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1. Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

Author

Murphy, Andrew J., Cheng, Changde, Williams, Justin, Shaw, Timothy I., Pinto, Emilia M., Dieseldorff-Jones, Karissa, Brzezinski, Jack, Renfro, Lindsay A., Tornwall, Brett, Huff, Vicki, Hong, Andrew L., Mullen, Elizabeth A., Crompton, Brian, Dome, Jeffrey S., Fernandez, Conrad V., Geller, James I., Ehrlich, Peter F., Mulder, Heather, Oak, Ninad, Maciezsek, Jamie, Jablonowski, Carolyn M., Fleming, Andrew M., Pichavaram, Prahalathan, Morton, Christopher L., Easton, John, Nichols, Kim E., Clay, Michael R., Santiago, Teresa, Zhang, Jinghui, Yang, Jun, Zambetti, Gerard P., Wang, Zhaoming, Davidoff, Andrew M., and Chen, Xiang

Published
2023
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2. Multiple TP53 p.R337H haplotypes and implications for tumor susceptibility

Author

Pinto, Emilia M., Fridman, Cintia, Figueiredo, Bonald C., Salvador, Hector, Teixeira, Manuel R., Pinto, Carla, Pinheiro, Manuela, Kratz, Christian P., Lavarino, Cinzia, Legal, Edith A.M. F., Le, Anh, Kelly, Gregory, Koeppe, Erika, Stoffel, Elena M., Breen, Kelsey, Hahner, Stefanie, Heinze, Britta, Techavichit, Piti, Krause, Amanda, Ogata, Tsutomu, Fujisawa, Yasuko, Walsh, Michael F., Rana, Huma Q., Maxwell, Kara N., Garber, Judy E., Rodriguez-Galindo, Carlos, Ribeiro, Raul C., and Zambetti, Gerard P.

Published
2024
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4. 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

Author

Zambetti Gerard P, Garrison Sean P, Bernstein Alison I, and O'Malley Karen L

Subjects
Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Background Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although the etiology is unknown, insight into the disease process comes from the dopamine (DA) derivative, 6-hydroxydopamine (6-OHDA), which produces PD-like symptoms. Studies show that 6-OHDA activates stress pathways, such as the unfolded protein response (UPR), triggers mitochondrial release of cytochrome-c, and activates caspases, such as caspase-3. Because the BH3-only protein, Puma (p53-upregulated mediator of apoptosis), is activated in response to UPR, it is thought to be a link between cell stress and apoptosis. Results To test the hypothesis that Puma serves such a role in 6-OHDA-mediated cell death, we compared the response of dopaminergic neurons from wild-type and Puma-null mice to 6-OHDA. Results indicate that Puma is required for 6-OHDA-induced cell death, in primary dissociated midbrain cultures as well as in vivo. In these cultures, 6-OHDA-induced DNA damage and p53 were required for 6-OHDA-induced cell death. In contrast, while 6-OHDA led to upregulation of UPR markers, loss of ATF3 did not protect against 6-OHDA. Conclusions Together, our results indicate that 6-OHDA-induced upregulation of Puma and cell death are independent of UPR. Instead, p53 and DNA damage repair pathways mediate 6-OHDA-induced toxicity.

Published
2011
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5. Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

Author

Srivastava Kumar, Ganti Ramapriya, Zambetti Gerard P, Ribeiro Raul C, Mastellaro Maria, Seidinger Ana, Assumpção Juliana G, Shurtleff Sheila, Pei Deqing, Zeferino Luiz, Dufloth Rozany M, Brandalise Silvia, and Yunes José

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not associated with Li-Fraumeni syndrome. However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context. Methods We conducted a case-control study to determine the prevalence of the R337H mutation by sequencing TP53 exon 10 in 123 women with breast cancer and 223 age- and sex-matched control subjects from southern Brazil. Fisher's test was used to compare the prevalence of the R337H. Results The R337H mutation was found in three patients but in none of the controls (p = 0.0442). Among the carriers, two had familial history of cancer meeting the Li-Fraumeni-like criteria. Remarkably, tumors in each of these three cases underwent loss of heterozygosity by eliminating the mutant TP53 allele rather than the wild-type allele. Polymorphisms were identified within the TP53 (R72P and Ins16) and MDM2 (SNP309) genes that may further diminish TP53 tumor suppressor activity. Conclusion These results demonstrate that the R337H mutation can significantly increase the risk of breast cancer in carriers, which likely depends on additional cooperating genetic factors. These findings are also important for understanding how low-penetrant mutant TP53 alleles can differentially influence tumor susceptibility.

Published
2008
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6. A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence

Author

Surakhy, Mirvat, Wallace, Marsha, Bond, Elisabeth, Grochola, Lukasz Filip, Perez, Husein, Di Giovannantonio, Matteo, Zhang, Ping, Malkin, David, Carter, Hannah, Parise, Ivy Zortea S, Zambetti, Gerard, Komechen, Heloisa, Paraizo, Mariana M, Pagadala, Meghana S, Pinto, Emilia M, Lalli, Enzo, Figueiredo, Bonald C, and Bond, Gareth L

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Prevention, Human Genome, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Cancer, Adolescent, Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Age Factors, Age of Onset, Alcohol Dehydrogenase, Child, Child, Preschool, Female, Genes, p53, Genome-Wide Association Study, Humans, Incidence, Infant, Male, Polymorphism, Single Nucleotide, Tretinoin, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundGenome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in Southern Brazil due to the TP53 p.R337H (R337H) germline mutation. The heterogeneous risk among carriers suggests other genetic modifiers could exist.MethodsWe analysed clinical, genotype and gene expression data derived from paediatric ACC, R337H carriers, and adult ACC patients. We restricted our analyses to single nucleotide polymorphisms (SNPs) previously identified in GWASs to associate with disease or human traits.ResultsA SNP, rs971074, in the alcohol dehydrogenase 7 gene significantly and reproducibly associated with allelic differences in ACC age-of-onset in both cohorts. Patients homozygous for the minor allele were diagnosed up to 16 years earlier. This SNP resides in a gene involved in the retinoic acid (RA) pathway and patients with differing levels of RA pathway gene expression in their tumours associate with differential ACC progression.ConclusionsThese results identify a novel genetic component to ACC development that resides in the retinoic acid pathway, thereby informing strategies to develop management, preventive and therapeutic treatments for ACC.

Published
2020

7. Pediatric Adrenocortical Carcinoma: The Nuts and Bolts of Diagnosis and Treatment and Avenues for Future Discovery.

Author

O'Neill, Allison F, Ribeiro, Raul C, Pinto, Emilia M, Clay, Michael R, Zambetti, Gerard P, Orr, Brent A, Weldon, Christopher B, and Rodriguez-Galindo, Carlos

Subjects
OVERALL survival, DNA methylation, SURGICAL excision, BOLTS & nuts, SYMPTOMS, ADRENAL tumors
Abstract

Adrenocortical tumors (ACTs) are infrequent neoplasms in children and adolescents and are typically associated with clinical symptoms reflective of androgen overproduction. Pediatric ACTs typically occur in the context of a germline TP53 mutation, can be cured when diagnosed at an early stage, but are difficult to treat when advanced or associated with concurrent TP53 and ATRX alterations. Recent work has demonstrated DNA methylation patterns suggestive of prognostic significance. While current treatment standards rely heavily upon surgical resection, chemotherapy, and hormonal modulation, small cohort studies suggest promise for multi-tyrosine kinases targeting anti-angiogenic pathways or immunomodulatory therapies. Future work will focus on novel risk stratification algorithms and combination therapies intended to mitigate toxicity for patients with perceived low-risk disease while intensifying therapy or accelerating discoveries aimed at improving survival for patients with difficult-to-treat disease. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Data from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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10. Supplementary Data File 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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11. Supplementary Figure 15 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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12. Supplementary Table 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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13. Supplementary Data File 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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14. Supplementary Methods from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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15. Supplementary Figure 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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16. Supplementary Table 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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17. Supplementary Figure 9 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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18. Supplementary Data File 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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19. Supplementary Figure 6 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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20. Supplementary Figure 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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21. Supplementary Figure 4 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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22. Supplementary Figure 8 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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23. Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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24. Supplementary Figure 7 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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25. Spatial trends in congenital malformations and stream water chemistry in Southern Brazil

Author

Ibañez, Humberto C., Melanda, Viviane S., Gerber, Viviane K.Q., Licht, Otavio A.B., Ibañez, Marilea V.C., Aguiar Júnior, Terêncio R., Mello, Rosiane G., Komechen, Heloisa, Andrade, Diancarlos P., Picharski, Gledson L., Figueiredo, Damasio P.G., Pianovski, Mara A.D., Figueiredo, Mirna M.O., Custódio, Gislaine, Parise, Ivy Z.S., Castilho, Laura M., Paraizo, Mariana M., Edinger, Chloe, Fiori, Carmem M.C.M., Pedrini, Hélio, Kiesel Filho, Nilton, Fabro, Ana Luiza M.R., Fachin, Rayssa D., Ogradowski, Karin R.P., Parise, Guilherme A., Saldiva, Paulo H.N., Legal, Edith F., Rosati, Roberto, Rodriguez-Galindo, Carlos, Ribeiro, Raul C., Zambetti, Gerard P., Lalli, Enzo, and Figueiredo, Bonald C.

Published
2019
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26. KDM5A Regulates a Translational Program that Controls p53 Protein Expression

Author

Hu, Dongli, Jablonowski, Carolyn, Cheng, Pei-Hsin, AlTahan, Alaa, Li, Chunliang, Wang, Yingdi, Palmer, Lance, Lan, Cuixia, Sun, Bingmei, Abu-Zaid, Ahmed, Fan, Yiping, Brimble, Mark, Gamboa, Nicolas T., Kumbhar, Ramhari C., Yanishevski, David, Miller, Kyle M., Kang, Guolian, Zambetti, Gerard P., Chen, Taosheng, Yan, Qin, Davidoff, Andrew M., and Yang, Jun

Published
2018
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29. Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., additional, Fang, Jie, additional, Fleming, Andrew M., additional, Gil, Hyea Jin, additional, Boghossian, Andrew S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Morton, Christopher L., additional, Zambetti, Gerard P., additional, Davidoff, Andrew M., additional, Yang, Jun, additional, and Murphy, Andrew J., additional

Published
2023
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35. Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

Author

Murphy, Andrew J., Chen, Xiang, Pinto, Emilia M., Williams, Justin S., Clay, Michael R., Pounds, Stanley B., Cao, Xueyuan, Shi, Lei, Lin, Tong, Neale, Geoffrey, Morton, Christopher L., Woolard, Mary A., Mulder, Heather L., Gil, Hyea Jin, Rehg, Jerold E., Billups, Catherine A., Harlow, Matthew L., Dome, Jeffrey S., Houghton, Peter J., Easton, John, Zhang, Jinghui, George, Rani E., Zambetti, Gerard P., and Davidoff, Andrew M.

Published
2019
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36. Pintotable1.xlsx from Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants

Author

Pinto, Emilia M., primary, Maxwell, Kara N., primary, Halalsheh, Hadeel, primary, Phillips, Aaron, primary, Powers, Jacquelyn, primary, MacFarland, Suzanne, primary, Walsh, Michael F., primary, Breen, Kelsey, primary, Formiga, Maria N., primary, Kriwacki, Richard, primary, Nichols, Kim E., primary, Mostafavi, Roya, primary, Wang, Jinling, primary, Clay, Michael R., primary, Rodriguez-Galindo, Carlos, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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37. Data from Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants

Author

Pinto, Emilia M., primary, Maxwell, Kara N., primary, Halalsheh, Hadeel, primary, Phillips, Aaron, primary, Powers, Jacquelyn, primary, MacFarland, Suzanne, primary, Walsh, Michael F., primary, Breen, Kelsey, primary, Formiga, Maria N., primary, Kriwacki, Richard, primary, Nichols, Kim E., primary, Mostafavi, Roya, primary, Wang, Jinling, primary, Clay, Michael R., primary, Rodriguez-Galindo, Carlos, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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38. Supplementary Materials, Supplementary Figures 1-5 from Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants

Author

Pinto, Emilia M., primary, Maxwell, Kara N., primary, Halalsheh, Hadeel, primary, Phillips, Aaron, primary, Powers, Jacquelyn, primary, MacFarland, Suzanne, primary, Walsh, Michael F., primary, Breen, Kelsey, primary, Formiga, Maria N., primary, Kriwacki, Richard, primary, Nichols, Kim E., primary, Mostafavi, Roya, primary, Wang, Jinling, primary, Clay, Michael R., primary, Rodriguez-Galindo, Carlos, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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39. Supplementary Table S2 from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Author

Jeffers, John R., primary, Pinto, Emilia M., primary, Rehg, Jerold E., primary, Clay, Michael R., primary, Wang, Jinling, primary, Neale, Geoffrey, primary, Heath, Richard J., primary, Lozano, Guillermina, primary, Lalli, Enzo, primary, Figueiredo, Bonald C., primary, Pappo, Alberto S., primary, Rodriguez-Galindo, Carlos, primary, Chen, Wenan, primary, Pounds, Stanley, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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40. Supplementary Figure S1 from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Author

Jeffers, John R., primary, Pinto, Emilia M., primary, Rehg, Jerold E., primary, Clay, Michael R., primary, Wang, Jinling, primary, Neale, Geoffrey, primary, Heath, Richard J., primary, Lozano, Guillermina, primary, Lalli, Enzo, primary, Figueiredo, Bonald C., primary, Pappo, Alberto S., primary, Rodriguez-Galindo, Carlos, primary, Chen, Wenan, primary, Pounds, Stanley, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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41. Supplementary Table 6 from Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study

Author

Pinto, Emilia Modolo, primary, Rodriguez-Galindo, Carlos, primary, Choi, John Kim, primary, Pounds, Stanley, primary, Liu, Zhifa, primary, Neale, Geoffrey, primary, Finkelstein, David, primary, Hicks, John M., primary, Pappo, Alberto S., primary, Figueiredo, Bonald C., primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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42. Data from A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers

Author

Powers, Jacquelyn, primary, Pinto, Emilia M., primary, Barnoud, Thibaut, primary, Leung, Jessica C., primary, Martynyuk, Tetyana, primary, Kossenkov, Andrew V., primary, Philips, Aaron H., primary, Desai, Heena, primary, Hausler, Ryan, primary, Kelly, Gregory, primary, Le, Anh N., primary, Li, Marilyn M., primary, MacFarland, Suzanne P., primary, Pyle, Louise C., primary, Zelley, Kristin, primary, Nathanson, Katherine L., primary, Domchek, Susan M., primary, Slavin, Thomas P., primary, Weitzel, Jeffrey N., primary, Stopfer, Jill E., primary, Garber, Judy E., primary, Joseph, Vijai, primary, Offit, Kenneth, primary, Dolinsky, Jill S., primary, Gutierrez, Stephanie, primary, McGoldrick, Kelly, primary, Couch, Fergus J., primary, Levin, Brooke, primary, Edelman, Morris C., primary, Levy, Carolyn Fein, primary, Spunt, Sheri L., primary, Kriwacki, Richard W., primary, Zambetti, Gerard P., primary, Ribeiro, Raul C., primary, Murphy, Maureen E., primary, and Maxwell, Kara N., primary

Published
2023
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43. Supplementary Data from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Author

Jeffers, John R., primary, Pinto, Emilia M., primary, Rehg, Jerold E., primary, Clay, Michael R., primary, Wang, Jinling, primary, Neale, Geoffrey, primary, Heath, Richard J., primary, Lozano, Guillermina, primary, Lalli, Enzo, primary, Figueiredo, Bonald C., primary, Pappo, Alberto S., primary, Rodriguez-Galindo, Carlos, primary, Chen, Wenan, primary, Pounds, Stanley, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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44. Supplementary Data from A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers

Author

Powers, Jacquelyn, primary, Pinto, Emilia M., primary, Barnoud, Thibaut, primary, Leung, Jessica C., primary, Martynyuk, Tetyana, primary, Kossenkov, Andrew V., primary, Philips, Aaron H., primary, Desai, Heena, primary, Hausler, Ryan, primary, Kelly, Gregory, primary, Le, Anh N., primary, Li, Marilyn M., primary, MacFarland, Suzanne P., primary, Pyle, Louise C., primary, Zelley, Kristin, primary, Nathanson, Katherine L., primary, Domchek, Susan M., primary, Slavin, Thomas P., primary, Weitzel, Jeffrey N., primary, Stopfer, Jill E., primary, Garber, Judy E., primary, Joseph, Vijai, primary, Offit, Kenneth, primary, Dolinsky, Jill S., primary, Gutierrez, Stephanie, primary, McGoldrick, Kelly, primary, Couch, Fergus J., primary, Levin, Brooke, primary, Edelman, Morris C., primary, Levy, Carolyn Fein, primary, Spunt, Sheri L., primary, Kriwacki, Richard W., primary, Zambetti, Gerard P., primary, Ribeiro, Raul C., primary, Murphy, Maureen E., primary, and Maxwell, Kara N., primary

Published
2023
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45. Data from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Author

Jeffers, John R., primary, Pinto, Emilia M., primary, Rehg, Jerold E., primary, Clay, Michael R., primary, Wang, Jinling, primary, Neale, Geoffrey, primary, Heath, Richard J., primary, Lozano, Guillermina, primary, Lalli, Enzo, primary, Figueiredo, Bonald C., primary, Pappo, Alberto S., primary, Rodriguez-Galindo, Carlos, primary, Chen, Wenan, primary, Pounds, Stanley, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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46. Supplementary Figure 1 from Establishment and Characterization of the First Pediatric Adrenocortical Carcinoma Xenograft Model Identifies Topotecan as a Potential Chemotherapeutic Agent

Author

Pinto, Emilia M., primary, Morton, Christopher, primary, Rodriguez-Galindo, Carlos, primary, McGregor, Lisa, primary, Davidoff, Andrew M., primary, Mercer, Kimberly, primary, Debelenko, Larisa V., primary, Billups, Catherine, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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47. Supplementary Table 5 from Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study

Author

Pinto, Emilia Modolo, primary, Rodriguez-Galindo, Carlos, primary, Choi, John Kim, primary, Pounds, Stanley, primary, Liu, Zhifa, primary, Neale, Geoffrey, primary, Finkelstein, David, primary, Hicks, John M., primary, Pappo, Alberto S., primary, Figueiredo, Bonald C., primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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48. Data Supplement from Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study

Author

Pinto, Emilia Modolo, primary, Rodriguez-Galindo, Carlos, primary, Choi, John Kim, primary, Pounds, Stanley, primary, Liu, Zhifa, primary, Neale, Geoffrey, primary, Finkelstein, David, primary, Hicks, John M., primary, Pappo, Alberto S., primary, Figueiredo, Bonald C., primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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49. Supplementary Figure 2 from Establishment and Characterization of the First Pediatric Adrenocortical Carcinoma Xenograft Model Identifies Topotecan as a Potential Chemotherapeutic Agent

Author

Pinto, Emilia M., primary, Morton, Christopher, primary, Rodriguez-Galindo, Carlos, primary, McGregor, Lisa, primary, Davidoff, Andrew M., primary, Mercer, Kimberly, primary, Debelenko, Larisa V., primary, Billups, Catherine, primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
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50. Supplementary Table 1 from Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study

Author

Pinto, Emilia Modolo, primary, Rodriguez-Galindo, Carlos, primary, Choi, John Kim, primary, Pounds, Stanley, primary, Liu, Zhifa, primary, Neale, Geoffrey, primary, Finkelstein, David, primary, Hicks, John M., primary, Pappo, Alberto S., primary, Figueiredo, Bonald C., primary, Ribeiro, Raul C., primary, and Zambetti, Gerard P., primary

Published
2023
Full Text
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