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7 results on '"Zeng, Huolin"'

4. Postsurgery Subjective Cognitive and Short-Term Memory Impairment Among Middle-Aged Chinese Patients

Author

Yang, Lei, primary, Chen, Wenwen, additional, Yang, Di, additional, Chen, Dongxu, additional, Qu, Yuanyuan, additional, Hu, Yao, additional, Liu, Di, additional, He, Junhui, additional, Tang, Yuling, additional, Zeng, Huolin, additional, Li, Haiyang, additional, Zhang, Yuyang, additional, Ye, Zi, additional, Liu, Jin, additional, Li, Qian, additional, and Song, Huan, additional

Published
2023
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5. Association of pre-existing depression and anxiety with Omicron variant infection

Author

Yang, Huazhen, Yang, Lei, Chen, Wenwen, Zeng, Yu, Zhang, Yanan, Tang, Yuling, Zeng, Huolin, Yang, Di, Qu, Yuanyuan, Hu, Yao, Liu, Di, Song, Jie, Fang, Fang, Valdimarsdóttir, Unnur A., Li, Qian, and Song, Huan

Abstract

Pre-existing psychiatric disorders were linked to an increased susceptibility to COVID-19 during the initial outbreak of the pandemic, while evidence during Omicron prevalence is lacking. Leveraging data from two prospective cohorts in China, we identified incident Omicron infections between January 2023 and April 2023. Participants with a self-reported history or self-rated symptoms of depression or anxiety before the Omicron pandemic were considered the exposed group, whereas the others were considered unexposed. We employed multivariate logistic regression models to examine the association of pre-existing depression or anxiety with the risk of any or severe Omicron infection indexed by medical interventions or severe symptoms. Further, we stratified the analyses by polygenic risk scores (PRSs) for COVID-19 and repeated the analyses using the UK Biobank data. We included 10,802 individuals from the Chinese cohorts (mean age = 51.1 years, 45.6% male), among whom 7841 (72.6%) were identified as cases of Omicron infection. No association was found between any pre-existing depression or anxiety and the overall risk of Omicron infection (odds ratio [OR] =1.04, 95% confidence interval [CI] 0.95–1.14). However, positive associations were noted for severe Omicron infection, either as infections requiring medical interventions (1.26, 1.02–1.54) or with severe symptoms (≥3: 1.73, 1.51–1.97). We obtained comparable estimates when stratified by COVID-19 PRS level. Additionally, using clustering method, we identified eight distinct symptom patterns and found associations between pre-existing depression or anxiety and the patterns characterized by multiple or complex severe symptoms including cough and taste and smell decline (ORs = 1.42–2.35). The results of the UK Biobank analyses corroborated findings of the Chinese cohorts. In conclusion, pre-existing depression and anxiety was not associated with the risk of Omicron infection overall but an elevated risk of severe Omicron infection, supporting the continued efforts on monitoring and possible early intervention in this high-risk population during Omicron prevalence.

Published
2024
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7. Preoperative psychological symptoms and chronic postsurgical pain: analysis of the prospective China Surgery and Anaesthesia Cohort study.

Author

Chen, Dongxu, Yang, Huazhen, Yang, Lei, Tang, Yuling, Zeng, Huolin, He, Junhui, Chen, Wenwen, Qu, Yuanyuan, Hu, Yao, Xu, Yueyao, Liu, Di, Song, Huan, and Li, Qian

Subjects
*POSTOPERATIVE pain, *CHRONIC pain, *SLEEP quality, *COHORT analysis, *SYMPTOMS, *SLEEP interruptions, *PAIN
Abstract

Both preoperative psychological symptoms and chronic postsurgical pain (CPSP) are prevalent conditions and major concerns among surgery patients, with inconclusive associations. Based on the China Surgery and Anaesthesia Cohort (CSAC), we recruited 8350 surgery patients (40–65 yr old) from two medical centres between July 2020 and March 2023. Patients with preoperative psychological symptoms (i.e. anxiety, depression, stress reaction, and poor sleep quality) were identified using corresponding well-established scales. We then examined the associations of individual preoperative psychological symptoms and major patterns of preoperative psychological symptoms (identified by k -means clustering analysis) with CPSP, and different pain trajectories within 3 months. Lastly, mediation analyses were conducted to elucidate the mediating role of surgery/anaesthesia-related factors and the presence of 1-month postoperative psychological symptoms on the studied associations. We included 1302 (1302/8350, 15.6%) CPSP patients. When analysed separately, all studied preoperative psychological symptoms were associated with increased CPSP risk, with the most pronounced odds ratio noted for anxiety (1.52, 95% confidence interval [CI] 1.23–1.86). Compared with patients clustered in the minor symptom group, excess risk of CPSP and experiencing an increasing pain trajectory was increased among patients with preoperative psychological symptoms featured by sleep disturbances (odds ratio=1.46, 95% CI 1.25–1.70 for CPSP and 1.58, 95% CI 1.20–2.08 for increasing pain trajectory) and multiple psychological symptoms (1.84 [95% CI 1.48–2.28] and 4.34 [95% CI 3.20–5.88]). Mediation analyses revealed acute/subacute postsurgical pain and psychological symptoms existing 1 month after surgery as notable mediators of the observed associations. The presence of preoperative psychological symptoms might individually or jointly increase the risk of chronic postsurgical pain or experiencing deterioration in pain trajectory. Interventions for managing acute/subacute postsurgical pain and psychological symptoms at 1 month after surgery might help reduce such risk. ChiCTR2000034039. [ABSTRACT FROM AUTHOR]

Published
2024
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