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1. THU-500 Networks in focus: profile of immune-related adverse events in first-line immunotherapy for hepatocellular carcinoma

Author

Fortuny, Marta, primary, García-Calonge, Marta, additional, Arrabal, Oscar, additional, Zamparelli, Marco Sanduzzi, additional, Castano-Garcia, Andrés, additional, Iserte, Gemma, additional, Piedra-Cerezal, Ana Maria, additional, Llarch, Neus, additional, Mauro, Ezequiel, additional, Mesa, Alicia, additional, Rodriguez, Manuel, additional, Saborido, Belen, additional, Rimola, Jordi, additional, Torres, Ferran, additional, Varela, Maria, additional, and Reig, María, additional

Published
2024
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4. Macrotrabecular-massive pattern is associated with aggressive factors, but it is not an independent predictor of tumor recurrence and overall survival in patients with hepatocellular carcinoma treated with liver resection

Author

Mauro, Ezequiel, primary, Fuster, Carla, additional, Ferrer, Joana, additional, Caballol, Berta, additional, Zamparelli, Marco Sanduzzi, additional, Bruix, Jordi, additional, Fuster, Josep, additional, Reig, María, additional, Díaz, Alba, additional, and Forner, Alejandro, additional

Published
2023
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5. Interim analysis of the ACTION trial: Cabozantinib for hepatocellular carcinoma patients who discontinued first line treatment other than sorafenib or due to sorafenib intolerance

Author

Zamparelli, Marco Sanduzzi, primary, Martinez, Sergio Muñoz, additional, Calvo, Mariona, additional, Varela, Maria, additional, Llarch, Neus, additional, Iserte, Gemma, additional, Laquente, Berta, additional, Castano-Garcia, Andrés, additional, Lledó, José Luis, additional, Perelló, Christie, additional, Domenech, Gemma, additional, Mauro, Ezequiel, additional, García-Criado, Maria Ángeles, additional, Ayuso, Carmen, additional, Kateb, Angels, additional, Rimola, Jordi, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2023
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6. Early Nivolumab addition to Regorafenib in patients with hepatocellular carcinoma progressing under 1st line therapy (GOING trial). Interim analysis and safety profile

Author

Zamparelli, Marco Sanduzzi, primary, Matilla, Ana M, additional, Lledó, Jose Luis, additional, Martinez, Sergio Muñoz, additional, Varela, Maria, additional, Iñarrairaegui, Mercedes, additional, Perelló, Christie, additional, Minguez, Beatriz, additional, Llarch, Neus, additional, Perez, Laura Marquez, additional, Guerrero, Antonio, additional, Iserte, Gemma, additional, Castano-Garcia, Andrés, additional, Carrión, Laura, additional, Rimola, Jordi, additional, García-Criado, Maria Ángeles, additional, Domenech, Gema, additional, Boix, Loreto, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2022
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7. The evolutionary scenario of hepatocellular carcinoma in Italy: an update

Author

Bucci, Laura, Garuti, Francesca, Lenzi, Barbara, Pecorelli, Anna, Farinati, Fabio, Giannini, Edoardo G., Granito, Alessandro, Ciccarese, Francesca, Rapaccini, Gian Lodovico, Di Marco, Maria, Caturelli, Eugenio, Zoli, Marco, Borzio, Franco, Sacco, Rodolfo, Cammà, Calogero, Virdone, Roberto, Marra, Fabio, Felder, Martina, Morisco, Filomena, Benvegnù, Luisa, Gasbarrini, Antonio, Svegliati‐Baroni, Gianluca, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Colecchia, Antonio, Bernardi, Mauro, Trevisani, Franco, Biselli, Maurizio, Caraceni, Paolo, Cucchetti, Alessandro, Domenicali, Marco, Gramenzi, Annagiulia, Magalotti, Donatella, Napoli, Lucia, Negrini, Giulia, Piscaglia, Fabio, Serra, Carla, Tovoli, Francesco, Marafatto, Filippo, Murer, Francesca, Peserico, Giulia, Pozzan, Caterina, Vanin, Veronica, Moscatelli, Alessandro, Pellegatta, Gaia, Picciotto, Antonino, Savarino, Vincenzo, Poggio, Paolo Del, Olmi, Stefano, de Matthaeis, Nicoletta, Balsamo, Claudia, Vavassori, Elena, Roselli, Paola, Dell’Isola, Serena, Ialungo, Anna Maria, Rastrelli, Elena, Barcellona, Maria Rosa, Cabibbo, Giuseppe, Costantino, Andrea, Maida, Marcello, Affronti, Andrea, Mega, Andrea, Rinninella, Emanuele, Mismas, Valeria, Dall’Aglio, Anna Chiara, Feletti, Valentina, Lanzi, Arianna, Cappa, Federica Mirici, Neri, Elga, Stefanini, Giuseppe Francesco, Tamberi, Stefano, Biasini, Elisabetta, Porro, Emanuela, Guarino, Maria, Gemini, Stefano, Schiadà, Laura, Chiaramonte, Maria, Marchetti, Fabiana, Valerio, Matteo, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Coccoli, Piero, Zamparelli, Marco Sanduzzi, Aburas, Sami, and Inghilesi, Andrea Lorenzo

Published
2017
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8. Hepatocellular carcinoma recurrence in patients with curative resection or ablation: impact of HCV eradication does not depend on the use of interferon

Author

Petta, S., Cabibbo, G., Barbara, M., Attardo, S., Bucci, L., Farinati, F., Giannini, E. G., Tovoli, F., Ciccarese, F., Rapaccini, G. L., Di Marco, M., Caturelli, E., Zoli, M., Borzio, F., Sacco, R., Virdone, R., Marra, F., Felder, M., Morisco, F., Benvegnù, L., Gasbarrini, A., Svegliati‐Baroni, G., Foschi, F. G., Olivani, A., Masotto, A., Nardone, G., Colecchia, A., Persico, M., Boccaccio, V., Craxì, A., Bruno, S., Trevisani, F., Cammà, C., Biselli, Maurizio, Caraceni, Paolo, Cucchetti, Alessandro, Domenicali, Marco, Piscaglia, Fabio, Gramenzi, Annagiulia, Granito, Alessandro, Magalotti, Donatella, Serra, Carla, Negrini, Giulia, Napoli, L., Napoli, Lucia, Salvatore, Veronica, Benevento, Francesca, Gazzola, Alessia, Murer, Francesca, Pozzan, Caterina, Vanin, Veronica, Moscatelli, Alessandro, Pellegatta, Gaia, Picciotto, Antonino, Savarino, Vincenzo, Poggio, Paolo Del, Olmi, Stefano, de Matthaeis, Nicoletta, Balsamo, Claudia, Vavassori, Elena, Roselli, Paola, DellʼIsola, Serena, Ialungo, Anna Maria, Rastrelli, Elena, Rini, Francesca, Costantino, Andrea, Affronti, Andrea, Affronti, Marco, Mascari, Marta, Mega, Andrea, Pompili, Maurizio, Rinninella, Emanuele, Mismas, Valeria, DallʼAglio, Anna Chiara, Feletti, Valentina, Lanzi, Arianna, Cappa, Federica Mirici, Neri, Elga, Stefanini, Giuseppe Francesco, Tamberi, Stefano, Biasini, Elisabetta, Missale, Gabriele, Guarino, Maria, Ortolani, Alessio, Chiaramonte, Maria, Marchetti, Fabiana, Valerio, Matteo, Aburas, Sami, Inghilesi, Andrea L., Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Coccoli, Piero, and Zamparelli, Marco Sanduzzi

Published
2017
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9. THU-124 - Interim analysis of the ACTION trial: Cabozantinib for hepatocellular carcinoma patients who discontinued first line treatment other than sorafenib or due to sorafenib intolerance

Author

Zamparelli, Marco Sanduzzi, Martinez, Sergio Muñoz, Calvo, Mariona, Varela, Maria, Llarch, Neus, Iserte, Gemma, Laquente, Berta, Castano-Garcia, Andrés, Lledó, José Luis, Perelló, Christie, Domenech, Gemma, Mauro, Ezequiel, García-Criado, Maria Ángeles, Ayuso, Carmen, Kateb, Angels, Rimola, Jordi, Bruix, Jordi, and Reig, María

Published
2023
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11. Regorafenib improves survival after sorafenib treatment in patients with recurrent hepatocellular carcinoma after liver transplantation, compared to best supportive care

Author

Iavarone, Massimo, primary, Invernizzi, Federica, additional, Zavaglia, Claudio, additional, Zamparelli, Marco Sanduzzi, additional, Fraile, Miguel, additional, Czauderna, Carolin, additional, Di Costanzo, Giuseppe, additional, Bhoori, Sherrie, additional, Pinter, Matthias, additional, Manini, Matteo Angelo, additional, Amaddeo, Giuliana, additional, Fernandez, Ainhoa, additional, Pinero, Federico, additional, Blanco Rodriguez, Maria Jose, additional, Anders, Maria Margarita, additional, Aballay Soteras, Gabriel Alejandro, additional, Villadsen, Gerda Elisabeth, additional, Cesarini, Lucia, additional, Mazza, Stefano, additional, Díaz-Gonzázlez, Álvaro, additional, Gonzalez Dieguez, Maria Luisa, additional, Tortora, Raffaella, additional, Weinmann, Arndt, additional, Mazzaferro, Vincenzo, additional, Romero, Mario, additional, Crespo, Gonzalo, additional, Regnault, Helene, additional, De Giorgio, Massimo, additional, Varela, Maria, additional, Donato, Maria Francesca, additional, Worns, Marcus-Alexander, additional, Bruix, Jordi, additional, Lampertico, Pietro, additional, and Reig, María, additional

Published
2020
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12. Empowerment of liver cancer patients for an improved management of post-embolization syndrome: impact of a nurses educational program

Author

Llarch, Neus, primary, Iserte, Gemma, additional, Sapena, Víctor, additional, Zamparelli, Marco Sanduzzi, additional, Martinez, Sergio Muñoz, additional, Burrel, Marta, additional, Barrufet, Marta, additional, Bermudez, Patricia, additional, Darnell, Anna, additional, Forner, Alejandro, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2020
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13. Impact of a nurse educational program for patient empowerment during sequential systemic therapy for hepatocellular carcinoma

Author

Iserte, Gemma, primary, Llarch, Neus, additional, Sapena, Vićtor, additional, Zamparelli, Marco Sanduzzi, additional, Martinez, Sergio Muñoz, additional, Forner, Alejandro, additional, Rimola, Jordi, additional, Darnell, Anna, additional, Belmonte, Ernest, additional, Ayuso, Carmen, additional, Bruix, Jordi, additional, and Reig, Mariá, additional

Published
2020
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14. The “six-and-twelve” score in a prospective cohort of patients with hepatocellular carcinoma treated with trans-arterial chemoembolization following a fixed schedule

Author

Zamparelli, Marco Sanduzzi, primary, Burrel, Marta, additional, Darnell, Anna, additional, Sapena, Víctor, additional, Barrufet, Marta, additional, Bermudez, Patricia, additional, Sotomayot, Alejandro, additional, Llarch, Neus, additional, Iserte, Gemma, additional, Belmonte, Ernest, additional, Forner, Alejandro, additional, Rimola, Jordi, additional, Ayuso, Carmen, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2020
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15. THU584 - Early Nivolumab addition to Regorafenib in patients with hepatocellular carcinoma progressing under 1st line therapy (GOING trial). Interim analysis and safety profile

Author

Zamparelli, Marco Sanduzzi, Matilla, Ana M, Lledó, Jose Luis, Martinez, Sergio Muñoz, Varela, Maria, Iñarrairaegui, Mercedes, Perelló, Christie, Minguez, Beatriz, Llarch, Neus, Perez, Laura Marquez, Guerrero, Antonio, Iserte, Gemma, Castano-Garcia, Andrés, Carrión, Laura, Rimola, Jordi, García-Criado, Maria Ángeles, Domenech, Gema, Boix, Loreto, Bruix, Jordi, and Reig, María

Published
2022
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16. A meta-analysis of single HCV-untreated arm of studies evaluating outcomes after curative treatments of HCV-related hepatocellular carcinoma

Author

Cabibbo, Giuseppe, Petta, Salvatore, Barbã ra, Marco, Missale, Gabriele, Virdone, Roberto, Caturelli, Eugenio, Piscaglia, Fabio, Morisco, Filomena, Colecchia, Antonio, Farinati, Fabio, Giannini, Edoardo, Trevisani, Franco, Craxã¬, Antonio, Colombo, Massimo, Cammã , Calogero, Bucci, Laura, Zoli, Marco, Garuti, Francesca, Lenzi, Barbara, Biselli, Maurizio, Caraceni, Paolo, Cucchetti, Alessandro, Gramenzi, Annagiulia, Granito, Alessandro, Magalotti, Donatella, Serra, Carla, Negrini, Giulia, Napoli, Lucia, Salvatore, Veronica, Benevento, Francesca, Benvegnã¹, Luisa, Gazzola, Alessia, Murer, Francesca, Pozzan, Caterina, Vanin, Veronica, Moscatelli, Alessandro, Pellegatta, Gaia, Picciotto, Antonino, Savarino, Vincenzo, Ciccarese, Francesca, Del Poggio, Paolo, Olmi, Stefano, de Matthaeis, Nicoletta, Balsamo, Mariella Di Marco Claudia, Vavassori, Elena, Roselli, Paola, Dell’Isola, Serena, Ialungo, Anna Maria, Rastrelli, Elena, Attardo, Simona, Rossi, Margherita, Costantino, Andrea, Affronti, Andrea, Affronti, Marco, Mascari, Marta, Felder, Martina, Mega, Andrea, Gasbarrini, Antonio, Pompili, Maurizio, Rinninella, Emanuele, Sacco, Rodolfo, Mismas, Valeria, Foschi, Francesco Giuseppe, Dall’Aglio, Anna Chiara, Feletti, Valentina, Lanzi, Arianna, Cappa, Federica Mirici, Neri, Elga, Stefanini, Giuseppe Francesco, Tamberi, Stefano, Olivani, Andrea, Biasini, Elisabetta, Nardone, Gerardo, Guarino, Maria, Svegliati-Baroni, Gialuca, Ortolani, Alessio, Masotto, Alberto, Marchetti, Fabiana, Valerio, Matteo, Marra, Fabio, Aburas, Sami, Inghilesi, Andrea L, Cappelli, Alberta, Golfieri, Rita, Mosconi, MARIA CRISTINA, Renzulli, Matteo, Coccoli, Piero, Zamparelli, Marco Sanduzzi, Benvegnu', Luisa, Cabibbo, Giuseppe, Petta, Salvatore, Barbàra, Marco, Missale, Gabriele, Virdone, Roberto, Caturelli, Eugenio, Piscaglia, Fabio, Morisco, Filomena, Colecchia, Antonio, Farinati, Fabio, Giannini, Edoardo, Trevisani, Franco, Craxì, Antonio, Colombo, Massimo, Cammà, Calogero, Nardone, GERARDO ANTONIO PIO, Cabibbo, G., Petta, S., Barbara, M., Missale, G., Virdone, R., Caturelli, E., Piscaglia, F., Morisco, F., Colecchia, A., Farinati, F., Giannini, E., Trevisani, F., Craxi, A., Colombo, M., Camma, C., Bucci, L., Zoli, M., Garuti, F., Lenzi, B., Biselli, M., Caraceni, P., Cucchetti, A., Gramenzi, A., Granito, A., Magalotti, D., Serra, C., Negrini, G., Napoli, L., Salvatore, V., Benevento, F., Benvegnu, L., Gazzola, A., Murer, F., Pozzan, C., Vanin, V., Moscatelli, A., Pellegatta, G., Picciotto, A., Savarino, V., Ciccarese, F., Del Poggio, P., Olmi, S., de Matthaeis, N., Balsamo, M. D. M. C., Vavassori, E., Roselli, P., Dell'Isola, S., Ialungo, A. M., Rastrelli, E., Attardo, S., Rossi, M., Costantino, A., Affronti, A., Affronti, M., Mascari, M., Felder, M., Mega, A., Gasbarrini, A., Pompili, M., Rinninella, E., Sacco, R., Mismas, V., Foschi, F. G., Dall'Aglio, A. C., Feletti, V., Lanzi, A., Cappa, F. M., Neri, E., Stefanini, G. F., Tamberi, S., Olivani, A., Biasini, E., Nardone, G., Guarino, M., Svegliati-Baroni, G., Ortolani, A., Masotto, A., Marchetti, F., Valerio, M., Marra, F., Aburas, S., Inghilesi, A. L., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Coccoli, P., Zamparelli, M. S., Barbã ra, Marco, Craxã¬, Antonio, Cammã , Calogero, Bucci, Laura, Zoli, Marco, Garuti, Francesca, Lenzi, Barbara, Biselli, Maurizio, Caraceni, Paolo, Cucchetti, Alessandro, Gramenzi, Annagiulia, Granito, Alessandro, Magalotti, Donatella, Serra, Carla, Negrini, Giulia, Napoli, Lucia, Salvatore, Veronica, Benevento, Francesca, Benvegnã¹, Luisa, Gazzola, Alessia, Murer, Francesca, Pozzan, Caterina, Vanin, Veronica, Moscatelli, Alessandro, Pellegatta, Gaia, Picciotto, Antonino, Savarino, Vincenzo, Ciccarese, Francesca, Del Poggio, Paolo, Olmi, Stefano, de Matthaeis, Nicoletta, Balsamo, Mariella Di Marco Claudia, Vavassori, Elena, Roselli, Paola, Dellâ isola, Serena, Ialungo, Anna Maria, Rastrelli, Elena, Attardo, Simona, Rossi, Margherita, Costantino, Andrea, Affronti, Andrea, Affronti, Marco, Mascari, Marta, Felder, Martina, Mega, Andrea, Gasbarrini, Antonio, Pompili, Maurizio, Rinninella, Emanuele, Sacco, Rodolfo, Mismas, Valeria, Foschi, Francesco Giuseppe, Dallâ aglio, Anna Chiara, Feletti, Valentina, Lanzi, Arianna, Federica Mirici, Cappa, Neri, Elga, Stefanini, Giuseppe Francesco, Tamberi, Stefano, Olivani, Andrea, Biasini, Elisabetta, Nardone, Gerardo, Guarino, Maria, Svegliati-Baroni, Gialuca, Ortolani, Alessio, Masotto, Alberto, Marchetti, Fabiana, Valerio, Matteo, Marra, Fabio, Aburas, Sami, Inghilesi, Andrea L, Cappelli, Alberta, Golfieri, Rita, Mosconi, Cristina, Renzulli, Matteo, Coccoli, Piero, Zamparelli, Marco Sanduzzi, Camma', C., Benvegnã¹, L., Balsamo, M., Dell’Isola, S., Ialungo, A., Foschi, F., Dall’Aglio, A., Cappa, F., Stefanini, G., Inghilesi, A., and Zamparelli, M.

Subjects
Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, recurrence, Hepatitis C virus, medicine.medical_treatment, medicine.disease_cause, survival, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Adjuvant therapy, hepatocellular carcinoma, prognosis, recurrences, Humans, Survival analysis, Hepatology, business.industry, Liver Neoplasms, medicine.disease, Hepatitis C, 030220 oncology & carcinogenesis, Meta-analysis, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, Adjuvant, prognosi
Abstract

Background & Aims: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival. Methods: Studies reporting time-dependent outcomes (HCC recurrence or death) after potentially curative treatment of HCV-related early HCC were identified in MEDLINE through May 2016. Data on patient populations and outcomes were extracted from each study by three independent observers and combined using a distribution-free summary survival curve. Primary outcomes were actuarial probabilities of recurrence and survival. Results: Eleven studies met the inclusion criteria. Pooled estimates of actuarial recurrence rates were 7.4% at 6months and 47.0% at 2years. Pooled estimates of actuarial survival rates were 79.8% at 3years and 58.6% at 5years. Heterogeneity among studies was highly significant for all outcomes. By univariate meta-regression analyses, lower serum albumin, randomized controlled trial study design and follow-up were independently associated with higher recurrence risk, whereas tumour size and alpha-foetoprotein levels were associated with higher mortality. Conclusions: This meta-analysis showed that recurrence risk and survival are extremely variable in patients with successfully treated HCV-related HCC, providing a useful benchmark for indirect comparisons of the benefits of DAAs and for a correct design of randomized controlled trials in the adjuvant setting.

Published
2017

17. SAT-483-Hepatic epithelioid hemangioendotelioma: An international multicenter study

Author

Zamparelli, Marco Sanduzzi, primary, Rimola, Jordi, additional, Montironi, Carla, additional, Nunes, Vinicius, additional, Alves, Venancio Avancini Ferreira, additional, Sapena, Víctor, additional, Forner, Alejandro, additional, Carrilho, Flair Jose, additional, Díaz, Alba, additional, Fuster, Carla, additional, Ferrer, Joana, additional, Fuster, Josep, additional, Ayuso, Carmen, additional, Sole, Manel, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2019
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18. SAT-482-Incidence of hepatocellular carcinoma after hepatitis C cure with DAA in a cohort of patients with advanced liver disease: Results from a prospective screening program

Author

Zamparelli, Marco Sanduzzi, primary, Lens, Sabela, additional, Sapena, Víctor, additional, Llarch, Neus, additional, Pla, Anna, additional, Iserte, Gemma, additional, Bartres, Concepció, additional, Vilana, Ramón, additional, Bianchi, Luis, additional, Isabel, Nuñez, additional, Darnell, Anna, additional, Belmonte, Ernest, additional, Ayuso, Carmen, additional, García-Criado, Maria Ángeles, additional, Díaz, Alba, additional, Fuster, Carla, additional, Torres, Ferran, additional, Bruix, Jordi, additional, Forns, Xavier, additional, Reig, María, additional, and Mariño, Zoe, additional

Published
2019
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20. FRI-473-Safety and effectiveness of regorafenib in recurrent HCC after liver transplantation and progression on sorafenib: A real-life multicentre study

Author

Lavarone, Massimo, primary, Invernizzi, Federica, additional, Czauderna, Carolin, additional, Zamparelli, Marco Sanduzzi, additional, Bhoori, Sherrie, additional, Amaddeo, Giuliana, additional, Manini, Matteo Angelo, additional, Fraile, Miguel, additional, Anders, Maria Margarita, additional, Pinter, Matthias, additional, Rodriguez, Maria Jose Blanco, additional, Romero, Mario, additional, Alejandro, Aballay Soteras Gabriel, additional, Pinero, Federico, additional, Villadsen, Gerda Elisabeth, additional, Weinmann, Arndt, additional, Crespo, Gonzalo, additional, Mazzaferro, Vincenzo, additional, Regnault, Helene, additional, Giorgio, Massimo De, additional, Dieguez, Maria Luisa Gonzalez, additional, Donato, Maria Francesca, additional, Varela, Maria, additional, Marcus, Wörns, additional, Bruix, Jordi, additional, Lampertico, Pietro, additional, and Reig, María, additional

Published
2019
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23. AS150 - Regorafenib improves survival after sorafenib treatment in patients with recurrent hepatocellular carcinoma after liver transplantation, compared to best supportive care

Author

Iavarone, Massimo, Invernizzi, Federica, Zavaglia, Claudio, Zamparelli, Marco Sanduzzi, Fraile, Miguel, Czauderna, Carolin, Di Costanzo, Giuseppe, Bhoori, Sherrie, Pinter, Matthias, Manini, Matteo Angelo, Amaddeo, Giuliana, Fernandez, Ainhoa, Pinero, Federico, Blanco Rodriguez, Maria Jose, Anders, Maria Margarita, Aballay Soteras, Gabriel Alejandro, Villadsen, Gerda Elisabeth, Cesarini, Lucia, Mazza, Stefano, Díaz-Gonzázlez, Álvaro, Gonzalez Dieguez, Maria Luisa, Tortora, Raffaella, Weinmann, Arndt, Mazzaferro, Vincenzo, Romero, Mario, Crespo, Gonzalo, Regnault, Helene, De Giorgio, Massimo, Varela, Maria, Donato, Maria Francesca, Worns, Marcus-Alexander, Bruix, Jordi, Lampertico, Pietro, and Reig, María

Published
2020
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25. The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Author

Zamparelli, Marco Sanduzzi, Compare, Debora, Coccoli, Pietro, Rocco, Alba, Nardone, Olga Maria, Marrone, Giuseppe, Gasbarrini, Antonio, Grieco, Antonio, Nardone, Gerardo, Miele, Luca, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Grieco, Antonio (ORCID:0000-0002-0544-8993), Miele, Luca (ORCID:0000-0003-3464-0068), Zamparelli, Marco Sanduzzi, Compare, Debora, Coccoli, Pietro, Rocco, Alba, Nardone, Olga Maria, Marrone, Giuseppe, Gasbarrini, Antonio, Grieco, Antonio, Nardone, Gerardo, Miele, Luca, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Grieco, Antonio (ORCID:0000-0002-0544-8993), and Miele, Luca (ORCID:0000-0003-3464-0068)

Abstract

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

Published
2016

26. The Gut Bacteria-Driven Obesity Development.

Author

Compare, Debora, Rocco, Alba, Zamparelli, Marco Sanduzzi, and Nardone, Gerardo

Abstract

It is now well established that a healthy gut flora is largely responsible for the overall health of the host, while a perturbation in gut microbial communities can contribute to disease susceptibility. Obesity is a complex process involving genetic and environmental factors with an epidemiological burden that makes it a major public health issue. Studies of germ-free or gnotobiotic mice provided evidence that the diversity, as well as the presence and relative proportion of different microbes in the gut play active roles in energy homeostasis. Similarly, human studies showed that both the diversity of the microbiota and the Bacteroidetes/Firmicutes ratio are decreased in obese individuals. The 'obese microbiota' seems to be able to increase dietary energy harvest and favor weight gain and fat deposition. Although research in this field has just started and many of the available data are still conflicting, the results are providing exciting perspectives, and gut microbiota manipulation has already become a new target for both prevention and treatment of obesity. [ABSTRACT FROM AUTHOR]

Published
2016
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30. The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Author

Antonio Grieco, Luca Miele, Giuseppe Marrone, Olga Maria Nardone, Marco Sanduzzi Zamparelli, Debora Compare, Pietro Coccoli, Gerardo Nardone, Alba Rocco, Antonio Gasbarrini, Zamparelli, Marco Sanduzzi, Compare, Debora, Coccoli, Pietro, Rocco, Alba, Nardone, OLGA MARIA, Marrone, Giuseppe, Gasbarrini, Antonio, Grieco, Antonio, Nardone, GERARDO ANTONIO PIO, and Miele, Luca

Subjects
0301 basic medicine, medicine.medical_specialty, Cardiovascular disease, Gut microbiota, NAFLD, Catalysis, Molecular Biology, Spectroscopy, Computer Science Applications1707 Computer Vision and Pattern Recognition, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry, Settore MED/12 - GASTROENTEROLOGIA, Disease, Type 2 diabetes, Review, 030204 cardiovascular system & hematology, Gut flora, Bioinformatics, digestive system, Catalysi, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, Microbiome, lcsh:QH301-705.5, biology, Bacteria, Gastrointestinal Microbiome, Fatty liver, General Medicine, biology.organism_classification, medicine.disease, Obesity, Computer Science Applications, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, Cardiovascular Diseases
Abstract

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

Published
2016

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