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Objective: We conducted a retrospective study on the prognostic factors of aneurysmal subarachnoid hemorrhage (aSAH) patients in the author's Hospital from January 2019 to May 2023. To discuss the association of the blood lipid and glucose levels of patients with the prognosis of aSAH, and verify that high blood lipid and glucose levels are important factors affecting adverse prognosis. Methods: All patients with aSAH were collected as the case group, which was divided into two groups according to the modified Rankin Scores (mRS), the good prognosis group (Group A, mRS ＜ 3) and the adverse prognosis group (Group B,mRS ≥3). The clinical data of age, gender, accompanied chronic diseases (hypertension, diabetes), smoking, drinking, Glasgow Coma Scale (GCS), Hunt-Hess (H-H) grade, Modified Fisher grade, total cholesterol (TC) , triglyceride (TG) , high-density cholesterol lipoprotein (HDL-C) , low-density cholesterol lipoprotein (LDL-C) , blood glucose (BG) , responsible aneurysm diameter and location were recorded too. Correlations between blood lipid and glucose levels and Modified Fisher grade were assessed by the Spearman correlation analysis. The receiver operating characteristic (ROC) curve was utilized to evaluate the diagnostic efficacy. The effect of blood lipid and glucose levels on adverse prognosis was analyzed by Logistic regression models. Result: A total of 259 patients with aSAH were enrolled. The average age of all patients is (56.54 ± 10.52) years, including 96 males and 163 females. They were divided into Group A (n = 146) and Group B (n = 113). Univariate analysis results show that age, the levels of TC, TG, LDL-C, and BG were higher in Group B (P

The display platform of train provides the train driver with the key data of the running train and receives control command input. Its operation reliability is very important for safe driving. In order to quickly locate and response to the fault of the display platform and reduce the impact of the fault on train operation, the paper proposes a scheme for real-time diagnosis and data synchronization of train display platform operation status based on redundant display platform with two display units. Firstly, the self-diagnosis of the display unit was realized to monitor and diagnose the equipment status in real time based on the application layer, and to quickly locate the problems such as application exit, system crash and anomalies in resource utilization. Secondly, based on the RS422 communication link, a reliable communication protocol was defined to achieve the mutual diagnosis and data synchronization of operation status between multiple display units, and solve the problems of self-diagnosis failure in abnormal state of the unit and failure to obtain key data of faulty unit. A function verification experiment was carried out based on the train redundant display platform to verify the effectiveness of this scheme. The experimental results indicate that on the one hand, this scheme provides comprehensive self-diagnosis and redundant display unit state mutual diagnosis from the application layer, providing a basis for fault analysis and localization. On the other hand, it provides a way for two display units to work coordinately through key data synchronization and storage functions.

At present, China has the world's largest number of electric vehicles, and the total amount of charging power from electric vehicles is growing rapidly. Due to the small scale and high dispersion of a single electric vehicle, however, it is difficult for electric vehicles to participate the electricity market directly and share the dividends of electricity reform in China. Reducing electricity prices through the participation of electricity market can effectively encourage consumers to choose and use electric vehicles. Based on the analysis of the current Chinese electricity market, this paper studies the way in which electric vehicles participate in the electricity market in China, and designs corresponding market participation mechanisms.

This study examines the issue in standard and operational scenarios of microgrids that arise during critical conditions. Initially, the ideal energy storage size and discharge depth are identified for optimal microgrid planning under operating conditions. Subsequently, by utilizing the energy storage system and load response, the microgrid’s vulnerability is reduced and the cost of load shedding is minimized when in critical conditions, leading to the microgrid being disconnected from the main network and operating in island mode. This model aims to analyze how the system performance is influenced by the presence of storage systems and load response programs in a numerical scenario, particularly during severe weather events. In addition, the study examines the role of advanced control algorithms and communication systems in optimizing the operation of the microgrid. By implementing smart grid technologies, the microgrid can better manage its energy resources, anticipate fluctuations in demand, and respond quickly to changing conditions. This proactive approach helps to ensure the stability and reliability of the microgrid, even in the face of unforeseen challenges. Overall, this research contributes valuable insights into the challenges and opportunities facing microgrids in both normal and emergency situations. By identifying the most effective energy storage solutions, load response strategies, renewable energy integration methods, and advanced control systems, the study aims to enhance the resilience, efficiency, and sustainability of microgrid systems in the future. The results of the proposed approach in critical operational mode represent the optimal condition of the electrical microgrid with minimum cost and load shedding considering storage systems and load response programs.

The glass fiber reinforced resin matrix composite I-beams were designed and formed via a type of novel bending pultrusion processing technique, and the three-point bending tests were carried out to analyze the mechanical bending performances. The obtained results show that the main failure mode of the composite I-beam under the bending load is the upper structure (top flange) cracks along the length direction of the fibers, and the cracks simultaneously propagate downwards in the vertical direction. The bifurcated cracks can be found at the junction area between the top flange and web. In addition, the main bending failure mechanism of the composite I-beam includes the matrix cracking, propagation of cracks, and final fracture failure. In particular, noting that when the crack reaches the I-shaped neck position, the lateral bifurcation occurs, and the resulting secondary cracks further extend in two directions, which leads to the serious damage between the top flange and web, and the ultimate fracture failure occurs.

Abstract To evaluate the clinicopathological characteristics and prognosis of gastrointestinal vascular tumours. By reviewing the information from the electronic medical record system and pathology database of Hangzhou First People's Hospital affiliated with Zhejiang University School of Medicine and Jiaxing First People’s Hospital from June 2008 to December 2019, 31 patients pathologically diagnosed with vascular tumours were included in this study. The age of onset, sex differences, clinical manifestations, imaging and endoscopic characteristic manifestations, pathological characteristics, treatment methods and prognosis were analysed. The pathological classification was haemangiolymphangioma, haemangioma, and lymphangioma in 8, 14, and 9 cases, respectively. The age of onset was 44–66 years, with no significant difference according to sex (P = 0.583); 32.26% (10/31) of patients had no noticeable symptoms, 37.5% (12/31) of patients had gastrointestinal bleeding, and 6.45% (2/31) of patients, all with lymphangioma, had intestinal obstruction. The lesions were located in and below the duodenum. Endoscopy showed colour differences. Both endoscopic and surgical treatments were safe and effective. The mean survival time was 57.06 ± 35.64 months. Regarding vascular tumours without typical symptoms, the main pathological classification is haemangioma. Vascular tumours are often clinically identified because of bleeding or obstruction and can be treated with endoscopy or surgery. Clinical follow-up is recommended because no invasive manifestations or instances of recurrence were observed.

Objective To investigate the effect of modified Morita therapy combined with motor imagery training on pulmonary rehabilitation of elderly patients with chronic obstructive pulmonary disease(COPD). Methods Totally 130 elderly COPD patients were selected and divided into two groups according to the random number table method, with 65 cases in each group. During the rehabilitation treatment, the control group received modified Morita therapy intervention, and the observation group received modified Morita therapy combined with motor imagery training. The changes of lung function, negative emotion and quality of life before and after intervention were compared between the two groups. Results After intervention, the value of forced expiratory volume in 1 s (FEV1), forced expiratory volume in one second/predicted value ratio(FEV1%pred), forced vital capacity (FVC), FEV1/FVC of the observation group were higher than those of the control group (P＜0. 05). Scores of Self-rating Anxiety Scale (SAS), Self-rating Depression Scale(SDS)in the observation group were lower than those in the control group (P＜0. 05). The total score of St George's Respiratory Questionnaire (SGRQ) and dimension scores of symptom, activity and impact in the observation group were lower than those in the control group (P＜0. 05). Conclusion Modified Morita therapy combined with motor imagery training can promote pulmonary function recovery, relieve negative emotion, and improve quality of life in COPD patients. (目的 观察改良森田疗法结合运动想象应用于老年慢性阻塞性肺疾病(COPD)患者肺康复中的效果。方法 选择2019年1月—2020年3月呼吸内科收治的老年COPD患者130例, 按随机数字表法分为对照组和观察组, 各65例。在常规治疗和护理的基础上, 对照组给予改良森田疗法干预, 观察组给予改良森田疗法结合运动想象干预。对比2组干预前后肺功能、不良情绪及生活质量变化情况。结果 干预后观察组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1% pred)、用力肺活量(FVC)、第一秒用力呼气容积与用力肺活量比值(FEV1/FVC)指标均高于对照组(P＜0. 01)。干预后观察组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组(P＜0. 01)。干预后观察组圣乔治呼吸问卷(SGRQ)症状部分、活动部分、疾病影响部分及总分低于对照组(P＜0. 01)。结论 改良森田疗法结合运动想象应用于老年COPD患者肺康复中, 可促进患者肺功能康复, 缓解不良情绪, 提升生活质量。)

Increasing evidence indicates that the oncoprotein murine double minute (MDM2) binding protein (MTBP) can be considered a pro-oncogene of human malignancies; however, its function and mechanisms in hepatocellular carcinoma (HCC) are still not clear. In the present work, our results demonstrate that MTBP could function as a co-activator of transcription factor E26 transformation-specific sequence (ETS-1), which plays an important role in HCC cell proliferation and/or metastasis and promotes proliferation of HCC cells. Using luciferase and real-time polymerase chain reaction (qPCR) assays, MTBP was found to enhance the transcription factor activation of ETS-1. The results from chromatin co-immunoprecipitation showed that MTBP enhanced the recruitment of ETS-1 to its downstream gene’s (mmp1’s) promoter region with ETS-1 binding sites. In cellular and nude mice models, overexpression of MTBP was shown to promote the proliferation of MHCC97-L cells with low endogenous MTBP levels, whereas the knockdown of MTBP led to inhibition of the proliferation of MHCC97-H cells that possessed high endogenous levels of MTBP. The effect of MTBP on ETS-1 was confirmed in the clinical specimens; the expression of MTBP was positively correlated with the downstream genes of ETS-1, mmp3, mmp9, and uPA. Therefore, by establishing the role of MTBP as a novel co-activator of ETS-1, this work expands our knowledge of MTBP or ETS-1 and helps to provide new ideas concerning HCC-related research.

Glioma is a malignant primary brain tumor that occurs in the central nervous system and has threatened the well-being of millions of patients. It is well acknowledged that long non-coding RNA (lncRNA) SNHG3 participates in the regulation of proliferation, inflation, differentiation, and metastasis in many cancers. However, the regulatory effect of SNHG3 on glioma progression is still controversial. The expression of SNHG3 and HDGF was upregulated, whereas miR-384 was downregulated in glioma tissues, compared with the normal tissues. Interestingly, high SNHG3 contributed to low survival rate while low SNHG3 showed the opposite result. Moreover, SNHG3 or HDGF knockdown significantly suppressed proliferation, migration, and invasion and induced apoptosis in glioma. Meanwhile, restoration of HDGF abrogated the inhibition of SNHG3 silencing on glioma cell progression. Besides, miR-384 inhibitor attenuated SNHG3 silencing induced inhibition on HDGF mRNA and protein expression in A172 and SHG44 cells. LncRNA SNHG3 promotes cell proliferation, migration, and invasion in glioma by enhancing HDGF expression via miR-384 sponging, representing the promising targets for the development of novel therapeutic strategies.

When facing increasingly complex and fast-changing strategic situation, powerful strategic management system is crucial for large-scale power grid enterprises to ensure scientific decision-making, coordinated action and efficient management. This paper analyzes the new strategic management situation of large-scale power grid enterprises under the background of the integrated development of digital revolution and energy revolution. Based on the new situaiton, this paper carries out the demand analysis of the optimization of strategic management mechanism for power grid enterprises, and puts forward the core content of the strategic closed-loop management mechanism optimization. The mechanism optimization will ensure the forward-looking of power grid enterprises’ strategy formulation under the background of digital transformation. Additionally, the mechanism optimization will promote accurate identification of changes, scientific response and effective prevention of strategic risks.

This paper takes a 1.5 MW wind turbine wind farm in Jilin province as an example. It analyzes the improvement of blade lengthening in wind turbine power generation by optimizing control strategy and adopting intelligent control technology. And it compares the economic benefits of replacing 82 blades and 89 blades and provides a theoretical and practical basis for blade lengthening transformation of other wind farms.

LiCoO2 thin films were prepared on single crystal Si (100) by magnetron sputtering method and then annealed by different annealing temperatures, holding times and atmospheres. The effects of annealing processes on the surface morphologies, compositions, crystal structures and mechanical properties of LiCoO2 films were investigated. The results show that the surface average roughness of LiCoO2 film is reduced from 11.63 nm to 6.13 nm; annealing atmosphere has the greatest influence on the surface morphologies of LiCoO2 films. The LiCoO2 film composition is destroyed due to Li2O, CoO, Co3O4 by-products formed during annealing process. LiCoO2 film are crystallized under any annealing conditions, the average grain size is about 30 nm, annealing temperature has the greatest influence on the grain size and residual stress. After annealing, the hardness and young's modulus of LiCoO2 films are increased by an order of magnitude. Under the optimal annealing process (600 ℃, 60 min, pure O2 atmosphere), the ratio of H3/Er2 is 0.03 GPa, which shows excellent resistance to plastic deformation.

Objective. To analyze the correlation of intestinal cleanliness in each segment of the Boston Intestinal Preparation Scale. Methods. From February 2017 to October 2019, the data of patients who underwent colonoscopy in the Department of Gastroenterology, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, were collected. Statistical analysis was performed according to the Boston Intestinal Preparation Scale score, and the correlation of intestinal cleanliness in each region was obtained. Results. A total of 1739 patients were included. The overall score of BBPS was 6.77±1.88. The scores of each region were 2.04±0.84 (right lateral colon), 2.25±0.68 (transverse colon), and 2.48±0.64 (left colon). The difference between the regions was statistically significant (P

Transparent conductive oxide films have been widely used in liquid crystal displays, solar cells, electrochromic windows, gas sensors, curtain wall glass, heat-transfer glass for aircraft and high-speed trains (de-icing and defogging). The study of its preparation and treatment methods is also crucial and important. In order to prepare a highly transmissive and highly conductive ITO film, it is generally obtained by two methods: a crystalline high-quality thin film is deposited by a high-temperature preparation method directly, and an amorphous film is deposited at room temperature and then heat-treated. However, for substrates that are not resistant to high temperatures, they cannot be exposed to high temperatures for long periods of time. Therefore, it is significant to study the rapid heat treatment crystallization method, aiming at not only ensuring the application requirements of the ITO film, but also reducing the adverse effect of the crystallization method on the substrate. According to different application backgrounds and application requirements, selecting the appropriate preparation method and crystallization method are the key issues to obtaining highly transmissive and highly conductive films. This paper summarizes the current research progress of crystallization methods of ITO transparent conductive oxide films both at home and abroad. By comparing the mechanism, advantages and disadvantages of different thin film crystallization methods, it is found that the infrared annealing, laser annealing, and flash lamp annealing can achieve rapid crystallization of the thin film, and the temperature of substrate is lower than the temperature of film during the process. These methods are expected to replace the conventional furnace annealing crystallization method used in current commercial production for improving production efficiency, saving production costs, obtaining high-quality and high-performance transparent conductive oxide film. These methods are expected to be more widely used.

Malus halliana Koehne flowers have been used as a Chinese traditional medicine to treat metrorrhagia. In this study, the dynamic changes in its secondary metabolites and spectrum-effect relationship of inhibition on α-glucosidase during blooming were investigated. The changes in the contents of three flavonoids (phloretin-4’-O-glycosidase, afzeloside, and 3-hydroxyphloridzin) were determined by high performance liquid chromatography (HPLC) and changes in inhibitory effect on α-glucosidase were evaluated in vitro. Then, spectrum-effect relationship was evaluated by partial least square method. The results indicated that the contents of three flavonoids and inhibition of α-glucosidase activity in vitro showed a fluctuating downward trend, thereinto, the maximum contents of phloretin-4’-O-glycosidase, afzeloside, and 3-hydroxyphloridzin reached 157.43±0.36, 17.27±0.06 and 22.67±0.35 (mg/g), respectively. In spectrum-effect relationship assay, matched 40 mutual peaks, thereinto, P2, P5, P6-P12, P14 (3-hydroxyphloridzin), P16-P19, P20 (phloretin-4’-O-glycosidase), P24, P26, P29, P31, P33, P34, P36, P39 and P40 were positively correlated to inhibitory effect on α-glucosidase in vitro. P1, P3, P4, P13, P15, P21-P23, P27, P28, P30 (afzeloside), P32, P35, P37 and P38 were negatively related to inhibitory effect on α-glucosidase in vitro.

With the increasing wide application of organic or polymer substrates, amorphous transparent conducting oxides (a-TCOs) had been widely applied to thin-film transistors, polymer/organic solar cells, electrochromic devices, electromagnetic shielding and other areas due to the combined transparency and conductivity as well as stable properties, processing compatibilities with current technologies and free of post-annealing. A-TCOs films were not the amorphous counterpart of crystalline TCOs but prepared with special elements under certain conditions. After the brief introduction to the working principle of TCO, the even general amorphous transparent semiconducting oxide was addressed intensively. It was worth to note that compared with c-TCOs and classic silicon, the features of electronic structure of a-TCOs were the cations with special configuration (n-1)d10ns0. The stable amorphous structure and excellent properties can be conserved due to larger overlap integral between the adjacent atoms, high mobility and robustness. Particularly, the near range structure characterization such as the medium range order, band structure described by density of states and the metastability of amorphous structure and the related properties were introduced as well. Afterwards, the properties and features of N-type and P-type a-TCOs were exampled in details, especially the indium-based systems, such as excellent a-In-Zn-O films. Less example of P-type a-TCOs were shown as no general principle had been formed for that. Finally, many state-of-art applications including thin-film transistor are introduced. Based upon the current status and emerging trend, three potential research perspective directions of a-TCO have been delivered:(1) to further investigate non-indium based a-TCO; (2) to develop on the P-type TCO with novel principle and material systems; (3) to enable the alternative application that occupied by conventional silicon previously.

With the size of thin-film electronic devices decreasing, the film stress became an important reason for the failure of thin film devices. Film stress not only affected the membrane structure, but also associated with film optics, electricity, mechanics and other properties, therefore film stress turned into one hot spot in the research field of thin-film materials. This paper reviewed the latest research progress of film stress, substrate curvature method, X-ray diffraction technique and Raman spectroscopy, several frequently used stress measuring techniques were compared and analyzed, and composition ratios of thin film, substrate types, magnetron sputtering process parameters (sputtering power, work pressure, substrate temperature) and annealing etc. factors influencing thin film stress were summarized. It was found that substrate curvature method was suitable for measuring almost all kinds of thin film materials. X-ray diffraction and Raman spectroscopy were just fit for measuring materials with characteristic peaks. Nanoindentation method required extra stress-free samples as comparison experiments. During film fabrication and annealing process, film stress usually transited from compressive to tensile status, and several factors combined together could affect stress, so film stress could be reached the minimum value or even stress-free status through setting appropriate parameters. Finally, combined with film stress research status, accurate stress measurement methods for different materials as a thin-film stress research direction were introduced, and challenges in thin film detection range were pointed out.

The air-gap thickness is crucial to the operation of magnetic couplers,and it is of great significance for realizing speed adjustment of couplers through changing air-gap thickness. In order to investigate the relationship between air-gap thickness and adjustable-speed performance of axial-flux solid asynchronous magnetic couplers,a model for axial-flux magnetic couplers is established by combining equivalent magnetic circuit approach and Kirchhoff? s law of magnetic circuit. The magnetic circuit parameters of couplers are solved by utilizing the method of analytical calculation on the above model,then,the torque expression is obtained by integrating three-dimensional correction coefficient and torque formula. Moreover,by synthesizing the torque expression under constant torque load condition,the relationship between air-gap thickness and slip is derived,which is beneficial for acquiring the adjustable-speed relationship of axial-flux solid asynchronous magnetic couplers. The Matlab is used to solve the discretization of torque expression and adjustable-speed relationship,besides,the finite element simulations and experiments are also employed in the contrast and analyses,the accuracy of theoretical calculation is verified and the theoretical foundation for realizing precise speed adjustment of couplers is provided.

C32H34N10O6S2Zn, monoclinic, C2/c (no. 15), a = 24.243(4) Å, b = 11.2766(17) Å, c = 15.799(5) Å, β = 127.986(2)°, V = 3404.0(13) Å3, Z = 4, Rgt(F) = 0.0432, wRref(F2) = 0.1146, T = 100(2) K.

In order to explore the basic events and risk occurrence probability of fire and explosion accidents in CNG (Compressed Natural Gas) filling station, a corresponding Bayesian network risk model was established based on the fault tree of filling station. The prior probability was modified by introducing fuzzy mathematics in the process of transforming the fault tree into Bayesian network, and the posterior probability of the basic events of CNG filling station fire and explosion accidents was analyzed and calculated by GeNIe software. Finally, through case analysis, it is found out that the most dangerous factors that lead to the greatest risk of fire and explosion accidents in a filling station are: personnel misoperation, management defects, etc. After verifying the model, it shows that paying attention to the polymorphism of the base events and determining the rationality of the logical relationship between the base events can calculate the more accurate probability distribution of the base events, and at the same time provide reasonable suggestions for the accident prevention of the gas filling station.

As an important link in the development of urban-rural integration, equalization of basic public services in urban and rural areas is the foundation of urban-rural integration and an important aspect of improving the quality of life of urban and rural residents. To understand the level of equalization of basic public services in urban and rural areas, it is necessary to reasonably measure the level of equalization of basic public services. This article constructs an evaluation system for the equalization of basic public services in urban and rural areas from the four dimensions of public education, social security, medical and health, and infrastructure. The entropy method is used to obtain the equalization index of basic public services in Heilongjiang Province. On this basis, a comprehensive analysis of the equalization of basic public services in the integrated development of urban and rural areas is carried out and corresponding policy recommendations are put forward.

In order to study the transmission performance of the COMI and CIMO type coupler with the same structure parameters,the equivalent magnetic circuit method is used to analyze and derive the torque formula of the coupler,and the final torque expression is acquired by combining the torque formula and three dimensional correction coefficient. Also,the efficiency formula of magnetic coupler is derived. Then,the finite element simulations is used to analyze the transmission performance of the two kinds of couplers when they are under the same input speeds and slips ratio. The results indicate that COMI type coupler has the same transmission efficiency with the CIMO type coupler,but can get bigger torque when they have the same geometrical parameters,which means COMI type coupler has better transmission performance.