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Your search keyword '"Zeng, Heyang"' showing total 25 results
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25 results on '"Zeng, Heyang"'

24. Copper-catalyzed construction of ( Z )-benzo[ cd ]indoles: stereoselective intramolecular trans -addition and S N -Ar reaction.

Author

Wang X, Zeng H, Zhang W, Guo H, Jin T, Shi S, Jin X, Qu N, Liu L, and Zhang L

Subjects
Catalysis, Sulfonamides, 1-Naphthylamine, Indoles, Copper
Abstract

Substituted benzo[ cd ]indoles are one of the most attractive frameworks because of their wide range of biological and optical activities. Herein, a copper-catalyzed one-step synthesis of biologically important polysubstituted benzo[ cd ]indoles starting from 8-alkynyl-1-naphthylamine derivatives is reported. In this protocol, many substituents tolerated the reaction conditions and produced ( Z )-benzo[ cd ]indoles in good yields. Preliminary mechanistic studies indicated that the reaction proceeds via a stereoselective intramolecular trans -addition and S N -Ar reaction with high selectivity and high yields. The synthesized polysubstituted ( Z )-benzo[ cd ]indoles possess sulfonamide building blocks, which make them candidates for bioactive molecules.

Published
2022
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25. Palladium-Catalyzed Preparation of N -Substituted Benz[ c , d ]indol-2-imines and N -Substituted Amino-1-naphthylamides.

Author

Zhang Y, Liu T, Liu L, Guo H, Zeng H, Bi W, Qiu G, Gao W, Ran X, Yang L, Du G, and Zhang L

Subjects
Catalysis, Cyanides chemistry, Molecular Structure, Imines chemistry, Palladium chemistry
Abstract

Here, we report a novel and facile protocol for the synthesis of benz[ c , d ]indol-2-imines via palladium-catalyzed C-C and C-N coupling of 8-halo-1-naphthylamines with isocyanides in a single step. The reaction features broad substrate scopes and mild conditions, providing an efficient alternative for the construction of antiproliferative agents and BET bromodomain inhibitors. If 0.1 mL of H 2 O was added to this reaction, the N -substituted amino-1-naphthylamides could be obtained easily.

Published
2022
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