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Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221122577 for Association of HIV infection with clinical features and outcomes of patients with aortic aneurysms by Omar Chehab, Amjad Kanj, Ralph Zeitoun, Tanveer Mir, Irfan Shafi, Mohit Pahuja, Alexandros Briasoulis, Henrique Doria de Vasconcellos, Anum Minhas, Vinithra Varadarajan, Colin Wu, Armin Arbab-Zadeh, Wendy S Post, Katherine C Wu and João AC Lima in Vascular Medicine

Background: Emerging research indicates that high HDL-C levels might not be cardioprotective, potentially worsening cardiovascular disease(CVD)outcomes. Yet, there's no data on HDL-C's association with other CVD risk factors like myocardial fibrosis, a key aspect of cardiac remodeling predicting negative outcomes. We therefore aimed to study the association between HDL-C levels with interstitial myocardial fibrosis (IMF) and myocardial scar measured by CMR T1-mapping and late-gadolinium enhancement(LGE), respectively., Methods: There were 1,863 participants (mean age of 69-years) who had both serum HDL-C measurements and underwent CMR. Analysis was done among those with available indices of interstitial fibrosis (extracellular volume fraction[ECV];N=1,172 and native-T1;N=1,863) and replacement fibrosis by LGE(N=1,172). HDL-C was analyzed as both logarithmically-transformed and categorized into <40 (low), 40-59 (normal), and ≥60mg/dL (high). Multivariable linear and logistic regression models were constructed to assess the associations of HDL-C with CMR-obtained measures of IMF, ECV% and native-T1 time, and myocardial scar, respectively., Results: In the fully adjusted model, each 1-SD increment of log HDL-C was associated with a 1% increment in ECV%( p =0.01) and an 18-ms increment in native-T1( p <0.001). When stratified by HDL-C categories, those with high HDL-C(≥60mg/dL) had significantly higher ECV(β=0.5%, p =0.01) and native-T1(β =7ms, p =0.01) compared with those with normal HDL-C levels. Those with low HDL-C were not associated with IMF. Results remained unchanged after excluding individuals with a history of myocardial infarction. Neither increasing levels of HDL-C nor any HDL-C category was associated with the prevalence of myocardial scar., Conclusions: Increasing levels of HDL-C were associated with increased markers of IMF, with those with high levels of HDL-C being linked to subclinical fibrosis in a community-based setting., Competing Interests: A.R. reports inventorship rights to patents held by the University of Connecticut Health and Lipid Genomics. A.R. is the founder of Lipid Genomics. The remaining authors declare no competing interests.