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3. PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Author

Pavel, H., primary, Ajeawung, N., additional, Faure, R., additional, Poirier, D., additional, Kamnasaran, D., additional, Joshi, H., additional, Lun, X., additional, Zemp, F., additional, Sun, B., additional, Stechishin, O., additional, Luchman, A., additional, Kelly, J. J., additional, Weiss, S., additional, Hamilton, M. G., additional, Cairncross, G., additional, Senger, D. L., additional, Bell, J., additional, McFadden, G., additional, Forsyth, P. A., additional, Tzeng, S. Y., additional, Guerrero-Cazares, H., additional, Martinez, E. E., additional, Young, N. P., additional, Sunshine, J. C., additional, Quinones-Hinojosa, A., additional, Green, J. J., additional, Lei, L., additional, D'Amico, R., additional, Sisti, J., additional, Leung, R., additional, Sonabend, A. M., additional, Guarnieri, P., additional, Rosenfeld, S. S., additional, Bruce, J. N., additional, Canoll, P., additional, Baichwal, V. R., additional, Reeves, L., additional, Chad, B. L., additional, Zavitz, K. H., additional, Beelen, A. P., additional, Mather, G. G., additional, Carlson, R. O., additional, Manton, C., additional, Chandra, J., additional, Keir, S. T., additional, Reardon, D. A., additional, Saling, J. R., additional, Gray, L. S., additional, Bigner, D. D., additional, Friedman, H. S., additional, Zhang, J., additional, Brun, J., additional, Ogbomo, H., additional, Wang, Z., additional, Stojdl, D. J., additional, Kong, L.-Y., additional, Hatiboglu, M. A., additional, Wei, J., additional, Wang, Y., additional, McEnery, K. A., additional, Fuller, G. N., additional, Qiao, W., additional, Davies, M. A., additional, Priebe, W., additional, Heimberger, A. B., additional, Amendolara, B., additional, Gil, O., additional, Ivkovic, S., additional, Bruce, J., additional, Rosenfeld, S., additional, Finniss, S., additional, Perlstein, B., additional, Miller, C., additional, Okhrimenko, H., additional, Kazimirsky, G., additional, Cazacu, S., additional, Lemke, N., additional, Brodie, S., additional, Rempel, S. A., additional, Rosenblum, M., additional, Mikkelsen, T., additional, Margel, S., additional, Brodie, C., additional, Guvenc, H., additional, Demir, H., additional, Gupta, S., additional, Mazumder, S., additional, Ray-Chaundhury, A., additional, Li, T., additional, Li, C., additional, Nakano, I., additional, Rahman, R., additional, Rahman, C., additional, Smith, S., additional, Macarthur, D., additional, Rose, F., additional, Shakesheff, K., additional, Grundy, R. G., additional, Brenner, A. J., additional, Goins, B., additional, Bao, A., additional, Miller, J., additional, Trevino, A., additional, Zuniga, R., additional, Phillips, W. T., additional, Gilg, A. G., additional, Bowers, K. G., additional, Toole, B. P., additional, Maria, B. L., additional, Leung, G. K., additional, Sun, S., additional, Wong, S. T., additional, Zhang, X. Q., additional, Pu, J. K., additional, Lui, W. M., additional, Marino, A. M., additional, Hussaini, I. M., additional, Amos, S., additional, Simpson, K., additional, Redpath, G. T., additional, Lyons, C., additional, Dipierro, C., additional, Grant, G. A., additional, Wilson, C., additional, Salami, S., additional, Macaroni, P., additional, Li, S., additional, Park, J.-Y., additional, Needham, D., additional, Bigner, D., additional, Dewhirst, M., additional, Ohlfest, J., additional, Gallardo, J., additional, Argawal, S., additional, Mittapalli, R., additional, Donelson, R., additional, Elmquist, W. F., additional, Nicolaides, T., additional, Hariono, S., additional, Barkovich, K., additional, Hashizume, R., additional, Rowitch, D., additional, Weiss, W., additional, Sheer, D., additional, Baker, S., additional, Paugh, B., additional, Waldman, T., additional, Li, H., additional, Jones, C., additional, Forshew, T., additional, James, D., additional, Caroline, H., additional, Patrick, R., additional, Katrin, L., additional, Karl, F., additional, Ghazaleh, T., additional, Michael, W., additional, Albrecht, V., additional, Thorsteinsdottir, J., additional, Wagner, E., additional, Tonn, J.-C., additional, Ogris, M., additional, Schichor, C., additional, Charest, G., additional, Paquette, B., additional, Sanche, L., additional, Mathieu, D., additional, Fortin, D., additional, Qi, X., additional, Cuttitta, F., additional, Chu, Z., additional, Celerier, J., additional, Pakradouni, J., additional, Rixe, O., additional, Gragg, A., additional, Muller, S., additional, Banerjee, A., additional, Phillips, J., additional, Prados, M., additional, Haas-Kogan, D., additional, Gupta, N., additional, Florence, L., additional, Gwendoline, V. G., additional, Veronique, M., additional, Robert, K., additional, Agarwal, S., additional, Mittapalli, R. K., additional, Cen, L., additional, Carlson, B. L., additional, Sarkaria, J. N., additional, Sengupta, S., additional, Weeraratne, S. D., additional, Rallapalli, S., additional, Amani, V., additional, Pierre-Francois, J., additional, Teider, N., additional, Rotenberg, A., additional, Cook, J., additional, Pomeroy, S. L., additional, Jenses, F., additional, Cho, Y.-J., additional, Hjouj, M., additional, Last, D., additional, Guez, D., additional, Daniels, D., additional, Lavee, J., additional, Rubinsky, B., additional, Mardor, Y., additional, Serwer, L. P., additional, Noble, C. O., additional, Michaud, K., additional, Drummond, D. C., additional, Ozawa, T., additional, Zhou, Y., additional, Marks, J. D., additional, Bankiewicz, K., additional, Park, J. W., additional, Wang, W., additional, Cho, H., additional, Weintraub, M., additional, Jhaveri, N., additional, Torres, S., additional, Petasis, N., additional, Schonthal, A. H., additional, Louie, S. G., additional, Hofman, F. M., additional, Chen, T. C., additional, Grada, Z., additional, Hegde, M., additional, Schaffer, D. R., additional, Ghazi, A., additional, Byrd, T., additional, Dotti, G., additional, Wels, W., additional, Heslop, H. E., additional, Gottschalk, S., additional, Baker, M., additional, Ahmed, N., additional, Hamblett, K. J., additional, Kozlosky, C. J., additional, Liu, H., additional, Siu, S., additional, Arora, T., additional, Retter, M. W., additional, Matsuda, K., additional, Hill, J. S., additional, Fanslow, W. C., additional, Diaz, R. J., additional, Etame, A., additional, Meaghan, O., additional, Mainprize, T., additional, Smith, C., additional, Hynynen, K., additional, Rutka, J., additional, Pradarelli, J., additional, Yoo, J. Y., additional, Kaka, A., additional, Alvarez-Breckenridge, C., additional, Pan, Q., additional, Chiocca, E. A., additional, Teknos, T., additional, Kaur, B., additional, Lee, S. Y., additional, Slagle-Webb, B., additional, Sheehan, J. M., additional, Connor, J. R., additional, Cote, J., additional, Lepage, M., additional, Gobeil, F., additional, Kleijn, A., additional, Balvers, R., additional, Kloezeman, J., additional, Dirven, C., additional, Lamfers, M., additional, Leenstra, S., additional, See, W., additional, Tan, I.-L., additional, Pieper, R., additional, Jiang, H., additional, White, E., additional, Rios-Vicil, C. I., additional, Yung, W.-K. A., additional, Gomez-Manzano, C., additional, Fueyo, J., additional, Zemp, F. J., additional, McKenzie, B. A., additional, Mueller, S., additional, Yang, X., additional, Smirnov, I., additional, James, D. C., additional, Phillips, J. J., additional, Berger, M. S., additional, Rowitch, D. H., additional, Haas-Kogan, D. H., additional, Kennedy, B., additional, Gopalakrishnan, V., additional, Das, C., additional, Taylor, P., additional, Kommagani, R., additional, Su, X., additional, Aguilera, D., additional, Thomas, A., additional, Wolff, J., additional, Flores, E., additional, Kadakia, M., additional, Alkins, R., additional, Broderson, P., additional, Sodhi, R., additional, Chung, S. A., additional, McDonald, K. L., additional, Shen, H., additional, Day, B. W., additional, Stringer, B. W., additional, Johns, T., additional, Decollogne, S., additional, Teo, C., additional, Hogg, P. J., additional, Dilda, P. J., additional, Patel, T. R., additional, Zhou, J., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Vogelbaum, M. A., additional, Manchanda, P., additional, Ohlfest, J. R., additional, Kitange, G. J., additional, Mladek, A. C., additional, Schroeder, M. A., additional, Pokorny, J. L., additional, Mody, C., additional, Forsyth, P., additional, Dasgupta, T., additional, James, C. D., additional, Madhankumar, A. B., additional, Webb, B. S., additional, Park, A., additional, Harbaugh, K., additional, and Sheehan, J., additional

Published
2011
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4. Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Author

Zemp, F. J., primary, Lun, X., additional, McKenzie, B. A., additional, Zhou, H., additional, Maxwell, L., additional, Sun, B., additional, Kelly, J. J. P., additional, Stechishin, O., additional, Luchman, A., additional, Weiss, S., additional, Cairncross, J. G., additional, Hamilton, M. G., additional, Rabinovich, B. A., additional, Rahman, M. M., additional, Mohamed, M. R., additional, Smallwood, S., additional, Senger, D. L., additional, Bell, J., additional, McFadden, G., additional, and Forsyth, P. A., additional

Published
2013
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5. STEM CELLS

Author

Joshi, K., primary, Gupta, S., additional, Mazumder, S., additional, Okemoto, Y., additional, Angenieux, B., additional, Kornblum, H., additional, Nakano, I., additional, Synowitz, M., additional, Kumar, J., additional, Petrosino, S., additional, Imperatore, R., additional, Smith, E., additional, Wendt, P., additional, Erdmann, B., additional, Nuber, U., additional, Matiash, V., additional, Chirasani, S., additional, Cristino, L., additional, DiMarzo, V., additional, Kettenmann, H., additional, Glass, R., additional, Soroceanu, L., additional, Matlaf, L., additional, Cobbs, C., additional, Kim, Y.-W., additional, Kim, S. H., additional, Kwon, C., additional, Han, D.-y., additional, Kim, E. H., additional, Chang, J. H., additional, Liu, J.-L., additional, Kim, Y. H., additional, Kim, S., additional, Long, P. M., additional, Viapiano, M. S., additional, Jaworski, D. M., additional, Kanemura, Y., additional, Shofuda, T., additional, Kanematsu, D., additional, Matsumoto, Y., additional, Yamamoto, A., additional, Nonaka, M., additional, Moriuchi, S., additional, Nakajima, S., additional, Suemizu, H., additional, Nakamura, M., additional, Okada, Y., additional, Okano, H., additional, Yamasaki, M., additional, Price, R. L., additional, Song, J., additional, Bingmer, K., additional, Zimmerman, P., additional, Rivera, A., additional, Yi, J.-Y., additional, Cook, C., additional, Chiocca, E. A., additional, Kwon, C.-H., additional, Kang, S.-G., additional, Shin, H.-D., additional, Mok, H.-S., additional, Park, N.-R., additional, Sim, J. K., additional, Shin, H. J., additional, Park, Y. K., additional, Jeun, S. S., additional, Hong, Y.-K., additional, Lang, F. F., additional, McKenzie, B. A., additional, Zemp, F. J., additional, Lun, X., additional, Narendran, A., additional, McFadden, G., additional, Kurz, E., additional, Forsyth, P., additional, Talsma, C. E., additional, Flack, C. G., additional, Zhu, T., additional, He, X., additional, Soules, M., additional, Heth, J. A., additional, Muraszko, K., additional, Fan, X., additional, Chen, L., additional, Guerrero-Cazares, H., additional, Noiman, L., additional, Smith, C., additional, Beltran, N., additional, Levchenko, A., additional, Quinones-Hinojosa, A., additional, Peruzzi, P., additional, Godlewski, J., additional, Lawler, S. E., additional, Sarkar, S., additional, Doring, A., additional, Wang, X., additional, Kelly, J., additional, Hader, W., additional, Dunn, J. F., additional, Kinniburgh, D., additional, Robbins, S., additional, Cairncross, G., additional, Weiss, S., additional, Yong, V. W., additional, Vollmann-Zwerenz, A., additional, Velez-Char, N., additional, Jachnik, B., additional, Ramm, P., additional, Leukel, P., additional, Bogdahn, U., additional, Hau, P., additional, Kim, S.-H., additional, Lee, M. K., additional, Chwae, Y.-J., additional, Yoo, B. C., additional, Kim, K.-H., additional, Kristoffersen, K., additional, Stockhausen, M.- T., additional, Poulsen, H. S., additional, Kaluzova, M., additional, Machaidze, R., additional, Wankhede, M., additional, Hadjipanayis, C. G., additional, Romane, A. M., additional, Sim, F. J., additional, Wang, S., additional, Chandler-Militello, D., additional, Li, X., additional, Al Fanek, Y., additional, Walter, K., additional, Johnson, M., additional, Achanta, P., additional, Goldman, S. A., additional, Shinojima, N., additional, Hossain, A., additional, Takezaki, T., additional, Gumin, J., additional, Gao, F., additional, Nwajei, F., additional, Cheung, V., additional, Figueroa, J., additional, Pellegatta, S., additional, Orzan, F., additional, Anghileri, E., additional, Guzzetti, S., additional, Porrati, P., additional, Eoli, M., additional, Finocchiaro, G., additional, Fu, J., additional, Koul, D., additional, Yao, J., additional, Gumin, J. G., additional, Sulman, E., additional, Lang, F., additional, Aldape, K. K., additional, Colman, H., additional, Yung, A. W., additional, Aldape, K., additional, Alonso, M. M., additional, Manterola, L., additional, urquiza, L., additional, Cortes-Santiago, N., additional, Diez-Valle, R., additional, Tejada-Solis, S., additional, Garcia-foncillas, J., additional, Fueyo, J., additional, Gomez-Manzano, C., additional, Nguyen, S., additional, Stechishin, O., additional, Luchman, A., additional, Lathia, J. D., additional, Gallagher, J., additional, Li, M., additional, Myers, J., additional, Hjelmeland, A., additional, Huang, A., additional, Rich, J., additional, Bhat, K., additional, Vaillant, B., additional, Balasubramaniyan, V., additional, Ezhilarasan, R., additional, Hitomi, M., additional, Gadani, S., additional, Adkins, J., additional, Vasanji, A., additional, Wu, Q., additional, Soeda, A., additional, McLendon, R., additional, Chenn, A., additional, Park, D., additional, Weinstein, J. N., additional, Alfred Yung, W. K., additional, Zagzag, D., additional, Esencay, M., additional, Klopsis, D., additional, Liu, M., additional, Narayana, A., additional, Parker, E., additional, Golfinos, J., additional, Clark, P. A., additional, Kandela, I. K., additional, Weichert, J. P., additional, Kuo, J. S., additional, Fouse, S. D., additional, Nagarajan, R. P., additional, Nakamura, J., additional, James, C. D., additional, Chang, S., additional, Costello, J. F., additional, Gong, X., additional, Kankar, G., additional, Di, K., additional, Reeves, A., additional, Linskey, M., additional, Bota, D. A., additional, Schmid, R. S., additional, Bash, R. E., additional, Vitucci, M., additional, Werneke, A. M., additional, Miller, C. R., additional, Kim, E., additional, Kim, M., additional, Kim, K., additional, Lee, J., additional, Du, F., additional, Li, P., additional, Wechsler-Reya, R., additional, and Yang, Z.-j., additional

Published
2011
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7. Pre-clinical Experimental Therapeutics and Pharmacology

Author

Jensen, R. L., primary, Gilliespie, D., additional, Ajewung, N., additional, Faure, R., additional, Kamnasaran, D., additional, Poirier, D., additional, Tamura, K., additional, Wakimoto, H., additional, Rabkin, S. D., additional, Martuza, R. L., additional, Shah, K., additional, Hashizume, R., additional, Aoki, Y., additional, Serwer, L. P., additional, Drummond, D., additional, Noble, C., additional, Park, J., additional, Bankiewicz, K., additional, James, D. C., additional, Gupta, N., additional, Agerholm-Larsen, B., additional, Iversen, H. K., additional, Jensen, K. S., additional, Moller, J., additional, Ibsen, P., additional, Mahmood, F., additional, Gehl, J., additional, Corem, E., additional, Ram, Z., additional, Daniels, D., additional, Last, D., additional, Shneor, R., additional, Salomon, S., additional, Perlstein, B., additional, Margel, S., additional, Mardor, Y., additional, Charest, G., additional, Fortin, D., additional, Mathieu, D., additional, Sanche, L., additional, Paquette, B., additional, Li, H.-F., additional, Hariono, S., additional, Dasgupta, T., additional, Kim, J.-S., additional, Haas-Kogan, D., additional, Weiss, W. A., additional, James, C. D., additional, Waldman, T., additional, Nicolaides, T., additional, Ozawa, T., additional, Rao, S., additional, Sun, H., additional, Ng, C., additional, De La Torre, J., additional, Santos, R., additional, Prados, M., additional, Butowski, N., additional, Michaud, K., additional, Solomon, D. A., additional, Prados, M. D., additional, Pandya, H., additional, Gibo, D., additional, Debinski, W., additional, Vinchon-Petit, S., additional, Jarnet, D., additional, Jadaud, E., additional, Feuvret, L., additional, Garcion, E., additional, Menei, P., additional, Chen, R., additional, Yu, J.-C., additional, Liu, C., additional, Jaffer, Z. M., additional, Chabala, J. C., additional, Winssinger, N., additional, Rubenstein, A. E., additional, Emdad, L., additional, Kothari, H., additional, Qadeer, Z., additional, Binello, E., additional, Germano, I., additional, Hirschberg, H., additional, Baek, S.-K., additional, Kwon, Y. J., additional, Sun, C. H., additional, Li, S. C., additional, Madsen, S., additional, Liu, T., additional, Wang, S.-W., additional, Gibo, D. M., additional, Fan, Q.-W., additional, Cheng, C., additional, Hackett, C., additional, Feldman, M., additional, Houseman, B. T., additional, Oakes, S. A., additional, Debnath, J., additional, Shokat, K. M., additional, Sai, K., additional, Chen, F., additional, Qiu, Z., additional, Mou, Y., additional, Zhang, X., additional, Yang, Q., additional, Chen, Z., additional, Patel, T. R., additional, Zhou, J., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Banerjee, S., additional, Kaul, A., additional, Gianino, S. M., additional, Christians, U., additional, Gutmann, D. H., additional, Wu, J., additional, Shen, R., additional, Puduvalli, V., additional, Koul, D., additional, Alfred Yung, W. K., additional, Yun, J., additional, Sonabend, A., additional, Stuart, M., additional, Yanagihara, T., additional, Dashnaw, S., additional, Brown, T., additional, McCormick, P., additional, Romanov, A., additional, Sebastian, M., additional, Canoll, P., additional, Bruce, J. N., additional, Piao, L., additional, Joshi, K., additional, Lee, R. J., additional, Nakano, I., additional, Madsen, S. J., additional, Chou, C. C., additional, Blickenstaff, J. W., additional, Sun, C.-H., additional, Zhou, Y.-H., additional, Tome, C. M. L., additional, Wykosky, J., additional, Palma, E., additional, Nduom, E., additional, Machaidze, R., additional, Kaluzova, M., additional, Wang, Y., additional, Nie, S., additional, Hadjipanayis, C., additional, Saito, R., additional, Nakamura, T., additional, Sonoda, Y., additional, Kumabe, T., additional, Tominaga, T., additional, Lun, X., additional, Zemp, F., additional, Zhou, H., additional, Stechishin, O., additional, Kelly, J. J., additional, Weiss, S., additional, Hamilton, M. G., additional, Cairncross, G., additional, Rabinovich, B. A., additional, Bell, J., additional, McFadden, G., additional, Senger, D. L., additional, Forsyth, P. A., additional, Kang, P., additional, Jane, E. P., additional, Premkumar, D. R., additional, Pollack, I. F., additional, Yoo, J. Y., additional, Haseley, A., additional, Bratasz, A., additional, Powell, K., additional, Chiocca, E. A., additional, Kaur, B., additional, Johns, T. G., additional, Ferruzzi, P., additional, Mennillo, F., additional, De Rosa, A., additional, Rossi, M., additional, Giordano, C., additional, Magrini, R., additional, Benedetti, G., additional, Pericot, G. l., additional, Magnoni, L., additional, Mori, E., additional, Thomas, R., additional, Tunici, P., additional, Bakker, A., additional, Pradarelli, J., additional, Kaka, A., additional, Alvarez-Breckenridge, C., additional, Pan, Q., additional, Teknos, T., additional, Cen, L., additional, Ostrem, J. L., additional, Schroeder, M. A., additional, Mladek, A. C., additional, Fink, S. R., additional, Jenkins, R. B., additional, Sarkaria, J. N., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Park, A., additional, Pang, M., additional, Klinger, M., additional, Harbaugh, K. S., additional, Sheehan, J. M., additional, Connor, J. R., additional, Chen, T. C., additional, Wang, W., additional, Hofman, F. M., additional, Drummond, D. C., additional, Noble, C. O., additional, Park, J. W., additional, Zhou, Y., additional, Marks, J. D., additional, Alonso, M. M., additional, Gomez-Manzano, C., additional, Cortes-Santiago, N., additional, Roche, F. P., additional, Fueyo, J., additional, Johannessen, T.-C. A., additional, Grudic, A., additional, Tysnes, B. B., additional, Nigro, J., additional, Bjerkvig, R., additional, Joshi, A. D., additional, Parsons, W., additional, Velculescu, V. E., additional, Riggins, G. J., additional, Bindra, R. S., additional, Jasin, M., additional, Powell, S. N., additional, Fu, J., additional, Shen, R.-J., additional, Colman, H., additional, Lang, F. F., additional, Jensen, M. R., additional, Friedman, G. K., additional, Haas, M., additional, Cassady, K. A., additional, Gillespie, G. Y., additional, Nguyen, V., additional, Murphy, L. T., additional, Beauchamp, A. S., additional, Hollingsworth, C. K., additional, Mintz, A., additional, Garg, S., additional, Kridel, S., additional, Conrad, C. A., additional, Madden, T., additional, Ji, Y., additional, Priebe, W., additional, Seleverstov, O., additional, Purow, B. W., additional, Grant, G. A., additional, Wilson, C., additional, Campbell, M., additional, Humphries, P., additional, Li, S., additional, Li, J., additional, Johnson, A., additional, Bigner, D., additional, Dewhirst, M., additional, Pokorny, J. L., additional, Kitange, G. J., additional, Carlson, B. L., additional, Suphangul, M., additional, Petro, B., additional, Mukhtar, L., additional, Baig, M. S., additional, Villano, J., additional, Mahmud, N., additional, Keir, S. T., additional, Reardon, D. A., additional, Watson, M., additional, Shore, G. C., additional, Bigner, D. D., additional, Friedman, H. S., additional, and Gururangan, S., additional

Published
2010
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12. Q FEVER

Author

Zemp, F. Eugene

Abstract

The present war with its rapid means of transportation has focused our attention on diseases of far distant lands, some of which have never occurred in this country. The typhus fever group is of particular interest, and one should be ever on the alert for its appearance. Megaw's1 classification is based on the insect vector and is divided into the epidemic and nonepidemic forms. The epidemic form is true typhus, the louse being the insect vector. Under the nonepidemic form are classified flea typhus or Brill's disease; tick typhus, which includes Rocky Mountain spotted fever; Montana tick fever and others, and mite typhus, sometimes called Japanese river fever or tropical typhus. In 1935 a new fever entity was first noted among the meat workers in Brisbane, Queensland, Australia. The cases reported were studied by Derrick2 and Burnet and Freeman,3 who made their report in 1937. They described

Published
1943
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13. "Q FEVER"-Reply

Author

Zemp, F. Eugene

Abstract

To the Editor:—I appreciate your sending me the criticism of my paper on Q fever. With regard to the omission of the typhoid test being positive 1: 80, it is truly an omission that I was entirely unaware of. Fortunately I had saved all my data and many copies of the paper as it was written. The paper was rewritten and corrected many times in order to get it in correct form and that test was in the first typewritten copy, but evidently my secretary in recopying it several more times omitted it accidentally along with B paratyphoid A negative. In fact the entire line was omitted and I did not realize it until now. I was careful to be as exact as possible and to give credit where credit was due. You will note that the stool culture for typhoid also was negative.As to the positive complement

Published
1943
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14. Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma.

Author

Manoharan VT, Abdelkareem A, Gill G, Brown S, Gillmor A, Hall C, Seo H, Narta K, Grewal S, Dang NH, Ahn BY, Osz K, Lun X, Mah L, Zemp F, Mahoney D, Senger DL, Chan JA, and Morrissy AS

Subjects
Animals, Humans, Mice, Spatio-Temporal Analysis, Glioblastoma pathology, Glioblastoma genetics, Tumor Microenvironment, Brain Neoplasms pathology, Brain Neoplasms genetics, Neoplasm Invasiveness
Abstract

Background: Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of the tumor microenvironment (TME) contribute to overall tumor organization and to programs of invasion may reveal opportunities for improved therapeutic strategies., Results: Towards this goal, we apply a novel computational workflow to a spatiotemporally profiled GBM xenograft cohort, leveraging the ability to distinguish human tumor from mouse TME to overcome previous limitations in the analysis of diffuse invasion. Our analytic approach, based on unsupervised deconvolution, performs reference-free discovery of cell types and cell activities within the complete GBM ecosystem. We present a comprehensive catalogue of 15 tumor cell programs set within the spatiotemporal context of 90 mouse brain and TME cell types, cell activities, and anatomic structures. Distinct tumor programs related to invasion align with routes of perivascular, white matter, and parenchymal invasion. Furthermore, sub-modules of genes serving as program network hubs are highly prognostic in GBM patients., Conclusion: The compendium of programs presented here provides a basis for rational targeting of tumor and/or TME components. We anticipate that our approach will facilitate an ecosystem-level understanding of the immediate and long-term consequences of such perturbations, including the identification of compensatory programs that will inform improved combinatorial therapies., (© 2024. The Author(s).)

Published
2024
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15. The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.

Author

Hildebrand KM, Singla AK, McNeil R, Marritt KL, Hildebrand KN, Zemp F, Rajwani J, Itani D, Bose P, Mahoney DJ, Jirik FR, and Monument MJ

Subjects
Animals, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm genetics, Female, Hindlimb, Humans, Immune Checkpoint Inhibitors therapeutic use, Lymphocytes, Tumor-Infiltrating immunology, Macrophages immunology, Male, Mice, Mice, Transgenic, Muscle Neoplasms immunology, Muscle Neoplasms pathology, Muscle, Skeletal pathology, Mutation, Sarcoma immunology, Sarcoma pathology, Tumor Microenvironment genetics, Tumor Microenvironment immunology, Immune Checkpoint Inhibitors pharmacology, Muscle Neoplasms genetics, Proto-Oncogene Proteins p21(ras) genetics, Sarcoma genetics, Tumor Suppressor Protein p53 genetics
Abstract

Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for numerous adult cancers, however, these therapeutic strategies have been minimally effective in sarcoma so far. Clinically relevant, immunologically-competent, and transplantable pre-clinical sarcoma models are essential to advance sarcoma immunology research. Herein we show that Cre-mediated activation of KrasG12D, and deletion of Trp53, in the hindlimb muscles of C57Bl/6 mice results in the highly penetrant, rapid onset undifferentiated pleomorphic sarcomas (UPS), one of the most common human sarcoma subtypes. Cell lines derived from spontaneous UPS tumours can be reproducibly transplanted into the hindlimbs or lungs of naïve, immune competent syngeneic mice. Immunological characterization of both spontaneous and transplanted UPS tumours demonstrates an immunologically-'quiescent' microenvironment, characterized by a paucity of lymphocytes, limited spontaneous adaptive immune pathways, and dense macrophage infiltrates. Macrophages are the dominant immune population in both spontaneous and transplanted UPS tumours, although compared to spontaneous tumours, transplanted tumours demonstrate increased spontaneous lymphocytic infiltrates. The growth of transplanted UPS tumours is unaffected by host lymphocyte deficiency, and despite strong expression of PD-1 on tumour infiltrating lymphocytes, tumours are resistant to immunological checkpoint blockade. This spontaneous and transplantable immune competent UPS model will be an important experimental tool in the pre-clinical development and evaluation of novel immunotherapeutic approaches for immunologically cold soft tissue sarcomas., Competing Interests: The authors have declared that there are no competing interests that exist.

Published
2021
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16. Rhabdoviruses as vaccine platforms for infectious disease and cancer.

Author

Zemp F, Rajwani J, and Mahoney DJ

Subjects
Animals, Clinical Trials as Topic, Communicable Diseases virology, Genetic Vectors administration & dosage, Genetic Vectors immunology, Humans, Neoplasms drug therapy, Neoplasms virology, Oncolytic Viruses genetics, Oncolytic Viruses immunology, Rhabdoviridae genetics, Vaccines, Attenuated genetics, Vaccines, Attenuated immunology, Vaccines, Attenuated therapeutic use, Communicable Disease Control, Neoplasms prevention & control, Rhabdoviridae immunology
Abstract

The family Rhabdoviridae (RV) comprises a large, genetically diverse collection of single-stranded, negative sense RNA viruses from the order Mononegavirales. Several RV members are being developed as live-attenuated vaccine vectors for the prevention or treatment of infectious disease and cancer. These include the prototype recombinant Vesicular Stomatitis Virus (rVSV) and the more recently developed recombinant Maraba Virus, both species within the genus Vesiculoviridae. A relatively strong safety profile in humans, robust immunogenicity and genetic malleability are key features that make the RV family attractive vaccine platforms. Currently, the rVSV vector is in preclinical development for vaccination against numerous high-priority infectious diseases, with clinical evaluation underway for HIV/AIDS and Ebola virus disease. Indeed, the success of the rVSV-ZEBOV vaccine during the 2014-15 Ebola virus outbreak in West Africa highlights the therapeutic potential of rVSV as a vaccine vector for acute, life-threatening viral illnesses. The rVSV and rMaraba platforms are also being tested as 'oncolytic' cancer vaccines in a series of phase 1-2 clinical trials, after being proven effective at eliciting immune-mediated tumour regression in preclinical mouse models. In this review, we discuss the biological and genetic features that make RVs attractive vaccine platforms and the development and ongoing testing of rVSV and rMaraba strains as vaccine vectors for infectious disease and cancer.

Published
2018
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17. M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma.

Author

Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, and Forsyth PA

Abstract

Background: Myxoma virus (MYXV) is a promising oncolytic agent and is highly effective against immortalized glioma cells but less effective against brain tumor initiating cells (BTICs), which are believed to mediate glioma development/recurrence. MYXV encodes various proteins to attenuate host cell apoptosis, including an antiapoptotic Bcl-2 homologue known as M011L. Such proteins may limit the ability of MYXV to kill BTICs, which have heightened resistance to apoptosis. We hypothesized that infecting BTICs with an M011L-deficient MYXV construct would overcome BTIC resistance to MYXV., Methods: We used patient-derived BTICs to evaluate the efficacy of M011L knockout virus (vMyx-M011L-KO) versus wild-type MYXV (vMyx-WT) and characterized the mechanism of virus-induced cell death in vitro. To extend our findings in a novel immunocompetent animal model, we derived, cultured, and characterized a C57Bl/6J murine BTIC (mBTIC0309) from a spontaneous murine glioma and evaluated vMyx-M011L-KO efficacy with and without temozolomide (TMZ) in mBTIC0309-bearing mice., Results: We demonstrated that vMyx-M011L-KO induces apoptosis in BTICs, dramatically increasing sensitivity to the virus. vMyx-WT failed to induce apoptosis as M011L protein prevented Bax activation and cytochrome c release. In vivo, intracranial implantation of mBTIC0309 generated tumors that closely recapitulated the pathological and molecular profile of human gliomas. Treatment of tumor-bearing mice with vMyx-M011L-KO significantly prolonged survival in immunocompetent-but not immunodeficient-mouse models, an effect that is significantly enhanced in combination with TMZ., Conclusions: Our data suggest that vMyx-M011L-KO is an effective, well-tolerated, proapoptotic oncolytic virus and a strong candidate for clinical translation., (© The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2016
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18. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model.

Author

Koturbash I, Zemp F, Kolb B, and Kovalchuk O

Subjects
Animals, Cerebellum metabolism, DNA Damage, DNA Methylation, Female, Frontal Lobe metabolism, Hippocampus metabolism, Male, Mice, Mice, Inbred C57BL, Organ Specificity, Sex Characteristics, X-Rays, Cerebellum radiation effects, Frontal Lobe radiation effects, Hippocampus radiation effects, MicroRNAs radiation effects
Abstract

Ionizing radiation is an important treatment modality, but it is also a well-known genotoxic agent capable of damaging cells and tissues. Therefore radiation treatment can cause numerous side effects in exposed tissues and organs. Radiotherapy is a part of the front-line treatment regime for brain cancer patients, but can cause severe functional and morphological changes in exposed brain tissues. However, the mechanisms of radiation-induced effects in the brain are not well understood and are under-investigated. Recent data has implicated short RNAs, especially microRNAs, as important in radiation responses, yet nothing is known about radiation-induced changes in the brain microRNAome. We analyzed the effects of X-ray irradiation on microRNA expression in the hippocampus, frontal cortex, and cerebellum of male and female mice. Here, we report tissue-, time-, and sex-specific brain radiation responses, as well as show evidence of an interplay between microRNAs and their targets. Specifically, we show that changes in the expression of the miR-29 family may be linked, at least in part, to altered expression of de novo methyltransferase DNMT3a and changed global DNA methylation levels. Further, these sex-specific epigenetic changes may be correlated to the prevalence of radiation-induced cancers in males. We identified several microRNAs that can potentially serve as biomarkers of brain radiation exposure. In summary, our study may provide an important roadmap for further analysis of microRNA expression in different brain regions of male and female mice and for detailed dissection of radiation-induced brain responses., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2011
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19. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression.

Author

Kovalchuk O, Tryndyak VP, Montgomery B, Boyko A, Kutanzi K, Zemp F, Warbritton AR, Latendresse JR, Kovalchuk I, Beland FA, and Pogribny IP

Subjects
Animals, Blotting, Western, Cell Transformation, Neoplastic chemically induced, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic metabolism, DNA (Cytosine-5-)-Methyltransferases metabolism, Electrophoresis, Polyacrylamide Gel, Estradiol toxicity, Female, Gene Expression Regulation drug effects, Mammary Neoplasms, Experimental genetics, Mammary Neoplasms, Experimental metabolism, Methylation drug effects, Rats, DNA Methylation drug effects, Estrogens toxicity, Histones metabolism, Mammary Neoplasms, Experimental chemically induced, MicroRNAs genetics
Abstract

Breast cancer is the most common malignancy in women continuing to rise worldwide. Breast cancer emerges through a multi-step process, encompassing progressive changes from a normal cell to hyperplasia (with and without atypia), carcinoma in situ, invasive carcinoma, and metastasis. In the current study, we analyzed the morphological changes and alterations of DNA methylation, histone methylation and microRNA expression during estradiol-17beta (E(2))-induced mammary carcinogenesis in female August Copenhagen Irish (ACI) rats. E(2)-induced breast carcinogenesis in ACI rats provides a physiologically relevant and genetically defined animal model for studying human sporadic breast cancer. The pattern of morphological changes in mammary glands during E(2)-induced carcinogenesis was characterized by transition from normal appearing alveolar and ductular hyperplasia to focal hyperplastic areas of atypical glands and ducts accompanied by a rapid and sustained loss of global DNA methylation, LINE-1 hypomethylation, loss of histone H3 lysine 9 and histone H4 lysine 20 trimethylation, and altered microRNAs expression. More importantly, these alterations in the mammary tissue occurred after six weeks of E(2)-treatment, whereas the atypical hyperplasia, which represents a putative precursor lesion to mammary carcinoma in this model, was detected only after twelve weeks of exposure, demonstrating clearly that these events are directly associated with the effects of E(2) and are not a consequence of the preexisting preneoplastic lesions. The results of this study show that deregulation of cellular epigenetic processes plays a crucial role in the mechanism of E(2)-induced mammary carcinogenesis in ACI rats, especially in the tumor initiation process.

Published
2007
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20. Double-strand break repair in plants is developmentally regulated.

Author

Boyko A, Zemp F, Filkowski J, and Kovalchuk I

Subjects
Blotting, Western, Genes, Plant, Plants, Genetically Modified, Recombination, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Arabidopsis genetics, DNA Repair genetics, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic
Abstract

In this study, we analyzed double-strand break (DSB) repair in Arabidopsis (Arabidopsis thaliana) at various developmental stages. To analyze DSB repair, we used a homologous recombination (HR) and point mutation reversion assays based on nonfunctional beta-glucuronidase reporter genes. Activation of the reporter gene through HR or point mutation reversion resulted in the appearance of blue sectors after histochemical staining. Scoring of these sectors at 3-d intervals from 2 to 31 d post germination (dpg) revealed that, although there was a 100-fold increase in the number of genomes per plant, the recombination frequency only increased 30-fold. This translates to a recombination rate at 31 dpg (2.77 x 10(-8)) being only 30% of the recombination rate at 2 dpg (9.14 x 10(-8)). Conversely, the mutation frequency increased nearly 180-fold, resulting in a 1.8-fold increase in mutation rate from 2 to 31 dpg. Additional analysis of DSBs over the early developmental stages revealed a substantial increase in the number of strand breaks per unit of DNA. Furthermore, RNA analysis of Ku70 and Rad51, two key enzymes in two different DSB repair pathways, and further protein analysis of Ku70 revealed an increase in Ku70 levels and a decrease of Rad51 levels in the developing plants. These data suggest that DSB repair mechanisms are developmentally regulated in Arabidopsis, whereby the proportion of breaks repaired via HR substantially decreases as the plants mature.

Published
2006
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