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21 results on '"Zaykovskaya, Anna V."'

3. Immunogenicity and Protective Efficacy of a Single Intranasal Dose Vectored Vaccine Based on Sendai Virus (Moscow Strain) against SARS-CoV-2 Variant of Concern.

Author

Kochneva, Galina V., Kudrov, Gleb A., Zainutdinov, Sergei S., Shulgina, Irina S., Shipovalov, Andrei V., Zaykovskaya, Anna V., Borgoyakova, Mariya B., Starostina, Ekaterina V., Bodnev, Sergei A., Sivolobova, Galina F., Grazhdantseva, Antonina A., Ivkina, Daria I., Zadorozhny, Alexey M., Karpenko, Larisa I., and P'yankov, Oleg V.

Subjects
SARS-CoV-2 Delta variant, SENDAI virus, INTRANASAL administration, GOLDEN hamster, SARS-CoV-2
Abstract

The mouse paramyxovirus Sendai, which is capable of limited replication in human bronchial epithelial cells without causing disease, is well suited for the development of vector-based intranasal vaccines against respiratory infections, including SARS-CoV-2. Using the Moscow strain of the Sendai virus, we developed a vaccine construct, Sen-Sdelta(M), which expresses the full-length spike (S) protein of the SARS-CoV-2 delta variant. A single intranasal delivery of Sen-Sdelta(M) to Syrian hamsters and BALB/c mice induced high titers of virus-neutralizing antibodies specific to the SARS-CoV-2 delta variant. A significant T-cell response, as determined by IFN-γ ELISpot and ICS methods, was also demonstrated in the mouse model. Mice and hamsters vaccinated with Sen-Sdelta(M) were well protected against SARS-CoV-2 challenge. The viral load in the lungs and nasal turbinates, measured by RT-qPCR and TCID50 assay, decreased dramatically in vaccinated groups. The most prominent effect was revealed in a highly sensitive hamster model, where no tissue samples contained detectable levels of infectious SARS-CoV-2. These results indicate that Sen-Sdelta(M) is a promising candidate as a single-dose intranasal vaccine against SARS-CoV-2, including variants of concern. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses

Author

Yarovaya, Olga I., primary, Filimonov, Aleksandr S., additional, Baev, Dmitriy S., additional, Borisevich, Sophia S., additional, Zaykovskaya, Anna V., additional, Chirkova, Varvara Yu., additional, Marenina, Mariya K., additional, Meshkova, Yulia V., additional, Belenkaya, Svetlana V., additional, Shcherbakov, Dmitriy N., additional, Gureev, Maxim A., additional, Luzina, Olga A., additional, Pyankov, Oleg V., additional, Salakhutdinov, Nariman F., additional, and Khvostov, Mikhail V., additional

Published
2024
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5. Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Author

Shipovalov, Andrey V., primary, Zaykovskaya, Anna V., additional, Kudrov, Gleb A., additional, Drachkova, Irina A., additional, Antonets, Maria E., additional, Lyukhanov, Maksim P., additional, Bodnev, Sergey A., additional, Bauer, Tatyana V., additional, Tregubchak, Tatyana V., additional, Ivleva, Elena K., additional, Taranov, Oleg S., additional, and Pyankov, Oleg V., additional

Published
2023
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6. Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Siberian Populations

Author

Shaprova, Olga N., primary, Shanshin, Daniil V., additional, Kolosova, Evgeniia A., additional, Borisevich, Sophia S., additional, Soroka, Artem A., additional, Merkuleva, Iuliia A., additional, Nikitin, Artem O., additional, Volosnikova, Ekaterina A., additional, Ushkalenko, Nikita D., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, Elchaninova, Svetlana A., additional, Shcherbakov, Dmitry N., additional, and Ilyicheva, Tatiana N., additional

Published
2023
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7. SARS-CoV-2 RBD Conjugated to Polyglucin, Spermidine, and dsRNA Elicits a Strong Immune Response in Mice

Author

Volosnikova, Ekaterina A., primary, Merkuleva, Iuliia A., additional, Esina, Tatiana I., additional, Shcherbakov, Dmitry N., additional, Borgoyakova, Mariya B., additional, Isaeva, Anastasiya A., additional, Nesmeyanova, Valentina S., additional, Volkova, Natalia V., additional, Belenkaya, Svetlana V., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, Starostina, Ekaterina V., additional, Zadorozhny, Alexey M., additional, Zaitsev, Boris N., additional, Karpenko, Larisa I., additional, Ilyichev, Alexander A., additional, and Danilenko, Elena D., additional

Published
2023
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8. Usnic acid based thiazole-hydrazones as multi-targeting inhibitors of a wide spectrum of SARS-CoV-2 viruses.

Author

Yarovaya, Olga I., Filimonov, Aleksandr S., Baev, Dmitriy S., Borisevich, Sophia S., Chirkova, Varvara Yu., Zaykovskaya, Anna V., Mordvinova, Ekaterina D., Belenkaya, Svetlana V., Shcherbakov, Dmitriy N., Luzina, Olga A., Pyankov, Oleg V., and Salakhutdinov, Nariman F.

Subjects
SARS-CoV-2, COVID-19, SARS-CoV-2 Omicron variant, ACID derivatives, DRUG target
Abstract

Although the Covid-19 pandemic is officially over and the spread of coronavirus infection is no longer considered an international emergency, the virus continues to persist in the population, supporting the process of mutagenesis, which may lead to the emergence of more dangerous variants that can cause new outbreaks in the future. Therefore, the search for new effective drugs against the SARS-CoV-2 virus and other coronaviruses with a wide spectrum of activity remains an urgent task of medicinal chemistry. We synthesized a set of thiazolo-hydrazones based on (+)- and (−)-usnic acid and studied their ability to inhibit the main viral protease of the SARS-CoV-2 virus. It was shown that 9 out of 36 agents exhibit antiprotease activity in the range from 13 to 27 μM. The kinetic parameters of the four most active compounds were studied and molecular modeling of the possible interaction of these compounds with the active site of the main protease was carried out. Using six different strains (Wuhan, Delta, and four Omicron lines) of the SARS-CoV-2 virus, the antiviral activity of selected leader compounds was studied and it was shown that agent (+)-7a with a furan fragment has a pronounced antiviral activity against all strains. Additionally, the ability of the leading compounds to influence the stage of virus entry was studied, for which the activity of the compounds against the pseudoviral system with S glycoprotein on its surface was studied, as well as the ability to inhibit the interaction of recombinant ACE2 receptors with the RBD domain of the S protein by ELISA testing. It was found that the leading compounds are able to effectively inhibit pseudoviral particles without affecting the interaction of ACE2 and RBD. In order to search for a possible binding site for the leading compounds on the surface of the S-protein, molecular modeling was carried out. The N-terminal domain of the S protein was considered as a potential biological target, and it was found that the agents probably bind to the biliverdin site of the surface glycoprotein. Thus, we have identified new usnic acid derivatives that are active against a wide range of strains of the SARS-CoV-2 virus and have multi-targeting effects. [ABSTRACT FROM AUTHOR]

Published
2023
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10. (+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

Author

Filimonov, Aleksandr S., primary, Yarovaya, Olga I., additional, Zaykovskaya, Anna V., additional, Rudometova, Nadezda B., additional, Shcherbakov, Dmitriy N., additional, Chirkova, Varvara Yu., additional, Baev, Dmitry S., additional, Borisevich, Sophia S., additional, Luzina, Olga A., additional, Pyankov, Oleg V., additional, Maksyutov, Rinat A., additional, and Salakhutdinov, Nariman F., additional

Published
2022
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11. Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

Author

Yarovaya, Olga I., primary, Shcherbakov, Dmitriy N., additional, Borisevich, Sophia S., additional, Sokolova, Anastasiya S., additional, Gureev, Maxim A., additional, Khamitov, Edward M., additional, Rudometova, Nadezda B., additional, Zybkina, Anastasiya V., additional, Mordvinova, Ekaterina D., additional, Zaykovskaya, Anna V., additional, Rogachev, Artem D., additional, Pyankov, Oleg V., additional, Maksyutov, Rinat A., additional, and Salakhutdinov, Nariman F., additional

Published
2022
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12. Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?

Author

Merkuleva, Iuliia A., primary, Shcherbakov, Dmitry N., additional, Borgoyakova, Mariya B., additional, Isaeva, Anastasiya A., additional, Nesmeyanova, Valentina S., additional, Volkova, Natalia V., additional, Aripov, Vazirbek S., additional, Shanshin, Daniil V., additional, Karpenko, Larisa I., additional, Belenkaya, Svetlana V., additional, Kazachinskaia, Elena I., additional, Volosnikova, Ekaterina A., additional, Esina, Tatiana I., additional, Sergeev, Alexandr A., additional, Titova, Kseniia A., additional, Konyakhina, Yulia V., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, Kolosova, Evgeniia A., additional, Viktorina, Olesya E., additional, Shelemba, Arseniya A., additional, Rudometov, Andrey P., additional, and Ilyichev, Alexander A., additional

Published
2022
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13. Self-Assembled Particles Combining SARS-CoV-2 RBD Protein and RBD DNA Vaccine Induce Synergistic Enhancement of the Humoral Response in Mice

Author

Borgoyakova, Mariya B., primary, Karpenko, Larisa I., additional, Rudometov, Andrey P., additional, Volosnikova, Ekaterina A., additional, Merkuleva, Iuliia A., additional, Starostina, Ekaterina V., additional, Zadorozhny, Alexey M., additional, Isaeva, Anastasiya A., additional, Nesmeyanova, Valentina S., additional, Shanshin, Daniil V., additional, Baranov, Konstantin O., additional, Volkova, Natalya V., additional, Zaitsev, Boris N., additional, Orlova, Lyubov A., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, Danilenko, Elena D., additional, Bazhan, Sergei I., additional, Shcherbakov, Dmitry N., additional, Taranin, Alexander V., additional, and Ilyichev, Alexander A., additional

Published
2022
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14. Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression Systems

Author

Merkuleva, Iuliia A., primary, Shcherbakov, Dmitry N., additional, Borgoyakova, Mariya B., additional, Shanshin, Daniil V., additional, Rudometov, Andrey P., additional, Karpenko, Larisa I., additional, Belenkaya, Svetlana V., additional, Isaeva, Anastasiya A., additional, Nesmeyanova, Valentina S., additional, Kazachinskaia, Elena I., additional, Volosnikova, Ekaterina A., additional, Esina, Tatiana I., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, Borisevich, Sophia S., additional, Shelemba, Arseniya A., additional, Chikaev, Anton N., additional, and Ilyichev, Alexander A., additional

Published
2022
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15. Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses

Author

Fomenko, Vladislav V., primary, Rudometova, Nadezhda B., additional, Yarovaya, Olga I., additional, Rogachev, Artem D., additional, Fando, Anastasia A., additional, Zaykovskaya, Anna V., additional, Komarova, Nina I., additional, Shcherbakov, Dmitry N., additional, Pyankov, Oleg V., additional, Pokrovsky, Andrey G., additional, Karpenko, Larisa I., additional, Maksyutov, Rinat A., additional, and Salakhutdinov, Nariman F., additional

Published
2022
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16. Synthesis and Antiviral Activity of Camphene Derivatives against Different Types of Viruses

Author

Sokolova, Anastasiya S., primary, Putilova, Valentina P., additional, Yarovaya, Olga I., additional, Zybkina, Anastasiya V., additional, Mordvinova, Ekaterina D., additional, Zaykovskaya, Anna V., additional, Shcherbakov, Dmitriy N., additional, Orshanskaya, Iana R., additional, Sinegubova, Ekaterina O., additional, Esaulkova, Iana L., additional, Borisevich, Sophia S., additional, Bormotov, Nikolay I., additional, Shishkina, Larisa N., additional, Zarubaev, Vladimir V., additional, Pyankov, Oleg V., additional, Maksyutov, Rinat A., additional, and Salakhutdinov, Nariman F., additional

Published
2021
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17. Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006

Author

Lipatov, Aleksandr S., Evseenko, Vasily A., Yen, Hui-Ling, Zaykovskaya, Anna V., Durimanov, Alexander G., Zolotykh, Sergey I., Netesov, Sergey V., Drozdov, Ilya G., Onishchenko, Gennadiy G., Webster, Robert G., and Shestopalov, Alexander M.

Subjects
Influenza viruses -- Development and progression, Influenza viruses -- Risk factors, Influenza viruses -- Genetic aspects, Phylogeny -- Research, Poultry -- Diseases, Poultry -- Development and progression, Poultry -- Risk factors, Poultry -- Genetic aspects
Abstract

We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005-February 2006. Full genome sequences showed high homology [...]

Published
2007

18. Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate

Author

Karpenko, Larisa I., primary, Rudometov, Andrey P., additional, Sharabrin, Sergei V., additional, Shcherbakov, Dmitry N., additional, Borgoyakova, Mariya B., additional, Bazhan, Sergei I., additional, Volosnikova, Ekaterina A., additional, Rudometova, Nadezhda B., additional, Orlova, Lyubov A., additional, Pyshnaya, Inna A., additional, Zaitsev, Boris N., additional, Volkova, Natalya V., additional, Azaev, Mamedyar Sh., additional, Zaykovskaya, Anna V., additional, Pyankov, Oleg V., additional, and Ilyichev, Alexander A., additional

Published
2021
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19. H5N1 influenza virus, domestic birds, Western Siberia, Russia

Author

Shestopalov, Alexander M., Durimanov, Alexander G., Evseenko, Vasily A., Ternovoi, Vladimir A., Rassadkin, Yury. N., Razumova, Yulya V., Zaykovskaya, Anna V., Zolotykh, Sergey I., and Netesov, Sergey V.

Abstract

To the Editor: Highly pathogenic H5N1 avian influenza virus caused disease outbreaks in poultry and wild birds in several Asian, European, and African countries from 2003 to 2006. This virus [...]

Published
2006

20. Experimental infection of H5N1 HPAI in BALB/c mice

Author

Ignatyev George M, Ternovoi Vladimir A, Sharshov Kirill A, Zaykovskaya Anna V, Bukin Eugeny K, Evseenko Vasily A, and Shestopalov Alexander M

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In 2005 huge epizooty of H5N1 HPAI occurred in Russia. It had been clear that territory of Russia becoming endemic for H5N1 HPAI. In 2006 several outbreaks have occurred. To develop new vaccines and antiviral therapies, animal models had to be investigated. We choose highly pathogenic strain for these studies. Results A/duck/Tuva/01/06 belongs to Quinghai-like group viruses. Molecular markers – cleavage site, K627 in PB2 characterize this virus as highly pathogenic. This data was confirmed by direct pathogenic tests: IVPI = 3.0, MLD50 = 1,4Log10EID50. Also molecular analysis showed sensivity of the virus to adamantanes and neuraminidase inhibitors. Serological analysis showed wide cross-reactivity of this virus with sera produced to H5N1 HPAI viruses isolated earlier in South-East Asia. Mean time to death of infected animals was 8,19+/-0,18 days. First time acute delayed hemorrhagic syndrome was observed in mice lethal model. Hypercytokinemia was determined by elevated sera levels of IFN-gamma, IL-6, IL-10. Conclusion Assuming all obtained data we can conclude that basic model parameters were characterized and virus A/duck/Tuva/01/06 can be used to evaluate anti-influenza vaccines and therapeutics.

Published
2007
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21. Experimental infection of H5N1 HPAI in BALB/c mice

Author

Evseenko, Vasily A, primary, Bukin, Eugeny K, additional, Zaykovskaya, Anna V, additional, Sharshov, Kirill A, additional, Ternovoi, Vladimir A, additional, Ignatyev, George M, additional, and Shestopalov, Alexander M, additional

Published
2007
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