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Background:Rheumatoid arthritis (RA) is an inflammatory condition that mostly affects synovial joints. It produces severe swelling and ongoing inflammation, and as it worsens, the cartilage and bone begin to erode, resulting in deformed joints and bone erosion. Objectives:The purpose of this study is to evaluate the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies and determine the role of interleukin-1 beta (IL-1β), interleukin-18 (IL-18), interleukin-38 (IL-38), and transforming growth factor-beta2 (TGF-β2) in studied groups (RA patients and apparently healthy control). Materials and Methods:The study included collecting blood samples from a group of patients infected with RA involving 60 patients (21 male and 39 female), and the healthy group included 50 individuals as control group (21 males and 29 females). Results:The outcomes showed of anti-CCP a highly significant difference for RA patients compared to the control group by 0.603 ± 0.02 and 0.274 ± 0.01, respectively, and some immunological parameters that involve inflammation-promoting interleukins (IL-1β and IL-18), the results showed the significant differences at the level (P < 0.01) of patients was 126.79 ± 4.18 and 194.37 ± 12.71 compared with control 91.85 ± 2.11 and 92.27 ± 2.08, respectively. The identical results to measure anti-inflammatory interleukins (IL-38, TGF-β2) represented of patients were 190.43 ± 9.82 and 403.23 ± 21.20 compared with control group was 88.39 ± 1.56 and 115.59 ± 5.63, respectively. Conclusion:The immunological parameters represented high expression of pro-inflammatory interleukins (IL-1β and IL-18), so, elevation levels of anti-inflammatory interleukins (IL-38 and TGF-β2) of RA patients.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects the synovial joints and produces recurring inflammation of the synovial membrane, which ultimately causes joint degeneration, deformity, and disability. The current study included 110 blood samples collected from patients infected with rheumatoid arthritis (60) and 50 blood samples from controls. The results showed that investigation of some hematological tests revealed a high significant erythrocyte sedimentation rate (ESR) for the patient group compared to the control group (28.25 ± 2.72, 16.24 ± 1.83), respectively. But it is non-significant for patients for (WBC, RBC, and PLT) was (7.34 ± 0.25, 4.71 ± 0.08, and 248.26 ± 9.18), while the control group was (6.73 ±0.19, 4.96 ±0.10, and 263.64 ±8.26), respectively. As well as the result of the rheumatoid arthritis factor (Rh) level, there was a significant increase in patients with positive RF 45 (75.00%) and negative RF 15 (25.00%). while the result for the C-reactive protein (CRP) test for patients was positive 26 (43.33%) and negative 34 (56.67%).