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11. [Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia].

Author

Miliutina IuP, Arutiunian AV, Pustygina AV, Shcherbitskaia AD, Zalozniaia IV, and Zorina II

Subjects
Administration, Oral, Adrenal Glands physiopathology, Animals, Animals, Newborn, Disease Models, Animal, Female, Hyperhomocysteinemia etiology, Hyperhomocysteinemia physiopathology, Methionine administration & dosage, Oxidative Stress, Pregnancy, Prenatal Exposure Delayed Effects etiology, Prenatal Exposure Delayed Effects physiopathology, Rats, Rats, Wistar, Tyrosine analogs & derivatives, Tyrosine blood, Adrenal Glands metabolism, Catecholamines metabolism, Hyperhomocysteinemia metabolism, Methionine adverse effects, Prenatal Exposure Delayed Effects metabolism
Abstract

Catecholamine content has been studied in the adrenal gland of rat females whose pregnant mothers were loaded daily with L-methionine administered per os during all the pregnancy period, on the first day of postnatal life, and in one and two months after birth. The animal model of hyperhomocysteinemia used in the experiment has been shown to result in the catecholamine content decreasing in the adrenal gland of both newly born rat offspring with high serum level of homocysteine and one-month old offspring with their homocysteine level decreased to the normal values. It was found that nitrotyrosine level increased significantly in the blood serum of the offspring aged one and two months. The data obtained may testify to oxidative stress development.

Published
2014

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