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Abstract Myofibroblast buildup and prostatic fibrosis play a crucial role in the development of benign prostatic hyperplasia (BPH). Treatments specifically targeting myofibroblasts could be a promising approach for treating BPH. Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, holds the potential to intervene in this biological process. This study employs prostatic stromal fibroblasts to induce myofibroblast differentiation through TGFβ1 stimulation. As a result, tadalafil significantly inhibited prostatic stromal fibroblast proliferation and fibrosis process, compared to the control group. Furthermore, our transcriptome sequencing results revealed that tadalafil inhibited FGF9 secretion and simultaneously improved miR-3126-3p expression via TGFβ1 suppression. Overall, TGFβ1 can trigger pro-fibrotic signaling through miR-3126-3p in the prostatic stroma, and the use of tadalafil can inhibit this process.

Abstract Parallel tidal channel systems, characterized by commonly cross-shore orientation and regular spacing, represent a distinct class of tidal channel networks in coastal environments worldwide. Intriguingly, these cross-shore oriented channel systems can develop in environments dominated by alongshore tidal currents, for which the mechanisms remain elusive. Here, we combine remote sensing imagery analysis and morphodynamic simulations to demonstrate that the deflection of alongshore tidal currents at transitions in bed elevation determines the characteristic orientation of the parallel tidal channels. Numerical results reveal that sharp changes in bed elevation lead to nearly 90-degree intersection angles, while smoother transitions in bed profiles result in less perpendicular channel alignments. These findings shed light on the potential manipulation of tidal channel patterns in coastal wetlands, thus equipping coastal managers with a broader range of strategies for the sustainable management of these vital ecosystems in the face of climate change and sea level rise.

IntroductionTidal marsh wetlands provide essential and valuable services to the wider interconnected marine and coastal environment, although the complex intertwined processes in morphological evolution remain insufficiently understood owing to synchronized data scarcity, limiting the development of numerical models and management strategies.MethodsThis study investigated the hydrodynamic, biological, sediment and morphological processes on the Doulong tidal wetlands, Jiangsu, China, using a one-year field dataset that captured spatial and seasonal variations.Results and discussionOur results indicate that biophysical interactions among multiple processes could result in some overlooked sedimentary behaviours and bio-morphological patterns in tidal marsh wetlands. Firstly, the dominance of alongshore currents caused a rapid alongshore expansion of saltmarsh patches, by which the marsh edge achieved seaward advancing, markedly different from the widely reported cross-shore expansion. Secondly, results showed that the particle size of sediment near the marsh edge coarsened when plants withered and then fined when plants grew, indicating that the seasonal variation trend of sediment grain size in saltmarshes was opposite to the trend of vegetation biomass. Thirdly, the interaction between vegetation and stranded marine debris formed banded debris zones within the saltmarsh, where debris bands could cause a biomass reduction of up to 58%, disrupting the commonly-observed parabolic biomass-elevation relationship. Meanwhile, the seasonal variation of vegetation and hydrodynamics could alter the debris positions and hence result in the formation of multiple parallel debris bands. Overall, this study provides a synchronized dataset and elucidates specific bio-morphological relationships and processes that have thus far not been systematically documented, enhancing the comprehensive understanding of tidal marsh wetland evolution.

Salt marshes are among the most important coastal wetlands and provide critical ecological services, including climate regulation, biodiversity maintenance, and blue carbon sequestration. However, most salt marshes worldwide are shrinking, owing to the effects of natural and human factors, such as climate change and artificial reclamation. Therefore, it is essential to understand the decline in the morphological processes of salt marshes, and accordingly, the likely evolution of these marshes, in order to enable measures to be taken to mitigate this decline. To this end, this study presented an extensive systematic review of the current state of morphological models and their application to salt marshes. The emergence of process-based (PB) and data-driven (DD) models has contributed to the development of morphological models. In morphodynamic simulations in PB models, multiple physical and biological factors (e.g., the hydrodynamics of water bodies, sediment erosion, sediment deposition, and vegetation type) have been considered. The systematic review revealed that PB models have been extended to a broader interdisciplinary field. Further, most DD models are based on remote sensing database for the prediction of morphological characteristics with latent uncertainty. Compared to DD models, PB models are more transparent but can be complex and require a lot of computational power. Therefore, to make up for the shortcomings of each model, future studies could couple PB with DD models that consider vegetation, microorganisms, and benthic animals together to simulate or predict the biogeomorphology of salt marsh systems. Nevertheless, this review found that there is a lack of unified metrics to evaluate model performance, so it is important to define clear objectives, use multiple metrics, compare multiple models, incorporate uncertainty, and involve experts in the field to provide guidance in the further study.

Abstract Heat shock transcription factors (Hsf) are pivotal as essential transcription factors. They function as direct transcriptional activators of genes regulated by thermal stress and are closely associated with various abiotic stresses. Asparagus (Asparagus officinalis) is a vegetable of considerable economic and nutritional significance, abundant in essential vitamins, minerals, and dietary fiber. Nevertheless, asparagus is sensitive to environmental stresses, and specific abiotic stresses harm its yield and quality. In this context, Hsf members have been discerned through the reference genome, and a comprehensive analysis encompassing physical and chemical attributes, evolutionary aspects, motifs, gene structure, cis-acting elements, collinearity, and expression patterns under abiotic stresses has been conducted. The findings identified 18 members, categorized into five distinct subgroups. Members within each subgroup exhibited analogous motifs, gene structures, and cis-acting elements. Collinearity analysis unveiled a noteworthy pattern, revealing that Hsf members within asparagus shared one, two, and three pairs with counterparts in Arabidopsis, Oryza sativa, and Glycine max, respectively.Furthermore, members displayed tissue-specific expression during the seedling stage, with roots emerging as viable target tissue. Notably, the expression levels of certain members underwent modification under the influence of abiotic stresses. This study establishes a foundational framework for understanding Hsf members and offers valuable insights into the potential application of molecular breeding in the context of asparagus cultivation.

The rapid development of urbanization makes the phenomenon of urban heat islands even more serious. Predicting the impact of land cover change on urban heat island has become one of the research hotspots. Taking Wuhan, China, as an example, this study simulated the land type change in 2020 through the Cellular Automata-Markov-Chain (CA-Markov) model. The urban heat island in 2020 was simulated and analyzed in conjunction with the Weather Research & Forecasting Model (WRF), and the simulation results of wind velocity and temperature were confirmed using weather station observation data. Based on this, the land cover and urban heat island of Wuhan in 2030 were predicted. The temperature was found to be well-fit by CA-Markov simulated land use data, with an average inaccuracy of about 2.5°C for weather stations. Wind speed had a poor fitting effect; the average error was roughly 2 m/s. The built-up area was the center of the high temperature area both before and after the prediction, the water was the low temperature area, and the peak heat island happened at night. According to the forecast results, there will be more built-up land in 2030, and there will be a greater intensity of heat islands than in 2020.

Tidal flats and saltmarshes have been a long-standing research focus because of their high socio-economic and ecological values. The evolution of tidal flat–marsh systems is highly complex due to the intertwined processes operating over a variety of spatial and temporal scales. As a traditional research highlight, the role of regular hydrodynamic processes such as tides, waves, and river flows have been explored comprehensively with fruitful outcomes. Over past decades, the changing environment (e.g., sea level rise, increasing anthropogenic activities, and extreme weather conditions) has attracted more attention with many reported insightful results. More recent advances indicate that biological activities play a critical role in tidal flat–marsh morphodynamics but are still poorly understood. The field of research that connects the biological and physical processes is commonly described as “biogeomorphology” and requires the joint efforts by scientists from multiple disciplines ranging from hydraulics, ecology, and geography to sociology. This review aims to provide a synthesis of the current research status of tidal flat–marsh morphodynamics, with a particular emphasis on the understanding of various processes and feedbacks underlying the development of morphodynamic models. Some future research needs and challenges are identified to facilitate a more sustainable management strategy for tidal flats and saltmarshes under climate change.

Urbanization causes various climate-related environmental problems, such as the urban heat island phenomenon and extreme weather. As such, the outdoor thermal environment is worsening in cities, and researchers are increasingly concerned with mitigation measures. Here, we investigated the influence of a major railway station and the Yangtze River on the local thermal environment in a city with a subtropical climate. Field measurements were performed in Wuhan, China, from 21 July 2017, to 25 July 2017. The cooling effect of the Yangtze River modulated the surrounding urban environment substantially at night, especially in areas closer to the river border. During the afternoon, areas farther from the railway station experienced higher temperatures, that meant railway station showed a cooling effect. By contrast, at night, the temperature exhibited a decreasing trend with increasing distance, that meant railway station showed heat island effect. Moreover, there was a significant relationship between the percentage of the man-made area (versus natural area) and air temperature at night, where temperature increased with an increasing percentage of man-made area. The cooling effect of the Yangtze River and Wuchang railway station could be taken into account to mitigate the urban thermal environment in Wuhan in the summer.

A series of laboratory experiments have been conducted to explore the wind effect on Sediment Suspended Concentrations (SSCs) in fine-grained coastal systems. The paddle waves were overplayed with surface-blowing winds in a wind-wave flume to mimic offshore swells coupling with local wind waves during rough weather. Both SSCs and water turbulences under different wind and wave conditions have been investigated over two kinds of sediment beds (Sediment 1, S1, D50 = 52µm and Sediment 2, S2, D50 = 90µm). The High Concentration Layers (HCL) were formed under most of the wave-only conditions, while with the introduction of the stronger wind, more sediment suspensions were transported upward, increasing SSCs in upper water elevations. The finer sediment S1 is easier to suspend than S2 under the same conditions. The enhancement of the vertical turbulence intensity (σw) by winds is the main reason for the increase in SSCs. Meanwhile, because the wind-induced turbulence can hardly penetrate the HCL, the turbulence intensities outside the HCL can be further amplified compared to the experiment without a sediment bed. The wind contributes over 65% of the SSC enlargement above the HCL under a wind of 10m/s for S1, while less than 20% inside the HCL in most wind conditions. The sediment mixing coefficient (ϵs), a crucial parameter for suspended sediment modeling, was enhanced with stronger winds. Although the existing formulas for the vertical distribution of ϵs are valid under both wave-only and small winds (2.5 m/s) for both sediment beds, the enhancement of ϵs caused by strong winds cannot be captured, requiring further research.

Crab burrows play an important role in saltmarsh wetlands and are a useful indicator of wetland condition. The spatiotemporal distribution of crab burrows varies considerably in tidal wetlands. However, the reasons for these variations are poorly understood, in part, due to the limited availability of comprehensive field data. Based on a two-year continuous observation at a tidal wetland in the northern Jiangsu Coast, China, this study explored the relationship between crab burrow density and environmental variables, including median grain size, water content, organic matter content, soil salinity, and elevation. Our results show that the distribution of crab burrows was unimodal across the shore in winter and spring (Nov-Apr) when air temperature was relatively low, while bimodal in summer and autumn (May-Oct) when temperature was relatively high. The density of crab burrows was larger at areas with higher water content, higher organic matter content, and lower soil salinity, while it was lower with stronger hydrodynamics and lower suspended sediment concentration. Crab burrows were more abundant in vegetated areas than in un-vegetated areas. A backward stepwise model selection was performed based on R-square and Akaike information criterion (AIC) to distinguish the main driving factors that determine crab burrow distribution. Results suggested that the principal driving factors were organic matter content and soil salinity in all the seasons, with the addition of water content in warm seasons. Overall, this study provides a comprehensive field dataset for a more in-depth understanding of crab burrow distribution and a scientific basis for sustainable management of tidal wetlands.

To alleviate the urban heat island effect and reduce the consumption of electricity and expenditure caused by active cooling devices on hot days, many cities in tropical and subtropical areas emphasize the utilization of urban greening areas in current and future urban planning. We utilized the weather research and forecasting model (WRF) to simulate and study the impact of different greening area rates on the urban microclimate in business, residential, and industrial areas in Wuhan city. Meanwhile, we proposed two efficiency coefficients to evaluate the variable cooling benefit of the improvement of the greening area. The results show that greening areas and water bodies are the cooling sources of cities and that industrial areas benefit the most from improvements in the greening rate, with the average temperature declining by 1.06 °C with a 20% increase in the greening rate, while the corresponding values of residential and industrial areas were 0.98 °C and 0.92 °C, respectively. This research provides a reference for the future planning of tropical and subtropical areas to help improve the urban microclimate, thermal environment, and environmental comfort on hot days.

In this study, subjective questionnaires and a building energy simulation were utilized to investigate the impact of air conditioner operation on the energy consumption/savings of a model building with different types of exterior wall thermal insulation. The results indicate that an intermittent energy usage mode is generally used in residential buildings in hot summer and cold winter areas. Air conditioner operation behavior is affected by the human thermal experience. The greater the indoor temperature deviates from the human comfort range, the higher the air conditioner operation frequency. Under continuous energy usage mode, the annual heating and cooling effect of the exterior thermal insulation was found to be better than that of interior thermal insulation. Under the intermittent energy usage mode without considering residents’ temperature tolerance, the annual heating and cooling effect of the interior thermal insulation was better than that of the exterior insulation. Under the intermittent energy usage mode considering tolerance levels, the energy-saving effect of the interior and exterior thermal insulation of the exterior wall was different. In the case of low and medium temperature tolerance, the annual heating and cooling energy-saving effect of the interior thermal insulation was better than the exterior thermal insulation; in the case of high tolerance, the heating and cooling energy saving effect of the exterior thermal insulation was better.

Outdoor wind and thermal environments in residential areas are greatly affected by the distance between buildings. A short distance is conducive to providing shade, and a long distance can enhance ventilation between buildings. In this study, four cities with different latitudes in China (Guangzhou, Wuhan, Beijing, and Harbin) were selected to research the relationship between the distance between buildings and thermal environments of residential areas. The results show that (1) when the distance between buildings is small, it is easier for wind paths to form. Wind paths can strengthen the wind velocity. When the distance between buildings exceeds 40–50 m, the building density is small, the building’s resistance to the wind becomes smaller and smaller, and the wind speed will gradually increase. (2) When the distance is in the range of 20–50 m, the MRT (mean radiant temperature) rise rate of each city is similar. For every 10 m increase in the distance between buildings, the MRT increases by about 1.25 °C. (3) D = 50 m (D/H = 1.19) is an inflection point. When D is less than 50 m, within the range of 20–50 m, the smaller the D is, the lower the SET* (standard effective temperature) is, while when D is more than 50 m, the opposite trend is observed.

Lead halide perovskite quantum dots (PQDs) have demonstrated extremely excellent optical properties and great application potential in various optoelectronic devices. However, it is still a challenge to maintain both stability and multipeak emission performance for PQDs. In this work, we successfully synthesize multipeak emission CsPbCl1.5Br1.5:Eu3+–SiO2 PQDs employing molecular sieves through high-temperature solid-state reactions, and the energy transfer process is designed to enhance the emission of Eu3+. The excellent thermal stability of as-prepared PQDs has also been proved by thermal cycle test from 25 to 100 °C. Furthermore, the as-prepared doped PQDs are utilized for white light emitting diodes, which show excellent white light performance. The material is expected to be applied as a component on high-quality white LED devices, and our finding is believed to offer a new strategy for designing multipeak emission PQDs. [ABSTRACT FROM AUTHOR]

Mangrove forests are valuable ecosystems, but their extent and diversity are increasingly threatened by sea-level rise and anthropogenic pressures. Here we develop a bio-morphodynamic model that captures the interaction between multiple mangrove species and hydro-sedimentary processes across a dynamic coastal profile. Numerical experiments are conducted to elucidate the response of mangrove assemblages under a range of sea-level rise and sediment supply conditions, both in the absence and presence of anthropogenic barriers impeding inland migration. We find that mangrove coverage can increase despite sea-level rise if sediment supply is sufficient and landward accommodation space is available. Tidal barriers are mainly detrimental to mangrove coverage and result in species loss. Importantly, we show that bio-morphodynamic feedbacks can cause spatio-temporal variations in sediment delivery across the forest, leading to upper-forest sediment starvation and reduced deposition despite extended inundation. As such, bio-morphodynamic feedbacks can decouple accretion rates from inundation time, altering mangrove habitat conditions and causing mangrove diversity loss even when total forest coverage remains constant or is increasing. A further examination of bio-morphodynamic feedback strength reveals that vegetation-induced flow resistance linked to mangrove root density is a major factor steering the inundation-accretion decoupling and as such species distribution. Our findings have important implications for ecosystem vulnerability assessments, which should account for the interactions between bio-morphodynamics and mangrove diversity when evaluating the impacts of sea-level rise on species assemblages.

Summary: In response to blue light, cryptochromes photoexcite and interact with signal partners to transduce signal almost synchronously in plants. The detailed mechanism of CRY-mediated light signaling remains unclear: the photobiochemical reactions of cryptochrome are transient and synchronous, thus making the monitoring and analysis of each step difficult in plant cells. In this study, we reconstituted the Arabidopsis CRY2 signaling pathway in mammalian cells and investigated the biological role of Arabidopsis CRY2 in this heterologous system, eliminating the interferences of other plant proteins. Our results demonstrated that, besides being the light receptor, Arabidopsis CRY2 binds to DNA directly and acts as a transcriptional activator in a blue-light-enhanced manner. Similar to classic transcription factors, we found that the transcriptional activity of CRY2 is regulated by its dimerization and phosphorylation. In addition, CRY2 cooperates with CIB1 to regulate transcription by enhancing the DNA affinity and transcriptional activity of CIB1 under blue light. : Cryptochromes are the blue light receptors in plants. Yang et al. reconstitute the Arabidopsis thaliana CRY2 signaling pathway to investigate the mechanism of CRY2 transcriptional regulation in mammalian cells. They demonstrate that, besides being the light receptor, CRY2 binds DNA directly to activate transcription of FT in a blue-light-enhanced manner. Keywords: cryptochrome, transcriptional activity, DNA binding, phosphorylation, blue light specificity