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A thermal energy storage–updraft gasification device is a type of reactor that should be considered for use in solid waste gasification research that can save energy. However, the operating parameters and internal flow field during its operation remain unclear. In this study, a numerical model of the thermal energy storage–solid waste gasification device based on the computational fluid dynamics dense discrete phase model (CFD-DDPM) which had almost never been used before was established, and an innovative method that causes particles to be piled to simulate the gasification process was proposed according to the updraft fixed bed gasification characteristics; meanwhile, solid waste gasification experiments were conducted on the device. This study focused on the influence of moisture content and excess air coefficient on the gasification process of solid waste particles, and the velocity, pressure, temperature, and species distribution of the internal flow field of the device were analyzed. Simulation results showed that the higher the moisture content of particles, the greater the amplitude of changes in the internal physical field of the device. The fluid pressure drop is around 25 Pa–75 Pa for different working conditions. The combustible species of the gas of moist particles raise slightly with the increase in excess air coefficient, while the dry particles have the opposite effect. Compared with other gasification devices of the same type, the hydrogen production of this device is about 2–3 times higher. Our findings could facilitate the analysis, predict the operation status, and provide a theoretical basis for the improvement of this device.

Deep convolutional neural networks have achieved remarkable progress in recent years. However, the large volume of intermediate results generated during inference poses a significant challenge to the accelerator design for resource-constraint FPGA. Due to the limited on-chip storage, partial results of intermediate layers are frequently transferred back and forth between on-chip memory and off-chip DRAM, leading to a non-negligible increase in latency and energy consumption. In this paper, we propose block convolution, a hardware-friendly, simple, yet efficient convolution operation that can completely avoid the off-chip transfer of intermediate feature maps at run-time. The fundamental idea of block convolution is to eliminate the dependency of feature map tiles in the spatial dimension when spatial tiling is used, which is realized by splitting a feature map into independent blocks so that convolution can be performed separately on individual blocks. We conduct extensive experiments to demonstrate the efficacy of the proposed block convolution on both the algorithm side and the hardware side. Specifically, we evaluate block convolution on 1) VGG-16, ResNet-18, ResNet-50, and MobileNet-V1 for ImageNet classification task; 2) SSD, FPN for COCO object detection task, and 3) VDSR for Set5 single image super-resolution task. Experimental results demonstrate that comparable or higher accuracy can be achieved with block convolution. We also showcase two CNN accelerators via algorithm/hardware co-design based on block convolution on memory-limited FPGAs, and evaluation shows that both accelerators substantially outperform the baseline without off-chip transfer of intermediate feature maps.

After a coal seam is mined, the coal remaining in the goaf is prone to flooding and spontaneous combustion accidents. To explore the reignition (secondary oxidation) characteristics of long-flame coal after oxidation and water immersion, the experimental methods of thermogravimetric analysis and infrared spectroscopy were used to analyze coal samples of oxidation first and then water immersion (FO) and samples of water immersion first and then oxidization (FI) at different pre-oxidation temperatures. The results showed that the content of main oxygen-containing functional groups (hydroxyl, carbonyl, and carboxyl groups) of the FO120 (oxidation 120 °C first and then water immersion) coal sample increased, and the FI 90 (water immersion first and then oxidization 90 °C) coal sample decreased. Pre-oxidation at 120 °C will slow down the decrease in the extent of low-temperature secondary oxidation TG, as the pre-oxidation temperature increases, the total heat release of the FO coal samples first increase and then decrease, and the heat released is high at 120 °C. The FI coal samples transfer active sites during the water immersion process, and the high pre-oxidation temperature leads to the rapid increase of the speed of the primary active site, which leads to the transformation between the secondary active site and the oxygen-containing group, resulting in the cleavage of the oxygen-containing group and increasing the heat production. Water immersion pre-oxidation performed under different conditions has the dual effects of promoting and inhibiting spontaneous coal combustion. This result provides a theoretical basis for preventing spontaneous combustion in coal-mined areas in shallow coal seams after soaking in water.

To deeply explore the spontaneous combustion disaster of coal caused by air leakage and oxygen supply, low-temperature coal oxidation experiments under different oxygen concentrations (DOC) were carried out. Within the coal spontaneous combustion characteristic measurement system, a synchronous thermal analyzer (STA) and a Fourier transform infrared spectrometer (FTIR), the macro laws of gas and heat generation under DOC are analyzed, and the mechanism of the development of coal spontaneous combustion restricted by the lean-oxygen environment is also revealed. The results show that the change of oxygen concentration (OC) does not affect the critical temperature value and gas index change trend, but the lean-oxygen environment reduces the gas concentration and heat production rate very obviously. According to the temperature of the intersection, OC needs to be lowered to less than 5% when preventing spontaneous combustion of coal. The chain thermal reaction lags in the lean-oxygen environment, and the pyrolysis activity is significantly reduced. Meanwhile, the temperature points at T6 and T7 show significant differences. Furthermore, with increasing OC and temperature, the content of the aliphatic hydrocarbon presents an overall trend of first increasing, then decreasing, and continuously increasing after stage IV. It is concluded that •OH, aliphatic hydrocarbons, aromatic hydrocarbons, and carboxyl groups are the key groups for the coal spontaneous combustion evolution under DOC. To combine the spontaneous combustion reaction of coal in the DOC environment, the reaction path of the index gas in the macroscopic phenomenon and the reason for the concentration differences are revealed, the mechanism for exotherm varies caused by OC is clarified, and the microscopic inhibition affection on the chain reaction within the lean-oxygen environment is also explored. The results put forward the key groups evolution mechanism under the DOC for coal oxidation, which could provide the technical guidance for the fire prevention and control on coal mines.

The voltage balance of the series diodes is the premise to ensure the stable and reliable operation of the high voltage uncontrolled rectifier valve. When traditional RC and RCD voltage balancing methods are applied to high voltage uncontrolled rectifier valves in far-reaching offshore wind farms, the complex and changeable operating environment poses a challenge to the anti-interference of the balance effect of the snubber circuit. In this paper, an active RCD adaptive voltage balancing control strategy with strong anti-interference ability is proposed based on the establishment of the active RCD voltage balancing model of the high voltage uncontrolled rectifier valve. The parameter tuning method of the active RCD snubber circuit is given, and the auto-PID control strategy of the active RCD snubber circuit is proposed according to its nonlinear time-varying characteristics. The simulation example verifies that the active RCD adaptive voltage balancing strategy of the high voltage uncontrolled rectifier valve has strong anti-interference performance, which provides a reference for the design of the high voltage uncontrolled rectifier valve voltage sharing system in the far-reaching offshore wind farm.

In septic acute kidney injury (SAKI), the positive feedback between damaged mitochondria and accumulation of reactive oxygen species results in cell and tissue damage through multiple mechanisms. Removing the damaged mitochondria or neutralizing the reactive oxygen species has been considered beneficial to alleviating cell damage. The antioxidant Procyanidin B2 has been reported to inhibits reactive oxygen species and thereby reduces cell injury. However, it is unclear whether this effect is associated with clearance of damaged mitochondria. Here, we evaluated the efficacy of procyanidin B2 on SAKI, and focused on its effects on mitochondrial dynamics and removing damaged mitochondria via mitophagy. The results showed that the renal function, renal tubular cell vacuolization and oxidative stress were decreased in SAKI mice treated with procyanidin B2, moreover, skewed mitochondrial fusion/fission, mitochondrial mediated apoptosis and impaired mitophagy were improved in SAKI mice treated with procyanidin B2. In mechanism, the improvement of procyanidin B2 on mitochondrial dynamics were associated with increased nuclear translocation of the transcription factor, Nrf2. In summary, our findings highlighted that the protective efficacy of procyanidin B2 in reducing cellular damage in SAKI, and mechanisms improving mitochondrial dynamics and quality control at least in part by promoting Nrf2 translocation into the nucleus.

Recurrent hypoglycemia (RH) impairs secretion of counterregulatory hormones. Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory hormones are poorly understood.To study the effects of RH on metabolic pathways associated with glucose counterregulation within liver, white adipose tissue and skeletal muscle.Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors (GPCRs), their inhibitory regulators and downstream enzymes catalyzing glycogen metabolism, gluconeogenesis and lipolysis by qPCR and western blot. Then, we examined epinephrine-induced phosphorylation of PKA substrates to validate adrenergic sensitivity in each organ. Next, we measured hepatic and skeletal glycogen content, degree of breakdown by epinephrine and abundance of phosphorylated glycogen phosphorylase under hypoglycemia and that of phosphorylated glycogen synthase during recovery to evaluate glycogen turnover. Further, we performed pyruvate and lactate tolerance tests to assess gluconeogenesis. Additionally, we measured circulating FFA and glycerol to check lipolysis. The abovementioned studies were repeated in streptozotocin-induced diabetic rat model. Finally, we conducted epinephrine tolerance test to investigate systemic glycemic excursions to counterregulatory hormones. Saline-injected rats served as controls.RH increased counterregulatory hormone GPCR signaling in liver and epidydimal white adipose tissue (eWAT), but not in skeletal muscle. For glycogen metabolism, RH did not affect total content or epinephrine-stimulated breakdown in liver and skeletal muscle. Although RH decreased expression of phosphorylated glycogen synthase 2, it did not affect hepatic glycogen biosynthesis during recovery from hypoglycemia or after fasting-refeeding. For gluconeogenesis, RH upregulated fructose 1,6-bisphosphatase 1 and monocarboxylic acid transporter 1 that imports lactate as precursor, resulting in a lower blood lactate profile during hypoglycemia. In agreement, RH elevated fasting blood glucose and caused higher glycemic excursions during pyruvate tolerance test. For lipolysis, RH did not affect circulating levels of FFA and glycerol after overnight fasting or upon epinephrine stimulation. Interestingly, RH upregulated the trophic fatty acid transporter FATP1 and glucose transporter GLUT4 to increase lipogenesis in eWAT. These aforementioned changes of gluconeogenesis, lipolysis and lipogenesis were validated in streptozotocin-diabetic rats. Finally, RH increased insulin sensitivity to accelerate glucose disposal, which was attributable to upregulated visceral adipose GLUT4.RH caused metabolic adaptations related to counterregulation within peripheral organs. Specifically, adrenergic signaling was enhanced in liver and visceral fat, but not in skeletal muscle. Glycogen metabolism remained unchanged. Hepatic gluconeogenesis was augmented. Systemic lipolysis was unaffected, but visceral lipogenesis was enhanced. Insulin sensitivity was increased. These findings provided insights into mechanisms underlying clinical problems associated with intensive insulin therapy, such as high gluconeogenic flux and body weight gain.

Lysosomes are organelles involved in cell metabolism, waste degradation, and cellular material circulation. They play a key role in the maintenance of cellular physiological homeostasis. Compared with the lysosomal content of other organs, that of the kidney is abundant, and lysosomal abnormalities are associated with the occurrence and development of certain renal diseases. Lysosomal structure and function in intrinsic renal cells are impaired in diabetic kidney disease (DKD). Promoting lysosomal biosynthesis and/or restoring lysosomal function can repair damaged podocytes and proximal tubular epithelial cells, and delay the progression of DKD. Lysosomal homeostasis maintenance may be advantageous in alleviating DKD. Here, we systematically reviewed the latest advances in the relationship between lysosomal dyshomeostasis and progression of DKD based on recent literature to further elucidate the mechanism of renal injury in diabetes mellitus and to highlight the application potential of lysosomal homeostasis maintenance as a new prevention and treatment strategy for DKD. However, research on screening effective interventions for lysosomal dyshomeostasis is still in its infancy, and thus should be the focus of future research studies. The screening out of cell-specific lysosomal function regulation targets according to the different stages of DKD, so as to realize the controllable targeted regulation of cell lysosomal function during DKD, is the key to the successful clinical development of this therapeutic strategy.

Mitochondrial injury plays an important role in the occurrence and development of kidney diseases. However, the existing assays to determine mitochondrial function restrict our ability to understand the relationship between mitochondrial dysfunction and kidney damage. These limitations may be overcome by recent findings on urinary mitochondrial DNA (UmtDNA). Elevated UmtDNA level may serve as a surrogate biomarker of mitochondrial dysfunction, kidney damage, and progression and prognosis of kidney diseases. Herein, we review the recent research progress on UmtDNA in kidney diseases diagnosis and highlight the research areas that should be expanded in future as well as discuss the future perspectives.

Acute kidney injury (AKI) is a common clinical disease that can cause serious harm to the kidneys, but it has no effective treatment till now. The modulation of autophagy pathway regulation is considered a potentially effective therapeutic approach in AKI prevention and treatment. ZKSCAN3 has been shown to be an important transcription factor that negatively regulates autophagy activity in cancer tissues. In order to determine whether autophagy could be activated by knocking out ZKSCAN3 to exert the renal protective effect of autophagy, we constructed AKI models with Zkscan3 knockout (KO) mice and detected renal pathological changes and renal function changes as well as autophagy-related indicators. We found that Zkscan3 KO had no significant effect on kidney development. Besides, no significant changes in autophagy activity were observed under normal physiological or AKI conditions. In non-tumor tissues, ZKSCAN3 did not mediate transcriptional regulation of autophagy-related genes. These findings suggest that because ZKSCAN3 may not function in the transcriptional regulation of autophagy-related genes in non-tumor tissues, it may not be used as a therapeutic target for AKI.

Background Persistent elevated concentrations of urinary protein can destroy proximal tubule epithelial cells (PTECs) by inducing lysosomal abnormalities, thereby aggravating PTEC damage and renal fibrosis. However, the specific mechanisms of these serial biochemical events and methods for treating or preventing PTEC damage upon proteinuria need further investigation. Results In this study, electron microscopy and dual-labeled immunofluorescence analysis for identifying lysosome type revealed inadequate primary lysosome biogenesis and secondary lysosome accumulation in the PTECs of patients with minimal change nephrotic syndrome or membranous nephropathy who suffered from proteinuria. In vitro studies on HK-2 cells indicated that this abnormality was associated with decreased expression of transcription factor EB (TFEB). In contrast, TFEB overexpressing HK-2 cells under urinary protein overload exhibited significantly reduced accumulation of secondary lysosomes and increased proportion and quantity of primary lysosomes as indicated by dual-labeled immunofluorescence. Further, these cells could upregulate lysosomal degradation functions, as determined using Cathepsin L activity assays and flow cytometry for dye quenched-albumin. Conclusions These results indicate that abnormal TFEB expression is a key mechanism of lysosomal dyshomeostasis caused by protein overload in PTECs. TFEB is thus a potential therapeutic target for the treatment of urinary protein-related kidney disease.

Mitochondria are energy producers that play a vital role in cell survival. Mitochondrial dysfunction is involved in many diseases, including metabolic syndrome, neurodegenerative disorders, cardiomyopathies, cancer, obesity, and diabetic kidney disease, and challenges still remain in terms of treatments for these diseases. Mitochondrial quality control (MQC), which is defined as the maintenance of the quantity, morphology, and function of mitochondria, plays a pivotal role in maintaining cellular metabolic homeostasis and cell survival. Recently, growing evidence suggests that the transcription factor EB (TFEB) plays a pivotal role in MQC. Here, we systemically investigate the potential role and mechanisms of TFEB in MQC, which include the activation of mitophagy, regulation of mitochondrial biogenesis, reactive oxygen species (ROS) clearance, and the balance of mitochondria fission-fusion cycle. Importantly, we further discuss the therapeutic measures and effects aimed at TFEB on mitochondrial dysfunction-related diseases. Taken together, targeting TFEB to regulate MQC may represent an appealing therapeutic strategy for mitochondrial dysfunction related-diseases.

In this paper, we propose a novel one-hot representation for weights and activations in CNN model and demonstrate its benefits on hardware accelerator design. Specifically, rather than merely reducing the bitwidth, we quantize both weights and activations into n-bit integers that containing only one non-zero bit per value. In this way, the massive multiply and accumulates (MACs) are equivalent to additions of powers of two that can be efficiently calculated with histogram based computaitons. Experiments on the ImageNet classification task show that comparable accuracy can be obtained on our proposed One-Hot Networks (OHN) compared to conventional fixed-point networks. As case studies, we evaluate the efficacy of the one-hot data representation on two state-of-the-art CNN accelerators on FPGA, our preliminary results show that 50% and 68.5% resource saving can be achieved on DaDianNao and Laconic respectively. Besides, the one-hot optimized Laconic can further achieve an average speedup of> 4.94× on AlexNet.

The effect of electrostatic spraying on the formation of CO2 hydrate was experimentally studied. The effects of voltage (0, 0.5, 1.0, 1.5, 2.0 KV) and initial temperature (285.15, 282.15, 279.15 K) on the morphology, phase equilibrium temperature, induction time, rapid growth time, gas consumption, water to hydrate conversion and gas uptake rate of CO2 hydrate were analyzed. The CO2 hydrate primarily took the wall of the vessel as the nucleation site and grew from wall to the center of the reactor. The main morphological structure of CO2 hydrate were white filaments stacked in arcs, branches, and clusters. Low voltage-high initial temperature and high voltage-low initial temperature were conducive to improving the phase equilibrium temperature of CO2 hydrate. The application of voltage would prolong the induction time and shorten the rapid growth time of CO2 hydrate, and the effect would be more apparent with the increase of voltage. Lowering the initial temperature would shorten the induction time, 23 min was observed at 1.0 KV and the initial temperature of 279.15 K. The gas consumption and water to hydrate conversion change with voltage were in an order of 1.0 > 0>2.0 > 1.5>0.5 KV at the same temperature. Only 1.0 KV could enhance CO2 gas consumption, water to hydrate conversion and gas consumption rate.

Visual Abstract, Highlights • Optimal treatment for patients with diabetes and myocardial infarction remains a challenge. • Hyperglycemia- and hyperinsulinemia-induced miR-24 reduction and O-GlcNAcylation in the diabetic heart contributes to poor survival in diabetic myocardial I/R and increased infarct size post-I/R. • Overexpression of miR-24 in murine hearts significantly reduces myocardial infarct size. • miR-24 targets multiple key proteins including O-GlcNac transferase, ATG4A (a key protein in autophagy), and BIM (a pro-apoptosis protein) to protect the myocardium from I/R injury. • miR-24 is a promising therapeutic candidate for diabetic I/R injury., Summary Management for patients with diabetes experiencing myocardial infarction remains a challenge. Here the authors show that hyperglycemia- and hyperinsulinemia-induced microRNA-24 (miR-24) reduction and O-GlcNAcylation in the diabetic heart contribute to poor survival and increased infarct size in diabetic myocardial ischemia/reperfusion (I/R). In a mouse model of myocardial I/R, pharmacological or genetic overexpression of miR-24 in hearts significantly reduced myocardial infarct size. Experimental validation revealed that miR-24 targets multiple key proteins, including O-GlcNac transferase, ATG4A, and BIM, to coordinately protect the myocardium from I/R injury. These results establish miR-24 as a promising therapeutic candidate for diabetic I/R injury.

During coal-mining processes underground, the coal spontaneous combustion caused by air leakage of narrow coal pillars and residual coal in goaf under pressure not only threatens the safety of mining of coal resources, but also leads to serious casualties. Therefore, the research of multi-field coupling for broken coal could be helpful to reveal the spontaneous combustion law of narrow coal pillars and residual coal in goaf and find the key for coal-fire prevention and control. Therefore, the uniaxial compression equipped with a temperature-programmed device is applied to conduct stress-heating tests on five types of coal particle sizes. Moreover, based on the Hertz contact deformation principle under the three-particle model, the thermodynamic hysteresis characteristics of broken coal under uniaxial stresses are theoretically analyzed. The results are shown as follows: (i) Uniaxial stress leads to significant hysteresis effects on the critical temperature of coal spontaneous combustion, heating rate, Graham’s Ratio-R2 temperature coefficient and pyrolysis temperature. (ii) As the particle radius increases, the growth rate of the exothermic intensity is suppressed, while it has no inhibitory effect on the critical temperature of the minimum exothermic intensity. (iii) The extreme point for the limit parameter of coal spontaneous combustion and the critical temperature shows the same corresponding hysteresis under uniaxial stress. The particle size ratio changes the limit parameter of coal spontaneous combustion obviously, and coal with a large particle size would reduce the risk of spontaneous combustion. (iv) The stress–strain curves and the stress-porosity curves are divided into stages, and it is found that the critical uniaxial stress of the porosity and strain of each coal sample is up to 4 MPa. Moreover, the temperature is the main reason for the hysteresis of permeability. The stress sensitivity of permeability declines with the effective stress rising, increases with the temperature going up, and decreases with the coal particle size reducing. (v) The hysteresis effect of uniaxial stress on coal spontaneous combustion first increases, then decreases, and finally increases.

Photocatalytic oxidation has been widely used in sulfur oxidation due to its mild reaction conditions. In order to improve the efficiency of removing sulfur from coal, especially the organic sulfur, TiO2, SiO2 and modified SiO2 were used as photocatalysts under UV lamp irradiation in the presence of 1-carboxymethyl-3-methylimidazole bisulfite ([HO2MMim][HSO4]) and hydrogen peroxide (H2O2). The results show that the photocatalysts played important roles in coal desulfurization. The desulfurization rate of [HO2MMim][HSO4]–H2O2 (1:10) treatment on coal was only 16.89%, while after adding TiO2, e.g. [HO2MMim][HSO4]–H2O2-TiO2 (1:10:4), it increases to 38.46% and the removing rate of organic sulfur approached 20.17% under normal temperature and pressure on a basis of photocatalysis. According to FTIR and XPS measurements, it is found that the catalytic oxidation can be accelerated in the presence of photocatalysts under ultraviolet irradiation, and the thiophene conversion can be enhanced significantly. Generally, TiO2 is more efficient in organic sulfur removal than SiO2 during photocatalytic oxidation. The results of quantum chemistry calculation indicates that thiophene sulfone could be produced much easier than the thiophene ring-cleaved reaction when thiophene was oxidized in the presence of hydroxyl radicals. In addition, compared to the traditional methods, the photocatalytic desulfurization only show a slight reduction of combustion heat value according to TG-DSC-DDSC measurements.

Object detection has made impressive progress in recent years with the help of deep learning. However, state-of-the-art algorithms are both computation and memory intensive. Though many lightweight networks are developed for a trade-off between accuracy and efficiency, it is still a challenge to make it practical on an embedded device. In this paper, we present a system-level solution for efficient object detection on a heterogeneous embedded device. The detection network is quantized to low bits and allows efficient implementation with shift operators. In order to make the most of the benefits of low-bit quantization, we design a dedicated accelerator with programmable logic. Inside the accelerator, a hybrid dataflow is exploited according to the heterogeneous property of different convolutional layers. We adopt a straightforward but resource-friendly column-prior tiling strategy to map the computation-intensive convolutional layers to the accelerator that can support arbitrary feature size. Other operations can be performed on the low-power CPU cores, and the entire system is executed in a pipelined manner. As a case study, we evaluate our object detection system on a real-world surveillance video with input size of 512x512, and it turns out that the system can achieve an inference speed of 18 fps at the cost of 6.9W (with display) with an mAP of 66.4 verified on the PASCAL VOC 2012 dataset., Accepted by ICCV 2019 Low-Power Computer Vision Workshop

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotropic virus type 1, human immunodeficiency virus type 1, and endogenous retroviruses) in the pathogenesis of SLE. More importantly, we explore the known mechanisms underlying the involvement of infectious agents in the pathogenesis of SLE, including molecular mimicry, epitope spreading, superantigen production, bystander activation, persistent viral infection, altered apoptosis, clearance deficiency, and epigenetic alterations (e.g., DNA methylation and microRNAs). However, some infectious agents (e.g., malaria parasites, hepatitis B virus, Toxoplasma gondii, and Helicobacter pylori) may exert protective effects on SLE. Therefore, the relationship between infection and SLE is multifaceted and multidirectional, including causative and/or protective associations, which warrant further investigation in the future.

Aims The renal tubule cells require a large number of mitochondria to supply ATP due to their high-energy demand during reabsorption and secretion against chemical gradients and result in mitochondria susceptible to disorder and injury during stress conditions. Injured mitochondria are eventually degraded by mitophagy, and disturbances in mitophagy are associated with the pathogenesis of acute kidney injury (AKI) such as diabetic nephropathy and glomerulosclerosis. However, whether a disturbance in mitophagy has occurred and the role it plays in (SAKI) is still unclear. Therefore, the aim of this study was to investigate the key features of mitophagy and mitochondrial dynamics in sepsis-induced acute kidney injury (SAKI). Main methods In this study, a murine septic AKI model induced by cecal ligation and puncture (CLP) was built; mitophagy and mitochondrial dynamics were measured in mice kidney in different time point. Key findings The results showed that mitochondrial dynamics were characterized by fission/fusion aberrant, however more inclined to fission, and mitochondrial associated apoptosis was elevated over-time during SAKI. Furthermore, mitophagy was impaired in the later phase of SAKI, although elevated in early stage of SAKI. The results indicate that the underlying mechanisms of impaired mitophagy may associate with the cleavage of Parkin via caspases activated by NLRP3, at least partly. Significance It is conceivable that this selective autophagic process and quality control machinery was impaired, leading to the accumulation of damaged mitochondria, oxidative stress, and cell death. Therefore, a targeted approach, by enhancing mitophagy during SAKI, may be a promising therapeutic strategy.

NEW FINDINGS What is the central question of this study? Research has reported that some sensory input, such as auditory and olfactory input, can affect subliminal visual processing. However, it is important to address whether tactile input, another form of elementary sensory input, could influence the interocular rivalry process. What is the main finding and its importance? We present several pieces of evidence regarding the influences of familiar tactile shapes and temperature on continuous flash suppression. Our findings provide support for the hypothesis that there is a cross-modal effect on subconscious visual semantic processing of Chinese characters. More specifically, tactile sensations affect subliminal processing of visual information. ABSTRACT Tactile and visual sensations are the most vital human functions for obtaining environmental information. However, whether tactile information influences visual processing remains unclear. In this study, a breaking continuous flash suppression (b-CFS) protocol was used to measure the extent to which tactile sensations facilitate visual processing subconsciously. In experiment 1, finger stimulation with cold and hot temperatures served as primers for the words 'cold' and 'hot', which were in turn suppressed by CFS. In experiment 2, subjects viewed the upright or inverted word 'cell phone', with or without tactile priming of holding a cell phone in their hand. Results demonstrated that the tactile primer significantly shortened the reaction time in the touch group compared with the control group in both experiments. Thus, the tactile sensation of a familiar article and/or temperature appears to facilitate corresponding visual semantic recognition to break CFS earlier.