22 results on '"Zachary Werner"'
Search Results
2. Crisis Averted: Clinical T1b Renal Mass with Concurrent Arteriovenous Malformation and Renal Vein Thrombus
- Author
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David Zekan, Kareem Wasef, Zachary Werner, Robert Grammer, Cara Lombard, Adam Luchey, and Ali Hajiran
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Arteriovenous malformations (AVMs) secondary to renal-cell carcinoma (RCC) are well-described in the literature. Independently, renal vein and inferior vena cava tumor thrombi can be detected in locally-advanced RCC. A 67-year-old gentleman presented with a cT1b renal mass detected on workup for elevated creatinine. Multiphase CT imaging obtained for partial nephrectomy surgical-planning revealed an initially-missed renal cortical AVM. This drastically changed the plan for intervention, including use of an open approach with AVM embolization by interventional radiology prior and avoidance of a nephron-sparing approach. Final pathology confirmed the AVM and a subclinical renal vein thrombus masked by arterial flow on CT imaging, making this the first concurrent case described in the literature. Herein, we describe avoidance of catastrophic intraoperative hemorrhage by careful review of preoperative imaging and provide a literature review of imaging modalities for both renal surgical-planning and detection of tumor thrombi in RCC.
- Published
- 2022
- Full Text
- View/download PDF
3. Using Postmarket Surveillance to Assess Safety-Related Events in a Digital Rehabilitation App (Kaia App): Observational Study
- Author
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Deeptee Jain, Kevin Norman, Zachary Werner, Bar Makovoz, Turner Baker, and Stephan Huber
- Subjects
Medical technology ,R855-855.5 - Abstract
BackgroundLow back pain (LBP) affects nearly 4 out of 5 individuals during their lifetime and is the leading cause of disability globally. Digital therapeutics are emerging as effective treatment options for individuals experiencing LBP. Despite the growth of evidence demonstrating the benefits of these therapeutics in reducing LBP and improving functional outcomes, little data has been systematically collected on their safety profiles. ObjectiveThis study aims to evaluate the safety profile of a multidisciplinary digital therapeutic for LBP, the Kaia App, by performing a comprehensive assessment of reported adverse events (AEs) by users as captured by a standardized process for postmarket surveillance. MethodsAll users of a multidisciplinary digital app that includes physiotherapy, mindfulness techniques, and education for LBP (Kaia App) from 2018 to 2019 were included. Relevant messages sent by users via the app were collected according to a standard operating procedure regulating postmarket surveillance of the device. These messages were then analyzed to determine if they described an adverse event (AE). Messages describing an AE were then categorized based on the type of AE, its seriousness, and its relatedness to the app, and they were described by numerical counts. User demographics, including age and gender, and data on app use were collected and evaluated to determine if they were risk factors for increased AE reporting. ResultsOf the 138,337 active users of the Kaia App, 125 (0.09%) reported at least one AE. Users reported 0.00014 AEs per active day on the app. The most common nonserious AE reported was increased pain. Other nonserious AEs reported included muscle issues, unpleasant sensations, headache, dizziness, and sleep disturbances. One serious AE, a surgery, was reported. Details of the event and its connection to the intervention were not obtainable, as the user did not provide more information when asked to do so; therefore, it was considered to be possibly related to the intervention. There was no relationship between gender and AE reporting (P>.99). Users aged 25 to 34 years had reduced odds (odds ratio [OR] 0.31, 95% CI 0.08-0.95; P=.03) of reporting AEs, while users aged 55 to 65 years (OR 2.53, 95% CI 1.36-4.84, P=.002) and ≥75 years (OR 4.36, 95% CI 1.07-13.26; P=.02) had increased odds. AEs were most frequently reported by users who had 0 to 99 active days on the app, and less frequently reported by users with more active days on the app. ConclusionsThis study on the Kaia App provides the first comprehensive assessment of reported AEs associated with real-world use of digital therapeutics for lower back pain. The overall rate of reported AEs was very low, but significant reporting bias is likely to be present. The AEs reported were generally consistent with those described for in-person therapies for LBP.
- Published
- 2021
- Full Text
- View/download PDF
4. Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
- Author
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Erin Meyers, Zachary Werner, David Wichman, Hunter L. Mathews, Richard A. Radcliffe, Joseph H. Nadeau, and Jerry A. Stitzel
- Subjects
chromosome substitution strains ,two-bottle choice ,nicotinic acetylcholine receptor ,mapping ,knockout ,Psychiatry ,RC435-571 - Abstract
The gene CHRNA5 is strongly associated with the level of nicotine consumption in humans and manipulation of the expression or function of Chrna5 similarly alters nicotine consumption in rodents. In both humans and rodents, reduced or complete loss of function of Chrna5 leads to increased nicotine consumption. However, the mechanism through which decreased function of Chrna5 increases nicotine intake is not well-understood. Toward a better understanding of how loss of function of Chrna5 increases nicotine consumption, we have initiated efforts to identify genetic modifiers of Chrna5 deletion-dependent oral nicotine consumption in mice. For this, we introgressed the Chrna5 knockout (KO) mutation onto a panel of C57BL/6J-Chr#A/J/NAJ chromosome substitution strains (CSS) and measured oral nicotine consumption in 18 CSS and C57BL/6 (B6) mice homozygous for the Chrna5 KO allele as well as their Chrna5 wild type littermates. As expected, nicotine consumption was significantly increased in Chrna5 KO mice relative to Chrna5 wildtype mice on a B6 background. Among the CSS homozygous for the Chrna5 KO allele, several exhibited altered nicotine consumption relative to B6 Chrna5 KO mice. Sex-independent modifiers were detected in CSS possessing A/J chromosomes 5 and 11 and a male-specific modifier was found on chromosome 15. In all cases nicotine consumption was reduced in the CSS Chrna5 KO mice relative to B6 Chrna5 KO mice and consumption in the CSS KO mice was indistinguishable from their wild type littermates. Nicotine consumption was also reduced in both Chrna5 KO and wildtype CSS mice possessing A/J chromosome 1 and increased in both KO and wild type chromosome 17 CSS relative to KO and wild type B6 mice. These results demonstrate the presence of several genetic modifiers of nicotine consumption in Chrna5 KO mice as well as identify loci that may affect nicotine consumption independent of Chrna5 genotype. Identification of the genes that underlie the altered nicotine consumption may provide novel insight into the mechanism through which Chrna5 deletion increases nicotine consumption and, more generally, a better appreciation of the neurobiology of nicotine intake.
- Published
- 2021
- Full Text
- View/download PDF
5. Congenital Megaprepuce: Literature Review and Surgical Correction
- Author
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Zachary Werner, Ali Hajiran, and Osama Al-Omar
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Congenital megaprepuce (CMP) is a type of buried penis characterized by extensive redundancy and ballooning of the inner prepuce as a result of preputial stenosis and phimosis. The malformation typically presents with difficulty voiding, often requiring manual expression of stagnant urine. Multiple techniques have been reported for the treatment of CMP with varying levels of positive outcomes. The authors provide a review of published literature, in addition to describing the procedure and results of our surgical technique in three children aged eleven months, two years, and twelve years. The literature review was conducted using PubMed with keywords “congenital megaprepuce,” “megaprepuce,” “buried penis,” “CMP,” and “correction.” Results were then differentiated based on presence or absence of true congenital megaprepuce and the surgical correction thereof. Regarding our cases, all patients completed the procedure with excellent cosmesis and without complication. Our technique is shown to provide consistent, excellent esthetic outcome across a wide range of ages and may be replicated by others.
- Published
- 2019
- Full Text
- View/download PDF
6. Ossifying Renal Tumor of Infancy: Laparoscopic Treatment and Literature Review
- Author
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Ali Hajiran, Morris Jessop, Zachary Werner, Chad Crigger, John Barnard, Jeffrey Vos, and Michael Ost
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
We present an unusual case of a rare ossifying renal tumor of infancy. A 6-month-old male initially presented with gross hematuria and without any palpable abdominal mass. Renal ultrasound and MRI showed a right lower pole, calcified, endophytic renal mass. Laparoscopic radical nephrectomy was performed without complications. Pathology demonstrated an ossifying renal tumor of infancy. We report this case, in addition to a review of the literature for similar cases, to highlight a rare renal tumor in infancy that can be managed laparoscopically.
- Published
- 2018
- Full Text
- View/download PDF
7. Assessing the effectiveness of antimicrobial pouch use for infection prevention in sacral neuromodulation
- Author
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Tyler Trump, Katharina Mitchell, Zachary Werner, Omar Duenas-Garcia, Robert Shapiro, and Stanley Zaslau
- Subjects
Urology ,Obstetrics and Gynecology - Published
- 2023
8. MP53-02 PEDIATRIC RENAL TRAUMA AT A LEVEL-1 TRAUMA CENTER IN RURAL STATE: 10-YEAR INSTITUTIONAL REVIEW AND PROTOCOL IMPLEMENTATION
- Author
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Zachary Werner, Luke O'Connor, Ahmed Abdelhalim, and Osama Al-Omar
- Subjects
Urology - Published
- 2023
9. Pediatric renal trauma at a level 1 trauma center in a rural state: A 10-year institutional review and protocol implementation
- Author
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Zachary Werner, Luke O'Connor, Kareem Wasef, Ahmed Abdelhalim, and Osama Al-Omar
- Subjects
Urology ,Pediatrics, Perinatology and Child Health - Published
- 2023
10. Implementation of a Standardized Renal Trauma Protocol at a Level 1 Trauma Center: 7-Year Protocol and 10-Year Institutional Review
- Author
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Zachary Werner, Ahmad Haffar, Emma Bacharach, Jennifer Knight-Davis, Ali Hajiran, and Adam Luchey
- Subjects
Research and Reports in Urology ,Urology - Abstract
Zachary Werner,1 Ahmad Haffar,2 Emma Bacharach,1 Jennifer Knight-Davis,3 Ali Hajiran,1 Adam Luchey1 1Department of Urology, West Virginia University, Morgantown, WV, USA; 2School of Medicine, West Virginia University, Morgantown, WV, USA; 3Department of Surgery, West Virginia University, Morgantown, WV, USACorrespondence: Ahmad Haffar, School of Medicine, West Virginia University, Suite 6300 Health Sciences Center Morgantown, Morgantown, WV, 26505, USA, Tel +304 993-2237, Fax +304 293-2807, Email aihaffar@mix.wvu.eduObjective: Current urologic renal trauma guidelines favor conservative management. In 2012, we implemented an institution-wide renal trauma protocol to standardize management. This protocol details initiation of DVT (deep vein thrombosis) prophylaxis, cessation of bed rest, and frequency of laboratory studies. We hypothesized that low-grade injuries (grade IâIII) could be managed without urologic consultation and that our chemical DVT prophylaxis regimen would not pose an increased risk of hemorrhage requiring transfusion.Methods: We performed a cross-sectional analysis of a prospectively maintained database containing all renal trauma at our institution from 2009 to 2019. We segregated injuries based on grade, presence of multi-organ trauma, and evaluated the presence and types of intervention, initiation of chemical DVT prophylaxis, and post-DVT prophylaxis hemorrhage requiring transfusion.Results: We identified 295 cases of renal trauma, of which 62 were isolated injuries. Forty-three of the isolated renal injuries were transferred from outside facilities, 70% of which were classified as low-grade injuries. There were 220 low-grade lacerations and 75 high-grade lacerations. No grade I or II lacerations required any interventions. Two (2.5%) grade III lacerations required IR embolization. Twenty-five (41%) grade IV lacerations required intervention, of which five were nephrectomy. Seven (54%) grade V lacerations required intervention, of which 5 were nephrectomies. Upon review of our protocol with early ambulation and DVT prophylaxis, there were no cases of isolated renal injury where initiation of either treatment resulted in delayed hemorrhage requiring transfusion or surgical intervention.Conclusion: Only 2/220 low-grade renal lacerations required intervention. Our data suggest that grade I and II renal lacerations can be managed safely without urologic consultation. Consultation is warranted for grade III injuries given the possibility of initial understaging. Furthermore, we believe our renal laceration protocol in our admittedly small, isolated sample has shown our DVT prophylaxis initiation to not pose increased risk.Keywords: renal, trauma, review, protocol, thromboembolic
- Published
- 2022
11. First American Cancer Patient to Receive Dicycloplatin (DCP) Chemotherapy Achieves Remission After Seven Weeks of DCP Capsules – A Case Report
- Author
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MOHAMAD W. SALKINI, XUQING YANG, FAYYAZ HAIDER HASHMI, STANLEY J. KANDZARI, THOMAS HOGAN, CHAD MORLEY, DAVID ZEKAN, ZACHARY WERNER, DORIAN J. WILLIAMS, YI GUO, THOMAS LEWIS MATTHEW, MICHAEL SPANGLER, and JING JIE YU
- Subjects
Cancer Research ,Oncology ,General Medicine - Published
- 2022
12. Surgical Correction of True Diphallia in a Newborn Male
- Author
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John A Ozolek, Chad Crigger, Osama Al-Omar, Yasamin Samadi, Amr A. Elbakry, and Zachary Werner
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Urology ,Infant, Newborn ,Urethral duplication ,Diphallia ,Lipoma ,Penoscrotal transposition ,Surgical correction ,medicine.disease ,Surgery ,Bifid scrotum ,medicine ,Humans ,Sacral dimple ,medicine.symptom ,Chordee ,business ,Penis - Abstract
Diphallia is an exceedingly rare anomaly characterized by partial or complete duplication of the phallus. Approximately 100 cases have been reported worldwide since its initial documentation, and incidence is estimated at 1 in 5 to 6 million live births. Therapeutic management is dependent on the extent of the anomaly, ranging from phallic excision to complex reconstructive procedures in cases of broader systemic involvement. We present the case of congenital true diphallia with associated penoscrotal transposition, bifid scrotum, partial urethral duplication, ventral chordee, large scrotal lipoma and sacral dimple. We further present a review of available literature pertaining to diphallia.
- Published
- 2021
13. Complicating the already complex? Readability scores in bladder exstrophy and its treatment
- Author
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Ahmad Haffar, Christian Morrill, Adelaide Garcia, Zachary Werner, Chad Crigger, and John P. Gearhart
- Abstract
PurposeClassic bladder exstrophy (CBE), is a complex congenital malformation affecting formation of the lower abdominal wall and bladder. This study evaluates the readability of common online resources regarding CBE and its treatment. We hypothesize that high levels of reading comprehension are reflected in these resources, which may not be suitable to the general population for understanding this condition.MethodsThe search terms “bladder exstrophy” and “bladder exstrophy treatment” were reviewed on the Google search engine. The first 100 search results for each search query were collected. The readability of each webpage was assessed using a combination of four independent validated formulae: the Gunning-Fog index (GFI), SMOG grade (Simple Measure of Gobbledygook), Dale-Chall index (DCI), and the Flesch-Kincaid grade (FKG).ResultsA total of 200 search results were examined using the two search queries, yielding 72 unique webpages that fit the inclusionary criteria. The mean readability scores across all websites were a GFI of 14.3, SMOG score of 10, DCI of 9.06, and a FKG of 11.6. These scores correlate to adjusted grade levels of college sophomore, 11th grade, college, and 11th grade respectively. There was no significant difference of readability between website categories across GFI (p = 0.32), SMOG (p = 0.38), DCI (p = 0.33), and FKG (p = 0.36).ConclusionThis study demonstrates that online health information regarding CBE and its treatment is written at least the 11th grade reading level or above. This highlights the necessity to simplify online resources pertaining to CBE.
- Published
- 2022
- Full Text
- View/download PDF
14. EDITORIAL COMMENT
- Author
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Zachary Werner and John Barnard
- Subjects
Urology - Published
- 2023
15. Assessing comprehension of online information in the United States for third-line treatment of overactive bladder
- Author
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Zachary Werner, Tyler Trump, Stanley Zaslau, and Robert Shapiro
- Subjects
Urology ,Obstetrics and Gynecology - Abstract
Overactive bladder (OAB) affects up to 43% of women. Treatment ranges from lifestyle modification to invasive therapies. Nearly 75% of patients report using the internet to gain health information creating a need for interpretable, online resources. This study is aimed at evaluating the readability of online resources for OAB treatment in the US population.Google and Bing were queried regarding "sacral neuromodulation," "peripheral tibial nerve stimulation (PTNS)," and "bladder botox." The first 20 results from each search engine were assessed, representing over 90% of accessed search results. Websites were categorized as institutional/reference, commercial, nonprofit, or personal. The Gunning fog (GF), Simple Measure of Gobbledygook (SMOG), and Dale-Chall (DC) validated readability scores were used to assess results.Sacral neuromodulation yielded 27 eligible results. The associated mean readability scores correlated with levels of college senior (GF), high school junior (SMOG), and college level (DC). PTNS yielded 31 eligible results. The associated mean readability scores correlated with levels of college senior (GF), high school senior (SMOG), and college level (DC). Bladder botox yielded 17 eligible results. The associated mean readability scores correlated with levels of college sophomore (GF), high school junior (SMOG), and college level (DC). There was no difference between the therapies regarding readability. Sixty-one percent of websites were institutional/reference, 24% were commercial, 13% were nonprofit, and 2% were personal.High levels of reading comprehension are required by the general US population to understand OAB information obtained through the internet. These findings highlight a need for simplification of online resources pertaining to OAB.
- Published
- 2022
16. Congenital Megaprepuce: Literature Review and Surgical Correction
- Author
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Ali Hajiran, Osama Al-Omar, and Zachary Werner
- Subjects
medicine.medical_specialty ,business.industry ,030232 urology & nephrology ,Buried penis ,Cosmesis ,Case Report ,General Medicine ,Surgical correction ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,medicine.disease ,Congenital megaprepuce ,Manual expression ,Surgery ,03 medical and health sciences ,Stenosis ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Medicine ,Difficulty voiding ,business ,Complication - Abstract
Congenital megaprepuce (CMP) is a type of buried penis characterized by extensive redundancy and ballooning of the inner prepuce as a result of preputial stenosis and phimosis. The malformation typically presents with difficulty voiding, often requiring manual expression of stagnant urine. Multiple techniques have been reported for the treatment of CMP with varying levels of positive outcomes. The authors provide a review of published literature, in addition to describing the procedure and results of our surgical technique in three children aged eleven months, two years, and twelve years. The literature review was conducted using PubMed with keywords “congenital megaprepuce,” “megaprepuce,” “buried penis,” “CMP,” and “correction.” Results were then differentiated based on presence or absence of true congenital megaprepuce and the surgical correction thereof. Regarding our cases, all patients completed the procedure with excellent cosmesis and without complication. Our technique is shown to provide consistent, excellent esthetic outcome across a wide range of ages and may be replicated by others.
- Published
- 2019
17. Using Postmarket Surveillance to Assess Safety-Related Events in a Digital Rehabilitation App (Kaia App): Observational Study (Preprint)
- Author
-
Deeptee Jain, Kevin Norman, Zachary Werner, Bar Makovoz, Turner Baker, and Stephan Huber
- Abstract
BACKGROUND Low back pain (LBP) affects nearly 4 out of 5 individuals during their lifetime and is the leading cause of disability globally. Digital therapeutics are emerging as effective treatment options for individuals experiencing LBP. Despite the growth of evidence demonstrating the benefits of these therapeutics in reducing LBP and improving functional outcomes, little data has been systematically collected on their safety profiles. OBJECTIVE This study aims to evaluate the safety profile of a multidisciplinary digital therapeutic for LBP, the Kaia App, by performing a comprehensive assessment of reported adverse events (AEs) by users as captured by a standardized process for postmarket surveillance. METHODS All users of a multidisciplinary digital app that includes physiotherapy, mindfulness techniques, and education for LBP (Kaia App) from 2018 to 2019 were included. Relevant messages sent by users via the app were collected according to a standard operating procedure regulating postmarket surveillance of the device. These messages were then analyzed to determine if they described an adverse event (AE). Messages describing an AE were then categorized based on the type of AE, its seriousness, and its relatedness to the app, and they were described by numerical counts. User demographics, including age and gender, and data on app use were collected and evaluated to determine if they were risk factors for increased AE reporting. RESULTS Of the 138,337 active users of the Kaia App, 125 (0.09%) reported at least one AE. Users reported 0.00014 AEs per active day on the app. The most common nonserious AE reported was increased pain. Other nonserious AEs reported included muscle issues, unpleasant sensations, headache, dizziness, and sleep disturbances. One serious AE, a surgery, was reported. Details of the event and its connection to the intervention were not obtainable, as the user did not provide more information when asked to do so; therefore, it was considered to be possibly related to the intervention. There was no relationship between gender and AE reporting (P>.99). Users aged 25 to 34 years had reduced odds (odds ratio [OR] 0.31, 95% CI 0.08-0.95; P=.03) of reporting AEs, while users aged 55 to 65 years (OR 2.53, 95% CI 1.36-4.84, P=.002) and ≥75 years (OR 4.36, 95% CI 1.07-13.26; P=.02) had increased odds. AEs were most frequently reported by users who had 0 to 99 active days on the app, and less frequently reported by users with more active days on the app. CONCLUSIONS This study on the Kaia App provides the first comprehensive assessment of reported AEs associated with real-world use of digital therapeutics for lower back pain. The overall rate of reported AEs was very low, but significant reporting bias is likely to be present. The AEs reported were generally consistent with those described for in-person therapies for LBP.
- Published
- 2020
18. Using Postmarket Surveillance to Assess Safety-Related Events in a Digital Rehabilitation App (Kaia App): Observational Study
- Author
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Deeptee Jain, Zachary Werner, Kevin Norman, Stephan Huber, Turner Baker, and Bar Makovoz
- Subjects
safety ,medicine.medical_specialty ,Original Paper ,Rehabilitation ,business.industry ,medicine.medical_treatment ,adverse event ,digital health ,Health Informatics ,Human Factors and Ergonomics ,Odds ratio ,Low back pain ,lower back pain ,multidisciplinary pain treatment ,Reporting bias ,Back pain ,medicine ,Physical therapy ,KaiA ,Observational study ,pain ,medicine.symptom ,business ,Adverse effect ,digital therapeutics - Abstract
Background Low back pain (LBP) affects nearly 4 out of 5 individuals during their lifetime and is the leading cause of disability globally. Digital therapeutics are emerging as effective treatment options for individuals experiencing LBP. Despite the growth of evidence demonstrating the benefits of these therapeutics in reducing LBP and improving functional outcomes, little data has been systematically collected on their safety profiles. Objective This study aims to evaluate the safety profile of a multidisciplinary digital therapeutic for LBP, the Kaia App, by performing a comprehensive assessment of reported adverse events (AEs) by users as captured by a standardized process for postmarket surveillance. Methods All users of a multidisciplinary digital app that includes physiotherapy, mindfulness techniques, and education for LBP (Kaia App) from 2018 to 2019 were included. Relevant messages sent by users via the app were collected according to a standard operating procedure regulating postmarket surveillance of the device. These messages were then analyzed to determine if they described an adverse event (AE). Messages describing an AE were then categorized based on the type of AE, its seriousness, and its relatedness to the app, and they were described by numerical counts. User demographics, including age and gender, and data on app use were collected and evaluated to determine if they were risk factors for increased AE reporting. Results Of the 138,337 active users of the Kaia App, 125 (0.09%) reported at least one AE. Users reported 0.00014 AEs per active day on the app. The most common nonserious AE reported was increased pain. Other nonserious AEs reported included muscle issues, unpleasant sensations, headache, dizziness, and sleep disturbances. One serious AE, a surgery, was reported. Details of the event and its connection to the intervention were not obtainable, as the user did not provide more information when asked to do so; therefore, it was considered to be possibly related to the intervention. There was no relationship between gender and AE reporting (P>.99). Users aged 25 to 34 years had reduced odds (odds ratio [OR] 0.31, 95% CI 0.08-0.95; P=.03) of reporting AEs, while users aged 55 to 65 years (OR 2.53, 95% CI 1.36-4.84, P=.002) and ≥75 years (OR 4.36, 95% CI 1.07-13.26; P=.02) had increased odds. AEs were most frequently reported by users who had 0 to 99 active days on the app, and less frequently reported by users with more active days on the app. Conclusions This study on the Kaia App provides the first comprehensive assessment of reported AEs associated with real-world use of digital therapeutics for lower back pain. The overall rate of reported AEs was very low, but significant reporting bias is likely to be present. The AEs reported were generally consistent with those described for in-person therapies for LBP.
- Published
- 2020
19. Ossifying Renal Tumor of Infancy: Laparoscopic Treatment and Literature Review
- Author
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Chad Crigger, Zachary Werner, John Barnard, Ali Hajiran, Michael C. Ost, Morris Jessop, and Jeffrey A. Vos
- Subjects
medicine.medical_specialty ,Unusual case ,business.industry ,030232 urology & nephrology ,Renal ultrasound ,Case Report ,General Medicine ,Renal tumor ,urologic and male genital diseases ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,Gross hematuria ,Palpable abdominal mass ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Renal mass ,Laparoscopic radical nephrectomy ,Radiology ,business ,Laparoscopic treatment - Abstract
We present an unusual case of a rare ossifying renal tumor of infancy. A 6-month-old male initially presented with gross hematuria and without any palpable abdominal mass. Renal ultrasound and MRI showed a right lower pole, calcified, endophytic renal mass. Laparoscopic radical nephrectomy was performed without complications. Pathology demonstrated an ossifying renal tumor of infancy. We report this case, in addition to a review of the literature for similar cases, to highlight a rare renal tumor in infancy that can be managed laparoscopically.
- Published
- 2018
20. Duplicated Vas Deferens Found Incidentally during Inguinal Hernia Repair
- Author
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Jessop Morris, Zachary Werner, Kimberly Shilling Bailey, and Jennifer Rokosz
- Subjects
Male ,Incidental Findings ,medicine.medical_specialty ,business.industry ,Vas deferens ,Hernia, Inguinal ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Inguinal hernia ,Vas Deferens ,medicine.anatomical_structure ,medicine ,Humans ,business - Published
- 2019
21. Peptides as Orthopedic Biomaterials
- Author
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Derek E. Andreini, Malcolm Xing, Zachary Werner, Bingyun Li, and Christopher D. Bell
- Subjects
Metal ,Chemical engineering ,Tissue engineering ,Chemistry ,Magnesium ,Mg alloys ,visual_art ,Drug delivery ,visual_art.visual_art_medium ,chemistry.chemical_element ,Tissue healing ,Zinc ,Metabolic activity - Abstract
Biodegradable metals, including magnesium (Mg), iron (Fe) and zinc (Zn), have been proposed and developed for temporary implants with the expectation to degrade and be absorbed gradually in vivo during the tissue healing process. Compared to Mg alloys and Fe alloys, the standard electrode potential of Zn is between that of Mg and Fe, so its degradation rate has been proved to be more likely in line with the clinical demand. In addition, Zn is one of the essential trace elements in human body and plays essential roles in many enzymes and in cell metabolic activity, proliferation and differentiation. Therefore, the recent progress of Zn-based metallic biomaterials is reviewed in this chapter for the development of high-performance metallic biomaterials.
- Published
- 2017
22. Radiation biology and oncology in the genomic era
- Author
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Sarah L. Kerns, William A. Hall, Zachary Werner, Barry S. Rosenstein, Harry Ostrer, Catharine M L West, Yuhchyau Chen, and Kuang-Hsiang Chuang
- Subjects
Genetic Markers ,0301 basic medicine ,Radiogenomics ,Genomics ,Review Article ,Computational biology ,Biology ,Medical Oncology ,Methylation ,Radiation Tolerance ,Epigenesis, Genetic ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Histone methylation ,Tumor Microenvironment ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiosensitivity ,Epigenetics ,Precision Medicine ,Genotyping ,Histone Acetyltransferases ,Radiobiology ,Acetylation ,General Medicine ,DNA Methylation ,Precision medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,DNA methylation ,Cytokines ,Forecasting - Abstract
Radiobiology research is building the foundation for applying genomics in precision radiation oncology. Advances in high-throughput approaches will underpin increased understanding of radiosensitivity and the development of future predictive assays for clinical application. There is an established contribution of genetics as a risk factor for radiotherapy side effects. An individual’s radiosensitivity is an inherited polygenic trait with an architecture that includes rare mutations in a few genes that confer large effects and common variants in many genes with small effects. Current thinking is that some will be tissue specific, and future tests will be tailored to the normal tissues at risk. The relationship between normal and tumor cell radiosensitivity is poorly understood. Data are emerging suggesting interplay between germline genetic variation and epigenetic modification with growing evidence that changes in DNA methylation regulate the radiosensitivity of cancer cells and histone acetyltransferase inhibitors have radiosensitizing effects. Changes in histone methylation can also impair DNA damage response signaling and alter radiosensitivity. An important effort to advance radiobiology in the genomic era was establishment of the Radiogenomics Consortium to enable the creation of the large radiotherapy cohorts required to exploit advances in genomics. To address challenges in harmonizing data from multiple cohorts, the consortium established the REQUITE project to collect standardized data and genotyping for ~5,000 patients. The collection of detailed dosimetric data is important to produce validated multivariable models. Continued efforts will identify new genes that impact on radiosensitivity to generate new knowledge on toxicity pathogenesis and tests to incorporate into the clinical decision-making process.
- Published
- 2018
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