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Your search keyword '"Zampeta, F. Isabella"' showing total 8 results
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8 results on '"Zampeta, F. Isabella"'

2. Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology

Author

Pandya, Nikhil J., Wang, Congwei, Costa, Veronica, Lopatta, Paul, Meier, Sonja, Zampeta, F. Isabella, Punt, A. Mattijs, Mientjes, Edwin, Grossen, Philip, Distler, Tania, Tzouros, Manuel, Martí, Yasmina, Banfai, Balazs, Patsch, Christoph, Rasmussen, Soren, Hoener, Marius, Berrera, Marco, Kremer, Thomas, Dunkley, Tom, Ebeling, Martin, Distel, Ben, Elgersma, Ype, and Jagasia, Ravi

Published
2021
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4. Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome

Author

Avagliano Trezza, Rossella, Sonzogni, Monica, Bossuyt, Stijn N. V., Zampeta, F. Isabella, Punt, A. Mattijs, van den Berg, Marlene, Rotaru, Diana C., Koene, Linda M. C., Munshi, Shashini T., Stedehouder, Jeffrey, Kros, Johan M., Williams, Mark, Heussler, Helen, de Vrij, Femke M. S., Mientjes, Edwin J., van Woerden, Geeske M., Kushner, Steven A., Distel, Ben, and Elgersma, Ype

Published
2019
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7. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb

Author

Deryckere, Astrid, primary, Stappers, Elke, additional, Dries, Ruben, additional, Peyre, Elise, additional, van den Berghe, Veronique, additional, Conidi, Andrea, additional, Zampeta, F. Isabella, additional, Francis, Annick, additional, Bresseleers, Marjolein, additional, Stryjewska, Agata, additional, Vanlaer, Ria, additional, Maas, Elke, additional, Smal, Ihor V., additional, van IJcken, Wilfred F. J., additional, Grosveld, Frank G., additional, Nguyen, Laurent, additional, Huylebroeck, Danny, additional, and Seuntjens, Eve, additional

Published
2020
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8. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricularsubventricular zone to the olfactory bulb.

Author

Deryckere, Astrid, Stappers, Elke, Dries, Ruben, Peyre, Elise, van den Berghe, Veronique, Conidi, Andrea, Zampeta, F. Isabella, Francis, Annick, Bresseleers, Marjolein, Stryjewska, Agata, Vanlaer, Ria, Maas, Elke, Smal, Ihor V., van IJcken, Wilfred F. J., Grosveld, Frank G., Nguyen, Laurent, Huylebroeck, Danny, and Seuntjens, Eve

Subjects
OLFACTORY bulb, DEVELOPMENTAL neurobiology, SMAD proteins, NEURONAL differentiation, INTERNEURONS, FETAL tissues, NEURAL stem cells
Abstract

The transcription factor Zeb2 controls fate specification and subsequent differentiation and maturation of multiple cell types in various embryonic tissues. It binds many protein partners, including activated Smad proteins and the NuRD co-repressor complex. How Zeb2 subdomains support cell differentiation in various contexts has remained elusive. Here, we have studied the role of Zeb2 and its domains in neurogenesis and neural differentiation in the young postnatal ventricular-subventricular zone (V-SVZ), where neural stem cells generate olfactory bulb-destined interneurons. Conditional Zeb2 knockouts and separate acute loss- and gain-of-function approaches indicated that Zeb2 is essential to control apoptosis and neuronal differentiation of V-SVZ progenitors before and after birth, and identified Sox6 as Zeb2-dependent and potential downstream target gene. Zeb2 genetic inactivation impaired the differentiation potential of the VSVZ niche in a cell-autonomous fashion. We also provide evidence that its normal function in the VSVZ involves non-autonomous mechanisms as well. Additionally, we could demonstrate distinct roles for Zeb2 protein-binding domains, suggesting that Zeb2 partners co-determine neuronal output from the mouse V-SVZ in both quantitative and qualitative manners in early postnatal life. [ABSTRACT FROM AUTHOR]

Published
2020
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