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Your search keyword '"Zemenová, Jana"' showing total 11 results
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11 results on '"Zemenová, Jana"'

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4. Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy

Author

Popelová, Andrea, primary, Pražienková, Veronika, additional, Neprašová, Barbora, additional, Kasperová, Barbora Judita, additional, Hrubá, Lucie, additional, Holubová, Martina, additional, Zemenová, Jana, additional, Blum, David, additional, Železná, Blanka, additional, Galas, Marie-Christine, additional, Kuneš, Jaroslav, additional, and Maletínská, Lenka, additional more...

Published
2018
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6. Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin and vildagliptin and their combination

Author

Pelantová, Helena, Bugáňová, Martina, Holubová, Martina, Šedivá, Blanka, Zemenová, Jana, Sýkora, David, Kaválková, Petra, Haluzík, Martin, Železná, Blanka, Maletínská, Lenka, Kuneš, Jaroslav, and Kuzma, Marek more...

Subjects
léčba diabetu, NMR metabolomics, obesity, antidiabetic treatment, diabetes mellitus 2. typu, type 2 diabetes mellitus, moč, myši, NMR metabolomika, obezita, mouse, urine
Abstract

Metformin, vildagliptin and their combination are widely used for the treatment of diabetes, but little is known about the metabolic responses to these treatments. In the present study, NMR-based metabolomics was applied to detect changes in the urinary metabolomic profile of a mouse model of diet-induced obesity in response to these treatments. Additionally, standard biochemical parameters and the expression of enzymes involved in glucose and fat metabolism were monitored. Significant correlations were observed between several metabolites (e.g., N-carbamoyl-β-alanine, N1-methyl-4-pyridone-3-carboxamide, N1-methyl-2-pyridone-5-carboxamide, glucose, 3-indoxyl sulfate, dimethylglycine and several acylglycines) and the area under the curve of glucose concentrations during the oral glucose tolerance test. The present study is the first to present N-carbamoyl-β-alanine as a potential marker of type 2 diabetes mellitus and consequently to demonstrate the efficacies of the applied antidiabetic interventions. Moreover, the elevated acetate level observed after vildagliptin administration might reflect increased fatty acid oxidation. more...

Published
2016

11. Anorexigenic Lipopeptides Ameliorate Central Insulin Signaling and Attenuate Tau Phosphorylation in Hippocampi of Mice with Monosodium Glutamate-Induced Obesity

Author

Špolcová, Andrea, primary, Mikulášková, Barbora, additional, Holubová, Martina, additional, Nagelová, Veronika, additional, Pirnik, Zdenko, additional, Zemenová, Jana, additional, Haluzík, Martin, additional, Železná, Blanka, additional, Galas, Marie-Christine, additional, and Maletínská, Lenka, additional more...

Published
2015
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