Search

Your search keyword '"Zassinovich, G."' showing total 131 results
Start Over Author "Zassinovich, G."
131 results on '"Zassinovich, G."'

8. Effects of two pyridinalalkyliminerhodium(I) complexes in mice bearing MCa mammary carcinoma.

Author

Sava, Gianni, Zorzet, Sonia, Pacor, Sabrina, Mestroni, Giovanni, Zassinovich, Grazia, Sava, G, Zorzet, S, Pacor, S, Mestroni, G, and Zassinovich, G

Abstract

The examination of the differential effects of two square-planar rhodium(I) complexes on primary tumor growth and on the formation of spontaneous and artificially (i.v. tumor injection) induced lung metastases of MCa mammary carcinoma suggests different mechanisms of action, depending on the chemical characteristics of the compound used. Of the two complexes used, cyclooctadiene(2-pyridinalmethylimine)Rh(I) chloride and cyclooctadiene(2-pyridinalisopropylimine)Rh(I) chloride, the former compound confirmed the antineoplastic action previously shown in the Lewis lung carcinoma model. The activity of this derivative on lung metastasis formation seems to be unrelated to a cytotoxic action for tumor cells localized in the lungs. More likely, it appears that modifications occurring at the primary tumor level, probably different from a tumor-cell-directed lethality, are responsible for the reduction of spontaneous lung metastasis formation observed in treated animals. The hyperplasia of the spleen induced in treated animals seems to suggest that this compound is endowed with properties typical for biological response modifiers. [ABSTRACT FROM AUTHOR]

Published
1989
Full Text
View/download PDF

9. Inhibitory effects of some organometallic complexes of rhodium(I) and iridium(I) on carrageenin paw edema in rats

Author

Gianni Sava, Piccini P, Mestroni G, Zassinovich G, Bontempi A, Sava, Gianni, Piccini, P., Mestroni, G., Zassinovich, G., and Bontempi, A.

Subjects
Male, Rats, Inbred Strains, Metal based complexe, Carrageenan, Rubidium, Iridium, Rats, Rhodium, Metal based complexes, Carragenin oedema, Organometallic Compounds, Animals, Edema
Abstract

A group of 4 organometallic complexes of Rhodium (I) and 1 Iridium(I) was tested for the evaluation of their anti-inflammatory activity on carrageenin paw edema in rats. All the compounds used inhibited the development of paw edema by more than 50% at different dose-levels. The activity of the pyridinalmethylimine derivative [Rh(COD)PMI]+ Cl- had better results than that of [Rh(NBD)PMI]+ Cl- and even more than the dimeric complexes tested. The higher activity of [Ir(COD)Cl]2 as compared with [Rh(COD)Cl]2 suggests that it would be of interest to examine further Iridium(I) complexes, among which [Ir(COD)PMI]+ Cl- could be a good candidate.

Published
1987

11. Antineoplastic activity of planar rhodium(I) complexes in mice bearing Lewis lung carcinoma and P388 leukemia

Author

Gianni Sava, Zorzet S, Mestroni G, Zassinovich G, Sava, Gianni, Zorzet, Sonia, Mestroni, G., and Zassinovich, G.

Subjects
Lung Neoplasms, Rhodamines, Rhodium, Leukaemia, Animal tumours, Antineoplastic, Drug Evaluation, Preclinical, Antineoplastic Agents, Neoplasms, Experimental, Animal tumour, Leukemia, Lymphoid, Mice, Inbred C57BL, Mice, Xanthenes, Organometallic Compounds, Animals, Neoplasm Metastasis, Neoplasm Transplantation
Abstract

The antitumor effects of three rhodium(I) complexes were evaluated using two transplantable tumors of the mouse: Lewis lung carcinoma and P388 lymphocytic leukemia. The examination of the differential effects on primary tumor growth and on the formation of spontaneous pulmonary metastases, in mice bearing Lewis lung carcinoma, indicated that the complex having qualitatively the higher solubility in aqueous solutions and the higher resistance to inactivation via oxidation, displayed the more pronounced antineoplastic activity. The antileukemic effects, in mice bearing P388 lymphocytic leukemia, also seemed to depend on the chemical characteristics of the complex used, and the previously reported trend was particularly evident using an acute treatment performed 24 hr after tumor transplantation.

Published
1985

12. Antitumor effect of some rhodium(I) derivatives on MCa mammary carcinoma

Author

Gianni Sava, Pacor S, Ceschia V, Zassinovich G, Mestroni G, Sava, Gianni, Pacor, Sabrina, Ceschia, V., Zassinovich, G., and Mestroni, G.

Subjects
Experimental tumour, Lung Neoplasms, Experimental tumours, Mammary Neoplasms, Experimental, Antineoplastic Agents, Rhodium, Mammary carcinoma, Antineoplastic, Mice, Structure-Activity Relationship, Mice, Inbred CBA, Animals, Female
Abstract

The antitumor action of two square planar Rhodium complexes was tested on MCa mammary carcinoma and was seen to depend upon the compound used. The complex cyclooctadiene(2-pyridinalmethylimine)-Rh(I)chloride [Rh(COD)PMI]+ Cl- confirmed the antineoplastic action already shown in the Lewis lung carcinoma model. The examination of the activity of [Rh(COD)PMI]+ Cl- on the lung metastatic tumor indicates that its antineoplastic properties do not seem simply related to a cytotoxic action. It appears more likely that modifications occurring at the primary tumor level, probably different from lethal effects directed to tumor cells, are responsible for the reduction of spontaneous lung metastasis formation observed in the treated animals. The trophic effects observed on the spleen of the treated animals seem to suggest that these compounds are endowed with properties typical of biological response modifiers.

Published
1989

13. Antitumor effects of rhodium(I), iridium(I) and ruthenium(II) complexes in comparison with cis-dichloro-diamminoplatinum(II) in mice bearing Lewis lung carcinoma

Author

Sava, Gianni, Giraldi, Tullio, Mestroni, G., Zassinovich, G., Sava, Gianni, Giraldi, Tullio, Mestroni, G., and Zassinovich, G.

Subjects
Organometallic Compound, Animals, Antineoplastic Agents, Cisplatin, Iridium, Lethal Dose 50, Lung Neoplasms, Mice, Neoplasm Transplantation, Neoplasms, Experimental, Organometallic Compounds, Rhodium, Ruthenium, Animal, Antineoplastic Agent, Lung Neoplasm, Neoplasm
Abstract

The effects of square planar rhodium, [RhacacCOD]o and iridium, [IracacCOD]o complexes and of octahedral ruthenium, [cis-RuCl2 (DMSO)4]o complex have been examined in comparison with cis-dichlorodiammino platinum(II) (cis-PDD). The toxicity in BDF1 mice varies widely and decreasing LD50-values, ranging from 0.94 mg/kg to 1000 mg/kg, have been obtained for cis-PDD, [RhacacCOD]o, [IracacCOD]o and [cis-RuCl2(DMSO)4]o, respectively. All the tested complexes similarly inhibit the growth of subcutaneous Lewis lung carcinoma and the development of spontaneous as well as of artificial metastases, with the exception of [IracacCOD]o which is inactive on metastases. The antitumor activity of [RhacacCOD]o and [cis-RuCl2(DMSO)4]o appears interesting, since it is of the same magnitude as that of cis-PDD, considering also that they were found to be only marginally nephrotoxic.

Published
1983

19. Antitumor action of two rhodium and ruthenium complexes in comparison with cis-diamminedichloroplatinum(II)

Author

Giraldi T, Gianni Sava, Bertoli G, Mestroni G, Zassinovich G, T., Giraldi, Sava, Gianni, G., Bertoli, G., Mestroni, and G., Zassinovich

Subjects
Animals, Carcinoma, Ehrlich Tumor, Cisplatin, DNA, Neoplasm, Intestinal Mucosa, Kidney, Leukemia L1210, Mice, Neoplasm Proteins, Organophosphorus Compounds, RNA, Neoplasm, Rhodium, Ruthenium, Spleen, DNA, Neoplasm, Tumour, Platinum, Ruthenium, Rhodium, Antineoplastic, Kidney, Neoplasm Proteins, Mice, Organophosphorus Compounds, Animals, RNA, Neoplasm, Cisplatin, Intestinal Mucosa, Carcinoma, Ehrlich Tumor, Leukemia L1210, Spleen
Published
1977

Catalog

Books, media, physical & digital resources
See catalog results