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1. Integrated electronic controller for dynamic self-configuration of photonic circuits

Author

Sacchi, Emanuele, Zanetto, Francesco, Martinez, Andrés Ivan, SeyedinNavadeh, SeyedMohammad, Morichetti, Francesco, Melloni, Andrea, Sampietro, Marco, and Ferrari, Giorgio

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Reconfigurable photonic integrated circuits (PICs) can implement arbitrary operations and signal processing functionalities directly in the optical domain. Run-time configuration of these circuits requires an electronic control layer to adjust the working point of their building elements and make them compensate for thermal drifts or degradations of the input signal. As the advancement of photonic foundries enables the fabrication of chips of increasing complexity, developing scalable electronic controllers becomes crucial for the operation of complex PICs. In this paper, we present an electronic application-specific integrated circuit (ASIC) designed for reconfiguration of PICs featuring numerous tuneable elements. Each channel of the ASIC controller independently addresses one optical component of the PIC, as multiple parallel local feedback loops are operated to achieve full control. The proposed design is validated through real-time reconfiguration of a 16-channel silicon photonics adaptive beam coupler. Results demonstrate automatic coupling of an arbitrary input beam to a single-mode waveguide, dynamic compensation of beam wavefront distortions and successful transmission of a 50 Gbit/s signal through an optical free-space link. The low power consumption and compactness of the electronic chip provide a scalable paradigm that can be seamlessly extended to larger photonic architectures., Comment: Manuscript contains both main text and supplementary information

Published
2025

2. Self-Adaptive Integrated Photonic Receiver for Turbulence Compensation in Free Space Optical Links

Author

Martinez, Andres Ivan, Cavicchioli, Gabriele, Seyedinnavadeh, Seyedmohammad, Zanetto, Francesco, Sampietro, Marco, DAcierno, Alessandro, Morichetti, Francesco, and Melloni, Andrea

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

In Free Space Optical (FSO) communication systems, atmospheric turbulence distorts the propagating beams, causing a random fading in the received power. This perturbation can be compensated using a multi-aperture receiver that samples the distorted wavefront on different points and adds the various signals coherently. In this work, we report on an adaptive optical receiver that compensates in real time for scintillation in FSO links. The optical front-end of the receiver is entirely integrated in a silicon photonic chip hosting a 2D Optical Antenna Array and a self-adaptive analog Programmable Optical Processor made of a mesh of tunable Mach-Zehnder interferometers. The photonic chip acts as an adaptive interface to couple turbulent FSO beams to single-mode guided optics, enabling energy and cost-effective operation, scalability to systems with a larger number of apertures, modulation-format and data-protocol transparency, and pluggability with commercial fiber optics transceivers. Experimental results demonstrate the effectiveness of the proposed receiver with optical signals at a data rate of 10 Gbit/s transmitted in indoor FSO links where different turbulent conditions, even stronger than those expected in outdoor links of hundreds of meters, are reproduced.

Published
2024

4. Real-Time Reconfiguration of Free-Space Optical Receivers by Means of Fully Integrated CMOS Controller

Author

Sacchi, Emanuele, Zanetto, Francesco, Morichetti, Francesco, Melloni, Andrea, Sampietro, Marco, Ferrari, Giorgio, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Valle, Maurizio, editor, Gastaldo, Paolo, editor, and Limiti, Ernesto, editor

Published
2025
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5. Integrating CMOS Analog Electronics in Silicon Photonics

Author

Zanetto, Francesco, Crico, Monica, De Gaetano, Samuele, Ferrari, Giorgio, Sampietro, Marco, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Valle, Maurizio, editor, Gastaldo, Paolo, editor, and Limiti, Ernesto, editor

Published
2025
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6. Bio-reconfigurable Impedance-Based Platform for Multiplexing Diagnostic

Author

Maurina, Arianna Adelaide, de Oliveira Figares, Cainã, Damin, Francesco, Chiara Capelli, Sola, Laura, Chiari, Marcella, Zanetto, Francesco, Ferrari, Giorgio, Sampietro, Marco, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Valle, Maurizio, editor, Gastaldo, Paolo, editor, and Limiti, Ernesto, editor

Published
2025
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9. Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation

Author

Alberto Ferrarese, Marco Senzolo, Anna Maria Cattelan, Lolita Sasset, Sara Battistella, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Martina Gambato, Filippo Pelizzaro, Stefania Vio, Domenico Bassi, Umberto Cillo, and Patrizia Burra

Subjects
enterobacterales, sepsis, acute on chronic liver failure, Surgery, RD1-811
Abstract

Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of such infections, particularly in advanced disease stages. In clinical practice, the onset of a bacterial infection can lead to further deterioration of hepatic and extra-hepatic function, potentially resulting in acute decompensation or acute-on-chronic liver failure. This has significant clinical implications, particularly for patients awaiting a transplant. In this review, we will discuss the latest evidence on the diagnosis and therapy of bacterial infections in patients with decompensated cirrhosis. Additionally, we will analyze the impact of bacterial infections in the context of liver transplantation, discussing debated topics such as the timing of transplantation in patients with infections, potential implications for prioritization, effects on post-operative recovery, grafts, and patient survival.

Published
2024
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10. CMOS Electronic Circuits in Standard Silicon Photonics

Author

Crico, Monica, De Gaetano, Samuele, Martinez, Andrés, Morichetti, Francesco, Melloni, Andrea, Ferrari, Giorgio, Sampietro, Marco, Zanetto, Francesco, Witzens, Jeremy, editor, Poon, Joyce, editor, Zimmermann, Lars, editor, and Freude, Wolfgang, editor

Published
2024
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15. Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study

Author

Alsina-Casanova, Miguel, Andersson, Ola, Arias-Llorente, Rosa Patricia, Berenger, Adeline, Bielska, Edyta, Boia, Marioara, Birkenmaier, André, Biros, Jakub, Blanquart, Anne Laure, Boggini, Tiziana, Boileau, Pascal, Bokiniec, Renata, Bresesti, Ilia, Broad, Katherine, Cavallaro, Giacomo, Chauvel, Jennifer, Cseszneki, Borbála, Dani, Carlo, Demová, Klaudia, Dornis, Diana, Duban, Marie-Pierre, Dziadkowiec-Motyl, Karolina, Erzen, Nika, Fanczal, Eszter, Fernández-Castiñeira, Sara, Galuschka, Libusa, Gandaputra, Ellen, García-Muñoz Rodrigo, Fermín, Gebauer, Corinna, Grimault, Hélène, Grund, Kristina, Gsöllpointner, Melanie, Gualdi, Silvia, Guaragni, Brunetta, Hahn, Markus, Haiden, Nadja, Hasmasanu, Monica, Iacob, Daniela, Ivanici, Mihaela, Jernej, Raphaela, Juren, Tomáš, Karcz, Karolina, Kornhauser, Lilijana, Królak-Olejnik, Barbara, Legnevall, Lena, Lehnerer, Verena, Levine, Emmanuelle, Ley, David, Del Carmen López Castillo, María, Magarotto, Mariella, Martini, Silvia, Maruniak-Chudek, Iwona, Moita, Rita, Mosuro, Anjola, Nowicka, Agnieszka, O'Reilly, Daniel, Pantea, Manuela, Pérez-Muñuzuri, Alejandro, Perme, Tina, Picciau, Laura, Pratesi, Simone, Prins, Sandra, Radicioni, Maurizio, Raffaeli, Genny, Roldan-López, Reyes, Roué, Jean-Michel, Węglarz, Beata Rzepecka, Sibrecht, Greta, Snijder, Pauline, Starčević, Mirta, Szántó, Emese, Teixeira, Liliana, Torrejon, Laura, Martí, Lourdes Urquía, Vanbuggenhout, Laurien, Zanetto, Lorenzo, Houben, Nina A.M., Lopriore, Enrico, Fijnvandraat, Karin, Caram-Deelder, Camila, Carrascosa, Marta Aguar, Beuchée, Alain, Brække, Kristin, Cardona, Francesco, Debeer, Anne, Domingues, Sara, Ghirardello, Stefano, Grizelj, Ruza, Hadžimuratović, Emina, Heiring, Christian, Krivec, Jana Lozar, Malý, Jan, Matasova, Katarina, Moore, Carmel Maria, Muehlbacher, Tobias, Szabó, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, de Jager, Justine, Reibel-Georgi, Nora Johanna, New, Helen V., Stanworth, Simon J., Deschmann, Emöke, Roehr, Charles C., Dame, Christof, le Cessie, Saskia, van der Bom, Johanna, and Fustolo-Gunnink, Suzanne

Published
2024
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22. Multibeam Free Space Optics Receiver Enabled by a Programmable Photonic Mesh

Author

Milanizadeh, Maziyar, SeyedinNavadeh, SeyedMohammad, Zanetto, Francesco, Grimaldi, Vittorio, De Vita, Christian, Klitis, Charalambos, Sorel, Marc, Ferrari, Giorgio, Miller, David A. B., Melloni, Andrea, and Morichetti, Francesco

Subjects
Physics - Applied Physics, Electrical Engineering and Systems Science - Signal Processing, Physics - Optics
Abstract

Free-space optics (FSO) is an attractive technology to meet the ever-growing demand for wireless bandwidth in next generation networks. To increase the spectral efficiency of FSO links, transmission over spatial division multiplexing (SDM) can be exploited, where orthogonal light beams have to be shaped according to suitable amplitude, phase, and polarization profiles. In this work, we show that a programmable photonic circuits, consisting of a silicon photonic mesh of tunable Mach-Zehnder Interferometers (MZIs) can be used as an adaptive multibeam receiver for a FSO communication link. The circuit can self-configure to simultaneously receive and separate, with negligible mutual crosstalk, signals carried by orthogonal FSO beams sharing the same wavelength and polarization. This feature is demonstrated on signal pairs either arriving at the receiver from orthogonal directions (direction-diversity) or being shaped according to different orthogonal spatial modes (mode-diversity), even in the presence of some mixing during propagation. The performance of programmable mesh as an adaptive multibeam receiver is assessed by means of data channel transmission at 10 Gbit/s a wavelength of 1550 nm, but the optical bandwidth of the receiver (>40 nm) allows its use at much higher data rates as well as in wavelength-division multiplexing SDM communication links.

Published
2021

23. Il 'silenzio eloquente' di Filomela nel Tereo di Sofocle (e nel romanzo di Achille Tazio)

Author

Giuseppe Zanetto

Subjects
Intertestualità e intervisualità, Achille Tazio, Tereo di Sofocle, Iconografia e tragedia attica, Greek language and literature. Latin language and literature, PA
Abstract

Nel V libro del suo romanzo, Achille Tazio descrive dettagliatamente un quadro che rappresenta il mito di Procne, Filomela e Tereo. Molti studiosi hanno ipotizzato un possibile rapporto con il Tereo di Sofocle, il dramma che nell’antichità ebbe importanza fondamentale per la conoscenza della vicenda. Il presente contributo ridiscute l’intero problema, focalizzandosi soprattutto su due punti. 1) L’ekphrasis di Achille Tazio dà una rappresentazione molto vivida della scena del riconoscimento: con la sua enfasi sull’azione agita, come se i personaggi fossero impegnati in una performance, il dettato del testo evoca chiaramente un contesto teatrale. 2) Negli anni di Sofocle si può ritenere che gli Ateniesi collegassero il mito di Procne e Filomela non solo con l’immagine dell’uccisione di Iti e del banchetto antropofagico (temi molto praticati dai ceramografi), ma anche con la scena del “peplo parlante”, che era riprodotta nelle metope del Partenone. Questa era probabilmente la “scena madre” del Tereo di Sofocle, un drammaturgo molto sensibile alle suggestioni iconografiche. Achille Tazio, che aveva accesso al testo completo del dramma sofocleo, compose la sua ekphrasis avendo negli occhi questa scena.

Published
2024
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25. Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

Author

Maria Agostini, Sofia, Balcar, Lorenz, Battistella, Sara, Chromy, David, Cornberg, Markus, Deterding, Katja, Fernandez, Inmaculada, Fernandez-Rodriguez, Conrado, Gea, Francisco, Koeck, Fiona, Krawanja, Julia, Neumayer, Daniela, Riado, Daniel, Rincón, Diego, Schwabl, Philipp, Simbrunner, Benedikt, Trauner, Michael, Uson, Clara, Wedemeyer, Heiner, Semmler, Georg, Alonso López, Sonia, Pons, Monica, Lens, Sabela, Dajti, Elton, Griemsmann, Marie, Zanetto, Alberto, Burghart, Lukas, Hametner-Schreil, Stefanie, Hartl, Lukas, Manzano, Marisa, Rodriguez-Tajes, Sergio, Zanaga, Paola, Schwarz, Michael, Gutierrez, María Luisa, Jachs, Mathias, Pocurull, Anna, Polo, Benjamín, Ecker, Dominik, Mateos, Beatriz, Izquierdo, Sonia, Real, Yolanda, Ahumada, Adriana, Bauer, David Josef Maria, Mauz, Jim Benjamin, Casanova-Cabral, Michelle, Gschwantler, Michael, Russo, Francesco Paolo, Azzaroli, Francesco, Maasoumy, Benjamin, Reiberger, Thomas, Forns, Xavier, Genesca, Joan, Bañares, Rafael, and Mandorfer, Mattias

Published
2024
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31. Liver transplantation for HBV-related liver disease: Impact of prophylaxis for HBV on HCC recurrence

Author

Burra, Patrizia, Battistella, Sara, Turco, Laura, Morelli, Maria Cristina, Frassanito, Gabriella, De Maria, Nicola, Pasulo, Luisa, Fagiuoli, Stefano, Di Benedetto, Clara, Donato, Maria Francesca, Magro, Bianca, Pagano, Duilio, Bhoori, Sherrie, Mazzaferro, Vincenzo, Lauterio, Andrea, De Carlis, Luciano, Forastiere, Domenico, Rendina, Maria, Angrisani, Debora, Lanza, Alfonso Galeota, Scandali, Giulia, Svegliati Baroni, Gianluca, Piano, Salvatore, Angeli, Paolo, Manuli, Chiara, Martini, Silvia, De Simone, Paolo, Vacca, Pier Giuseppe, Ghinolfi, Davide, Lionetti, Raffaella, Giannelli, Valerio, Mameli, Laura, Fornasiere, Ezio, Toniutto, Pierluigi, Biolato, Marco, Ponziani, Francesca Romana, Lenci, Ilaria, Ferrarese, Alberto, Passigato, Nicola, Marenco, Simona, Giannini, Edoardo, Ferri, Flaminia, Trapani, Silvia, Grossi, Paolo, Aghemo, Alessio, Zanetto, Alberto, and Russo, Francesco Paolo

Published
2024
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34. Genetic and Phenotypic Evaluation of European Maize Landraces as a Tool for Conservation and Valorization of Agrobiodiversity

Author

Carlotta Balconi, Agustin Galaretto, Rosa Ana Malvar, Stéphane D. Nicolas, Rita Redaelli, Violeta Andjelkovic, Pedro Revilla, Cyril Bauland, Brigitte Gouesnard, Ana Butron, Alessio Torri, Ana Maria Barata, Natalija Kravic, Valérie Combes, Pedro Mendes-Moreira, Danela Murariu, Hrvoje Šarčević, Beate Schierscher-Viret, Morgane Vincent, Anne Zanetto, Bettina Kessel, Delphine Madur, Tristan Mary-Huard, André Pereira, Domnica Daniela Placinta, Alexandre Strigens, Alain Charcosset, and Sandra Goritschnig

Subjects
maize, genebanks, evaluation network, conservation, genetic groups, genetic diversity, Biology (General), QH301-705.5
Abstract

The ECPGR European Evaluation Network (EVA) for Maize involves genebanks, research institutions, and private breeding companies from nine countries focusing on the valorization of maize genetic resources across Europe. This study describes a diverse collection of 626 local landraces and traditional varieties of maize (Zea mays L.) from nine European genebanks, including criteria for selection of the collection and its genetic and phenotypic diversity. High-throughput pool genotyping grouped the landraces into nine genetic groups with a threshold of 0.6 admixture, while 277 accessions were designated admixed and likely to have resulted from previous breeding activities. The grouping correlated well with the geographic origins of the collection, also reflecting the various pathways of introduction of maize to Europe. Phenotypic evaluations of 588 accessions for flowering time and plant architecture in multilocation trials over three years confirmed the great diversity within the collection, although phenotypic clusters only partially correlated with the genetic grouping. The EVA approach promotes conservation of genetic resources and opens an opportunity to increase genetic variability for developing improved varieties and populations for farmers, with better adaptation to specific environments and greater tolerance to various stresses. As such, the EVA maize collection provides valuable sources of diversity for facing climate change due to the varieties’ local adaptation.

Published
2024
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37. National, longitudinal NASCITA birth cohort study: prevalence of overweight at 12 months of age in children born healthy

Author

Antonio Clavenna, Massimo Cartabia, Maurizio Bonati, Federico Marchetti, Giorgio Tamburlini, Antonio Addis, Michele Valente, Rita Campi, Stefania Manetti, Valeria Carraro, Sergio Conti Nibali, Renato Sansone, Patrizia Rogari, Annalisa Campomori, Luca De Fiore, Renata Bortolus, Sergio Cattani, Cristiana Piloni, Valeria Renzetti, Rosario Cavallo, Gherardo Rapisardi, Giacomo Toffol, Vicenza Briscioli, Carla Cafaro, Cristoforo Cocchiara, Isodiana Crupi, Patrizia Del Balzo, Laura Dell’edera, Chiara Di Francesco, Alberto Ferrando, Francesca Grassa, Chiara Guidoni, Claudio Mangialavori, Stefano Marinoni, Francesca Marongiu, Fausta Matera, Paolo Moretti, Laura Olimpi, Angela Pasinato, Ilaria Porro, Ippolita Roncoroni, Raffaella Schiro’, Patrizia Seppia, Federica Zanetto, Anna Aloisio, Elisabetta Anedda, Giuliana Apuzzo, Giovanna Argo, Anna Armenio, Emanuela Ballerini, Monica Benedetti, Daniela Bertoli, Stefano Bollettini, Chiara Bottalico, Aurora Bottiglieri, Vincenza Briscioli, Antonella Bruno, Laura Brusadin, Mariantonietta Caiazzo, Patrizia Calamita, Miriana Callegari, Rosaria Cambria, Maria Cristina Cantù, Domenico Capomolla, Anna Caracciolo, Maria Concetta Carbone, Gaetano Carrassi, Maria Laura Cartiglia, Sara Casagranda, Ornella Castiglione, Rosario Salvatore Cavallo, Teresa Cazzato, Maria Angela Cazzuffi, Jennifer Chiarolanza, Rosaria China, Nicoletta Cimadamore, Roberto Cionini, Cristina Ciuffo, Damiano Colazzo, Anna Maria Costantini, Claudio Cravidi, Marialuisa Criscione, Rita D’Agostino, Daniela Danieli, Luigi De Carlo, Marina De Sanctis, Giuseppina De Santes, Gian Piero Del Bono, Maria Elisabetta Di Pietro, Maria Chiara Dini, Paolo Fiammengo, Micaela Foco, Maria Teresa Fonte, Maria Frigeri, Andrea Galvagno, Matteo Gaudino, Stefania Genoni, Silvia Girotto, Gianluca Gornati, Marta Gozzi, Enrica Heritier, Antonella Lavagetto, Raffaele Limauro, Alessandra Magnelli, Maria Gabriella Maiolino, Monica Malventano, Silvia Marchi, Natale Maresca, Federico Marolla, Agata Martinelli, Chiara Martinez, Nicoletta Mascarello, Carla Matiotti, Elisabetta Mazzucchi, Donatella Moggia, Manuela Musetti, Paolo Nardini, Alberto Neri, Patrizia Neri, Flavia Nicoloso, Laura Maria Olimpi, Giancarlo Ottonello, Giacinta Padula, Paolo Maria Paganuzzi, Rosanna Palazzi, Alessandra Palmero, Maria Chiara Parisini, Giovannina Pastorelli, Marilena Pavoni, Lucia Peccarisi, Antonella Pellacani, Cristina Perrera, Michela Picciotti, Ivo Picotto, Tiziana Piunti, Francesca Preziosi, Giuseppe Primavera, Miriam Prodi, Maria Letizia Rabbone, Innocenza Rafele, Laura Reali, Franziska Stefanie Rempp, Ada Riundi, Paolo Rosas, Annarita Russo, Mariagrazia Saccà, Elisabetta Sala, Francesca Sala, Francesca Santus, Vittoria Sarno, Alessandra Savino, Raffaella Schirò, Giuseppa Scornavacca, Maria Francesca Siracusano, Adelisa Spalla, Gloria Sturaro, Maria Grazia Toma, Ettore Tomagra, Maria Tortorella, Fausta Trentadue, Marina Trevisan, Silvia Tulisso, Roberta Usella, Anna Valente, Mariangela Valera, Edda Vernile, Valeria Vicario, Lucia Vignutelli, Paolo Vinci, Lucia Vizziello, Rosette Zand, Marco Zanette, Graziano Zucchi, Maria Luisa Zuccolo, Eleonora Morabito, Chiara Liz Pandolfini, Chiara Segre’, Rossella Claudia Cannavo’, Melania Maria Cera, Emma Maria Giugnini, and Giovanni Giuliano Semprini

Subjects
Pediatrics, RJ1-570
Abstract

Objective To estimate the prevalence of overweight at 12 months in an Italian birth cohort and to identify factors related to an increased likelihood of being overweight.Methods The Italian NASCITA birth cohort was analysed. Infants were classified as underweight (

Published
2023
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44. Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV)

Author

Maria Giovanna Quaranta, Luisa Cavalletto, Francesco Paolo Russo, Vincenza Calvaruso, Luigina Ferrigno, Alberto Zanetto, Benedetta Mattioli, Roberta D’Ambrosio, Valentina Panetta, Giuseppina Brancaccio, Giovanni Raimondo, Maurizia Rossana Brunetto, Anna Linda Zignego, Carmine Coppola, Andrea Iannone, Elisa Biliotti, Elena Rosselli Del Turco, Marco Massari, Anna Licata, Francesco Barbaro, Marcello Persico, Filomena Morisco, Maurizio Pompili, Federica Cerini, Massimo Puoti, Teresa Santantonio, Antonio Craxì, Loreta A. Kondili, Liliana Chemello, and on behalf of PITER Collaborating Investigators

Subjects
hepatocellular carcinoma, hepatitis C virus, direct-acting antiviral, sustained virological response, real-life cohort, Microbiology, QR1-502
Abstract

The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in people with advanced liver disease even after SVR. We weighted the HCC risk in people with cirrhosis achieving HCV eradication through DAA treatment and compared it with untreated participants in the multicenter prospective Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. Propensity matching with inverse probability weighting was used to compare DAA-treated and untreated HCV-infected participants with liver cirrhosis. Kaplan–Meier analysis and competing risk regression analysis were performed. Within the first 36 months, 30 de novo HCC cases occurred in the untreated group (n = 307), with a weighted incidence rate of 0.34% (95%CI: 0.23–0.52%), compared to 63 cases among SVR patients (n = 1111), with an incidence rate of 0.20% (95%CI: 0.16–0.26%). The 12-, 24-, and 36-month HCC weighted cumulative incidence rates were 6.7%, 8.4%, and 10.0% in untreated cases and 2.3%, 4.5%, and 7.0% in the SVR group. Considering death or liver transplantation as competing events, the untreated group showed a 64% higher risk of HCC incidence compared to SVR patients (SubHR 1.64, 95%CI: 1.02–2.62). Other variables independently associated with the HCC occurrence were male sex, increasing age, current alcohol use, HCV genotype 3, platelet count ≤ 120,000/µL, and albumin ≤ 3.5 g/dL. In real-life practice, the high efficacy of DAA in achieving SVR is translated into high effectiveness in reducing the HCC incidence risk.

Published
2024
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