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1. Assessing sociodemographic and regional disparities in Oncotype DX Genomic Prostate Score uptake.

Author

Mukand, Nita H., Chirikova, Ekaterina, Lichtensztajn, Daphne, Negoita, Serban, Aboushwareb, Tamer, Bennett, John, Brooks, James D., Leppert, John T., Chung, Benjamin I., Li, Christopher, Schwartz, Stephen M., Gershman, Susan T., Insaf, Tabassum, Morawski, Bozena M., Stroup, Antionette, Wu, Xiao‐Cheng, Doherty, Jennifer A., Petkov, Valentina I., Zambon, Joao Paulo, and Gomez, Scarlett Lin

Subjects
HEALTH services accessibility, SOCIOECONOMIC disparities in health, SOCIAL determinants of health, PROSTATE cancer patients, RACE, PROSTATE cancer
Abstract

Background: The Oncotype DX Genomic Prostate Score (ODX‐GPS) is a gene expression assay that predicts disease aggressiveness. The objective of this study was to identify sociodemographic and regional factors associated with ODX‐GPS uptake. Methods: Data from Surveillance Epidemiology and End Results registries on men with localized prostate cancer with a Gleason score of 3 + 3 or 3 + 4, PSA ≤20 ng/mL, and stage T1c to T2c disease from 2013 through 2017 were linked with ODX‐GPS data. Census‐tract level neighborhood socioeconomic status (nSES) quintiles were constructed using a composite socioeconomic score. Multivariable logistic regression was used to estimate the associations of ODX‐GPS uptake with age at diagnosis, race and ethnicity, nSES, geographic region, insurance type, and marital status, accounting for National Comprehensive Cancer Network risk group, year of diagnosis, and clustering by census tract. Results: Among 111,434 eligible men, 5.5% had ODX‐GPS test uptake. Of these, 78.3% were non‐Hispanic White, 9.6% were Black, 6.7% were Hispanic, and 3.6% were Asian American. Black men had the lowest odds of ODX‐GPS uptake (odds ratio, 0.70; 95% confidence interval [CI], 0.63–0.76). Those in the highest versus lowest quintile of nSES were 1.64 times more likely (95% CI, 1.38–2.94) to have ODX‐GPS uptake. The odds of ODX‐GPS uptake were statistically significantly higher among men residing in the Northeast, West, and Midwest compared to the South. Conclusions: Disparities in ODX‐GPS uptake by race, ethnicity, nSES, and geographical region were identified. Concerted efforts should be made to ensure that this clinical test is equitably available. Among 2013–2017 cases of localized prostate cancer from the Surveillance, Epidemiology, and End Results registries, Black men, Hispanic men, and men living in the South had the lowest odds of Oncotype DX Genomic Prostate Score (ODX‐GPS) ordering. Oncotype DX‐GPS ordering increased monotonically with increasing neighborhood socioeconomic status at diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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5. One-shot versus multidose perioperative antibiotic prophylaxis after kidney transplantation: A randomized, controlled clinical trial

Author

Orlando, Giuseppe, Manzia, Tommaso Maria, Sorge, Roberto, Iaria, Giuseppe, Angelico, Roberta, Sforza, Daniele, Toti, Luca, Peloso, Andrea, Patel, Timil, Katari, Ravi, Zambon, Joao Paulo, Maida, Andrea, Salerno, Maria Paola, Clemente, Katia, Di Cocco, Pierpaolo, De Luca, Linda, Tariciotti, Laura, Famulari, Antonio, Citterio, Franco, Tisone, Giuseppe, Pisani, Francesco, and Romagnoli, Jacopo

Published
2015
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10. Contributors

Author

Abolbashari, Mehran, primary, Ahn, Jaimo, additional, Akel, Salem, additional, Allickson, Julie G., additional, Almeida-Porada, Graça, additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Au, Patrick, additional, Aufiero, Danielle, additional, Baptista, Pedro M., additional, Bartel, Ronnda L., additional, Bartholomew, Amelia, additional, Baum, Elona, additional, Bemden, Angie Botto-van, additional, Bitar, Khalil N., additional, Boxer, Lynne, additional, Brown, Matthew P., additional, Brown, Heather L., additional, Bryant, Stephanie J., additional, Carvalho, Pedro P., additional, Chandra, Prafulla, additional, Chapman, John R., additional, Das, Shreyasi, additional, Deegan, Daniel B., additional, Dhal, Abritee, additional, Donnenberg, Albert D., additional, Durdy, Matthew B., additional, Durfor, Charles N., additional, Edelman, Elazer R., additional, Fink, Donald, additional, Fischkoff, Steven, additional, Frey-Vasconcells, Joyce L., additional, Führmann, Tobias, additional, Gacchina Johnson, Carmen, additional, Gadish, Or, additional, Gambhir, Sanjiv S., additional, Gee, Adrian P., additional, Gomes, Manuela E., additional, Hankenson, Kurt D., additional, Hariri, Robert J., additional, Hatcher, Heather C., additional, Heidaran, Mohammad, additional, Huss, Ralf, additional, Hyde, John, additional, Ikada, Yoshito, additional, Jain, Deepak, additional, Jain, Paul A., additional, Jokerst, Jesse V., additional, Jungebluth, Philipp, additional, Kandyba, Eve, additional, Kaplan, David S., additional, Karandish, Safa, additional, Kasper, F. Kurtis, additional, Kelkar, Sneha S., additional, Kenyon, Norma, additional, Kobielak, Krzysztof, additional, Kramer, Jesse, additional, Lee, Sang Jin, additional, Lee, Mark H., additional, Leung, Yvonne, additional, Lim, Mei Ling, additional, Littman, Neil J., additional, Macchiarini, Paolo, additional, Malik, Nafees N., additional, Mann, Brenda K., additional, Marra, Kacey G., additional, Marx, Robert E., additional, Mastrangelo, Lina, additional, McCright, Brent, additional, McFarland, Richard, additional, Mendicino, Michael, additional, Mikos, Antonios G., additional, Mitrousis, Nikolaos, additional, Mohs, Aaron M., additional, Moore, Thomas, additional, Moran, Emma C., additional, Niles, Walter, additional, Niu, Guoguang, additional, Nomi, Masashi, additional, Nunez, Tamara, additional, Perry, Robert, additional, Pfotenhauer, Robert P., additional, Porada, Christopher D., additional, Premenand, Kavitha, additional, Prestwich, Glenn D., additional, Raghavan, Shreya, additional, Rao, Mahendra, additional, Ratcliffe, Anthony, additional, Rego, Stephen, additional, Reis, Rui L., additional, Rich, Ivan N., additional, Rodrigues, Márcia T., additional, Rubin, J. Peter, additional, Sampson, Steven, additional, Sapoznik, Etai, additional, Sharp, John G., additional, Shoichet, Molly S., additional, Skuk, Daniel, additional, Snyder, Evan Y., additional, Soker, Shay, additional, Somara, Sita, additional, Spencer, Tom, additional, Stewart, Suzanne, additional, Sundivakkam, Premenand, additional, Szilagyi, Erszebet, additional, Tatara, Alexander M., additional, Tobe, Brian, additional, Tremblay, Jacques P., additional, Trounson, Alan O., additional, Tuladhar, Anup, additional, Tull, Lori, additional, Valentin, Jolene E., additional, Vyas, Dipen, additional, Wang, Zhan, additional, Winquist, Alicia, additional, Witten, Celia, additional, Wong, Mark E.K., additional, Yoo, James J., additional, Yoon, Diana, additional, Zakhem, Elie, additional, and Zambon, Joao Paulo, additional

Published
2015
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11. Renal System

Author

Zambon, Joao Paulo, primary, Chandra, Prafulla, additional, Atala, Anthony, additional, and Yoo, James J., additional

Published
2015
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12. Pancreatic Islets Regeneration

Author

Patel, Timil, primary, Salvatori, Marcus, additional, Hemal, Sij, additional, Peloso, Andrea, additional, Katari, Ravi, additional, Zambon, Joao Paulo, additional, Soker, Shay, additional, and Orlando, Giuseppe, additional

Published
2014
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13. List of Contributors

Author

Afroze, Syeda H., primary, Alpini, Gianfranco, additional, Anderson, Eric C., additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baiguera, Silvia, additional, Baiocchi, Leonardo, additional, Baptista, Pedro M., additional, Bejarano-Pineda, Lorena, additional, Benedetti, Enrico, additional, Beraldi, Rosanna, additional, Berdichevski, Alexandra, additional, Bhuyan, Mohammod, additional, Bishop, Alex G., additional, Bitar, Khalil N., additional, Blose, Kory J., additional, Brasile, Lauren, additional, Braza, Faouzi, additional, Breuer, Christopher K., additional, Brouard, Sophie, additional, Brown, Bryan N., additional, Burke, George W., additional, Butler, Peter E., additional, Butler, Colin R., additional, Calderon, Damelys, additional, Cancedda, Ranieri, additional, Cantero Peral, Susana, additional, Carbone, Marco, additional, Castanares-Zapatero, Diego, additional, Castro Santa, Edward, additional, Chatenoud, Lucienne, additional, Chawla, Reema, additional, Chen, Linda, additional, Chiono, Valeria, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Ciccarelli, Olga, additional, Collienne, Christine, additional, Corradini, Francesca, additional, Cortiella, Joaquin, additional, Cravedi, Paolo, additional, Cypel, Marcelo, additional, Da Sacco, Stefano, additional, Date, Hiroshi, additional, Davies, Paige S., additional, De Coppi, Paolo, additional, De Luca, Michele, additional, Dean, Ethan W., additional, Degauque, Nicolas, additional, Domínguez-Bendala, Juan, additional, Dubernard, Jean Michel, additional, ElBackly, Rania M., additional, English, Karen, additional, Fändrich, Fred, additional, Farney, Alan C., additional, Faulk, Denver M., additional, García-Arrarás, José E., additional, Gianello, Pierre, additional, Giangreco, Adam, additional, Glaser, Shannon S., additional, Gobble, Ryan, additional, Goldstein, Aaron S., additional, Grant, Christa N., additional, Grikscheit, Tracy C., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guillot, Pascale V., additional, Hamilton, Nicholas, additional, Hantson, Philippe, additional, Hemal, Sij, additional, Hematti, Peiman, additional, Hynds, Robert E., additional, Inverardi, Luca, additional, Jacquet, Luc M., additional, Janes, Sam M., additional, Jell, Gavin, additional, Jensen, Kendal, additional, Jochmans, Ina, additional, Kanai, Nobuo, additional, Katari, Ravi, additional, Keshavjee, Shaf, additional, Kim, Jaehyup, additional, Kim, Yeonhee, additional, King, Nancy M.P., additional, Kobayashi, Eiji, additional, Koshiba, Takaaki, additional, Krawiec, Jeffrey T., additional, Kurobe, Hirotsugu, additional, Lai, Quirino, additional, Lanzoni, Giacomo, additional, Laterre, Pierre-François, additional, Lerut, Jan P., additional, Lerut, Toni, additional, Li, Ou, additional, Macchiarini, Paolo, additional, Maghsoudlou, Panagiotis, additional, Mamode, Nizam, additional, Manzia, Tommaso M., additional, Martinez-Fernandez, Almudena, additional, Martovetsky, Gleb, additional, Mastrogiacomo, Maddalena, additional, Masuda, Shigeo, additional, McQuilling, John P., additional, Mehra, Mandeep R., additional, Menasché, Philippe, additional, Meng, Fanyin, additional, Mironi-Harpaz, Iris, additional, Mirzazadeh, Majid, additional, Moiemen, Naiem S., additional, Moran, Emma, additional, Muiesan, Paolo, additional, Nardo, Tiziana, additional, Nelson, Timothy J, additional, Netti, Paolo A., additional, Neuberger, James M., additional, Nigam, Sanjay K., additional, Ohe, Hidenori, additional, Okano, Teruo, additional, Opara, Emmanuel C., additional, Orgill, Dennis P., additional, Otte, Jean-Bernard, additional, Ozer, Sinan, additional, Pareta, Rajesh A., additional, Patel, Timil, additional, Pellegrini, Graziella, additional, Peloso, Andrea, additional, Perin, Laura, additional, Petruzzo, Palmina, additional, Pinheiro, Rafael S., additional, Pirenne, Jacques, additional, Poindexter, Lauren K., additional, Pucéat, Michel, additional, Pugliese, Alberto, additional, Raghavan, Shreya, additional, Rahal, Kinan, additional, Rama, Paolo, additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Reyna-Soriano, Daniel, additional, Rico Juri, Juan M., additional, Ricordi, Camillo, additional, Roberts, Keith J., additional, Rocco, Kevin A., additional, Rodriguez-Devora, Jorge I., additional, Rogers, Jeffrey, additional, Rudnick, David A., additional, Ruggenenti, Piero, additional, Sageshima, Junichiro, additional, Salvatori, Marcus, additional, Samavedi, Satyavrata, additional, Sannino, Alessandro, additional, Scalera, Irene, additional, Sedaghati, Tina, additional, Sedrakyan, Sargis, additional, Seifalian, Alexander M., additional, Seifalian, Amelia, additional, Seliktar, Dror, additional, Selvaggi, Gennaro, additional, Shapira-Schweitzer, Keren, additional, Shinoka, Toshiharu, additional, Shupe, Thomas, additional, Smith, Nicholas R., additional, Soulillou, Jean-Paul, additional, Spinelli, Valentina, additional, Sutherland, David E.R., additional, Tara, Shuhei, additional, Teratani, Takumi, additional, Terzic, Andre, additional, Thomas, Sunu S., additional, Tisone, Giuseppe, additional, Totonelli, Giorgia, additional, Tzakis, Andreas, additional, Tzvetanov, Ivo G., additional, Udelsman, Brooks V., additional, Uygun, Basak E., additional, Vacanti, Joseph P., additional, Van Caenegem, Olivier, additional, Van Dyke, Mark, additional, Van Raemdonck, Dirk E., additional, Vorp, David A., additional, Vyas, Dipen, additional, Wang, Kun, additional, Weinbaum, Justin S., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wittebole, Xavier, additional, Wong, Melissa H., additional, Wood, Kathryn J., additional, Xu, Tao, additional, Yamato, Masayuki, additional, You, Sylvaine, additional, Yuan, Yuyu, additional, Zambon, Joao Paulo, additional, Zattoni, Michela, additional, and Zhu, Lei, additional

Published
2014
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21. Kidney transplantation, bioengineering and regeneration: an originally immunology-based discipline destined to transition towards ad hoc organ manufacturing and repair

Author

Rogers, Jeffrey, primary, Katari, Ravi, additional, Gifford, Sheyna, additional, Tamburrini, Riccardo, additional, Edgar, Lauren, additional, Voigt, Marcia R, additional, Murphy, Sean V, additional, Igel, Daniel, additional, Mancone, Sara, additional, Callese, Tyler, additional, Colucci, Nicola, additional, Mirzazadeh, Majid, additional, Peloso, Andrea, additional, Zambon, Joao Paulo, additional, Farney, Alan C, additional, Stratta, Robert J, additional, and Orlando, Giuseppe, additional

Published
2015
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23. Renal Extracellular Matrix Scaffolds From Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retains Critical Growth Factors

Author

Peloso, Andrea, primary, Petrosyan, Astgik, additional, Da Sacco, Stefano, additional, Booth, Christopher, additional, Zambon, Joao Paulo, additional, O'Brien, Timothy, additional, Aardema, Charles, additional, Robertson, John, additional, De Filippo, Roger E, additional, Soker, Shay, additional, Stratta, Robert J, additional, Perin, Laura, additional, and Orlando, Giuseppe, additional

Published
2015
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25. Histological changes induced by Polyglycolic-Acid (PGA) scaffolds seeded with autologous adipose or muscle-derived stem cells when implanted on rabbit bladder

Author

Zambon, Joao Paulo, primary, de Sá Barretto, Letícia Siqueira, additional, Nakamura, Ahy Nathally Sawaki e, additional, Duailibi, Silvio, additional, Leite, Kátia, additional, Magalhaes, Renata S, additional, Orlando, Giuseppe, additional, Ross, Christina L, additional, Peloso, Andrea, additional, and Almeida, Fernando G, additional

Published
2014
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29. Kidney transplantation, bioengineering and regeneration: an originally immunology-based discipline destined to transition towards ad hoc organ manufacturing and repair.

Author

Rogers, Jeffrey, Katari, Ravi, Gifford, Sheyna, Tamburrini, Riccardo, Edgar, Lauren, Voigt, Marcia R, Murphy, Sean V, Igel, Daniel, Mancone, Sara, Callese, Tyler, Colucci, Nicola, Mirzazadeh, Majid, Peloso, Andrea, Zambon, Joao Paulo, Farney, Alan C, Stratta, Robert J, and Orlando, Giuseppe

Subjects
KIDNEY transplantation, TREATMENT of chronic kidney failure, BIOENGINEERING, REGENERATIVE medicine, AUTOGRAFTS, EXTRACELLULAR matrix
Abstract

Kidney transplantation (KT), as a modality of renal replacement therapy (RRT), has been shown to be both economically and functionally superior to dialysis for the treatment of end-stage renal disease (ESRD). Progress in KT is limited by two major barriers: a) a chronic and burgeoning shortage of transplantable organs and b) the need for chronic immunosuppression following transplantation. Although ground-breaking advances in transplant immunology have improved patient survival and graft durability, a new pathway of innovation is needed in order to overcome current obstacles. Regenerative medicine (RM) holds the potential to shift the paradigm in RRT, through organ bioengineering. Manufactured organs represent a potentially inexhaustible source of transplantable grafts that would bypass the need for immunosuppressive drugs by using autologous cells to repopulate extracellular matrix (ECM) scaffolds. This overview discusses the current status of renal transplantation while reviewing the most promising innovations in RM therapy as applied to RRT. [ABSTRACT FROM PUBLISHER]

Published
2016
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