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565 results on '"Zanovello Paola"'

1. MicroRNA expression in HTLV-1 infection and pathogenesis

Author

Zanovello Paola, Corti Giorgio, De Bellis Gianluca, Guffanti Alessandro, Basso Katia, Corradin Alberto, Pise-Masison Cynthia A, Bortoluzzi Stefania, Biasiolo Marta, Ruggero Katia, D'Agostino Donna M, Bronte Vincenzo, and Ciminale Vincenzo

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2011
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2. Impact of γ-chain cytokines on EBV-specific T cell cultures

Author

Zanovello Paola, Trento Cristina, Turrini Riccardo, Merlo Anna, Dolcetti Riccardo, and Rosato Antonio

Subjects
Medicine
Abstract

Abstract Background Recent preclinical adoptive immunotherapy studies in murine models prompt to employ "proper" rather than "as many as possible" antigen-specific T cells to gain better therapeutic results. Ideally, "proper" T cells are poorly differentiated in vitro, but retain the capacity to fully differentiate into effector cells in vivo, where they can undergo long-term survival and strong proliferation. Such requirements can be achieved by modifying culture conditions, namely using less "differentiating" cytokines than IL-2. Methods To evaluate this issue in human T cell cultures, we exploited a well characterized and clinical-grade protocol finalized at generating EBV-specific CTL for adoptive immunotherapy. In particular, we studied the impact of IL-7, IL-15 and IL-21 compared to IL-2 on different aspects of T cell functionality, namely growth kinetics, differentiation/activation marker expression, cytokine production, and short-term and long-term cytotoxicity. Results Results disclosed that the culture modifications we introduced in the standard protocol did not improve activity nor induce substantial changes in differentiation marker expression of EBV-specific CTL. Conclusions Our data indicated that the addition of γ-chain cytokines other than IL-2 for the generation of EBV-specific T cell cultures did not produce the improvements expected on the basis of recent published literature. This fact was likely due to the intrinsic differences between murine and human models and highlights the need to design ad hoc protocols rather than simply modify the cytokines added in culture.

Published
2010
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3. A gene expression signature associated with survival in metastatic melanoma

Author

Rossi Carlo R, Mocellin Simone, Chiarion-Sileni Vanna, Montesco Maria C, Francescato Samuela, Turcatel Gianluca, Callegaro Andrea, Mandruzzato Susanna, Bicciato Silvio, Wang Ena, Marincola Francesco M, and Zanovello Paola

Subjects
Medicine
Abstract

Abstract Background Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction of clinical outcome. We investigated whether genome screening by means of high-throughput gene microarray might provide clinically useful information on patient survival. Methods Forty-three tumor tissues from 38 patients with stage III and stage IV melanoma were profiled with a 17,500 element cDNA microarray. Expression data were analyzed using significance analysis of microarrays (SAM) to identify genes associated with patient survival, and supervised principal components (SPC) to determine survival prediction. Results SAM analysis revealed a set of 80 probes, corresponding to 70 genes, associated with survival, i.e. 45 probes characterizing longer and 35 shorter survival times, respectively. These transcripts were included in a survival prediction model designed using SPC and cross-validation which allowed identifying 30 predicting probes out of the 80 associated with survival. Conclusion The longer-survival group of genes included those expressed in immune cells, both innate and acquired, confirming the interplay between immunological mechanisms and the natural history of melanoma. Genes linked to immune cells were totally lacking in the poor-survival group, which was instead associated with a number of genes related to highly proliferative and invasive tumor cells.

Published
2006
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4. Melanoma-restricted genes

Author

Zanovello Paola, Seliger Barbara, Taylor Phil R, Hu Nan, Mandruzzato Susanna, Zavaglia Katia, Panelli Monica C, Wang Ena, Freedman Ralph S, and Marincola Francesco M

Subjects
Medicine
Abstract

Abstract Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affect the relationship between tumor and host immune cells but, taken one at the time, none yielded a convincing explanation. With explorative purposes, high-throughput technology was applied here to portray transcriptional characteristics unique to metastatic cutaneous melanoma that may or may not be relevant to its immunogenic potential. Several functional signatures could be identified descriptive of immune or other biological functions. In addition, the transcriptional profile of metastatic melanoma was compared with that of primary renal cell cancers (RCC) identifying several genes co-coordinately expressed by the two tumor types. Since RCC is another immune responsive tumor, commonalities between RCC and melanoma may help untangle the enigma of their potential immune responsiveness. This purely descriptive study provides, therefore, a map for the investigation of metastatic melanoma in future clinical trials and at the same time may invite consideration of novel therapeutic targets.

Published
2004
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11. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

Author

Marigo, Ilaria, Zilio, Serena, Desantis, Giacomo, Mlecnik, Bernhard, Agnellini, Andrielly H.R., Ugel, Stefano, Sasso, Maria Stella, Qualls, Joseph E., Kratochvill, Franz, Zanovello, Paola, Molon, Barbara, Ries, Carola H., Runza, Valeria, Hoves, Sabine, Bilocq, Amélie M., Bindea, Gabriela, Mazza, Emilia M.C., Bicciato, Silvio, Galon, Jérôme, Murray, Peter J., and Bronte, Vincenzo

Published
2016
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15. Current and past research between Tebtynis and Padua

Author

Deotto, Giulia, primary, Begg, Ian, additional, Menegazzi, Alessandra, additional, Urbani, Carlo, additional, Meleri, Andrea, additional, Toninello, Luca, additional, Magnini, Luigi, additional, Burigana, Laura, additional, De Guio, Armando, additional, Angelini, Ivana, additional, Bettineschi, Cinzia, additional, Molin, Gianmario, additional, Salemi, Giuseppe, additional, and Zanovello, Paola, additional

Published
2018
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17. Supplementary Figure 1 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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18. Data from Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

Author

Nardo, Giorgia, primary, Favaro, Elena, primary, Curtarello, Matteo, primary, Moserle, Lidia, primary, Zulato, Elisabetta, primary, Persano, Luca, primary, Rossi, Elisabetta, primary, Esposito, Giovanni, primary, Crescenzi, Marika, primary, Casanovas, Oriol, primary, Sattler, Ulrike, primary, Mueller-Klieser, Wolfgang, primary, Biesalski, Barbara, primary, Thews, Oliver, primary, Canese, Rossella, primary, Iorio, Egidio, primary, Zanovello, Paola, primary, Amadori, Alberto, primary, and Indraccolo, Stefano, primary

Published
2023
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19. Supplementary Methods from Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

Author

Nardo, Giorgia, primary, Favaro, Elena, primary, Curtarello, Matteo, primary, Moserle, Lidia, primary, Zulato, Elisabetta, primary, Persano, Luca, primary, Rossi, Elisabetta, primary, Esposito, Giovanni, primary, Crescenzi, Marika, primary, Casanovas, Oriol, primary, Sattler, Ulrike, primary, Mueller-Klieser, Wolfgang, primary, Biesalski, Barbara, primary, Thews, Oliver, primary, Canese, Rossella, primary, Iorio, Egidio, primary, Zanovello, Paola, primary, Amadori, Alberto, primary, and Indraccolo, Stefano, primary

Published
2023
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20. Supplementary Figure 6 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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23. Supplementary Figure 4 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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24. Supplementary Figure 2 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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25. Supplementary Figure Legends 1-9 from Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

Author

Nardo, Giorgia, primary, Favaro, Elena, primary, Curtarello, Matteo, primary, Moserle, Lidia, primary, Zulato, Elisabetta, primary, Persano, Luca, primary, Rossi, Elisabetta, primary, Esposito, Giovanni, primary, Crescenzi, Marika, primary, Casanovas, Oriol, primary, Sattler, Ulrike, primary, Mueller-Klieser, Wolfgang, primary, Biesalski, Barbara, primary, Thews, Oliver, primary, Canese, Rossella, primary, Iorio, Egidio, primary, Zanovello, Paola, primary, Amadori, Alberto, primary, and Indraccolo, Stefano, primary

Published
2023
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26. Supplementary Table from Common Cancer Biomarkers

Author

Basil, Christopher F., primary, Zhao, Yingdong, primary, Zavaglia, Katia, primary, Jin, Ping, primary, Panelli, Monica C., primary, Voiculescu, Sonia, primary, Mandruzzato, Susanna, primary, Lee, Hueling M., primary, Seliger, Barbara, primary, Freedman, Ralph S., primary, Taylor, Phil R., primary, Hu, Nan, primary, Zanovello, Paola, primary, Marincola, Francesco M., primary, and Wang, Ena, primary

Published
2023
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27. Data from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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28. Supplementary Figure 5 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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29. Supplementary Figures 1-9 from Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

Author

Nardo, Giorgia, primary, Favaro, Elena, primary, Curtarello, Matteo, primary, Moserle, Lidia, primary, Zulato, Elisabetta, primary, Persano, Luca, primary, Rossi, Elisabetta, primary, Esposito, Giovanni, primary, Crescenzi, Marika, primary, Casanovas, Oriol, primary, Sattler, Ulrike, primary, Mueller-Klieser, Wolfgang, primary, Biesalski, Barbara, primary, Thews, Oliver, primary, Canese, Rossella, primary, Iorio, Egidio, primary, Zanovello, Paola, primary, Amadori, Alberto, primary, and Indraccolo, Stefano, primary

Published
2023
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30. Supplementary Figure 3 from Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma-specific CD8+ T Lymphocytes

Author

De Palma, Raffaele, primary, Marigo, Ilaria, primary, Del Galdo, Francesco, primary, De Santo, Carmela, primary, Serafini, Paolo, primary, Cingarlini, Sara, primary, Tüting, Thomas, primary, Lenz, Julia, primary, Basso, Giuseppe, primary, Milan, Gabriella, primary, Zanovello, Paola, primary, and Bronte, Vincenzo, primary

Published
2023
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32. Supplementary Methods, Figures 1-3 from Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Author

Bobisse, Sara, primary, Rondina, Maria, primary, Merlo, Anna, primary, Tisato, Veronica, primary, Mandruzzato, Susanna, primary, Amendola, Mario, primary, Naldini, Luigi, primary, Willemsen, Ralph A., primary, Debets, Reno, primary, Zanovello, Paola, primary, and Rosato, Antonio, primary

Published
2023
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38. Tra luci e ombre: le nuove ricerche su una mummia

Author

Martino, Gottardo, Gambino, Claudia, Deotto, Giulia, Ciapini, Emanuele Marcello, Stranmare, Roberto, Giuliano, Scattolin, Salemi, Giuseppe, Faresin, Emanuela, Filippo, Merola, Carrara, Nicola, Bellavitis, Maddalena, Bettineschi, Cinzia, and Zanovello, Paola

Subjects
ddc:930
Published
2022

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