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Your search keyword '"Zamudio, Sergio R."' showing total 22 results
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22 results on '"Zamudio, Sergio R."'

1. Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy

Author

Diaz-Villegas, Veronica, primary, Pichardo-Macías, Luz Adriana, additional, Juárez-Méndez, Sergio, additional, Ignacio-Mejía, Iván, additional, Cárdenas-Rodríguez, Noemí, additional, Vargas-Hernández, Marco Antonio, additional, Mendoza-Torreblanca, Julieta Griselda, additional, and Zamudio, Sergio R., additional

Published
2024
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6. Levetiracetam Mechanisms of Action: From Molecules to Systems

Author

Contreras-García, Itzel Jatziri, primary, Cárdenas-Rodríguez, Noemí, additional, Romo-Mancillas, Antonio, additional, Bandala, Cindy, additional, Zamudio, Sergio R., additional, Gómez-Manzo, Saúl, additional, Hernández-Ochoa, Beatriz, additional, Mendoza-Torreblanca, Julieta Griselda, additional, and Pichardo-Macías, Luz Adriana, additional

Published
2022
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15. The high-fructose intake of dams during pregnancy and lactation exerts sex-specific effects on adult rat offspring metabolism.

Author

Tobar-Bernal, Francisca A., Zamudio, Sergio R., and Quevedo-Corona, Lucía

Abstract

Experimental studies have demonstrated the effects of maternal fructose consumption during pregnancy and lactation on metabolic alterations in their offspring, especially male offspring. However, few studies have focused on female offspring after providing fructose in food to dam rats. Here, we studied whether offspring of both sexes were differentially affected by a maternal high-fructose diet (HFD). For this purpose, Sprague-Dawley rats were fed during pregnancy and lactation with a standard diet (SD) or a HFD (50% w/w). After weaning, offspring were fed an SD; 3 days later, dams were sacrificed, and their offspring were sacrificed on postnatal day 90. Body weight (BW), food and water intake (only for dams), and various biomarkers of metabolic syndrome were measured. When compared to the SD-fed dams, HFD-fed dams had a reduction in BW and food and water intake. Conversely, adiposity, liver weight, liver lipids, and plasma levels of glucose, insulin, cholesterol, triglycerides, and uric acid were increased in HFD-fed dams. Moreover, the BW, food consumption, weight of retroperitoneal fat pads, and liver lipids increased in female and male offspring of HFD-fed dams. Interestingly, the pups of HFD-fed mothers showed increased levels of leptin and insulin resistance and decreased levels of adiponectin which were more pronounced in male offspring than in female offspring. In contrast, a higher increase in BW was shown earlier in female offspring. Thus, high-fructose consumption by dams during pregnancy and lactation led to sex-specific developmental programming of the metabolic syndrome phenotype in adult offspring. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion

Author

Guzmán-Velázquez, Sonia, Garcés-Ramírez, Linda, Flores, Gonzalo, De La Cruz, Fidel, and Zamudio, Sergio R.

Subjects
endocrine system, lcsh:Therapeutics. Pharmacology, Article Subject, nervous system, lcsh:RM1-950, Research Article
Abstract

The neonatal ventral hippocampal lesion (nVHL) has been widely used as an animal model for schizophrenia. Rats with an nVHL show several delayed behavioral alterations that mimic some symptoms of schizophrenia. Sprague-Dawley (SD) rats with an nVHL have a decrease in D3 receptors in limbic areas, but the expression of D3 receptors in Wistar (W) rats with an nVHL is unknown. The 7-Hydroxy-2-(N,N-di-n-propylamino) tetralin (7-OH-DPAT) has been reported as a D3-preferring agonist. Thus, we investigated the effect of (±)-7-OH-DPAT (0.25 mg/kg) on the motor activity in male adult W and SD rats after an nVHL. The 7-OH-DPAT caused a decrease in locomotion of W rats with an nVHL, but it did not change the locomotion of SD rats with this lesion. Our results suggest that the differential effect of 7-OH-DPAT between W and SD rats with an nVHL could be caused by a different expression of the D3 receptors. These results may have implications for modeling interactions of genetic and environmental factors involved in schizophrenia.

Published
2011

22. Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion.

Author

Guzmán-Velázquez, Sonia, Garcés-Ramírez, Linda, Flores, Gonzalo, De La Cruz, Fidel, and Zamudio, Sergio R.

Abstract

The neonatal ventral hippocampal lesion (nVHL) has been widely used as an animal model for schizophrenia. Rats with an nVHL show several delayed behavioral alterations that mimic some symptoms of schizophrenia. Sprague-Dawley (SD) rats with an nVHL have a decrease in D3 receptors in limbic areas, but the expression of D3 receptors in Wistar (W) rats with an nVHL is unknown. The 7-Hydroxy-2-(N,N-di-n-propylamino) tetralin (7-OH-DPAT) has been reported as a D3-preferring agonist. Thus, we investigated the effect of (±)-7-OH-DPAT (0.25 mg/kg) on the motor activity in male adult W and SD rats after an nVHL. The 7-OH-DPAT caused a decrease in locomotion of W rats with an nVHL, but it did not change the locomotion of SD rats with this lesion. Our results suggest that the differential effect of 7-OH-DPAT between W and SD rats with an nVHL could be caused by a different expression of the D3 receptors. These results may have implications for modeling interactions of genetic and environmental factors involved in schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2011
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