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11 results on '"Zakheim, Daniel"'

1. Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression

Author

Wortzel, Inbal, Seo, Yura, Akano, Ife, Shaashua, Lee, Tobias, Gabriel Cardial, Hebert, Jakob, Kim, Kyung-A, Kim, DooA, Dror, Shani, Liu, Yanshen, Azrak, Griffin Campbell, Cioffi, Michele, Johnson, Kofi Ennu, Hennika, Tammy, Twerski, Meshulam Zisha, Kushner, Alexis, Math, Robert, Han, Yoon Dae, Han, Dai Hoon, Jung, Minsun, Park, Juyeong, Paik, Soonmyung, Shin, Jeon-Soo, Lee, Min Goo, Russo, Marco Vincenzo, Zakheim, Daniel, Barnes, Jesse, Mehta, Sunjoy, Manova, Katia, Schwartz, Robert E., Thakur, Basant Kumar, Boudreau, Nancy, Matei, Irina, Zhang, Haiying, Sidoli, Simone, Bromberg, Jacqueline, David, Yael, Kim, Han Sang, and Lyden, David

Published
2024
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2. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Author

Inoue, Daichi, Polaski, Jacob T, Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J, Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X, Durham, Benjamin H, Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K, and Abdel-Wahab, Omar

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Cancer, Rare Diseases, Hematology, Stem Cell Research, Genetics, 2.1 Biological and endogenous factors, Animals, Base Sequence, CRISPR-Cas Systems, Cell Self Renewal, Cell Transformation, Neoplastic, Clone Cells, Female, Genetic Predisposition to Disease, Genome, Human, Hematologic Diseases, Hematopoietic Stem Cells, Humans, Introns, Male, Mice, Knockout, Neoplasms, Noonan Syndrome, Pedigree, RNA, RNA Splicing, Ribonucleoproteins, Spleen, Transcription Factors, Mice, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulatory functions, physiologic roles of the minor spliceosome are not well understood. For example, the minor spliceosome component ZRSR2 is subject to recurrent, leukemia-associated mutations, yet functional connections among minor introns, hematopoiesis and cancers are unclear. Here, we identify that impaired minor intron excision via ZRSR2 loss enhances hematopoietic stem cell self-renewal. CRISPR screens mimicking nonsense-mediated decay of minor intron-containing mRNA species converged on LZTR1, a regulator of RAS-related GTPases. LZTR1 minor intron retention was also discovered in the RASopathy Noonan syndrome, due to intronic mutations disrupting splicing and diverse solid tumors. These data uncover minor intron recognition as a regulator of hematopoiesis, noncoding mutations within minor introns as potential cancer drivers and links among ZRSR2 mutations, LZTR1 regulation and leukemias.

Published
2021

3. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma

Author

Erazo, Tatiana, Evans, Chiara M., Zakheim, Daniel, Chu, Eren L., Refermat, Alice Yunsi, Asgari, Zahra, Yang, Xuejing, Da Silva Ferreira, Mariana, Mehta, Sanjoy, Russo, Marco Vincenzo, Knezevic, Andrea, Zhang, Xi-Ping, Chen, Zhengming, Fennell, Myles, Garippa, Ralph, Seshan, Venkatraman, de Stanchina, Elisa, Barbash, Olena, Batlevi, Connie Lee, Leslie, Christina S., Melnick, Ari M., Younes, Anas, and Kharas, Michael G.

Published
2022
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7. Salivary Gland Tissue Engineering and Repair

Author

Pradhan-Bhatt, Swati, primary, Cannon, Kevin, additional, Zakheim, Daniel, additional, Harrington, Daniel A, additional, Duncan, Randall L, additional, Jia, Xinqiao, additional, Farach-Carson, Mary C, additional, and Witt, Robert L, additional

Published
2015
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8. List of Contributors

Author

Ahadian, Samad, primary, Akiyaman, Kentaro, additional, Alansari, Sarah, additional, Alikhani, Mani, additional, Alikhani, Mona, additional, Arthur, Agnieszka, additional, Arulkumar, Shylaja, additional, Baiguera, Silvia, additional, Bianco, Alessandra, additional, Bissada, Nabil F., additional, Bleicher, Françoise, additional, Bliley, Jacqueline M., additional, Bosshardt, Dieter D., additional, Botero, Tatiana M., additional, Braga, Raquel, additional, Briggs, Kristen K., additional, Brooks, Patricia J., additional, Cannon, Kevin, additional, Carrouel, Florence, additional, Chavez, Miquella G., additional, Cheng, Ming-Te, additional, Christ, George J., additional, Cook, Colin A., additional, Cooper, Paul R., additional, Cox, Timothy C., additional, Cunningham, Michael L., additional, Dashe, Jesse, additional, Davidovitch, Ze’ev, additional, Davies, Lindsay C., additional, Del Gaudio, Costantino, additional, Diekwisch, Thomas G.H., additional, Diogenes, Anibal, additional, Duncan, Randall L., additional, Edwards, Paul C., additional, El-Bialy, Tarek, additional, Enlow, Donald H., additional, Farach-Carson, Mary C., additional, Farges, Jean-Christophe, additional, Feinberg, Stephen E., additional, Felfy, Hady, additional, Freeman, Phillip N., additional, Freilich, Martin, additional, Fujie, Toshinori, additional, Gao, Changyou, additional, Giannobile, William V., additional, Gong, Siew-Ging, additional, Grayson, Warren L., additional, Greene, Robert M., additional, Gronthos, Stan, additional, Gruber, Reinhard, additional, Häkkinen, Lari, additional, Hanna, Craig, additional, Hargreaves, Kenneth M., additional, Satoshi, Emilio Hara, additional, Harrington, Daniel A., additional, Hashmi, Basma, additional, Heino, Jyrki, additional, Hing, Anne V., additional, Holmes, Christina, additional, Honda, Masaki J., additional, Horst, Jeremy A., additional, Hu, Michael S., additional, Hughes, Francis J., additional, Hung, Ben P., additional, Huri, Pinar Yilgor, additional, Ingber, Donald E., additional, Isokawa, Keitaro, additional, Izumi, Kenji, additional, James, Eric N., additional, Jia, Xinqiao, additional, Jin, Yan, additional, Emily Joo, E., additional, Juuri, Emma, additional, Kagami, Hideaki, additional, Kaji, Hirokazu, additional, Kang, Mo K., additional, Kashi, A., additional, Kato, Hiroko, additional, Kaur, Jasvir, additional, Keller, Letitia V., additional, Kemp, Paul D., additional, Khademhosseini, Ali, additional, Khoo, Edmund, additional, Kim, Hae-Won, additional, King, William J., additional, Kirschner, Richard E., additional, Klein, Ophir D., additional, Knowles, Jonathan C., additional, Koivisto, Leeni, additional, Kökten, Tunay, additional, Krebsbach, Paul H., additional, Kuboki, Takuo, additional, Kuchler-Bopp, Sabine, additional, Kucska, Simone, additional, Kuhn, Liisa, additional, Larjava, Hannu, additional, Lee, Eun-Jung, additional, Lee, Joo-Hee, additional, Lee, Oscar K., additional, Lee, Yoo Bin, additional, Lesot, Hervé, additional, Lewis, Mark P., additional, Li, Bei, additional, Li, Luyan, additional, Lim, Jung Yul, additional, Liu, Xing, additional, Liu, Xiaohua, additional, Lo, David D., additional, Longaker, Michael T., additional, Peter Lorenz, H., additional, Lott, David G., additional, Lungová, Vlasta, additional, Ma, Lie, additional, Macchiarini, Paolo, additional, Mammoto, Tadanori, additional, Marei, Mona K., additional, Marolt, Darja, additional, Marra, Kacey G., additional, Martin, Neil R.W., additional, Matalová, Eva, additional, Matsue, Tomokazu, additional, Mehrazarin, Shebli, additional, Mina, Mina, additional, Modo, Michel, additional, Mokry, Jaroslav, additional, Morsczeck, Christian, additional, Moussa, Rania M., additional, Murphy, Neal C., additional, Mushegyan, Vagan, additional, Nagy, Naglaa B., additional, Nair, Lakshmi S., additional, Nayar, Harry, additional, Nör, Jacques E., additional, Obregón, Raquel, additional, Oh, Tae-Ju, additional, Oka, Kyoko, additional, Ostrovidov, Serge, additional, Park, No-Hee, additional, Passineau, Michael J., additional, Passipieri, Juliana A., additional, Pisal, Rishikaysh, additional, Player, Darren, additional, Pradhan-Bhatt, Swati, additional, Parthiban, Selvakumar Prakash, additional, Prochazka, Jan, additional, Prochazkova, Michaela, additional, Qu, Tiejun, additional, Ramalingam, Murugan, additional, Ramón-Azcón, Javier, additional, Rana, Deepti, additional, Ray, Herbert L., additional, Reed, David A., additional, Reinhardt, Dieter P., additional, Richard, Béatrice, additional, Riehl, Brandon D., additional, Rios, Hector F., additional, Peter Rubin, J., additional, Saad, Manal M., additional, Sachar, Ashneet, additional, Sah, Robert L., additional, Saha, Subrata, additional, Saito, Yoko, additional, Sampathkumar, Kaarunya, additional, Sangsuwon, Chinapa, additional, Seo, Byoung Moo, additional, Sharpe, Paul, additional, Shi, Songtao, additional, Shih, Yu-Ru V., additional, Shiku, Hitoshi, additional, Shin, Seung Yun, additional, Sjöqvist, Sebastian, additional, Sloan, Alastair J., additional, Smith, Anthony (Tony) J., additional, Song, In Seok, additional, Stephens, Neil, additional, Stephens, Phil, additional, Svoboda, Kathy K.H., additional, Tabrizian, Maryam, additional, Teixeira, Cristina, additional, Teixeira, Fabricio B., additional, Temple, Joshua P., additional, Thesleff, Irma, additional, Thivichon-Prince, Béatrice, additional, Toriumi, Taku, additional, Treasure, Trevor E., additional, Um, Soyoun, additional, Vishwakarma, Ajaykumar, additional, Wang, Chunfen, additional, Watson, Deborah, additional, Watson, Jeffrey B., additional, Wen, Bo, additional, Witt, Robert L., additional, Wong, Mark E., additional, Yamada, Kenneth M., additional, Yassin, Hala H., additional, Zakheim, Daniel, additional, Zhang, Bing, additional, and Zimmermann, Andrew S., additional

Published
2015
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9. ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1

Author

Inoue, Daichi, primary, Polaski, Jacob T., additional, Taylor, Justin, additional, Castel, Pau, additional, Chen, Sisi, additional, Kobayashi, Susumu, additional, Hogg, Simon J., additional, Hayashi, Yasutaka, additional, Bello Pineda, Jose Mario, additional, Penson, Alexander V, additional, Marabti, Ettaib El, additional, Erickson, Caroline, additional, Fukumoto, Miki, additional, Yamazaki, Hiromi, additional, Fukui, Chie, additional, Lu, Sydney X., additional, Durham, Benjamin H., additional, Liu, Bo, additional, Mehta, Sanjoy, additional, Zakheim, Daniel, additional, Garippa, Ralph, additional, Chew, Guo-Liang, additional, McCormick, Frank, additional, Bradley, Robert K., additional, and Abdel-Wahab, Omar, additional

Published
2020
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11. ZRSR2Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1

Author

Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Bello Pineda, Jose Mario, Penson, Alexander V, Marabti, Ettaib El, Erickson, Caroline, Fukumoto, Miki, Yamazaki, Hiromi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., and Abdel-Wahab, Omar

Abstract

Mutations in RNA splicing factors are amongst the most common genetic alterations in myeloid malignancies. Mutations in the splicing factors SF3B1, SRSF2, and U2AF1occur as heterozygous, missense mutations and have been shown to confer a change-of-function. In contrast, the X chromosome encoded ZRSR2is enriched in nonsense/frameshift mutations in males, consistent with loss of function. To date however, we do not understand the basis for enrichment of ZRSR2 mutations in leukemia. Moreover, ZRSR2 is the only one of these factors that primarily functions in the minor spliceosome. While most introns are spliced by the major spliceosome, a small subset (<1%) of introns are recognized by a separate complex, the minor spliceosome. Although minor (or “U12”) introns are present in only ~800 genes in humans, their sequences and positions are highly evolutionarily conserved - more so than their U2 counterparts. The high conservation of minor introns suggests key regulatory roles yet few functional roles for the minor spliceosome in regulating biological phenotypes are known.

Published
2020
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