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25 results on '"Zeneroli M.L."'

5. A possible mechanism of resistance to death during cell proliferation in hepatocellular carcinoma: The mitochondrial benzodiazepine receptor system

Author

Venturini, I., primary, Zeneroli, M.L., additional, Corsi, L., additional, Pellicci, R., additional, Ardizzone, G., additional, Arrigo, A., additional, Farina, F., additional, Ferrarese, C., additional, Pecora, N., additional, Frigo, M., additional, Avallone, R., additional, and Baraldi, M., additional

Published
1998
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6. Mitochondrial benzodiazepine receptor system in hepatocellular carcinoma: a possible mechanism of resistance to death during cell proliferation

Author

Venturini, I., primary, Zeneroli, M.L., additional, Corsi, L., additional, Pellicci, R., additional, Ardizzone, G., additional, Arrigo, A., additional, Farina, F., additional, Ferrarese, C., additional, Pecora, N., additional, Frigo, M., additional, Avallone, R., additional, and Baraldi, M., additional

Published
1998
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25. Endozepines in recurrent stupor

Author

Pasquale Montagna, M.L. Zeneroli, Pietro Cortelli, Rossella Avallone, Elio Lugaresi, Mario Baraldi, Roberto Riva, Jessica Mandrioli, Agostino Baruzzi, Lorenzo Corsi, Paolo Tinuper, Cortelli P., Avallone R., Baraldi M., Zeneroli M.L., Mandrioli J., Corsi L., Riva R., Tinuper P., Lugaresi E., Baruzzi A., and Montagna P.

Subjects
Flumazenil, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Endozepine, medicine.drug_class, Endozepines, Benzodiazepines, Idiopathic recurrent stupor, Hepatic encephalopathy, Idiopathic recurrent stupor, Endozepines, Benzodiazepines, chemistry.chemical_compound, Cerebrospinal fluid, Recurrence, Physiology (medical), Internal medicine, medicine, Humans, Coma, Hepatic encephalopathy, Diazepam Binding Inhibitor, Benzodiazepine, business.industry, GABAA receptor, Stupor, Electroencephalography, Lorazepam, Receptors, GABA-A, medicine.disease, Endocrinology, Neurology, chemistry, Hepatic Encephalopathy, Neurology (clinical), medicine.symptom, business, medicine.drug
Abstract

Summary Stupor is a condition from which the subject can be aroused only by vigorous stimuli. Most patients with stupor have a diffuse organic cerebral dysfunction. Rarely stupor is recurrent and no specific causes can be found. Patients with idiopathic recurrent stupor were awakened by i.v. administration of an antagonist (flumazenil) of the benzodiazepine recognition site located in the GABA A receptor. Since no exogenous benzodiazepines were detected in plasma and cerebrospinal fluid by high performance liquid chromatography, an excess of endogenous benzodiazepine-like compounds (endozepines) was proposed as the cause of stupor. The existence of endozepines, their widespread distribution in the CNS and their involvement in hepatic encephalopathy are established. However, the origin of these compounds, how biosynthesis occurs and the mechanisms and causes through which they alter brain functions are poorly understood. The fact that a number of synthetic benzodiazepines are difficult to detect using conventional techniques and the discovery that some cases of recurrent stupor were caused by fraudulent administration of lorazepam question whether the concept of endozepine recurrent stupor can be sustained. This review summarizes the state of endozepine physiology and pharmacology and the clinical syndromes attributed to their involvement. A diagnostic work-up to define endozepine-induced recurrent stupor is suggested.

Published
2005

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