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13. Fifth International Serum Exchange Workshop for Insulin Autoantibody (IAA) Standardization

Author

Greenbaum, C. J., Wilkin, T. J., Palmer, J. P., Agopian, M. S., Arnaiz -Villena, A., Becker, D., Becker, F., Bosi, E., Bottazzo, G. F., Bouix, O., Colman, P., Dawkins, R. L., De Leiva, A., Dean, B. M., DiMario, U., Eisenbarth, G. S., Elliot, R. B., Gorus, F., Huang, W., Humbel, R., Julia, M. R., Karjalainen, J., Keilacker, H., Kuglin, B., Kwan, J., Levy -Marchal, C., MacLaren, N., McEvoy, R. C., Molenaar, J. L., Reinauer, K. M., Scherbaum, W., Sodoyez, J. C., Vialettes, B., Zanchetta, R., and Ziegler, A. G.

Published
1992
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14. Primary Ovarian Insufficiency due to Steroidogenic Cell Autoimmunity Is Associated with a Preserved Pool of Functioning Follicles

Author

La Marca, A., Marzotti, S., Brozzetti, A., Stabile, G., Artenisio, A. C., Bini, V., Giordano, R., De Bellis, A., Volpe, A., Falorni, A., Ambrosi, B., Angeli, A., Arnaldi, G., Arvat, E., Baccarelli, A., Barbetta, L., Beck Peccoz, P., Bellastella, A., Betterle, C., Bizzarro, A., Boscaro, M., Cavagnini, F., Celleno, R., Dal Prà, C., Dotta, Francesco, Ghigo, E., Laureti, S., Libè, R., Lorè, F., Mannelli, M., Mantero, F., Mantovani, G., Paccotti, P., Pecori Giraldi, F., Perniola, R., Santeusanio, F., Terzolo, M., Tiberti, C., Toja, P., Torlontano, M., Toscano, V., Trischitta, V., Zanchetta, R., LA MARCA, A, Marzotti, S, Brozzetti, A, Stabile, G, Artenisio, Ac, Bini, V, Giordano, R, DE BELLIS, Annamaria, Volpe, A, and Falorni, A.

Subjects
Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry (medical), Adult, Anti-Mullerian Hormone, medicine.medical_specialty, Adolescent, Cell, Primary ovarian insufficiency, Radioimmunoassay, Enzyme-Linked Immunosorbent Assay, 030209 endocrinology & metabolism, Primary Ovarian Insufficiency, Biology, medicine.disease_cause, Autoimmunity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ovarian Follicle, Internal medicine, medicine, Humans, Inhibins, Ovarian follicle, Gonadal Steroid Hormones, Amenorrhea, Autoantibodies, Analysis of Variance, 030219 obstetrics & reproductive medicine, Estradiol, Autoantibody, Luteinizing Hormone, Middle Aged, medicine.disease, Obesity, Diabetes and Metabolism, medicine.anatomical_structure, Female, Follicle Stimulating Hormone, medicine.symptom, Hormone
Abstract

Primary ovarian insufficiency (POI) is defined as hypergonadotropic amenorrhea before the age of 40 yr. In 4-5% of patients with POI, an ovarian autoimmune process is present.Serum concentrations of antimüllerian hormone (AMH) have been determined in 26 women with POI due to steroidogenic cell autoimmunity (SCA-POI), 66 with nonautoimmune idiopathic POI (iPOI), 40 postmenopausal women (PMW), and 44 healthy fertile women (HW). SCA-POI was diagnosed according to presence of steroidogenic enzyme autoantibodies (17alpha-hydroxylase, side chain cleavage, and 21-hydroxylase autoantibodies).AMH concentrations were significantly higher in women with SCA-POI than women with iPOI (P = 0.018) or PMW (P = 0.03) but significantly lower than HW (P0.0001). AMH was detected in 11 of 26 women with SCA-POI (42%) and seven of 66 with iPOI (11%) (P = 0.002). Serum concentrations above the fifth percentile of the normal range (0.6 ng/ml) were detected in nine of 26 women with SCA-POI (35%) and four of 66 with iPOI (6%) (P = 0.001). Eight of 12 women with SCA-POI with less than 5 yr (67%) and one of 14 with longer disease duration (7%) had AMH concentrations within the normal range (P = 0.003). AMH concentrations correlated inversely with disease duration in women with SCA-POI (rho = -0.563, P = 0.003) but not women with iPOI. AMH correlated inversely with FSH serum concentrations in HW (rho = -0.584, P0.001) but not PMW or women with POI.Two thirds of women with recent-onset SCA-POI had normal AMH concentrations. Women with SCA-POI, differently from those with iPOI, present a preserved ovarian follicle pool for several years after diagnosis of ovarian insufficiency.

Published
2009
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19. Addison’s disease in Padua: a survey on 650 patients

Author

Betterle, Corrado, Scarpa, R, Morlin, L, Garelli, Silvia, Lazzarotto, F., Cervato, S, Albergoni, Mp, Masiero, S, Parolo, A, Reato, G, Zanchetta, R, Chen, S, Rees Smith, B, and Furmaniak, J.

Published
2011

22. Evaluation of the AIRE gene mutations in a cohort of Italian patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) and intheir relatives

Author

Cervato, S, Mariniello, B, Lazzarotto, F, Morlin, L, Zanchetta, R, Radetti, G, DE LUCA, Filippo, Valenzise, Mariella, Giordano, R, Rizzo, D, Giordano, C, and Betterle, C.

Subjects
POLYGLANDULAR SYNDROME TYPE 1, EXTENSIVE CLINICAL EXPERIENCE, SYNDROME TYPE I, ADDISONS-DISEASE, AUTOANTIBODIES, COMMON, AUTOANTIGENS, THYROIDITIS, POPULATION, PROTEIN
Published
2009

23. ADDISON'S DISEASE

Author

Betterle, Corrado, Zanchetta, R, Prieur, ANNE MARIE, and Addisons, D. I. S. E. A. S. E. IN E. D.

Published
2008

30. ADRENALITIS

Author

Betterle, Corrado and Zanchetta, R.

Published
2006

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