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Alzheimer's is a progressive and degenerative disease affecting millions worldwide, incapacitating them physically and cognitively. This study aims to perform a comparative analysis of Machine Learning models to determine the model with the best performance in predicting Alzheimer's disease. The models used were Random Forest (RF), Adaptive Boosting (AdaBoost), Support Vector Machine (SVM), K-nearest Neighbors (KNN), and Logistic Regression (LR). Two datasets called OASIS were used to train the models, the first one had a total of 436 records and 12 variables, while the second one stored 373 records and 15 variables. The article's content is divided into six main sections: introduction, literature review, methodological approach, results, discussions, and conclusions. After processing and pooling the datasets, RF, SVM, and LR proved the best predictors, achieving 96% accuracy, precision, sensitivity, and F1 score. This study highlights the efficacy of RF, SVM, and LR in predicting Alzheimer's disease, offering a significant advance toward understanding and management of this disease, which supports the relevance of implementing these models in future research and clinical applications., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2025 The Authors.)

Monkeypox is a rare disease caused by the monkeypox virus. This disease was considered eradicated in 1980 and was believed to affect rodents and not humans. However, recent years have seen a massive outbreak of monkeypox in humans, setting off worldwide alerts from health agencies. As of September 2022, the number of confirmed cases in Peru had reached 1964. Although most monkeypox patients have been discharged, we cannot neglect the monitoring of the population with respect to the monkeypox virus. Lately, the population has started to express their feelings and opinions through social media, specifically Twitter, as it is the most used social medium and is an ideal space to gather what people think about the monkeypox virus. The information imparted through this medium can be in different formats, such as text, videos, images, audio, etc. The objective of this work is to analyze the positive, negative, and neutral feelings of people who publish their opinions on Twitter with the hashtag #Monkeypox. To find out what people think about this disease, a hybrid-based model architecture built on CNN and LSTM was used to determine the prediction accuracy. The prediction result obtained from the total monkeypox data was 83% accurate. Other performance metrics were also used to evaluate the model, such as specificity, recall level, and F1 score, representing 99%, 85%, and 88%, respectively. The results also showed the polarity of feelings through the CNN-LSTM confusion matrix, where 45.42% of people expressed neither positive nor negative opinions, while 19.45% expressed negative and fearful feelings about this infectious disease. The results of this work contribute to raising public awareness about the monkeypox virus.