Search

Your search keyword '"Zee, Robert Y.L."' showing total 186 results
Start Over Author "Zee, Robert Y.L."
186 results on '"Zee, Robert Y.L."'

19. Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the women's genome health study

Author

Ridker, Paul M., Pare, Guillaume, Parker, Alex, Zee, Robert Y.L., Danik, Jacqueline S., Buring, Julie E., Kwiatkowski, David, Cook, Nancy R., Miletich, Joseph P., and Chasman, Daniel I.

Subjects
C-reactive protein -- Research, Human genome -- Research, Metabolic syndrome X -- Genetic aspects, Women -- Genetic aspects, Women -- Health aspects, Biological sciences
Abstract

A genome-wide association studies among several women is conducted to analyze the impact of genetic variations on the levels of C-reactive protein (CRP) in humans. The loci related to the metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR are shown to be completely associated with the increasing levels of CRP.

Published
2008

20. Haplotype analysis of the [beta]2 adrenergic receptor gene and risk of myocardial infarction in humans

Author

Zee, Robert Y.L., Cook, Nancy R., Reynolds, Rebecca, Cheng, Suzanne, and Ridker, Paul M.

Subjects
Genetic polymorphisms -- Research, Haplotypes -- Research, Heart attack -- Causes of, Epinephrine -- Receptors, Epinephrine -- Research, Genetic research, Biological sciences
Abstract

Polymorphisms in the [beta]2 adrenergic receptor (ADRB2), in particular G16R, Q27E, and T164I, have been implicated in the pathogenesis of cardiovascular and metabolic phenotypes. However, no prospective, genetic-epidemiological data are available on the risk of cardiovascular disease associated with these variants. Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we evaluated the G16R, Q27E, and T164I polymorphisms among 523 individuals who subsequently developed myocardial infarction and among 2092 individuals who remained free of reported cardiovascular events during follow-up. The haplotype frequency distribution was significantly different among cases and controls ([X.sup.2/7d.f.] = 20.92, P = 0.0039). Haplotype-based logistic regression, adjusting for age, smoking, and randomized treatment group, indicated that G16-Q27-I164 (odds ratio 0.178, 95% C.I. 0.043-0.737, P = 0.017) and (non-G16-Q27)-T164 (odds ratio 1.235, 95% C.I. 1.031-1.480, P = 0.022) haplotypes were significantly associated with altered risk of myocardial infarction. These findings remained after further adjustment for BMI, history of hypertension, and presence or absence of diabetes. In conclusion, variation in haplotype frequencies for the [beta]2 adrenergic receptor gene was found to be associated with risk of myocardial infarction.

Published
2005

26. A Meta-Analysis of Candidate Gene Polymorphisms and Ischemic Stroke in 6 Study Populations: Association of Lymphotoxin-Alpha in Nonhypertensive Patients

Author

Wang, Xingyu, Cheng, Suzanne, Brophy, Victoria H., Erlich, Henry A., Mannhalter, Christine, Berger, Klaus, Lalouschek, Wolfgang, Browner, Warren S., Shi, Yu, Ringelstein, E Bernd, Kessler, Christof, Luedemann, Jan, Lindpaintner, Klaus, Liu, Lisheng, Ridker, Paul M., Zee, Robert Y.L., and Cook, Nancy R.

Published
2009
Full Text
View/download PDF

48. Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study

Author

Lin, Jennifer, Castonguay, Amy J., Barton, Nathaniel S., Buring, Julie E., and Zee, Robert Y.L.

Abstract

Background: To date, no prospective epidemiological data are available, particularly in women, on mean leukocyte telomere length as a risk predictor. Methods: Using leukocyte DNA samples collected at baseline in a prospective cohort of over 28,000 initially healthy women, we examined the relationship between mean leukocyte telomere repeat copy number to single gene copy number (TSR) in 134 incident cases of colorectal carcinoma (CRC), and 357 matched controls; all were Caucasian. Results: The observed loge-transformed TSRs were similar between cases and controls (p=0.79). Using an adjusted analysis, we found no evidence for an association of the loge-TSRs with CRC risk [adjusted odds ratio (OR)=0.943, 95% confidence interval (CI)=0.647–1.376, p=0.762]. Stratified analysis by median follow-up time, or postmenopausal status also showed similar null findings. Conclusions: In concordance with our previous findings in Caucasian men, the present study in Caucasian women found no evidence for an association of mean leukocyte telomere length with risk of incident CRC, further suggesting that leukocyte telomere length may not be a useful indicator for risk assessment. Clin Chem Lab Med 2010;48:259–62.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results