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12. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia

Author

Messina, C, Valsecchi, MG, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Lombardi, A, Masera, G, and Zanesco, L

Published
1998
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21. Risk management of HBsAg or anti-HCV positive healthcare workers in hospital

Author

Mele, A., Ippolito, G., Craxì, A., Coppola, R.C., Petrosillo, N., Piazza, M., Puro, V., Rizzetto, M., Sagliocca, L., Taliani, G., Zanetti, A., Barni, M., Bianco, E., Bollero, E., Cargnel, A., Cattaneo, M., Chiaramonte, M., Conti, E., D'Amelio, R., De Stefano, D.M., Di Giulio, S., Franco, E., Gallo, G., Levrero, M., Mannella, E., Merli, S., Milazzo, F., Moiraghi, A., Polillo, R., Prati, D., Ragni, P., Sagnelli, E., Scognamiglio, P., Sommella, L., Stroffolini, T., Terrana, T., Tosolini, G., Vitiello, E., Zanesco, L., Ziparo, V., Maffei, C., Moro, M.L., Satolli, R., and Traversa, G.

Published
2001
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22. Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation

Author

Guardiola, Ph., Pasquini, R., Dokal, I., Ortega, J.J., van Weel-Sipman, M., Marsh, J.C.W., Ball, S.E., Locatelli, F., Vermylen, C., Skinner, R., Ljungman, P., Miniero, R., Shaw, P.J., Souillet, G., Michallet, M., Bekassy, A.N., Krivan, G., Di Bartolomeo, P., Heilmann, C., Zanesco, L., Cahn, J.Y., Arcese, W., Bacigalupo, A., and Gluckman, E.

Published
2000
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25. PROSPECTIVE STUDY OF 84 PATIENTS WITH WISKOTT-ALDRICH SYNDROME AND X-RECESSIVE PIASTRINOPENIA: RESULTS OF THE APPLICATION OF COMMON PROTOCOL FOR DIAGNOSIS AND TREATMENT OF WAS/XLT

Author

Soresina, A., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Biondi, A., Mattia, D., Aiuti, A., Maurizio Arico', Azzari, C., Cornelli, P. E., Rossi, P., Martino, S., Specchia, F., Pignata, C., Izzi, G., Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., Plebani, A., Pietrogrande, M. C., Porta, F., Soresina, A., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Biondi, A., De Mattia, D., Aiuti, A., Arico, M., Azzari, C., Cornelli, P. E., Rossi, P., Martino, S., Specchia, F., Pignata, Claudio, Izzi, G., Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., Plebani, A., Pietrogrande, M. C., and Porta, F.

Published
2012

26. The Quality of Life of Children and Adolescents with X-Linked Agammaglobulinemia

Author

Soresina A., Nacinovich R., Bomba M., Cassani M., Molinaro A., Sciotto A., Martino S., Cardinale F., De Mattia D., Putti C., Dellepiane R.M., Felici L., Parrinello G., Neri F., Plebani A., Pierani P., DeMattia D., Martire B., Armenio L., Dammacco F., Ranieri G., Masi M., Miniaci A., Pession A., Rondelli R., Notarangelo L. D., Cao, Cossu F., Del Giacco S., Manconi P., Evangelista I., Magro S., Morgione S., STRISCIUGLIO, PIETRO, Anastasio E., Schillirò G., Paganelli R., Sticca M., Sperlì D., Carpino L., Bernini G., Azzari C., Maggi E., Romagnani S., Matucci A., Vultaggio A., Castagnola E., Gattorno M., Presta G., Civino A., Gambaretto G., Fasoli S., Salpietro C., Pietrogrande M.C., DellePiane R.M., Panisi C., Cambiaghi G., Pietrogrande M., Roncarolo M.G., Aiuti A., Masera G., Biondi A., Sala A., PIGNATA, CLAUDIO, Poggi V., Menna G., Di Nardo R., D'Apuzzo A., Pelliccia A., Correra A., Marone G., SPADARO, GIUSEPPE, Carli M., Zanesco L., Basso G., Putti M.C., Semenzato G., Agostini C., Amato G.M., Aricò M., Trizzino A., Izzi G., Bertolini P., Locatelli F., Zecca M., Rondini G., Marseglia G.L., Maccario R., Bossi G., Favre C., Consolini R., Vecchi V., Sacchini P., Rinaldi G., Ugazio A.G., Rossi P., Livadiotti S., Cancrini C., Finocchi A., Stabile A., Duse M., Iacobini M., Quinti I., Moschese V., Cecere F., Morgese G., Acquaviva A., De Zan G., Strafella S., Tamaro P., Rabusin M., Tovo P.A., Nespoli L., Marinoni M., Porcellini A., Cazzola G.A., Annarosa, Soresina, Renata, Nacinovich, Monica, Bomba, Morena, Cassani, Molinaro, Anna, Antonella, Sciotto, Silvana, Martino, Fabio, Cardinale, Domenico, Mattia, Caterina, Putti, Rosa Maria, Dellepiane, Leonardo, Felici, Giovanni, Parrinello, Francesca, Neri, Alessandro, Plebani, Soresina, A, Nacinovich, R, Bomba, M, Cassani, M, Molinaro, A, Sciotto, A, Martino, S, Cardinale, F, De Mattia, D, Putti, C, Dellepiane, R, Felici, L, Parrinello, G, Neri, F, Plebani, A, Soresina, A., Nacinovich, R., Bomba, M., Cassani, M., Molinaro, A., Sciotto, A., Martino, S., Cardinale, F., De Mattia, D., Putti, C., Dellepiane, R. M., Felici, L., Parrinello, G., Neri, F., Plebani, A., Pierani, P., Demattia, D., Martire, B., Armenio, L., Dammacco, F., Ranieri, G., Masi, M., Miniaci, A., Pession, A., Rondelli, R., Notarangelo, L. D., Cao, Cossu, F., Del Giacco, S., Manconi, P., Evangelista, I., Magro, S., Morgione, S., Strisciuglio, Pietro, Anastasio, E., Schillirò, G., Paganelli, R., Sticca, M., Sperlì, D., Carpino, L., Bernini, G., Azzari, C., Maggi, E., Romagnani, S., Matucci, A., Vultaggio, A., Castagnola, E., Gattorno, M., Presta, G., Civino, A., Gambaretto, G., Fasoli, S., Salpietro, C., Pietrogrande, M. C., Panisi, C., Cambiaghi, G., Pietrogrande, M., Roncarolo, M. G., Aiuti, A., Masera, G., Biondi, A., Sala, A., Pignata, Claudio, Poggi, V., Menna, G., Di Nardo, R., D'Apuzzo, A., Pelliccia, A., Correra, A., Marone, G., Spadaro, Giuseppe, Carli, M., Zanesco, L., Basso, G., Putti, M. C., Semenzato, G., Agostini, C., Amato, G. M., Aricò, M., Trizzino, A., Izzi, G., Bertolini, P., Locatelli, F., Zecca, M., Rondini, G., Marseglia, G. L., Maccario, R., Bossi, G., Favre, C., Consolini, R., Vecchi, V., Sacchini, P., Rinaldi, G., Ugazio, A. G., Rossi, P., Livadiotti, S., Cancrini, C., Finocchi, A., Stabile, A., Duse, M., Iacobini, M., Quinti, I., Moschese, V., Cecere, F., Morgese, G., Acquaviva, A., De Zan, G., Strafella, S., Tamaro, P., Rabusin, M., Tovo, P. A., Nespoli, L., Marinoni, M., Porcellini, A., and Cazzola, G. A.

Subjects
Male, Pediatrics, medicine.medical_specialty, x-linked agammaglobulinemia, Activities of daily living, Adolescent, X-linked agammaglobulinemia, Health Status, Immunology, pedsql 4.0 generic core scale, Quality of life, children, Agammaglobulinemia, Surveys and Questionnaires, Activities of Daily Living, health-related quality of life, parents, medicine, Humans, Immunology and Allergy, PedsQL 4.0 Generic Core Scale, Child, Settore MED/38 - Pediatria Generale e Specialistica, Health related quality of life, quality of live, business.industry, Immunoglobulins, Intravenous, Genetic Diseases, X-Linked, medicine.disease, Socioeconomic Factors, Child, Preschool, Mutation, Quality of Life, Female, X-linked agammaglobulinemia - children - parents - health-related quality of life - PedsQL 4.0 Generic Core Scale, business
Abstract

Introduction: The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases. Discussion: The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed. © 2008 Springer Science+Business Media, LLC.

Published
2009

27. Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation

Author

Messina, C, Locatelli, F, Lanino, E, Uderzo, C, Zacchello, G, Cesaro, S, Pillon, M, Perotti, C, Del Fante, C, Faraci, M, Rivabella, L, Calore, E, De Stefano, P, Zecca, M, Giorgiani, G, Brugiolo, A, Balduzzi, A, Dini, G, Zanesco, L, Dall'Amico, R, Messina C, Locatelli F, Lanino E, Uderzo C, Zacchello G, Cesaro S, Pillon M, Perotti C, Del Fante C, Faraci M, Rivabella L, Calore E, De Stefano P, Zecca M, Giorgiani G, Brugiolo A, Balduzzi A, Dini G, Zanesco L, Dall'Amico R, Messina, C, Locatelli, F, Lanino, E, Uderzo, C, Zacchello, G, Cesaro, S, Pillon, M, Perotti, C, Del Fante, C, Faraci, M, Rivabella, L, Calore, E, De Stefano, P, Zecca, M, Giorgiani, G, Brugiolo, A, Balduzzi, A, Dini, G, Zanesco, L, Dall'Amico, R, Messina C, Locatelli F, Lanino E, Uderzo C, Zacchello G, Cesaro S, Pillon M, Perotti C, Del Fante C, Faraci M, Rivabella L, Calore E, De Stefano P, Zecca M, Giorgiani G, Brugiolo A, Balduzzi A, Dini G, Zanesco L, and Dall'Amico R

Abstract

This study aimed to ascertain whether extracorporeal photochemotherapy (ECP) is an effective treatment for paediatric patients with refractory graft-versus-host disease (GVHD). From January 1992 to December 2000, 77 children (median age 8.6 years) with either acute (n = 33) or chronic (n = 44) GVHD, resistant to conventional immunosuppressive therapy, were treated with ECP in four Italian paediatric hospitals. After ECP, acute GVHD involving skin, liver and gut responded completely in 76%, 60% and 75% of patients respectively. The 5-year overall survival was 69% for responding patients vs 12% for non-responders (P = 0.001). Among the 44 children with chronic GVHD, 15 (44%) showed a complete response and 10 (29%) a significant improvement after ECP. The 5-year overall survival was 96% for responders vs 58% for non-responders (P = 0.04). Our results suggest that ECP is an effective treatment that may be useful in paediatric patients with either acute or chronic GVHD who have failed to respond to standard immunosuppressive therapy.

Published
2003

30. Studio prospettico di 53 pazienti con sindrome di Wiskott Aldrich e piastrinopenia X-recessiva :risultati dell'applicazione delle raccomandazioni AIEOP per WAS/XLT

Author

Soresina A.R., Mazzolari E., Cornelli P.E., Locatelli F., Ventura A., Dufour C., Galanello R., Zanesco L., Izzi G., De Mattia D., Azzari C., Ricci A., Mazza C., Giliani S., Rondelli R., Ugazio A.G., Plebani A., Notarangelo L.D., PESSION, ANDREA, Soresina AR., Mazzolari E., Cornelli PE., Locatelli F., Ventura A., Dufour C., Galanello R., Zanesco L., Izzi G., De Mattia D., Azzari C., Ricci A., Mazza C., Giliani S., Rondelli R., Pession A., Ugazio AG., Plebani A., and Notarangelo LD.

Published
2006

31. Anaplastic large cell lymphoma treated with a leukemia-like therapy

Author

ROSOLEN A, PILLON M, GARAVENTA A, BURNELLI R, D'AMORE ES, GIULIANO M, COMIS M, CESARO S, TETTONI K, LUISA MOLETI M, VISINTIN G, ZANESCO L., TAMARO, PAOLO, Rosolen, A, Pillon, M, Garaventa, A, Burnelli, R, D'Amore, E, Giuliano, M, Comis, M, Cesaro, S, Tettoni, K, LUISA MOLETI, M, Tamaro, Paolo, Visintin, G, and Zanesco, L.

Published
2005

32. CARATTERISTICHE CLINICO - IMMUNOLOGICHE DI 50 PAZIENTI CON SINDROME DI WISKOTT ALDRICH E PIASTRINOPENIA X-RECESSIVA:RISULTATI DELLE RACCOMANDAZIONI DIAGNOSTICO TERAPEUTICHE WAS-XLT AIEOP

Author

Soresina A., Mazzolari E., Cornelli P.E., Locatelli F., Ventura A., Dufour C., Galanello R., Zanesco L., Izzi G., De Mattia D., Azzari C., Ricci A., Mazza C., Giliani S., Rondelli R., plebani A., Ugazio A.G., Notarangelo L.D., PESSION, ANDREA, Soresina A., Mazzolari E., Cornelli PE., Locatelli F., Ventura A., Dufour C., Galanello R., Zanesco L., Izzi G., De Mattia D., Azzari C., Ricci A., Mazza C., Giliani S., Rondelli R., Pession A., plebani A., Ugazio AG., and Notarangelo LD.

Published
2005

33. Psychosocial life achievements in adults even if they received prophylactic cranial irradiation for acute lymphoblastic leukemia during childhood

Author

Pillon, M, Tridello, G, Rossi, A, Boaro, M, Messina, Chiara, Putti, M, Varotto, S, Petris, M, Scrimin, Sara, Zanesco, L, Rosolen, Angelo, and Basso, Giuseppe

Subjects
Adult, Male, Cancer Research, Pediatrics, medicine.medical_specialty, Adolescent, Lymphoblastic Leukemia, Disease, Young Adult, Surveys and Questionnaires, medicine, Humans, Survivors, Young adult, Child, Geographic area, Cranial radiotherapy, business.industry, Healthy population, Infant, Newborn, Infant, Hematology, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Achievement, Oncology, Socioeconomic Factors, Child, Preschool, lipids (amino acids, peptides, and proteins), Female, Prophylactic cranial irradiation, Cranial Irradiation, business, Psychosocial
Abstract

The aim of this study was to assess life goal achievements in long-term survivors (LTS) receiving cranial radiotherapy (CRT) as central nervous system (CNS) prophylaxis for acute lymphoblastic leukemia (ALL) during childhood, compared to healthy individuals. Participants in this study were 141 LTS treated in our center from 1961 to 1990. Questionnaires were mailed to LTS. Analyses were stratified by age classes comparing LTS and a matched healthy population living in the same geographic area, as well as comparing patients treated with 24 Gy vs. 18 Gy CRT. Survivors reached the same educational level as controls. Significant differences were noted according to age and CRT dose. LTS had similar employment rates to those of controls, but lower marriage rates. Most respondents described their life positively, but as worse in the 24 Gy group. This study highlights the good life satisfaction of our LTS despite the long-term effects of the disease and its treatment.

Published
2012

34. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation

Author

Crocchiolo, R., Zino, E., Vago, L., Oneto, R., Bruno, B., Pollichieni, S., Sacchi, N., Sormani, M. P., Marcon, J., Lamparelli, T., Fanin, R., Garbarino, L., Miotti, V., Bandini, G., Bosi, A., Ciceri, F., Bacigalupo, A., Fleischhauer, K., Midollo Osseo Gruppo Italiano Trapianto, D. I., Terapia Cellulare, Cellule Staminali Ematopoietiche Cse E., Italian Bone Marrow Donor Registry Collaboratori, Scalari P., Bontempelli, M., Prinoth, O., Carcassi, C., Marceno, R., Porfirio, Rombola, G., Lombardo, Ferrioli, G., Poli, F., Scalamogna, M., Mazzi, B., Rossi, F., Mascaretti, L., Albergoni, Salvaneschi, L., Salvaneschi, M., Valentini, Nesci, S., Papola, F., Scatena, Mariotti, Perrone, Laurenti, Grammatico, Paola, Mariani, M., Favoino, B., Guizzardi, Pontiero, Leoni, P., Rambaldi, A., Casini, M., Angelucci, E., Baronciani, D., La Nasa, G., Milone, G., Guidi, S., Van Lint, M. T., Dini, G., Corradini, P., Milani, R., Morra, E., Marenco, P., Deliliers, Lambretenghi G., Onida, F., Marcatti, M., Castagna, L., Pioltelli, P., Selleri, C., Zanesco, L., Scime, R., Musso, M., Alessandrino, E. P., Locatelli, F., Visani, G., Di Bartolomeo, P., Papineschi, F., Favre, C., Iori, A. P., Foa, Roberto, Locasciulli, A., Majolino, I., Majolino, P., Leone, G., Arcese, W., Cerretti, R., Carella, A. M., Cascavilla, N., Lauria, F., Mazza, P., Cerno, M., Benedetti, F., Crocchiolo, R, Zino, E, Vago, L, Oneto, R, Bruno, B, Pollichieni, S, Sacchi, N, Sormani, Mp, Marcon, J, Lamparelli, T, Fanin, R, Garbarino, L, Miotti, V, Bandini, G, Bosi, A, Ciceri, F, Bacigalupo, A, and Fleischhauer, K

Subjects
Adult, Disease-Free Survival, Donor Selection, Female, HLA-DRB1 Chains, Hematologic Neoplasms, Humans, Italy, Male, Middle Aged, Recurrence, Registries, Retrospective Studies, Risk Factors, Survival Rate, Transplantation, Homologous, Algorithms, HLA-DR Antigens, Hematopoietic Stem Cell Transplantation, Tissue Donors, Biochemistry, Immunology, Hematology, Cell Biology, Homologous, medicine.medical_treatment, Human leukocyte antigen, Hematopoietic stem cell transplantation, Medicine, Risk factor, Survival rate, Transplantation, HLA-DPB1, business.industry, Hazard ratio, Confidence interval, business, Settore MED/15 - Malattie del Sangue
Abstract

The importance of donor-recipient human leukocyte antigen (HLA)-DPB1 matching for the clinical outcome of unrelated hematopoietic stem cell transplantation (HSCT) is controversial. We have previously described an algorithm for nonpermissive HLA-DPB1 disparities involving HLA-DPB1*0901,*1001,*1701,*0301,*1401,*4501, based on T-cell alloreactivity patterns. By revisiting the immunogenicity of HLA-DPB1*02, a modified algorithm was developed and retrospectively tested in 621 unrelated HSCTs facilitated through the Italian Registry for onco-hematologic adult patients. The modified algorithm proved to be markedly more predictive of outcome than the original one, with significantly higher KaplanMeier probabilities of 2-year survival in permissive compared with nonpermissive transplantations (55% vs 39%, P = .005). This was the result of increased adjusted hazards of nonrelapse mortality (hazard ratio [HR] = 1.74; confidence interval [CI], 1.19-2.53; P = .004) but not of relapse (HR = 1.02; CI, 0.73-1.42; P = .92). The increase in the hazards of overall mortality by nonpermissive HLA-DPB1 disparity was similar in 10 of 10 (HR = 2.12; CI, 1.23-3.64; P = .006) and 9 of 10 allele-matched transplantations (HR = 2.21; CI, 1.28-3.80; P = .004), both in early-stage and in advanced-stage disease. These data call for revisiting current HLA matching strategies for unrelated HSCT, suggesting that searches should be directed up-front toward identification of HLA-DPB1 permissive, 10 of 10 or 9 of 10 matched donors. (Blood. 2009; 114:1437-1444) RI Porfirio, Berardino/I-1988-2012

Published
2009

35. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation

Author

Crocchiolo, R, Zino, E, Vago, L, Oneto, R, Bruno, B, Pollichieni, S, Sacchi, N, Sormani, Mp, Marcon, J, Lamparelli, T, Fanin, R, Garbarino, L, Miotti, V, Bandini, G, Bosi, A, Ciceri, F, Bacigalupo, A, Fleischhauer, K, Gruppo Italiano Trapianto di Midollo Osseo, Terapia Cellulare, Cellule Staminale Ematopoietiche e., Italian Bone Marrow Donor Registry, Scalari, P, Bontempelli, M, Prinoth, O, Carcassi, C, Marcenò, R, Porfirio, Rombolà, G, Lombardo, Ferrioli, G, Poli, F, Scalamogna, M, Mazzi, B, Rossi, F, Mascaretti, L, Albergoni, Salvaneschi, L, Martinetti, M, Valentini, Renzo, Nesci, S, Papola, F, Scatena, Mariotti, Perrone, Laurenti, Grammatico, P, Mariani, M, Favoino, B, Guizzardi, Pontiero, Leoni, P, Rambaldi, A, Casini, M, Angelucci, E, Baronciani, D, La Nasa, G, Milone, G, Guidi, S, Van Lint MT, Dini, G, Corradini, P, Milani, R, Morra, E, Marenco, P, Lambretenghi Deliliers, G, Onida, F, Marcatti, M, Castagna, L, Pioltelli, P, Selleri, C, Zanesco, L, Scimè, R, Musso, M, Alessandrino, Ep, Locatelli, F, Visani, G, Di Bartolomeo, P, Papineschi, Federico, Favre, C, Iori, Ap, Foà, R, Locasciulli, A, Majolino, I, Majolino, P, Leone, G, Arcese, W, Cerretti, R, Carella, Am, Cascavilla, N, Lauria, F, Mazza, P, Cerno, M, and Benedetti, F.

Published
2009

36. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia. AIEOP/FONOP-TMO group. Associzione Italiana Emato-Oncologia Pediatrica

Author

Messina, C, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Zanesco, L., VALSECCHI, MARIA GRAZIA, Messina, C, Valsecchi, M, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, A, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, and Zanesco, L

Subjects
Male, Antineoplastic Combined Chemotherapy Protocol, Adolescent, Infant, Newborn, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Transplantation, Autologous, Disease-Free Survival, Transplantation, Autologou, childhood lymphoblastic leukemia, meningeal relapse, autologous marrow transplantation, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Meningeal Neoplasms, Humans, Female, Meningeal Neoplasm, Child, Human, Bone Marrow Transplantation
Abstract

The purpose of this study was to assess the role of ABMT in children with ALL who are in 2nd CR after an early isolated CNS relapse. All children experiencing an isolated CNS relapse at 10 AIEOP centers (Associazione Italiana Emato-Oncologia Pediatrica) from 1986 to 1992 were eligible for this study. The series included 69 patients who relapsed within 3 years from diagnosis: 19 underwent ABMT, nine patients underwent ALLO-BMT from an HLA-identical sibling, and 41 received conventional chemotherapy (CHEMO). Statistical analysis was performed using a Cox's regression model, adjusting for the waiting time before transplantation and prognostic factors. The 5 years DFS was 56.3% (s.e. 12.3) for patients in the ABMT group. This compared favorably with the poor result (12.6% (s.e. 5.9)) seen in the CHEMO group. The risk of failures was reduced by one-third in the ABMT group as compared to the CHEMO group in the multivariate analysis (P < 0.01). In the ALLO group four out of nine patients were in CCR 4-5 years post-transplant. This study suggests that ABMT may also represent a valuable therapeutic choice for patients lacking a matched familiar donor in 2nd CR after an early isolated CNS relapse.

Published
1998

37. Application of common recommendations for diagnosis and treatment of Wiskott-Aldrich syndrome and X-recessive piastrinopenia: clinical and immunological characteristics of 65 patients with WAS/XLT

Author

Soresina, S. A., Mazzolari, E., Notarangelo, L. D., Ventura, A., Locatelli, F., Dufour, C., Galanello, R., Zanesco, L., Izzi, G., Mattia, D., Azzari, C., Cornelli, P. E., PAOLO ROSSI, Mazza, C., Moratto, D., Giliani, S., Rondelli, R., Pession, A., Ugazio, A. G., and Plebani, A.

Published
2008

46. Principi e Pratica di Pediatria

Author

Cacciar, E, Cao, A, Cavazzuti, Gb, Cicognani, A, Guaraldi, Gp, Guglielmi, M, Maggiore, Giuseppe, Mastroiacovo, P, Notarangelo, Ld, Panizon, F, Ventura, A, and Zanesco, L.

Published
2005

49. Safety and efficacy of caspofungin and liposomal amphotericin B, followed by voriconazole in young patients affected by refractory invasive mycosis

Author

Cesaro, S, Toffolutti, T, Messina, Chiara, Calore, E, Alaggio, Rita, Cusinato, R, Pillon, M, and Zanesco, L.

Subjects
Adult, Male, Antifungal Agents, Adolescent, Peptides, Cyclic, combination therapy, Echinocandins, Lipopeptides, combination therapy, antifungal therapy, aspergillosis, Caspofungin, Amphotericin B, Humans, aspergillosis, Child, Aspergillus fumigatus, Geotrichosis, Drug Synergism, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Triazoles, Hodgkin Disease, Survival Rate, antifungal therapy, Leukemia, Myeloid, Acute, Pyrimidines, Treatment Outcome, Mycoses, Myelodysplastic Syndromes, Liposomes, Drug Therapy, Combination, Female, Voriconazole, Peptides, Aspergillus flavus
Abstract

Data on the use of combination of liposomal amphotericin B and caspofungin followed by voriconazole, as maintenance or further rescue treatment, in 10 patients with invasive mycosis are reported.The diagnoses were acute leukemia (7), myelodysplastic syndrome (1) and Hodgkin's lymphoma (1). All patients developed an invasive mycosis (proven, 3; probable, 6; and possible, 1) refractory to first-line antifungal treatment (liposomal amphotericin B in all patients except one who received fluconazole).Rescue therapy with a combination of caspofungin and liposomal amphotericin B was well tolerated, hypokalemia, and thrombophlebitis being the most common side-effects. Combination therapy was administered for a median of 17 d, range 6-40. Among the nine patients with proven or probable mycosis, one was not evaluated because of early death caused by massive hemoptysis whilst in the remaining eight patients, the response was classified as complete, stable and failure in four, three, and one patients, respectively. Complete response was also observed in patient with possible mycosis. Eight of nine patients received voriconazole for a median of 75 d, range 42-194. Voriconazole was well tolerated although some drug interactions were observed during treatment with methotrexate and digoxin. After a median follow-up of 125 d, nine of 10 patients are alive. Overall, a favorable response to antifungal treatment (including the case of possible mycosis) was obtained in eight of 10 patients.These data suggest that medical antifungal treatment may be intensified in severely ill patients without significantly compromising patient safety. The combination of synergistic antifungal drugs as well as their sequential use warrants further investigation by a larger randomized controlled study.

Published
2004

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