., Li, X. Q., Li, Y. L., Liao, B., Lin, F. K., Lin, S. T., Liu, Y. D., Liu, Y. Y., Liu, Z. Z., Ma, H., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Qiao, C. K., Ren, J., Ruan, X. C., Sharma, V., She, Z., Singh, L., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Z., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yan, Y. L., Yang, L. T., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, X. H., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. Y., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We present the improved constraints on couplings of solar axions and more generic bosonic dark matter particles using 737.1 kg-days of data from the CDEX-1B experiment. The CDEX-1B experiment, located at the China Jinping Underground Laboratory, primarily aims at the direct detection of weakly interacting massive particles using a p-type point-contact germanium detector. We adopt the profile likelihood ratio method for analysis of data in the presence of backgrounds. An energy threshold of 160 eV was achieved, much better than the 475 eV of CDEX-1A with an exposure of 335.6 kg-days. This significantly improves the sensitivity for the bosonic dark matter below 0.8 keV among germanium detectors. Limits are also placed on the coupling $g_{Ae} < 2.48 \times 10^{-11}$ from Compton, bremsstrahlung, atomic-recombination and de-excitation channels and $g^{eff}_{AN} \times g_{Ae} < 4.14 \times 10^{-17}$ from a $^{57}$Fe M1 transition at 90\% confidence level., Comment: version accepted by PRD, 9 pages, 11 figures

Published
2019
Full Text
View/download PDF

2. Search for Light Weakly-Interacting-Massive-Particle Dark Matter by Annual Modulation Analysis with a Point-Contact Germanium Detector at the China Jinping Underground Laboratory

Author

Yang, L. T., Li, H. B., Yue, Q., Ma, H., Kang, K. J., Li, Y. J., Wong, H. T., Agartioglu, M., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Cheng, J. P., Deng, Z., Du, Q., Gong, H., Guo, Q. J., He, L., Hu, J. W., Hu, Q. D., Huang, H. X., Jia, L. P., Jiang, H., Li, H., Li, J. M., Li, J., Li, X., Li, X. Q., Li, Y. L., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y. Y., Liu, Z. Z., Ma, J. L., Mao, Y. C., Pan, H., Ren, J., Ruan, X. C., Sharma, V., She, Z., Shen, M. B., Singh, L., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, J. M., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, X. H., Zeng, M., Zeng, Z., Zhang, F. S., Zhang, Y. H., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., Zhu, J. J., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We present results on light weakly interacting massive particle (WIMP) searches with annual modulation (AM) analysis on data from a 1-kg mass $p$-type point-contact germanium detector of the CDEX-1B experiment at the China Jinping Underground Laboratory. Datasets with a total live time of 3.2 yr within a 4.2 yr span are analyzed with analysis threshold of 250 eVee. Limits on WIMP-nucleus (${\chi}$-$N$) spin-independent cross sections as function of WIMP mass ($m_{\chi}$) at 90\% confidence level (C.L.) are derived using the dark matter halo model. Within the context of the standard halo model, the 90\% C.L. allowed regions implied by the DAMA/LIBRA and CoGeNT AM-based analysis are excluded at $>$99.99\% and 98\% C.L., respectively. These results correspond to the best sensitivity at $m_{\chi}$$<$6$~{\rm GeV}/c^2$ among WIMP AM measurements to date., Comment: 5 pages, 4 figures

Published
2019
Full Text
View/download PDF

3. Observation of orbital ordering and origin of the nematic order in FeSe

Author

Cao, R. X., Hu, Jian, Dong, Jun, Zhang, J. B., Ye, X. S., Xu, Y. F., Chareev, D. A., Vasiliev, A. N., Wu, Bing, Zeng, X. H., Wang, Q. L., and Wu, Guoqing

Subjects
Condensed Matter - Superconductivity
Abstract

To elucidate the origin of nematic order in FeSe, we performed field-dependent 77Se-NMR measurements on single crystals of FeSe. We observed orbital ordering from the splitting of the NMR spectra and Knight shift and a suppression of it with magnetic field B0 up to 16 T applied parallel to the Fe-planes. There is a significant change in the distribution and magnitude of the internal magnetic field across the orbital ordering temperature Torb while stripe-type antiferromagnetism is absent. Giant antiferromagnetic (AFM) spin fluctuations measured by the NMR spin-lattice relaxation are gradually developed starting at ~ 40 K, which is far below the nematic ordering temperature Tnem. These results demonstrate that orbital ordering is the origin of the nematic order, and the AFM spin fluctuation is the driving mechanism of superconductivity in FeSe under the presence of the nematic order., Comment: 6 pages, 4 figures

Published
2018
Full Text
View/download PDF

4. Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search

Author

Jiang, H., Yang, L. T., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Wong, H. T., Agartioglu, M., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., He, L., Hu, J. W., Hu, Q. D., Huang, H. X., Jia, L. P., Li, H. B., Li, H., Li, J. M., Li, J., Li, X., Li, X. Q., Li, Y. L., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y. Y., Liu, Z. Z., Ma, H., Ma, J. L., Pan, H., Ren, J., Ruan, X. C., Sevda, B., Sharma, V., Shen, M. B., Singh, L., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, J. M., Wang, L., Wang, Q., Wang, Y., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yang, S. W., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, X. H., Zeng, M., Zeng, Z., Zhang, F. S., Zhang, Y. H., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., Zhu, J. J., and Zhu, Z. H.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The CDEX-10 experiment searches for light weakly-interacting massive particles, a form of dark matter, at the China JinPing underground laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1B spectrum. Both sets of results showed good consistency in the 0--12 keVee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper., Comment: version accepted by SCPMA, 8 pages, 11 figures and 2 tables

Published
2018
Full Text
View/download PDF

5. Limits on Light Weakly Interacting Massive Particles from the First 102.8 kg ${\times}$ day Data of the CDEX-10 Experiment

Author

Jiang, H., Jia, L. P., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Wong, H. T., Agartioglu, M., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., He, L., Hu, J. W., Hu, Q. D., Huang, H. X., Li, H. B., Li, H., Li, J. M., Li, J., Li, X., Li, X. Q., Li, Y. L., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y. Y., Liu, Z. Z., Ma, H., Ma, J. L., Pan, H., Ren, J., Ruan, X. C., Sevda, B., Sharma, V., Shen, M. B., Singh, L., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, J. M., Wang, L., Wang, Q., Wang, Y., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, X. H., Zeng, M., Zeng, Z., Zhang, F. S., Zhang, Y. H., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., Zhu, J. J., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report the first results of a light weakly interacting massive particles (WIMPs) search from the CDEX-10 experiment with a 10 kg germanium detector array immersed in liquid nitrogen at the China Jinping Underground Laboratory with a physics data size of 102.8 kg day. At an analysis threshold of 160 eVee, improved limits of 8 $\times 10^{-42}$ and 3 $\times 10^{-36}$ cm$^{2}$ at a 90\% confidence level on spin-independent and spin-dependent WIMP-nucleon cross sections, respectively, at a WIMP mass ($m_{\chi}$) of 5 GeV/${c}^2$ are achieved. The lower reach of $m_{\chi}$ is extended to 2 GeV/${c}^2$., Comment: 5 pages, 4 figures

Published
2018
Full Text
View/download PDF

6. Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

Author

Yang, L. T., Li, H. B., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Wong, H. T., Aǧartioǧlu, M., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., He, L., Hu, J. W., Hu, Q. D., Huang, H. X., Jia, L. P., Jiang, H., Li, H., Li, J. M., Li, J., Li, X., Li, X. Q., Li, Y. L., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Z. Z., Ma, H., Ma, J. L., Pan, H., Ren, J., Ruan, X. C., Sevda, B., Sharma, V., Shen, M. B., Singh, L., Singh, M. K., Tang, C. J., Tang, W. Y., Tian, Y., Wang, J. M., Wang, L., Wang, Q., Wang, Y., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yang, S. W., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, X. H., Zeng, M., Zeng, Z., Zhang, Y. H., Zhao, M. G., Zhao, W., Zhou, J. F., Zhou, Z. Y., Zhu, J. J., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report results of a search for light weakly interacting massive particle (WIMP) dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory (CJPL). Constraints on WIMP-nucleon spin-independent (SI) and spin-dependent (SD) couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV., Comment: 10 pages, 10 figures

Published
2017
Full Text
View/download PDF

8. Constraints on Axion couplings from the CDEX-1 experiment at the China Jinping Underground Laboratory

Author

Liu, S. K., Yue, Q., Kang, K. J., Cheng, J. P., Wong, H. T., Li, Y. J., Li, H. B., Lin, S. T., Chang, J. P., Chen, J. H., Chen, N., Chen, Q. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., He, H. J., He, Q. J., Huang, H. X., Jiang, H., Li, J. M., Li, J., Li, X., Li, X. Q., Li, X. Y., Li, Y. L., Lin, F. K., Lü, L. C., Ma, H., Ma, J. L., Mao, S. J., Qin, J. Q., Ren, J., Ruan, X. C., Sharma, V., Shen, M. B., Singh, L., Singh, M. K., Soma, A. K., Su, J., Tang, C. J., Wang, J. M., Wang, L., Wang, Q., Wu, S. Y., Wu, Y. C., Xianyu, Z. Z., Xiao, R. Q., Xing, H. Y., Xu, F. Z., Xu, Y., Xu, X. J., Xue, T., Yang, C. W., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H., Yu, X. Z., Zeng, X. H., Zeng, Z., Zhang, L., Zhang, Y. H., Zhao, M. G., Zhao, W., Zhou, Z. Y., Zhu, J. J., Zhu, W. B., Zhu, X. Z., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We report the results of searches for solar axions and galactic dark matter axions or axion-like particles with CDEX-1 experiment at the China Jinping Underground Laboratory, using 335.6 kg-days of data from a p-type point-contact germanium detector. The data are compatible with the background model and no excess signals are observed. Limits of solar axions on the model independent coupling $g_{Ae}<2.5\times10^{-11}$ from Compton, bremsstrahlung, atomic-recombination and deexcitation channel and $g^{\text{eff}}_{AN}\times g_{Ae}<6.1\times10^{-17}$ from $^{57}$Fe M1 transition at 90 % confidence level are derived. Within the framework of the DFSZ and KSVZ models, our results exclude the axion mass heavier than 0.9 eV/c$^{2}$ and 173 eV/c$^{2}$, respectively. The derived constraints for dark matter axions below 1 keV improves over the previous results., Comment: 8 pages, 8 figures

Published
2016
Full Text
View/download PDF

9. A Search of Low-Mass WIMPs with p-type Point Contact Germanium Detector in the CDEX-1 Experiment

Author

Zhao, W., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Wong, H. T., Lin, S. T., Chang, J. P., Chen, J. H., Chen, Q. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., Hao, X. Q., He, H. J., He, Q. J., Huang, H. X., Huang, T. R., Jiang, H., Li, H. B., Li, J., Li, J. M., Li, X., Li, X. Y., Li, Y. L., Lin, F. K., Liu, S. K., Lü, L. C., Ma, H., Ma, J. L., Mao, S. J., Qin, J. Q., Ren, J., Ruan, X. C., Sharma, V., Shen, M. B., Singh, L., Singh, M. K., Soma, A. K., Su, J., Tang, C. J., Wang, J. M., Wang, L., Wang, Q., Wu, S. Y., Wu, Y. C., Xianyu, Z. Z., Xiao, R. Q., Xing, H. Y., Xu, F. Z., Xu, Y., Xu, X. J., Xue, T., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H., Yu, X. Z., Zeng, M., Zeng, X. H., Zeng, Z., Zhang, L., Zhang, Y. H., Zhao, M. G., Zhou, Z. Y., Zhu, J. J., Zhu, W. B., Zhu, X. Z., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The CDEX-1 experiment conducted a search of low-mass (< 10 GeV/c2) Weakly Interacting Massive Particles (WIMPs) dark matter at the China Jinping Underground Laboratory using a p-type point-contact germanium detector with a fiducial mass of 915 g at a physics analysis threshold of 475 eVee. We report the hardware set-up, detector characterization, data acquisition and analysis procedures of this experiment. No excess of unidentified events are observed after subtraction of known background. Using 335.6 kg-days of data, exclusion constraints on the WIMP-nucleon spin-independent and spin-dependent couplings are derived., Comment: 12 pages, 19 figures

Published
2016
Full Text
View/download PDF

10. The CDEX-1 1 kg Point-Contact Germanium Detector for Low Mass Dark Matter Searches

Author

Kang, K-J, Yue, Q, Wu, Y-C, Cheng, J-P, Li, Y-J, Bai, Y, Bi, Y, Chang, J-P, Chen, N, Chen, Q-H, Chen, Y-H, Chuang, Y-C, Dend, Z, Du, Q, Gong, H, Hao, X-Q, He, Q-J, Hu, X-H, Huang, H-X, Huang, T-R, Jiang, H, Li, H-B, Li, J-M, Li, J, Li, X, Li, X-Y, Li, X-Q, Li, Y-L, Liao, H-Y, Lin, F-K, Lin, S-T, Liu, S-K, Lv, L-C, Ma, H, Mao, S-J, Qin, J-Q, Ren, J, Ruan, X-C, Shen, M-B, Singh, L, Singh, MK, Soma, AK, Su, J, Tang, C-J, Tseng, C-H, Wang, J-M, Wang, L, Wang, Q, Wong, T-KH, Wu, S-Y, Wu, W, Xing, H-Y, Xu, Y, Xue, T, Yang, L-T, Yang, S-W, Yi, N, Yu, C-X, Yu, H, Yu, X-Z, Zeng, X-H, Zeng, Z, Zhang, L, Zhang, Y-H, Zhao, M-G, Zhao, W, Zhong, S-N, Zhou, Z-Y, Zhu, J-J, Zhu, W-B, Zhu, X-Z, and Zhu, Z-H

Subjects
physics.ins-det, physics.ins-det, astro-ph.IM, hep-ex
Abstract

The CDEX Collaboration has been established for direct detection of lightdark matter particles, using ultra-low energy threshold p-type point-contactgermanium detectors, in China JinPing underground Laboratory (CJPL). The first1 kg point-contact germanium detector with a sub-keV energy threshold has beentested in a passive shielding system located in CJPL. The outputs from both thepoint-contact p+ electrode and the outside n+ electrode make it possible toscan the lower energy range of less than 1 keV and at the same time to detectthe higher energy range up to 3 MeV. The outputs from both p+ and n+ electrodemay also provide a more powerful method for signal discrimination for darkmatter experiment. Some key parameters, including energy resolution, dead time,decay times of internal X-rays, and system stability, have been tested andmeasured. The results show that the 1 kg point-contact germanium detector,together with its shielding system and electronics, can run smoothly with goodperformances. This detector system will be deployed for dark matter searchexperiments.

Published
2017

11. PandaX: A Liquid Xenon Dark Matter Experiment at CJPL

Author

Cao, X. G., Chen, X., Chen, Y. H., Cui, X. Y., Fang, D. Q., Fu, C. B., Giboni, K. L., Gong, H. W., Guo, G. D., He, M., Hu, J., Huang, X. T., Ji, X. D., Ju, Y. L., Li, S. L., Lin, Q., Liu, H. X., Liu, J. L., Liu, X., Lorenzon, W., Ma, Y. G., Mao, Y. J., Ni, K. X., Pushkin, K., Ren, X. X., Schubnell, M., Shen, M. B., Shi, Y. J., Stephenson, S., Tan, A. D., Tarle, G., Wang, H. W., Wang, J. M., Wang, M., Wang, X. M., Wang, Z., Wei, Y. H., Wu, S. Y., Xiao, M. J., Xiao, X., Xie, P. W., Ye, T., You, Y. H., Zeng, X. H., Zhang, H., Zhang, T., Zhao, H. Y., Zhao, L., Zhou, X. P., and Zhu, Z. H.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

PandaX is a large upgradable liquid-xenon detector system that can be used for both direct dark-matter detection and $^{136}$Xe double-beta decay search. It is located in the Jinping Deep-Underground Laboratory in Sichuan, China. The detector operates in dual-phase mode, allowing detection of both prompt scintillation, and ionization charge through proportional scintillation. The central time projection chamber will be staged, with the first stage accommodating a target mass of about 120\,kg. In stage II, the target mass will be increased to about 0.5\,ton. In the final stage, the detector can be upgraded to a multi-ton target mass. In this paper a detailed description of the stage-I detector design and performance results established during the commissioning phase is presented., Comment: 28 pages, 23 figures

Published
2014

12. Limits on light WIMPs from the CDEX-1 experiment with a p-type point-contact germanium detector at the China Jingping Underground Laboratory

Author

Yue, Q., Zhao, W., Kang, K. J., Cheng, J. P., Li, Y. J., Lin, S. T., Chang, J. P., Chen, N., Chen, Q. H., Chen, Y. H., Chuang, Y. C., Deng, Z., Du, Q., Gong, H., Hao, X. Q., He, H. J., He, Q. J., Huang, H. X., Huang, T. R., Jiang, H., Li, H. B., Li, J. M., Li, J., Li, X., Li, X. Y., Li, Y. L., Liao, H. Y., Lin, F. K., Liu, S. K., Lv, L. C., Ma, H., Mao, S. J., Qin, J. Q., Ren, J., Ruan, X. C., Shen, M. B., Singh, L., Singh, M. K., Soma, A. K., Su, J., Tang, C. J., Tseng, C. H., Wang, J. M., Wang, L., Wang, Q., Wong, H. T., Wu, S. Y., Wu, Y. C., Xianyu, Z. Z., Xiao, R. Q., Xing, H. Y., Xu, F. Z., Xu, Y., Xu, X. J., Xue, T., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H., Yu, X. Z., Zeng, X. H., Zeng, Z., Zhang, L., Zhang, Y. H., Zhao, M. G., Zhou, Z. Y., Zhu, J. J., Zhu, W. B., Zhu, X. Z., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report results of a search for light Dark Matter WIMPs with CDEX-1 experiment at the China Jinping Underground Laboratory, based on 53.9 kg-days of data from a p-type point-contact germanium detector enclosed by a NaI(Tl) crystal scintillator as anti-Compton detector. The event rate and spectrum above the analysis threshold of 475 eVee are consistent with the understood background model. Part of the allowed regions for WIMP-nucleus coherent elastic scattering at WIMP mass of 6-20 GeV are probed and excluded. Independent of interaction channels, this result contradicts the interpretation that the anomalous excesses of the CoGeNT experiment are induced by Dark Matter, since identical detector techniques are used in both experiments., Comment: 5 pages, 5 figures

Published
2014
Full Text
View/download PDF

13. Limits on light WIMPs with a germanium detector at 177 eVee threshold at the China Jinping Underground Laboratory

Author

Liu, S. K., Yue, Q., Kang, K. J., Cheng, J. P., Wong, H. T., Li, Y. J., Lin, S. T., Chang, J. P., Chen, N., Chen, Q. H., Chen, Y. H., Chuang, Y. C., Deng, Z., Du, Q., Gong, H., Hao, X. Q., He, H. J., He, Q. J., Huang, H. X., Huang, T. R., Jiang, H., Li, H. B., Li, J. M., Li, J., Li, X., Li, X. Q., Li, X. Y., Li, Y. L., Liao, H. Y., Lin, F. K., Lü, L. C., Ma, H., Mao, S. J., Qin, J. Q., Ren, J., Ruan, X. C., Shen, M. B., Singh, L., Singh, M. K., Soma, A. K., Su, J., Tang, C. J., Tseng, C. H., Wang, J. M., Wang, L., Wang, Q., Wu, S. Y., Wu, Y. C., Xianyu, Z. Z., Xiao, R. Q., Xing, H. Y., Xu, F. Z., Xu, Y., Xu, X. J., Xue, T., Yang, C. W., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H., Yu, X. Z., Zeng, X. H., Zeng, Z., Zhang, L., Zhang, Y. H., Zhao, M. G., Zhao, W., Zhou, Z. Y., Zhu, J. J., Zhu, W. B., Zhu, X. Z., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

The China Dark Matter Experiment reports results on light WIMP dark matter searches at the China Jinping Underground Laboratory with a germanium detector array with a total mass of 20 g. The physics threshold achieved is 177 eVee ("ee" represents electron equivalent energy) at 50% signal efficiency. With 0.784 kg-days of data, exclusion region on spin-independent coupling with the nucleon is derived, improving over our earlier bounds at WIMP mass less than 4.6 GeV., Comment: 8 pages, 13 figures, 2 tables. To be published in Phys. Rev. D

Published
2014
Full Text
View/download PDF

14. First results on low-mass WIMP from the CDEX-1 experiment at the China Jinping underground Laboratory

Author

Zhao, W., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Lin, S. T., Bai, Y., Bi, Y., Chang, J. P., Chen, N., Chen, Q. H., Chen, Y. H., Chuang, Y. C., Deng, Z., Du, C., Du, Q., Gong, H., Hao, X. Q., He, H. J., He, Q. J., Hu, X. H., Huang, H. X., Huang, T. R., Jiang, H., Li, H. B., Li, J. M., Li, J., Li, X., Li, X. Y., Li, Y. L., Liao, H. Y., Lin, F. K., Liu, S. K., Lv, L. C., Ma, H., Mao, S. J., Qin, J. Q., Ren, J., Ruan, X. C., Shen, M. B., Singh, L., Singh, M. K., Soma, A. K., Su, J., Tang, C. J., Tseng, C. H., Wang, J. M., Wang, L., Wang, Q., Wong, H. T., Wu, S. Y., Wu, W., Wu, Y. C., Xianyu, Z. Z., Xing, H. Y., Xu, Y., Xu, X. J., Xue, T., Yang, L. T., Yang, S. W., Yi, N., Yu, C. X., Yu, H., Yu, X. Z., Zeng, X. H., Zeng, Z., Zhang, L., Zhang, Y. H., Zhao, M. G., Zhong, S. N., Zhou, Z. Y., Zhu, J. J., Zhu, W. B., Zhu, X. Z., and Zhu, Z. H.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Extragalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

The China Dark matter Experiment collaboration reports the first experimental limit on WIMP dark matter from 14.6 kg-day of data taken with a 994 g p-type point-contact germanium detector at the China Jinping underground Laboratory where the rock overburden is more than 2400 m. The energy threshold achieved was 400 eVee. According to the 14.6 kg-day live data, we placed the limit of N= 1.75 * 10^{-40} cm^{2} at 90% confidence level on the spin-independent cross-section at WIMP mass of 7 GeV before differentiating bulk signals from the surface backgrounds., Comment: 5 pages, 5 figures

Published
2013
Full Text
View/download PDF

15. Direct Observation of Phase Oscillation Modes in Josephson-coupled Layered Superconductors

Author

Lai, Z. Y., Yao, X., Zeng, X. H., Zheng, H., Shen, W. Z., Chen, X. Y., and Shen, H. G.

Subjects
Condensed Matter - Superconductivity
Abstract

We have proposed to employ the microwave S parameters method to measure phase oscillation modes (POMs) in Josephson coupled-layered superconductors. For the first time, in SmBa2Cu3O7 (SmBCO) and YBa2Cu3O7-b (YBCO) at 77 K we have directly observed some POMs far below the Josephson plasma frequency. A series of discrete modes have been observed and discussed qualitatively in the POMs. The method may be a powerful and flexible tool in this field., Comment: 14 pages, 3 figures

Published
2006

16. Hole Doping Dependence of the Coherence Length in $La_{2-x}Sr_xCuO_4$ Thin Films

Author

Wen, H. H., Yang, H. P., Li, S. L., Zeng, X. H., Soukiassian, A. A., Si, W. D., and Xi, X. X.

Subjects
Condensed Matter - Superconductivity
Abstract

By measuring the field and temperature dependence of magnetization on systematically doped $La_{2-x}Sr_xCuO_4$ thin films, the critical current density $j_c(0)$ and the collective pinning energy $U_p(0)$ are determined in single vortex creep regime. Together with the published data of superfluid density, condensation energy and anisotropy, for the first time we derive the doping dependence of the coherence length or vortex core size in wide doping regime directly from the low temperature data. It is found that the coherence length drops in the underdoped region and increases in the overdoped side with the increase of hole concentration. The result in underdoped region clearly deviates from what expected by the pre-formed pairing model if one simply associates the pseudogap with the upper-critical field., Comment: 4 pages, 4 figures

Published
2003
Full Text
View/download PDF

17. Critical Current Density and Resistivity of MgB2 Films

Author

Rowell, J. M., Xu, S. Y., Zeng, X. H., Pogrebnyakov, A. V., Li, Q., Xi, X. X., Redwing, J. M., Tian, W., and Pan, X.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

The high resistivity of many bulk and film samples of MgB2 is most readily explained by the suggestion that only a fraction of the cross-sectional area of the samples is effectively carrying current. Hence the supercurrent (Jc) in such samples will be limited by the same area factor, arising for example from porosity or from insulating oxides present at the grain boundaries. We suggest that a correlation should exist, Jc ~ 1/{Rho(300K) - Rho(50K)}, where Rho(300K) - Rho(50K) is the change in the apparent resistivity from 300 K to 50 K. We report measurements of Rho(T) and Jc for a number of films made by hybrid physical-chemical vapor deposition which demonstrate this correlation, although the "reduced effective area" argument alone is not sufficient. We suggest that this argument can also apply to many polycrystalline bulk and wire samples of MgB2., Comment: 11 pages, 3 figures

Published
2003
Full Text
View/download PDF

18. The superconducting gap of \QTR{em}{in situ} $MgB_{2}$ thin films by microwave surface impedance measurements

Author

Hakim, N., Kusko, C., Sridhar, S., Soukiassian, A., Zeng, X. H., and Xi, X. X.

Subjects
Condensed Matter - Superconductivity
Abstract

Precision measurements of the microwave surface resistance $R_{s}$ of in situ $MgB_{2}$ films directly reveal an exponential behavior of $R_{s}$ at low temperature indicating a fully-gapped order parameter. The entire temperature dependence of $R_{s}$ is well described by a Mattis-Bardeen formalism but with a small gap ratio of $\Delta (0)/kT_{c}=0.72$, corresponding to $\Delta (0)=1.9meV$.

Published
2002
Full Text
View/download PDF

19. In situ epitaxial MgB2 thin films for superconducting electronics

Author

Zeng, X. H., Pogrebnyakov, A. V., Kotcharov, A., Jones, J. E., Xi, X. X., Lysczek, E. M., Redwing, J. M., Xu, S. Y., Li, Qi, Lettieri, J., Schlom, D. G., Tian, W., Pan, X. Q., and Liu, Z. K.

Subjects
Condensed Matter - Materials Science
Abstract

A thin film technology compatible with multilayer device fabrication is critical for exploring the potential of the 39-K superconductor magnesium diboride for superconducting electronics. Using a Hybrid Physical-Chemical Vapor Deposition (HPCVD) process, it is shown that the high Mg vapor pressure necessary to keep the MgB$_2$ phase thermodynamically stable can be achieved for the {\it in situ} growth of MgB$_2$ thin films. The films grow epitaxially on (0001) sapphire and (0001) 4H-SiC substrates and show a bulk-like $T_c$ of 39 K, a $J_c$(4.2K) of $1.2 \times 10^7$ A/cm$^2$ in zero field, and a $H_{c2}(0)$ of 29.2 T in parallel magnetic field. The surface is smooth with a root-mean-square roughness of 2.5 nm for MgB$_2$ films on SiC. This deposition method opens tremendous opportunities for superconducting electronics using MgB$_2$.

Published
2002
Full Text
View/download PDF

20. Superconducting properties of nanocrystalline MgB$_2$ thin films made by an in situ annealing process

Author

Zeng, X. H., Sukiasyan, A., Xi, X. X., Hu, Y. F., Wertz, E., Li, Qi, Tian, W., Sun, H. P., Pan, X. Q., Lettieri, J., Schlom, D. G., Brubaker, C. O., Liu, Zi-Kui, and Li, Qiang

Subjects
Condensed Matter - Materials Science, Condensed Matter - Superconductivity
Abstract

We have studied the structural and superconducting properties of MgB$_2$ thin films made by pulsed laser deposition followed by in situ annealing. The cross-sectional transmission electron microscopy reveals a nanocrystalline mixture of textured MgO and MgB$_2$ with very small grain sizes. A zero-resistance transition temperature ($T_{c0}$) of 34 K and a zero-field critical current density ($J_c$) of $1.3 \times 10^6$ A/cm$^2$ were obtained. The irreversibility field was $\sim$ 8 T at low temperatures, although severe pinning instability was observed. These bulk-like superconducting properties show that the in situ deposition process can be a viable candidate for MgB$_2$ Josephson junction technologies.

Published
2001
Full Text
View/download PDF

26. Honey combined with silver ion dressing in complicated chronic wound of the scalp: a case report.

Author

LIN, J.-Q., YANG, L.-L., YANG, X., ZENG, X.-H., ZHANG, Y., LI, Z.-P., and LIU, H.-Y.

Abstract

OBJECTIVE: Scalp wound healing is a complex process. Nonhealing wounds can become chronic wounds, which increase the trauma and economic burden on a patient and may even cause death in severe cases. Thus, it can be difficult to find an effective treatment for chronic wounds of the scalp. CASE PRESENTATION: We present a case of a 13-year-old female patient with a chronic wound caused by a scalp incision infection 3 months after two operations for craniotomy for arachnoid cyst resection and cystic lesion-cisterna magna drainage. After repeated dressing changes and two debridement operations, the incision had still not healed during the following year. The wound finally healed after 6 months of dressing changes by combining honey with silver ion dressings, and the incision had not re-ruptured after 10 months of follow-up. CONCLUSIONS: Honey combined with silver may be an effective method for the treatment of chronic scalp wounds. [ABSTRACT FROM AUTHOR]

Published
2022

28. Carrier relaxation time divergence in single and double layer cuprates

Author

Schneider, M. L., Rast, S., Onellion, M., Demsar, J., Taylor, A. J., Glinka, Y., Tolk, N. H., Ren, Y. H., Lüpke, G., Klimov, A., Xu, Y., Sobolewski, R., Si, W., Zeng, X. H., Soukiassian, A., Xi, X. X., Abrecht, M., Ariosa, D., Pavuna, D., Krapf, A., Manzke, R., Printz, J. O., Williamsen, M. S., Downum, K. E., Guptasarma, P., and Bozovic, I.

Published
2003
Full Text
View/download PDF

31. Measurements of the superconducting anisotropy in FeSe with a resonance frequency technique

Author

Cao, R. X., Dong, J., Wang, Q. L., Yang, Y. J., Zhao, C., Zeng, X. H., Chareev, D. A., Vasiliev, A. N., Wu, B., Wu, G., Cao, R. X., Dong, J., Wang, Q. L., Yang, Y. J., Zhao, C., Zeng, X. H., Chareev, D. A., Vasiliev, A. N., Wu, B., and Wu, G.

Abstract

Utilizing a novel method with the resonance frequency of a LC circuit, we measured the superconducting anisotropy of single crystals of an Fe-based superconductor FeSe with applied magnetic field up to 16 T. We found that the temperature dependence of the upper critical field H c2 (T) of FeSe coincides with the Werthamer-Helfand-Hohenberg (WHH) model when taking the Maki parameter α into consideration, suggesting an important role played by spin-paramagnetic effect in suppressing the superconductivity. When temperature T → 0, the values of H c2,≈c (0) and H c2,≈ab (0) derived from the WHH fitting are close to and fall within the range of the Pauli limit, for field H 0 applied parallel to the c-axis and to the ab-plane, respectively. As compared with other typical iron-based high-T c superconductors, lower values of H c2 (0) and higher superconducting anisotropy Γ(0) were observed in FeSe. © 2019 Author(s).

Published
2019

32. Observation of orbital ordering and origin of the nematic order in FeSe

Author

Cao, R. X., Hu, J., Dong, J., Zhang, J. B., Ye, X. S., Xu, Y. F., Chareev, D. A., Vasiliev, A. N., Wu, B., Zeng, X. H., Wang, Q. L., Wu, G., Cao, R. X., Hu, J., Dong, J., Zhang, J. B., Ye, X. S., Xu, Y. F., Chareev, D. A., Vasiliev, A. N., Wu, B., Zeng, X. H., Wang, Q. L., and Wu, G.

Abstract

In iron-based superconductors the interactions driving the nematic order that breaks the lattice four-fold rotational symmetry in the iron plane may also facilitate the Cooper pairing, but experimental determination of these interactions is challenging because the temperatures of the nematic order and the order of other electronic phases appear to match each other or to be close to each other. Here we performed field-dependent 77Se-nuclear magnetic resonance (NMR) measurements on single crystals of iron-based superconductor FeSe, with magnetic field B 0 up to 16 T. The 77Se-NMR spectra and Knight shift split when the direction of B 0 is away from the direction perpendicular to the iron planes (i.e. B 0 ∥ c) upon cooling in temperature, with a significant change in the distribution and magnitude of the internal magnetic field at the 77Se nucleus, but these do not happen when B 0 is perpendicular to the iron planes, thus demonstrating that there is an orbital ordering. Moreover, stripe-type antiferromagnetism is absent, while giant antiferromagnetic spin fluctuations measured by the NMR spin-lattice relaxation gradually developed starting at ∼40 K, which is far below the nematic order temperature T nem = 89 K. These results provide direct evidence of orbital-driven nematic order in FeSe. © 2019 The Author(s). Published by IOP Publishing Ltd on behalf of the Institute of Physics and Deutsche Physikalische Gesellschaft.

Published
2019

33. Limits on Light Weakly Interacting Massive Particles from the First 102.8 kg x day Data of the CDEX-10 Experiment

Author

Sun, T. X., Zhu, Z. H., Zhu, J. J., Zhou, Z. Y., Zhou, J. F., Zhao, M. G., Zhang, Y. H., Zhang, F. S., Zeng, Z., Zeng, M., Zeng, X. H., Yue, J. F., Yu, H. J., Yu, C. X., Yi, N., Yang, S. W., Yang, L. T., Xue, T., Li, H., Li, H. B., Huang, H. X., Hu, Q. D., Hu, J. W., Jiang, H., Jia, L. P., Yue, Q., Kang, K. J., Cheng, J. P., Li, Y. J., Wong, H. T., Xu, Y., Xing, H. Y., Wu, Y. C., Wu, S. Y., Wang, Y., Wang, Q., Wang, L., Wang, J. M., Wang, G. F., Tian, Y., Tang, W. Y., Tang, C. J., Singh, M. K., Singh, L., Shen, M. B., Sharma, V., Sevda, B., Ruan, X. C., Ren, J., Pan, H., Ma, J. L., Ma, H., Liu, Z. Z., Liu, Y. Y., Liu, Y. D., Liu, S. K., Lin, S. T., Lin, F. K., Liao, B., Li, Y. L., Li, X. Q., Agartioglu, M., An, H. P., Chang, J. P., Chen, J. H., Chen, Y. H., Deng, Z., Du, Q., Gong, H., He, L., Li, X., Li, J., and Li, J. M.

Abstract

We report the first results of a light weakly interacting massive particles (WIMPs) search from the CDEX-10 experiment with a 10 kg germanium detector array immersed in liquid nitrogen at the China Jinping Underground Laboratory with a physics data size of 102.8 kg day. At an analysis threshold of 160 eVee, improved limits of 8 x 10(-42) and 3 x 10(-36) cm(2) at a 90% confidence level on spin-independent and spin-dependent WIMP-nucleon cross sections, respectively, at a WIMP mass (m(chi)) of 5 GeV/c(2) are achieved. The lower reach of m(chi) is extended to 2 GeV/c(2).

Published
2018

38. Negative viral nucleic acid test of induced sputum: an additional criteria for COVID-19 patient’s discharge.

Author

ZHENG, S.-L., SUN, W.-L., SUN, L.-N., ZENG, X.-H., and WANG, Q.-X.

Abstract

OBJECTIVE: Concerns have been raised that patients with Coronavirus Disease 2019 (COVID-19) are still infectious with a re-positive nucleic acid test of the pharyngeal swab after hospital discharge. The aim of this study was to investigate the clinical relevance of induced sputum as an additional indicator for the current clinical discharge criteria of COVID-19 patients to prevent virus recurrence. PATIENTS AND METHODS: Twenty-one COVID-19 patients who met the national clinical discharge criteria were discharged from the hospital and tested daily for the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) nucleic acid in their pharyngeal swabs and every other day for the presence of SARS-CoV-2 in their induced sputum. Once the patient’s induced sputum was negative after two consecutive tests, testing was discontinued. RESULTS: Among 21 discharged patients from COVID-19, the first pharyngeal swab and induced sputum tests for viral nucleic acid were positive in 3 (14.3%) and 8 (38.1%) patients respectively. Induced sputum was significantly more positive than pharyngeal swab (p < 0.05). In our cohort, all pharyngeal swabs became negative at day 7, and all induced sputa turned negative at day 11 after discharge. Interestingly, patients with negative pharyngeal swabs experienced viral relapse, whereas patients with negative induced sputum did not revert to positivity. CONCLUSIONS: The detection rate of positive viral nucleic acid in induced sputum was high. Patients with negative induced sputum nucleic acid tests did not have a relapse of SARSCOV-2, indicating that viral nucleic acid testing of induced sputum should be used as an additional criterion for patients with national clinical discharge criteria COVID-19. [ABSTRACT FROM AUTHOR]

Published
2020

39. No infectious risk of COVID-19 patients with long-term fecal 2019-nCoV nucleic acid positive.

Author

WANG, Q.-X., HUANG, K.-C., QI, L., ZENG, X.-H., and ZHENG, S.-L.

Abstract

OBJECTIVE: It has recently been reported that some COVID-19 patients have long-term positive fecal nucleic acid after discharging from the hospital with negative nucleic acid in the respiratory tract, but it is unclear whether COVID-19 patients with positive longterm fecal nucleic acid tests have the risk of self-infection. PATIENTS AND METHODS: From January 25, 2020 to March 9, 2020, 5 COVID-19 patients with negative respiratory tract nucleic acid and positive fecal nucleic acid were observed and studied to explore whether these patients can re-infect themselves. Five patients with COVID-19 accompanied by diarrhea as the main gastrointestinal symptoms were carefully observed through clinical symptoms, imaging and other auxiliary examinations. The RT-PCR technology was used to continuously detect fecal and respiratory viral nucleic acids. The IgM antibody was detected on the 7th day of admission and IgM/IgG at the time of discharge. RESULTS: All 5 patients had symptoms of fever and diarrhea upon admission. The fecal nucleic acid was positive, as well as the throat swab was positive. All COVID-19 patients had positive IgM antibodies on the 7th day of admission and positive IgM and IgG at the time of discharge, and there were no abnormalities in the gastrointestinal examination on discharge. All 5 fecal nucleic acid tests were positive at the time of discharge. After continuous dynamic follow- up for 3-15 days, no clinical symptoms recurred, and the last nucleic acid test was negative. CONCLUSIONS: There is no risk of self-infection for COVID-19 patients with long-term 2019-nCoV nucleic acid positive in feces. [ABSTRACT FROM AUTHOR]

Published
2020

44. Influence of quantum effects on giant magnetoresistance for multilayer structures.

Author

Zeng, X. H., Chen, H. X., Xu, X. L., Ruda, H. E., and Qiao, Bi

Subjects
*MAGNETORESISTANCE, *MESOSCOPIC phenomena (Physics), *ELECTRIC conductivity
Abstract

A description of the nonlinear conductivity of mesoscopic systems is formulated and used to describe quantum effects in the giant magnetoresistance of multilayer structures, based on a subdynamics approach. Consideration of the nonlinear response makes it possible to discuss the influence of bias and temperature on giant magnetoresistance. Calculations show that for sandwich structures, the giant magnetoresistance increases when the bias increases, and decreases for negative bias. Compared with the influence of bias, the variation of giant magnetoresistance with temperature is small. [ABSTRACT FROM AUTHOR]

Published
2003
Full Text
View/download PDF

45. Experimental study of amplitude-frequency characteristics of high-transition-temperature radio frequency superconducting quantum interference devices.

Author

Zeng, X. H., Zhang, Y., Chesca, B., Barthel, K., Greenberg, Ya. S., and Braginski, A. I.

Subjects
*SUPERCONDUCTING quantum interference devices, *RADIO frequency
Abstract

We measured the amplitude-frequency characteristics of radio frequency superconducting quantum interference devices (rf SQUIDs) over a temperature range between 65 and 79 K. Using the expressions derived from the recently developed rf SQUID theory, valid also at large thermal fluctuations, we determined from these data the basic parameters of high-transition-temperature superconductor (HTS) rf SQUIDs. These parameters were: (a) the high-frequency coupling coefficient between the rf SQUID and the tank circuit resonator, k, (b) the SQUIDs hysteretic parameter, β, (c) the critical current of the Josephson junction, I[sub c], (d) its normal resistance, R[sub n], and (e) its noise parameter, Γ. We found a good agreement with the values of β(I[sub c]) and R[sub n] determined directly after destructively opening the SQUID loop. In accordance with the theoretical predictions, our experimental results show that at large thermal fluctuation levels (T≅77 K), rf SQUIDs with large loop inductance operate in nonhysteretic mode up to β values exceeding 3. Furthermore, we have shown that the optimal energy sensitivity is attained in the nonhysteretic mode at a value of β distinctly higher than 1. A quantitative comparison of white noise predicted by the theory with that obtained from the experiment showed a reasonable agreement. We also discussed the contribution of the phase information to the SQUID's signal and noise at optimum operation conditions, when a mixer was used as a signal detector. © 2000 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2000
Full Text
View/download PDF

49. Circ-CCDC66 accelerates proliferation and invasion of gastric cancer via binding to miRNA-1238-3p.

Author

YANG, M., WANG, G.-Y., QIAN, H., JI, X.-Y., LIU, C.-Y., ZENG, X.-H., LV, J., and SHI, Y.-X.

Abstract

OBJECTIVE: The aim of this study was to examine the expression of circ-CCDC66 in gastric cancer (GC) tissues and cell lines, as well as its correlation with the prognosis of GC. Moreover, the regulatory effects of circ-CCDC66 on biological behaviors of GC cells and its molecular mechanism were explored. PATIENTS AND METHODS: The relative expression level of circ-CCDC66 in GC tissues and cell lines was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between the circ-CCDC66 level and overall survival of GC patients was analyzed as well. The potential influences of circ-CCDC66 on proliferative and invasive abilities of GC cells were evaluated through 5-Ethynyl-2'-deoxyuridine (EdU), colony formation and transwell assay, respectively. Meanwhile, the cell cycle progression and apoptosis of GC cells affected by circ- CCDC66 were determined. In addition, the direct target miRNA of circ-CCDC66 was predicted and verified by bioinformatics method and Dual-Luciferase reporter gene assay, respectively. RESULTS: Circ-CCDC66 was significantly up-regulated in GC tissues and cell lines. Up-regulation of circ-CCDC66 indicated markedly worse prognosis of GC patients. Transfection of circ-CCDC66-siRNA remarkably attenuated proliferative and invasive abilities of BGC-823 and MGC-803 cells. Besides, GC cells were arrested in the G0/G1 phase, and the apoptotic rate was remarkably elevated after circ-CCDC66 knockdown. The Dual-Luciferase reporter gene assay verified that circ-CCDC66 bind to miRNA- 1238-3p by competing with LHX2 (LIM-homeobox domain 2). MiRNA-1238-3p was significantly down-regulated in GC cells, whereas LHX2 was up-regulated. Furthermore, overexpression of miRNA-1238-3p in GC cells markedly suppressed the LHX2 level. CONCLUSIONS: Circ-CCDC66 is highly expressed in GC tissues and cell lines. Knockdown of circ-CCDC66 attenuates proliferative and invasive abilities of GC cells. Our results indicate that circ-CCDC66/miRNA-1238-3p/LHX2 axis may be a promising target for GC treatment. [ABSTRACT FROM AUTHOR]

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results