30 results on '"Zargi, Miha"'
Search Results
2. Identification of three anatomical patterns of the spinal accessory nerve in the neck by neurophysiological mapping
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Lanisnik Bostjan, Zargi Miha, and Rodi Zoran
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spinal accessory nerve ,nerve mapping ,neck dissection ,anatomy ,shoulder disability ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Background. In spite of preservation of the accessory nerve there is still considerable proportion of patients with partial nerve damage during modified radical neck dissection (MRND).
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- 2014
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3. The music perception abilities of prelingually deaf children with cochlear implants
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Stabej, Katja Kladnik, Smid, Lojze, Gros, Anton, Zargi, Miha, Kosir, Andrej, and Vatovec, Jagoda
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- 2012
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4. Electrophysiologic analysis of injury to cranial nerve XI during neck dissection
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Lanisnik, Bostjan, Zargi, Miha, and Rodi, Zoran
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- 2016
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5. Risk factors for voice quality after radiotherapy for early glottic cancer
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Hočevar-Boltežar, Irena, Žargi, Miha, and Strojan, Primož
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- 2009
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6. The influence of cochlear implantation on some voice parameters
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Hocevar-Boltezar, Irena, Vatovec, Jagoda, Gros, Anton, and Zargi, Miha
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- 2005
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7. Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal
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Battelino, Saba, Hocevar-Boltezar, Irena, and Zargi, Miha
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Mitomycin -- Health aspects ,Adhesions -- Care and treatment ,Stenosis -- Care and treatment - Abstract
Abstract The ability of mitomycin C to inhibit fibroblasts in vitro has prompted its use during standard surgical procedures as a means of preventing the development of adhesions and stenosis. [...]
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- 2005
8. Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head-and-neck carcinoma
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S̆mid, Lojze, Budihna, Marjan, Zakotnik, Branko, S̆oba, Erika, Strojan, Primoz̆, Fajdiga, Igor, Z̆argi, Miha, Oblak, Irena, Dremelj, Marta, and LeS̆nic̆ar, Hotimir
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- 2003
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9. Instability of voice in adolescence: Pathologic condition or normal developmental variation?
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Boltezar, Irena Hocevar, Burger, Zora Radsel, and Zargi, Miha
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- 1997
10. Non food foreign body injuries
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Slapak, Ivo, Passali, Francesco Maria, Passali, Giulio Cesare, Gulati, Achal, Gregori, Dario, Foltran, Francesca, Ballali, Simonetta, Berchialla, Paola, Rodriguez, Hugo, Zaupa, Paola, Spitzer, Peter, Demetriades, Costantinos, Sokolova, Ljiljana, Petridou, Eleni, D'Alessandro, Antonella, Pais Clemente, Manuel Antonio Caldeira, Jakubíková, Jana, Van As, Sebastian, De Koning, Ton, Passali, Desiderio, Chinsky, Alberto, Brkic, Fuad, Mladina, Ranko, Kalakouta, Olga, Melis, Andreas, Máchalová, Michaela, Thomasen, Per Caye, Elsheikh, Enas, Ragab, Ahmed, Pitkäranta, Anne, Necker, Philippe Contencin, Derelle, Jocelyne, Duwelz, Magali, Francois, Martine, Pezzettigotta, Stephane, Righini, Christian, Stephane, Pezzettigotta, Bernhard, Roehrich, Jahnke, Volker, Onder, Goktas, Zieriacks, Petra, Kalampoki, Vicky, Simasko, Nikola, Skoulakis, Charalampos, Camaioni, Angelo, Cutrone, Cesare, Gaudini, Elisa, Messi, Gianni, Grasso, Domenico, Orlando, Claudio, Nicola Mansi, Mansi, Preziosi, Sabino, Villari, Giuseppe, Sorrentini, Italo, Trozzi, Marilena, Vigo, Alessandro, Nishida, Yoshifumi, Ussatayeva, Gainel, De Hoyos, Ricardo, Ologe, Foluwasayo Emmanuel, Nasrullah, Muazzam, Melendez, Amarilis, Chmielik, Mieckzyslaw, Belchior, Teresa, Cobzeanu, Mihail Dan, Gheorghe, Dan Cristian, Toader, Miorita, Iorgulescu, Lennaert, Codrut, Caius, Barkociová, Jana, Havelkova, Jana, Zargi, Miha, Pumarola, Felix, Rubio, Lorenzo, Stierna, Pontus, Hsu, Wei chung, Arj-Ong, Sakda, Chomchai, Chulathida, Rinkel, Rico, Hoep, Lennaert, Baskent, Erdinc Aydin, Erikci, Volkan Sarper, Onerci, Metin, Graham, John, Khwaja, Sadie, Raine, Christopher, Otolaryngology / Head & Neck Surgery, and CCA - Quality of life
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Perforation (oil well) ,Poison control ,Suicide prevention ,Occupational safety and health ,Age Distribution ,Injury prevention ,medicine ,Humans ,Registries ,Sex Distribution ,Child ,business.industry ,Infant, Newborn ,Infant ,Human factors and ergonomics ,General Medicine ,Odds ratio ,Consumer protection ,Foreign Bodies ,Surgery ,Europe ,Hospitalization ,Otorhinolaryngology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
Rationale and aim The aim of the present study is to acquire a better understanding of Non Food Foreign Bodies (NFFB) injuries in children with particular regard to the quantification of the risk of complications and hospitalization associated with patient characteristics, FB features, FB location and circumstances of the accident, as emerging from the SUSY Safe Web-Registry. Methods The present study uses data provided by the SUSY Safe Project, a DG SANCO co-funded project which was aimed to collect as many scientific data as possible regarding Foreign Bodies (FB) injuries in children aged 0–14 years and to serve as a basis for a knowledge-based consumer protection activity in the Europe market. FBs were characterized by size, shape and consistency. Descriptive statistics (absolute and relative number or median, I and III quartile according to the categorical or continuous variable, respectively) were calculated for each considered non food item characteristics; FB features distribution by children class age and site of obstruction were assessed. Two different outcomes were considered: hospitalization and complication. FBs which most frequently cause complications were identified. The association between children age, adult presence, object characteristics and outcomes was computed using crude odds ratios and the related 95% confidence intervals. Results 16,878 FB injuries in children aged 0–14 yrs have been recorded in the Susy Safe databases. FB type was specified in 10,564 cases; among them 7820 (74%) were due to a non food item. Almost two thirds of injuries occurred in patients 3 years or more old. 53% of patients were males, while 47% were females. When injury happened, the great part of children (86%) was playing. Almost 30% (2339) of injuries happened under adults’ supervision. Complications occurred in 299 cases and the most documented was infections (10% of cases) followed by perforation (5%). Conclusions The inhalation/aspiration of a FB, as well as the ingestion and the insertion in the orifices of a FB may result in significant morbidity. Particularly, long-standing or hazardous foreign bodies can cause extensive damage. Some objects, because of their composition, contour, or location, are particularly hazardous: for instance, objects with sharp edges pose a significant risk of laceration and perforation, while fragments of toys have been found only in 2 cases. Parents are frequently unconscious of hazard related with some objects and they are not adequately able to promptly recognize dangerous objects and risky situations. Moreover, also clinicians seem to pay little attention to adult role in the dynamic of the accident: in fact in case series descriptions, data regarding adult presence are often under-reported. On the contrary, since many injuries to children cannot be prevented without some degree of active behavior on the part of parents, the dissemination of information regarding safe behaviors and the implementation of educational strategies aiming to improve parent's attention toward this issue could be fundamental in preventing injuries and need to be promoted by family pediatricians and health practitioners.
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- 2012
11. Symptoms associated with button batteries injuries in children: An epidemiological review
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Buttazzoni, Elisa, Gregori, Dario, Paoli, Bibiana, Soriani, Nicola, Baldas, Solidea, Rodriguez, Hugo, Lorenzoni, Giulia, Marquez, Claudio Rene, Cuestas, Giselle, Sica, Graciela, Berchialla, Paola, Zaupa, Paola, Spitzer, Peter, Demetriades, Costantinos, Ŝlapák, Ivo, Sokolova, Ljiljana, Petridou, Eleni, Antonio, Manuel, Jakubíková, Jana, Sebastian Van, As, Koning, Ton De, Passali, Desiderio, Bouchikhi, Nourredine, Boufersaoui, Abderrahmane, Chinsky, Alberto, Tortosa, Susana, Blasio, Andrea Di, Rodriguez, Veronica, Taire, Damian, Razetti, Juan, Mariotti, Carlos Adolfo, Ariel, Achával Héctor, Zanetta, Adrian, Dario, Fajre, Pabón, Sonia Milena, Quijano, Alejandro, Nieto, Marìa Elena, Bordino, Lucas, Dallakyan, Nikolay, Dallakyan, David, Villca, Nelson, Brkic, Fuad, Umihanic, Sekib, Reis, Marcelo, Manrique, Dayse, Nkodo, Yves, Ludemann, Jeffrey, Chengpeng, Jiang, Puentes, Oscar Uriel Barón, Mladina, Ranko, De La Rosa, Evians Gomez, Kalakouta, Olga, Melis, Andreas, Zeitouni, Florence, Máchalová, Michaela, Slapak, Jan, Pecková, Pavla, Caye-Thomasen, Per, Chacon, Fernando Silva, Parker, John, Elsheikh, Enas, Ragab, Ahmed, Pitkäranta, Anne, Necker, Philippe Contencin, Derelle, Jocelyne, Duwelz, Magali, Francois, Martine, Pezzettigotta, Stephane, Righini, Christian, Chkhaidze, Ivane, Bernhard, Roehrich, Jahnke, Volker, Onder, Goktas, Zieriacks, Petra, Siegfried, Klaue, Koitschev, Assen, Kalampoki, Vicky, Simasko, Nikola, Skoulakis, Charalampos, Gulati, Achal, Nimbalkar, Somashekhar, Sharma, Yojana, Squicciarini, Marco, Damasco, Mirko, Camaioni, Angelo, Cutrone, Cesare, Gaudini, Elisa, Grassom, Domenico, Messi, Gianni, Mansi, Nicola, Orlando, Claudio, Preziosi, Sabino, Sorrentini, Italo, Villari, Giuseppe, Trozzi, Marilena, Vigo, Alessandro, Passali, Giulio Cesare, Passali, Francesco Maria, Piantanida, Renato, Giordano, Carlo, Mercuri, Leonardo, Cecconi, Alessandro, Giovari, Matteo, Calderini, Edoardo, Nishida, Yoshifumi, Saito, Tadashi, Ussatayeva, Gainel, De Hoyos Parra, Ricardo Antonio, Treviño Gonzalez, Jose Luis, Ramayo, Seraides, Ologe, Foluwasayo Emmanuel, Afolabi, Olushola, Nasrullah, Muazzam, Melendez, Amarilis, Milanes, Rafael, Chmielik, Mieckzyslaw, Belchior, Teresa, Cobzeanu, Mihail Dan, Gheorghe, Dan Cristian, Iorgulescu, Adelaida, Toader, Miorita, Codrut, Caius, Stankovic, Katarina, Barkociová, Jana, Havelkova, Beata, Jakubikova, Janka, Koman, Andrej, Zargi, Miha, Pumarola, Felix, Rubio, Lorenzo, Peco, Karina Pernías, Stierna, Pontus, Hsu, Wei-Chung, Arj-Ong, Sakda, Chomchai, Chulathida, Chotigavanich, Chanticha, Hoep, Lennaert, Rinkel, Rico, Berraies, Anissa, Baskent, Erdinc Aydin, Erikci, Volkan Sarper, Onerci, Metin, Graham, John, Khwaja, Sadie, Raine, Christopher, Haloob, Nora, Haedo, Ines Doassans Gómez, Mehta, Deepak, Casselbrant, Margaretha, and Toan, Pham Ngoc
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Male ,Pediatrics ,Databases, Factual ,Poison control ,Eating ,Registries ,Child ,Nose ,Button batteries ,Children injuries ,Choking ,Foreign bodies ,Ingestion ,Adolescent ,Child, Preschool ,Cough ,Crying ,Deglutition Disorders ,Epidemiologic Studies ,Esophagus ,Female ,Fever ,Foreign Bodies ,Humans ,Infant ,Infant, Newborn ,Inhalation ,Mouth ,Nasal Cavity ,Sialorrhea ,Stomach ,Symptom Assessment ,Electric Power Supplies ,Otorhinolaryngology2734 Pathology and Forensic Medicine ,General Medicine ,Perinatology and Child Health ,Dysphagia ,medicine.anatomical_structure ,Settore MED/31 - OTORINOLARINGOIATRIA ,medicine.symptom ,medicine.medical_specialty ,Pediatrics, Perinatology and Child Health ,Irritability ,Drooling ,Databases ,Injury prevention ,medicine ,Preschool ,Factual ,business.industry ,medicine.disease ,Newborn ,Otorhinolaryngology ,Foreign body ,business - Abstract
Objectives To provide an epidemiological framework of symptoms related to Foreign Body (FB) injuries due to Button Battery (BB). Methods Data on BB ingestion/inhalation have been obtained from the ButtonBatteryDB. The ButtonBatteryDB is a database collecting information on BB injuries in children (0–18 years of age). Data on 348 BB injures have been derived from the Registry of Foreign Body Injuries “Susy Safe” (269 cases) and from published scientific literature reporting case reports of FB injuries (79 cases). Results Most of injured children were male and BBs were found more often in the mouth/esophagus/stomach (ICD935) and in the nose (ICD932). Analyzing symptoms related to BB located in the esophagus/mouth/stomach, we found that children had higher probability of experiencing dysphagia (30.19%, 95% C.I. 17.83–42.55), fever and cough (26.42%, 95% C.I. 14.55–38.28), compared to the other symptoms. Referring to the probability that symptoms occurred simultaneously, fever and cough are more likely (3.72%, 95% C.I. 1.0–6-43) to jointly showing up in children with BB in mouth/esophagus/stomach (ICD935), followed by fever and dysphagia (2.66%, 95% C.I. 0.36–4.96) and by fever and irritability/crying, fever and drooling, dysphagia and irritability/crying (2.13% C.I. 0.00–4.19, 95% C.I.) Conclusions These findings provide new insight in clinical presentation of BB injuries: the identification of unique patterns of symptoms related to BB injuries is useful to perform an early diagnosis (and to guarantee a prompt medical reaction), also when the injury is un-witnessed.
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- 2015
12. Food foreign body injuries
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Sebastian van As, Arjan B., Yusof, Abdullah M., Millar, Alastair J.W., Gregori, Dario, Foltran, Francesca, Ballali, Simonetta, Berchialla, Paola, Rodriguez, Hugo, Zaupa, Paola, Spitzer, Peter, Demetriades, Costantinos, Slapák, Ivo, Sokolova, Ljiljana, Petridou, Eleni, D'Alessandro, Antonella, Clemente, Manuel Antonio Caldeira Pais, Jakubíková, Jana, As, Sebastian Van, Koning, Ton De, Passali, Desiderio, Chinsky, Alberto, Brkic, Fuad, Mladina, Ranko, Kalakouta, Olga, Melis, Andreas, Máchalová, Michaela, Caye-Thomasen, Per, Elsheikh, Enas, Ragab, Ahmed, Pitkäranta, Anne, Necker, Philippe Contencin, Derelle, Jocelyne, Duwelz, Magali, Francois, Martine, Pezzettigotta, Stephane, Righini, Christian, Stephane, Pezzettigotta, Buzarov, Jane, Bernhard, Roehrich, Jahnke, Volker, Onder, Goktas, Zieriacks, Petra, Kalampoki, Vicky, Simasko, Nikola, Skoulakis, Charalampos, Camaioni, Angelo, Cutrone, Cesare, Gaudini, Elisa, Grasso, Domenico, Mansi, Nicola, Messi, Gianni, Orlando, Claudio, Preziosi, Sabino, Sorrentini, Italo, Trozzi, Marilena, Vigo, Alessandro, Villari, Giuseppe, Passali, Giulio Cesare, Passali, Francesco Maria, Nishida, Yoshifumi, Ussatayeva, Gainel, Hoyos, Ricardo De, Ologe, Foluwasayo Emmanuel, Nasrullah, Muazzam, Melendez, Amarilis, Chmielik, Mieckzyslaw, Belchior, Teresa, Cobzeanu, Mihail Dan, Gheorghe, Dan Cristian, Iorgulescu, Adelaida, Caius-Codrut, Toader, Miorita, Barkociová, Jana, Havelkova, Beata, Zargi, Miha, Sebastian van As, A. B., Pumarola, Felix, Rubio, Lorenzo, Stierna, Pontus, Hsu, Wei Chung, Arj-Ong, Sakda, Chomchai, Chulathida, Hoep, Lennaert, Rinkel, Rico, Baskent, Erdinc Aydin, Erikci, Volkan Sarper, Onerci, Metin, Graham, John, Khwaja, Sadie, Raine, Christopher, and Otolaryngology / Head & Neck Surgery
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Larynx ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Poison control ,Atelectasis ,Age Distribution ,Injury prevention ,medicine ,Humans ,Prospective Studies ,Registries ,Esophagus ,Sex Distribution ,Child ,Nose ,business.industry ,Pharynx ,Infant, Newborn ,Infant ,General Medicine ,medicine.disease ,Foreign Bodies ,Surgery ,Europe ,Hospitalization ,medicine.anatomical_structure ,Otorhinolaryngology ,Food ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Foreign body ,business - Abstract
Rationale and aim: The purpose of this study is to acquire a better understanding of Food Foreign Bodies (FFB) injuries in children characterizing the risk of complications and prolonged hospitalization due to food items according to patients' characteristics, circumstances of the accident, Foreign Body (FB) features and FB location, as emerging from the SUSY Safe Web-Registry. Methods: The present study uses data provided by the SUSY Safe Project, a DG SANCO co-funded project started in February 2005, which was aimed at establishing an international registry of cases of Foreign Bodies (FB) injuries in children aged 0-14 years. The analysis was carried out on injuries due to a food item.FB location was reported according to ICD9-CM code: ears (ICD931), nose (ICD932), pharynx and larynx (ICD933) trachea, bronchi and lungs (ICD934), mouth, esophagus and stomach (ICD935).Age and gender injury distributions were assessed. Data regarding adult supervision and activity before injury were also evaluated. FBs which most frequently cause complications were identified. The association between children age, adult presence, object characteristics and hospitalization/complications was computed using unweighted odds ratios and the related 95% confidence intervals. Results: 16,878 FB injuries occurred in children aged 0-14 years have been recorded in the SUSY Safe databases. FB type was specified in 10,564 cases; among them 2744 (26%) were due to a food item. FB site was recorded in 1344 cases: FB was located in the ears in 99 patients, while 1140 occurred in the upper and lower respiratory tract; finally, 105 food items were removed from mouth, esophagus and stomach. Complications occurred in 176 cases and the most documented was pulmonary or bronchial infections (23%) followed emphysema or atelectasis and by and asthma (7%). Bones were the commonest retrieved FFB encountered in this study, while nuts seem to be the FFB most frequently associated to complications. Conclusions: On the basis of this study we make the strong recommendation that parents should be adequately educated and provide age-appropriate food to their children and be present in order to supervise them during eating especially during a critical period ranging from 2 to 3 years of age.
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- 2012
13. Electrophysiologic analysis of injury to cranial nerve XI during neck dissection
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Lanisnik, Bostjan, primary, Zargi, Miha, additional, and Rodi, Zoran, additional
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- 2015
- Full Text
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14. The influence of cochlear implantation on vowel articulation
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Hocevar-Boltezar, Irena, primary, Boltezar, Miha, additional, and Zargi, Miha, additional
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- 2008
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15. Patterns of failure in patients with locally advanced head and neck cancer treated postoperatively with irradiation or concomitant irradiation with Mitomycin C and Bleomycin
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Zakotnik, Branko, primary, Budihna, Marjan, additional, Smid, Lojze, additional, Soba, Erika, additional, Strojan, Primoz, additional, Fajdiga, Igor, additional, Zargi, Miha, additional, Oblak, Irena, additional, and Lesnicar, Hotimir, additional
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- 2007
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16. Change of Phonation Control After Cochlear Implantation
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Hocevar-Boltezar, Irena, primary, Radsel, Zora, additional, Vatovec, Jagoda, additional, Geczy, Branka, additional, Cernelc, Smilja, additional, Gros, Anton, additional, Zupancic, Janez, additional, Battelino, Saba, additional, Lavrencak, Bostjan, additional, and Zargi, Miha, additional
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- 2006
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17. The etiology of vestibular disorder in infants at risk
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Vatovec, Jagoda, primary, Veličkovič, Milivoj, additional, Šmid, Lojze, additional, Gros, Anton, additional, and Zargi, Miha, additional
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- 2003
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18. Does it make sense to preserve the stapedial muscle during surgical treatment for otosclerosis?
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Gros, Anton, primary, Zargi, Miha, additional, and Vatovec, Jagoda, additional
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- 2000
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19. Concomitant radiotherapy with mitomycin C and bleomycin compared with radiotherapy alone in inoperable head and neck cancer: final report
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Zakotnik, Branko, primary, S̆mid, Lojze, additional, Budihna, Marjan, additional, Les̆nic̆ar, Hotimir, additional, Soba, Erika, additional, Furlan, Ladica, additional, and Z̆argi, Miha, additional
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- 1998
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20. Radiotherapy, combined with simulataneous chemotherapy with Mitomycin C and bleomycin for inoperable head and neck cancer—preliminary report
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Smid, Lojze, primary, Lesnicar, Hotimir, additional, Zakotnik, Brane, additional, Soba, Erika, additional, Budihna, Marjan, additional, Furlan, Ladica, additional, Zargi, Miha, additional, and Rudolf, Zvone, additional
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- 1995
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21. In inverted papillomas HPV more likely represents incidental colonization than an etiological factor.
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Jenko, Klemen, Kocjan, Boštjan, Zidar, Nina, Poljak, Mario, Strojan, Primož, Žargi, Miha, Blatnik, Olga, Gale, Nina, Kocjan, Boštjan, Strojan, Primož, and Zargi, Miha
- Abstract
Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs. [ABSTRACT FROM AUTHOR]
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- 2011
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22. Laser Induced Fluorescence in Diagnostics of Laryngeal Cancer
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zargi, Miha, Smid, Lojze, Fajdiga, Igor, Bubnic, Bernarda, Lenarcic, Jadran, and Oblak, Pavel
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Zargi M, Smid L, Fajdiga I, BubniC B, LenarCiC J, Oblak P. Laser induced fluorescence in diagnostics of laryngeal cancer. Acta Otolaryngol (Stockh) 1997; Suppl 527: 125-127.Differences in autofluorescence between normal and malignant tissues offer new possibilities for detecting and localizing early laryngeal carcinomas. In the present study imaging was performed using a specially designed device that exploits differences in fluorescent properties of normal and cancerous tissues without photodynamic drugs. Fluorescence was induced by helium-cadmium laser, captured by an image-intensified camera and displayed on a video monitor after previous computerization. 40 patients were evaluated, of whom 20 had suspect malignancies. Laryngoscopic appearances during standard microlaryngoscopy, fluorescence images and computerized fluorescence intensities were compared to histopathological findings. The experience from this study shows that autofluorescence laryngoscopy may be a useful complementary method for detecting laryngeal malignancies.
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- 1997
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23. Effects of recurrent otitis media in infancy on auditory perception and speech
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Žargi, Miha and Boltežar, Irena Hočevar
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- 1992
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24. Connexin 26 (GJB2) and connexin 30 del(GJB6-D13S1830) mutations in Slovenians with prelingual non-syndromic deafness.
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Battellino, Saba, Rudolf, Gorazd, Zargi, Miha, Podkrajsek, Katarina Trebusak, and Peterlin, Borut
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GENETICS of deafness , *CONNEXINS , *DEAF people , *SLOVENES - Abstract
Objective: To analyze the frequencies and clinical significance of connexin 26 (GJB2) mutations and connexin 30 (GJB6) del(GJB6-D13S1830) mutation in congenital deaf patients in Slovenia. Materials and Methods: The frequency of the mutations in the connexin 26 gene and the frequency of del(GJB6-D13S1830) mutation in the connexin 30 gene were determined in a cohort of 218 deaf patients referred for evaluation in a tertiary referral university hospital. Results: Among 218 congenital deaf patients 58 (26.6%) of them had mutations on both alleles of the GJB2 gene, with c.35delG being the most common. As in other neighboring countries we have not found the del(GJB6-D13S1830) mutation in our sample. Conclusion: The c.35delG mutation in the GJB2 gene was the most common genetic cause of hearing loss in Slovenia. Homozygous c.35delG mutations (21.1%) and compound heterozygotes (4.55%) were established among Slovene patients with congenital hearing loss. As in other neighboring populations, none of the Slovenian patients carried the del(GJB6-D13S1830) mutation. [ABSTRACT FROM AUTHOR]
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- 2011
25. Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis.
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Hočevar-Boltežar I, Matičič M, Sereg-Bahar M, Gale N, Poljak M, Kocjan B, and Zargi M
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- Adolescent, Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Papillomavirus Infections complications, Papillomavirus Infections virology, Pilot Projects, Young Adult, Papillomaviridae immunology, Papillomavirus Infections prevention & control, Respiratory Tract Infections complications, Vaccination methods, Viral Vaccines administration & dosage
- Abstract
In the case of an aggressive course of recurrent respiratory papillomatosis (RRP), adjuvant therapy can be used besides surgery. The aim of the study was to investigate the influence of vaccination with a quadrivalent vaccine against human papilloma viruses (HPV) types 6, 11, 16 and 18 on the course of RRP. Eleven subjects aged 13-46 years with a rapid growth of laryngeal papillomas were included in the study. They were vaccinated with three doses of the quadrivalent prophylactic HPV vaccine (Silgard(®), MSD) and followed up for 12-52 months. The intervals between the successive surgical procedures, the extension of the disease (Derkay score) at each surgery, and the number of surgical procedures per year before vaccination and after its completion were compared. The mean interval between the surgical procedures was 271.2 days before the vaccination and 537.4 days after it (p = 0.034). The mean number of surgeries per year was 2.16 before the vaccination and 0.93 after it (p = 0.022). The Derkay score did not change significantly after vaccination. Complete remission of the disease was observed in one patient, partial response to the vaccination was observed in seven patients and no response was observed in three patients. In conclusion, vaccination with the quadrivalent HPV vaccine can favorably influence the course of RRP in patients with the rapid growth of the papillomas. It significantly prolongs the intervals between the surgical procedures and reduces the number of procedures needed in the majority of patients. The present investigation can serve as a pilot study for further research. For a final conclusion a longer follow-up and studies on more patients are necessary.
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- 2014
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26. In inverted papillomas HPV more likely represents incidental colonization than an etiological factor.
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Jenko K, Kocjan B, Zidar N, Poljak M, Strojan P, Zargi M, Blatnik O, and Gale N
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell virology, DNA, Viral analysis, Female, Humans, Male, Middle Aged, Papilloma, Inverted etiology, Papilloma, Inverted pathology, Paranasal Sinus Neoplasms etiology, Paranasal Sinus Neoplasms pathology, Retrospective Studies, Papilloma, Inverted virology, Papillomaviridae isolation & purification, Paranasal Sinus Neoplasms virology
- Abstract
Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs.
- Published
- 2011
- Full Text
- View/download PDF
27. Adjuvant therapy for laryngeal papillomatosis.
- Author
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Boltežar IH, Bahar MS, Zargi M, Gale N, Matičič M, and Poljak M
- Subjects
- Acyclovir analogs & derivatives, Acyclovir therapeutic use, Adolescent, Adult, Aged, Aged, 80 and over, Anticarcinogenic Agents therapeutic use, Antiviral Agents therapeutic use, Chemotherapy, Adjuvant, Child, Child, Preschool, Cidofovir, Cytosine analogs & derivatives, Cytosine therapeutic use, Female, Humans, Indoles therapeutic use, Infant, Laryngeal Diseases surgery, Male, Middle Aged, Organophosphonates therapeutic use, Papilloma surgery, Papillomavirus Vaccines therapeutic use, Vaccination, Valacyclovir, Valine analogs & derivatives, Valine therapeutic use, Laryngeal Diseases therapy, Papilloma therapy
- Abstract
Respiratory papillomatosis affects the larynx in most cases. It is a relatively rare disease, with potentially devastating consequences for the patient. Many studies have proven the viral etiology of the disease. Surgery is the most successful mode of treatment. Adjuvant therapy is used in cases of aggressive disease. The most successful adjuvant drugs are interferon, various virostatics (e.g., acyclovir, valacyclovir, and cidofovir) and indole-3-carbinol. Vaccination with a quadrivalent vaccine against HPV will probably decrease the incidence of respiratory papillomatosis or help in the treatment of the disease in the future. The results of adjuvant therapy of laryngeal papillomatosis at the University Department of ORL & HNS in Ljubljana are comparable to the results in other centers around the world.
- Published
- 2011
28. [Sentinel lymph node in oral and oropharyngeal epithelial tumors].
- Author
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Cizmarevic B and Zargi M
- Subjects
- Adult, Aged, Female, Frozen Sections, Histological Techniques, Humans, Lymph Nodes diagnostic imaging, Lymphatic Metastasis diagnostic imaging, Male, Methylene Blue, Middle Aged, Mouth pathology, Mouth Neoplasms diagnostic imaging, Neoplasm Staging, Oropharyngeal Neoplasms diagnostic imaging, Oropharynx pathology, Paraffin Embedding, Prospective Studies, Radionuclide Imaging, Radiopharmaceuticals, Sentinel Lymph Node Biopsy, Technetium Tc 99m Sulfur Colloid, Ultrasonography, Lymph Node Excision, Lymph Nodes pathology, Lymphatic Metastasis pathology, Mouth Neoplasms pathology, Neck Dissection, Oropharyngeal Neoplasms pathology
- Abstract
Carcinomatous metastases in regional lymph nodes worsen substantially the prognosis of patients with oral cavity and oropharyngeal cancer. Due to the high probability of occult metastasis (about 30%), during surgical resection of the primary tumor usually also elective dissection of lymph nodes is performed. Opinions on the extent of the elective neck dissection still differ, whereas selective dissection increasingly gains in importance. The aim of selective dissections, based on the predictability of formation of metastases, is the identification and exstirpation of the sentinel lymph node. In this prospective study the applicability of the concept of the sentinel lymph node in patients with oral cavity and oropharyngeal cancer was analysed. 12 patients with oral cavity and orophangeal cancer, staging T1-T3, all N0 (examined by palpation and sonography) were included. The localization of the sentinel(s) was determined preoperatively by radioisotope (Tc Nanocolloid). Sentinel(s) were identified first with a gamma probe (Neoprobe 2000); we then injected methylene blue into the peritumoral area for easier detection of the sentinel(s). The sentinels were removed and sent for frozen section examination. Regardless of the findings of the frozen section examination modified dissection was carried out. Later we compared frozen sections with paraffin microtome sections of sentinel(s) and of other exstirpated neck lymph nodes. We could identify the sentinel lymph node in all patients, in 6/12 patients we found several sentinels. If sentinels were not affected by tumor cells, there were no metastases in the downstream neck lymph nodes either. If in the sentinel lymph nodes no metastases can be determined, eliminating the environment alone could be sufficient. However, this assumption requires verification in a larger patient group.
- Published
- 2006
- Full Text
- View/download PDF
29. Success rate in revision stapes surgery for otosclerosis.
- Author
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Gros A, Vatovec J, Zargi M, and Jenko K
- Subjects
- Adolescent, Adult, Aged, Bone Conduction physiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Ossicular Prosthesis, Otosclerosis physiopathology, Oval Window, Ear physiopathology, Oval Window, Ear surgery, Prosthesis Failure, Recurrence, Reoperation, Retrospective Studies, Treatment Failure, Otosclerosis surgery, Postoperative Complications surgery, Stapes Surgery
- Abstract
Objective: The aim of this study was to evaluate the hearing results of revision stapes surgery performed because of previously failed operations and to determine the causes of failure., Study Design: Retrospective review of revision stapes operations., Setting: Tertiary referral center., Patients: Sixty-three consecutive revision stapes operations were performed in 56 patients over a period of 12 years (1992-2004). The indication for revision surgery was recurrent or persistent air-bone gap greater than 20 dB after primary surgical treatment of otosclerosis of the oval window., Results: All patients were operated on to improve hearing. Sixty-three revision stapes operations resulted in closure of the air-bone gap to 10 dB or less in 52.4% of cases. The average postoperative air-bone gap was 13.1 dB, and the mean pure-tone average improvement was 12.9 dB. In six patients (9.5%), revision surgery produced no change in hearing, and in four (6.3%) the hearing decreased by 5 dB or more. In one patient, the operation resulted in a profound hearing loss. Prosthesis malfunction was the most common primary cause of failure (60.3%). The original prosthesis was replaced with a new one in 48 cases. In 30 of these (62.5%), closure of the air-bone gap to within 10 dB was achieved. In 15 cases, the prosthesis was not replaced, and in only four of these (26.7%), closure of the air-bone gap within 10 dB was obtained (p < 0.022)., Conclusion: Revision stapes surgery is less likely to be successful than the primary operation. Closure of the air-bone gap to within 10 dB was achieved in 52.4% of patients. The success rate was better in cases where the original prosthesis was replaced with a new one. The risk for decreased bone-conduction threshold does not seem to be higher than in primary surgery.
- Published
- 2005
- Full Text
- View/download PDF
30. Repair of anterior floor of mouth defects by a central or paramedian island tongue flap.
- Author
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Fischinger J and Zargi M
- Subjects
- Aged, Deglutition physiology, Female, Humans, Male, Middle Aged, Mouth Neoplasms physiopathology, Postoperative Complications etiology, Plastic Surgery Procedures methods, Speech physiology, Treatment Outcome, Mouth surgery, Mouth Neoplasms surgery, Surgical Flaps, Tongue surgery
- Abstract
One method for restoring the anterior floor of mouth defects resulting from T(1) and especially T(2) cancer excision involves the creation of a myomucosal island flap from the dorsal median portion of the tongue and transferring it as a transit flap to the floor of the mouth. We are not the first to advocate this method. In this paper we present a previously unreported, slightly modified technique utilizing this tongue flap. The modification consists of a 90 degrees twisting of the flap to achieve a more appropriate adaptation to the defect. In the case of spreading carcinoma from the floor of the mouth to the central portion of the tongue, a similar paramedian one-sided tongue flap was created instead of a central island tongue flap. Our present experience consists of a small series of 12 patients. The procedures were successful in all patients. No remarkable disturbances of speech or deglutition were observed in any of the patients. There were two complications: one haematoma and one partial necrosis of the tip of the tongue. In our opinion, the reconstruction of the anterior floor of mouth defects using a central island tongue flap has not gained the popularity it deserves.
- Published
- 2003
- Full Text
- View/download PDF
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