Miller SM, Valovich McLeod TC, Zaslow TL, Wilson JC, Master CL, Snedden TR, Halstead ME, Grady MF, Fazekas ML, Santana JA, Coel RA, and Howell DR
Background: A validated clinical risk tool has been developed to identify pediatric and adolescent patients at risk of developing persisting symptoms after concussion, but has not been prospectively investigated within a sample of athletes seen after concussion by primary care sports medicine physicians and/or athletic trainers., Purpose: To determine whether a validated clinical risk prediction tool for persistent postconcussive symptoms (PPCSs) predicted which patients would develop PPCSs when obtained within 14 days of concussion among a multicenter sample of adolescent athletes., Study Design: Cohort study; Level of evidence, 2., Methods: Pediatric and adolescent patients (8-18 years of age) from 7 pediatric medical centers and 6 secondary school athletic training facilities who were diagnosed with a concussion and presented ≤14 days after concussion were enrolled as part of the Sport Concussion Outcomes in Pediatrics (SCOPE) study during their initial visit and were followed until symptom resolution. Clinical risk scores (Predicting and Preventing Post-concussive Problems in Pediatrics [5P]) and total symptom severity were obtained using the Post-Concussion Symptom Inventory at the initial visit (mean, 4.9 ± 2.9 days after concussion). Participants were then compared based on symptom resolution time: PPCS group (≥28 days to symptom resolution) and no-PPCS group (<28 days). The authors assessed the odds of developing PPCSs based on the 5P risk score using a binary logistic regression model and the utility of the clinical risk prediction tool to identify total time to symptom resolution using a Cox proportional hazards model., Results: A total of 184 participants enrolled, underwent initial evaluation, and were followed until symptom resolution (mean age, 15.2 ± 2.1 years; 35% female). The mean time to symptom resolution across the entire sample was 17.6 ± 3.7 days; 16% (n = 30) of participants developed PPCS. Those in the PPCS group had significantly greater mean initial total 5P risk scores than those in the no-PPCS group (7.9 ± 1.7 vs 5.9 ± 2.3, respectively; P < .001). After adjustment for initial symptom severity, time to assessment, and assessment setting, a higher initial total 5P risk score was associated with a significantly greater odds of developing PPCSs (adjusted odds ratio, 1.49; 95% CI, 1.07-2.08; P = .019). Furthermore, a higher 5P risk score was significantly associated with longer total symptom resolution time (hazard ratio, 0.80; 95% CI, 0.74-0.88; P < .001)., Conclusion: In a multicenter sample of youth athletes seen in different outpatient health care settings, the 5P risk score accurately predicted which athletes may be at risk for developing PPCSs., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: This study was supported by the Pediatric Research in Sports Medicine (PRiSM) Society Research Interest Group initiative (PRiSM Concussion RIG). The database in this investigation was managed through a REDCap award (National Institutes of Health/National Center for Advancing Translational Sciences [NCATS] Colorado Clinical and Translational Science Award [CTSA] grant No. UL1 TR002535), contents are the authors’ sole responsibility and do not necessarily represent official NIH views. S.M.M. serves on the USA Cheer Safety Council and as an assistant team physician for the Dallas Stars National Hockey League Hockey Club. T.C.V.M. serves on the USA Swimming Concussion Task Force and the National Football League Head, Neck, and Spine Committee. J.C.W. has received research support from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (R01HD108133) and is a network team physician for US Soccer. C.L.M. has received research funding from the National Institute of Neurologic Diseases and Stroke (5R01NS097549-06), National Eye Institute (1R34EY030582-01A1, 2R01EY023261-06), National Institute for Nursing Research (5R01NR018425-03), Centers for Disease Control and Prevention (1U01CE003479-01-00), Department of Defense (W81XWH21C0103, W81XWH2210590), Chuck Noll Foundation, Children’s Hospital of Philadelphia Frontier Programs, and American Medical Society for Sports Medicine. She serves in an uncompensated role as the concussion physician for Shipley School; on the medical advisory boards for Untold Foundation, Pink Concussions, and Headway Foundation; and on the board of trustees for the American College of Sports Medicine, the board of directors for the American Medical Society for Sports Medicine and Pediatric Research in Sports Medicine, and the executive committee of the Committee on Sports Medicine and Fitness for the American Academy of Pediatrics. M.E.H. is the venue medical director for the St Louis City SC Major League Soccer team. R.A.C. serves as team physician for the World Surf League and is a volunteer medical consultant and speaker for Hawai’i Concussion Awareness Management Program. D.R.H. has received research support from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (R03HD094560, R01HD108133), the National Institute of Neurological Disorders And Stroke (R01NS100952, R43NS108823), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R13AR080451), 59th Medical Wing Department of the Air Force, MINDSOURCE Brain Injury Network, the Tai Foundation, the Colorado Clinical and Translational Sciences Institute (UL1 TR002535?05), and the Denver Broncos Foundation. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.