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1,084 results on '"Zenz, Thorsten"'

1. Hairy cell leukemia variant and WHO classification correspondence Re: 5th edition WHO classification haematolymphoid tumors: lymphoid neoplasms

Author

Grever, Michael, Andritsos, Leslie, Anghelina, Mirela, Arons, Evgeny, Banerji, Versha, Barrientos, Jacqueline, Bhat, Seema A., Blachly, James, Broccoli, Alessandro, Call, Timothy, Dearden, Claire, Dietrich, Sascha, Else, Monica, Epperla, Narendranath, Fagarasanu, Andrei, Falini, Brunangelo, Forconi, Francesco, Gozzetti, Alessandro, Hampel, Paul, Hermel, David J., Iyengar, Sunil, Johnston, James B., Juliusson, Gunnar, Kreitman, Robert J., Lauria, Francesco, Lozanski, Gerard, Oakes, Christopher C., Parikh, Sameer A., Park, Jae, Quest, Graeme, Rai, Kanti, Ravandi, Farhad, Robak, Tadeusz, Rogers, Kerry A., Saven, Alan, Seymour, John F., Tadmor, Tamar, Tallman, Martin S., Tam, Constantine S., Tiacci, Enrico, Troussard, Xavier, Wörmann, Bernhard, Zent, Clive S., Zenz, Thorsten, and Zinzani, Pier Luigi

Published
2024
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2. Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial

Author

Liebers, Nora, Bruch, Peter-Martin, Terzer, Tobias, Hernandez-Hernandez, Miguel, Paramasivam, Nagarajan, Fitzgerald, Donnacha, Altmann, Heidi, Roider, Tobias, Kolb, Carolin, Knoll, Mareike, Lenze, Angela, Platzbecker, Uwe, Röllig, Christoph, Baldus, Claudia, Serve, Hubert, Bornhäuser, Martin, Hübschmann, Daniel, Müller-Tidow, Carsten, Stölzel, Friedrich, Huber, Wolfgang, Benner, Axel, Zenz, Thorsten, Lu, Junyan, and Dietrich, Sascha

Published
2023
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3. Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY

Author

Mansouri, Larry, Thorvaldsdottir, Birna, Sutton, Lesley-Ann, Karakatsoulis, Georgios, Meggendorfer, Manja, Parker, Helen, Nadeu, Ferran, Brieghel, Christian, Laidou, Stamatia, Moia, Riccardo, Rossi, Davide, Catherwood, Mark, Kotaskova, Jana, Delgado, Julio, Rodríguez-Vicente, Ana E., Benito, Rocío, Rigolin, Gian Matteo, Bonfiglio, Silvia, Scarfo, Lydia, Mattsson, Mattias, Davis, Zadie, Gogia, Ajay, Rani, Lata, Baliakas, Panagiotis, Foroughi-Asl, Hassan, Jylhä, Cecilia, Skaftason, Aron, Rapado, Inmaculada, Miras, Fatima, Martinez-Lopez, Joaquín, de la Serna, Javier, Rivas, Jesús María Hernández, Thornton, Patrick, Larráyoz, María José, Calasanz, María José, Fésüs, Viktória, Mátrai, Zoltán, Bödör, Csaba, Smedby, Karin E., Espinet, Blanca, Puiggros, Anna, Gupta, Ritu, Bullinger, Lars, Bosch, Francesc, Tazón-Vega, Bárbara, Baran-Marszak, Fanny, Oscier, David, Nguyen-Khac, Florence, Zenz, Thorsten, Terol, Maria Jose, Cuneo, Antonio, Hernández-Sánchez, María, Pospisilova, Sarka, Mills, Ken, Gaidano, Gianluca, Niemann, Carsten U., Campo, Elias, Strefford, Jonathan C., Ghia, Paolo, Stamatopoulos, Kostas, and Rosenquist, Richard

Published
2023
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5. R-CODOX-M/R-IVAC versus DA-EPOCH-R in patients with newly diagnosed Burkitt lymphoma (HOVON/SAKK): final results of a multicentre, phase 3, open-label, randomised trial

Author

Chamuleau, Martine E D, Stenner, Frank, Chitu, Dana A, Novak, Urban, Minnema, Monique C, Geerts, Paul, Stevens, Wendy B C, Zenz, Thorsten, van Imhoff, Gustaaf W, Wu, Ka Lung, Demandt, Astrid M P, Kersten, Marie Jose, Terpstra, Wim E, Tick, Lidwine W, Deeren, Dries, Van Den Neste, Eric, Gregor, Michael, Veelken, Hendrik, Böhmer, Lara H, Caspar, Clemens B, Mutsaers, Pim, Refos, Jeannine M, Sewsaran, Robby, Fu, Liping, Seefat, Rianne L, Uyl-de Groot, Carin A, Dirnhofer, Stefan, Van Den Brand, Michiel, de Jong, Daphne, Nijland, Marcel, and Lugtenburg, Pieternella

Published
2023
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6. Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression

Author

Ecker, Veronika, Brandmeier, Lisa, Stumpf, Martina, Giansanti, Piero, Moreira, Aida Varela, Pfeuffer, Lisa, Fens, Marcel H.A.M., Lu, Junyan, Kuster, Bernhard, Engleitner, Thomas, Heidegger, Simon, Rad, Roland, Ringshausen, Ingo, Zenz, Thorsten, Wendtner, Clemens-Martin, Müschen, Markus, Jellusova, Julia, Ruland, Jürgen, and Buchner, Maike

Published
2023
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10. Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

Author

Herbst, Sophie A., Vesterlund, Mattias, Helmboldt, Alexander J., Jafari, Rozbeh, Siavelis, Ioannis, Stahl, Matthias, Schitter, Eva C., Liebers, Nora, Brinkmann, Berit J., Czernilofsky, Felix, Roider, Tobias, Bruch, Peter-Martin, Iskar, Murat, Kittai, Adam, Huang, Ying, Lu, Junyan, Richter, Sarah, Mermelekas, Georgios, Umer, Husen Muhammad, Knoll, Mareike, Kolb, Carolin, Lenze, Angela, Cao, Xiaofang, Österholm, Cecilia, Wahnschaffe, Linus, Herling, Carmen, Scheinost, Sebastian, Ganzinger, Matthias, Mansouri, Larry, Kriegsmann, Katharina, Kriegsmann, Mark, Anders, Simon, Zapatka, Marc, Del Poeta, Giovanni, Zucchetto, Antonella, Bomben, Riccardo, Gattei, Valter, Dreger, Peter, Woyach, Jennifer, Herling, Marco, Müller-Tidow, Carsten, Rosenquist, Richard, Stilgenbauer, Stephan, Zenz, Thorsten, Huber, Wolfgang, Tausch, Eugen, Lehtiö, Janne, and Dietrich, Sascha

Published
2022
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11. Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

Author

Mangolini, Maurizio, Maiques-Diaz, Alba, Charalampopoulou, Stella, Gerhard-Hartmann, Elena, Bloehdorn, Johannes, Moore, Andrew, Giachetti, Giorgia, Lu, Junyan, Roamio Franklin, Valar Nila, Chilamakuri, Chandra Sekkar Reddy, Moutsopoulos, Ilias, Rosenwald, Andreas, Stilgenbauer, Stephan, Zenz, Thorsten, Mohorianu, Irina, D’Santos, Clive, Deaglio, Silvia, Hodson, Daniel J., Martin-Subero, Jose I., and Ringshausen, Ingo

Published
2022
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12. Consensus opinion from an international group of experts on measurable residual disease in hairy cell leukemia

Author

Ravandi, Farhad, Kreitman, Robert J., Tiacci, Enrico, Andritsos, Leslie, Banerji, Versha, Barrientos, Jacqueline C., Bhat, Seema A., Blachly, James S., Broccoli, Alessandro, Call, Timothy, Chihara, Dai, Dearden, Claire, Demeter, Judit, Dietrich, Sasha, Else, Monica, Epperla, Narendranath, Falini, Brunangelo, Forconi, Francesco, Gladstone, Douglas E., Gozzetti, Alessandro, Iyengar, Sunil, Johnston, James B., Jorgensen, Jeffrey, Juliusson, Gunnar, Lauria, Francesco, Lozanski, Gerard, Parikh, Sameer A., Park, Jae H., Polliack, Aaron, Quest, Graeme, Robak, Tadeusz, Rogers, Kerry A., Saven, Alan, Seymour, John F., Tadmor, Tamar, Tallman, Martin S., Tam, Constantine S., Thompson, Philip A., Troussard, Xavier, Zent, Clive S., Zenz, Thorsten, Zinzani, Pier Luigi, Wörmann, Bernhard, Rai, Kanti, and Grever, Michael

Published
2022
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13. Genetic and phenotypic attributes of splenic marginal zone lymphoma

Author

Bonfiglio, Ferdinando, Bruscaggin, Alessio, Guidetti, Francesca, Terzi di Bergamo, Lodovico, Faderl, Martin, Spina, Valeria, Condoluci, Adalgisa, Bonomini, Luisella, Forestieri, Gabriela, Koch, Ricardo, Piffaretti, Deborah, Pini, Katia, Pirosa, Maria Cristina, Cittone, Micol Giulia, Arribas, Alberto, Lucioni, Marco, Ghilardi, Guido, Wu, Wei, Arcaini, Luca, Baptista, Maria Joao, Bastidas, Gabriela, Bea, Silvia, Boldorini, Renzo, Broccoli, Alessandro, Buehler, Marco Matteo, Canzonieri, Vincenzo, Cascione, Luciano, Ceriani, Luca, Cogliatti, Sergio, Corradini, Paolo, Derenzini, Enrico, Devizzi, Liliana, Dietrich, Sascha, Elia, Angela Rita, Facchetti, Fabio, Gaidano, Gianluca, Garcia, Juan Fernando, Gerber, Bernhard, Ghia, Paolo, Gomes da Silva, Maria, Gritti, Giuseppe, Guidetti, Anna, Hitz, Felicitas, Inghirami, Giorgio, Ladetto, Marco, Lopez-Guillermo, Armando, Lucchini, Elisa, Maiorana, Antonino, Marasca, Roberto, Matutes, Estella, Meignin, Veronique, Merli, Michele, Moccia, Alden, Mollejo, Manuela, Montalban, Carlos, Novak, Urban, Oscier, David Graham, Passamonti, Francesco, Piazza, Francesco, Pizzolitto, Stefano, Rambaldi, Alessandro, Sabattini, Elena, Salles, Gilles, Santambrogio, Elisa, Scarfò, Lydia, Stathis, Anastasios, Stüssi, Georg, Geyer, Julia T., Tapia, Gustavo, Tarella, Corrado, Thieblemont, Catherine, Tousseyn, Thomas, Tucci, Alessandra, Vanini, Giorgio, Visco, Carlo, Vitolo, Umberto, Walewska, Renata, Zaja, Francesco, Zenz, Thorsten, Zinzani, Pier Luigi, Khiabanian, Hossein, Calcinotto, Arianna, Bertoni, Francesco, Bhagat, Govind, Campo, Elias, De Leval, Laurence, Dirnhofer, Stefan, Pileri, Stefano A., Piris, Miguel A., Traverse-Glehen, Alexandra, Tzankov, Alexander, Paulli, Marco, Ponzoni, Maurilio, Mazzucchelli, Luca, Cavalli, Franco, Zucca, Emanuele, and Rossi, Davide

Published
2022
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14. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Author

Wilke, Anne C., Doebele, Carmen, Zindel, Alena, Lee, Kwang Seok, Rieke, Sara A., Ceribelli, Michele, Comoglio, Federico, Phelan, James D., Wang, James Q., Pikman, Yana, Jahn, Dominique, Häupl, Björn, Schneider, Constanze, Scheich, Sebastian, Tosto, Frances A., Bohnenberger, Hanibal, Stauder, Philipp, Schnütgen, Frank, Slabicki, Mikolaj, Coulibaly, Zana A., Wolf, Sebastian, Bojarczuk, Kamil, Chapuy, Björn, Brandts, Christian H., Stroebel, Philipp, Lewis, Caroline A., Engelke, Michael, Xu, Xincheng, Kim, Hahn, Dang, Thanh Hung, Schmitz, Roland, Hodson, Daniel J., Stegmaier, Kimberly, Urlaub, Henning, Serve, Hubert, Schmitt, Clemens A., Kreuz, Fernando, Knittel, Gero, Rabinowitz, Joshua D., Reinhardt, Hans Christian, Vander Heiden, Matthew G., Thomas, Craig, Staudt, Louis M., Zenz, Thorsten, and Oellerich, Thomas

Published
2022
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15. B‐cell maturation antigen‐directed bispecific antibodies in plasmablastic lymphoma.

Author

Hofer, Kevin D., Wolfensberger, Nathan, Bachofner, Adrian, Schneidawind, Corina, Stühler, Claudia, Bühler, Marco M., Abela, Irene A., Müller, Nicolas J., Zenz, Thorsten, Manz, Markus G., Rösler, Wiebke, Khanna, Nina, and Schneidawind, Dominik

Subjects
T helper cells, NUCLEIC acid hybridization, BISPECIFIC antibodies, JAK-STAT pathway, DIAGNOSIS of HIV infections
Abstract

Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of large B‐cell lymphoma that primarily affects individuals with immunodeficiency, particularly those who are HIV positive. PBL commonly presents in males at an advanced stage and often affects extranodal regions such as the oral cavity and gastrointestinal tract. The prognosis for PBL is poor, with limited treatment options and low overall survival rates. This article discusses the potential use of bispecific antibodies, specifically teclistamab, in the treatment of refractory PBL in an HIV-positive patient. The case study highlights the efficacy of teclistamab and the importance of donor selection for allogeneic stem cell transplantation in EBV-positive lymphomas. However, further research is needed to establish standardized treatment guidelines for PBL. [Extracted from the article]

Published
2024
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18. Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia

Author

Lu, Junyan, Cannizzaro, Ester, Meier-Abt, Fabienne, Scheinost, Sebastian, Bruch, Peter-Martin, Giles, Holly A. R., Lütge, Almut, Hüllein, Jennifer, Wagner, Lena, Giacopelli, Brian, Nadeu, Ferran, Delgado, Julio, Campo, Elías, Mangolini, Maurizio, Ringshausen, Ingo, Böttcher, Martin, Mougiakakos, Dimitrios, Jacobs, Andrea, Bodenmiller, Bernd, Dietrich, Sascha, Oakes, Christopher C., Zenz, Thorsten, and Huber, Wolfgang

Published
2021
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19. Hairy cell leukemia and COVID-19 adaptation of treatment guidelines

Author

Grever, Michael, Andritsos, Leslie, Banerji, Versha, Barrientos, Jacqueline C., Bhat, Seema, Blachly, James S., Call, Timothy, Cross, Matthew, Dearden, Claire, Demeter, Judit, Dietrich, Sasha, Falini, Brunangelo, Forconi, Francesco, Gladstone, Douglas E., Gozzetti, Alessandro, Iyengar, Sunil, Johnston, James B., Juliusson, Gunnar, Kraut, Eric, Kreitman, Robert J., Lauria, Francesco, Lozanski, Gerard, Parikh, Sameer A., Park, Jae, Polliack, Aaron, Ravandi, Farhad, Robak, Tadeusz, Rogers, Kerry A., Saven, Alan, Seymour, John F., Tadmor, Tamar, Tallman, Martin S., Tam, Constantine S., Tiacci, Enrico, Troussard, Xavier, Zent, Clive, Zenz, Thorsten, Zinzani, Pier Luigi, and Wörmann, Bernhard

Published
2021
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20. Correction: Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY

Author

Mansouri, Larry, Thorvaldsdottir, Birna, Sutton, Lesley-Ann, Karakatsoulis, Georgios, Meggendorfer, Manja, Parker, Helen, Nadeu, Ferran, Brieghel, Christian, Laidou, Stamatia, Moia, Riccardo, Rossi, Davide, Catherwood, Mark, Kotaskova, Jana, Delgado, Julio, Rodríguez-Vicente, Ana E., Benito, Rocío, Rigolin, Gian Matteo, Bonfiglio, Silvia, Scarfo, Lydia, Mattsson, Mattias, Davis, Zadie, Gogia, Ajay, Rani, Lata, Baliakas, Panagiotis, Foroughi-Asl, Hassan, Jylhä, Cecilia, Skaftason, Aron, Rapado, Inmaculada, Miras, Fatima, Martinez-Lopez, Joaquín, de la Serna, Javier, Rivas, Jesús María Hernández, Thornton, Patrick, Larráyoz, María José, Calasanz, María José, Fésüs, Viktória, Mátrai, Zoltán, Bödör, Csaba, Smedby, Karin E., Espinet, Blanca, Puiggros, Anna, Gupta, Ritu, Bullinger, Lars, Bosch, Francesc, Tazón-Vega, Bárbara, Baran-Marszak, Fanny, Oscier, David, Nguyen-Khac, Florence, Zenz, Thorsten, Terol, Maria Jose, Cuneo, Antonio, Hernández-Sánchez, María, Pospisilova, Sarka, Mills, Ken, Gaidano, Gianluca, Niemann, Carsten U., Campo, Elias, Strefford, Jonathan C., Ghia, Paolo, Stamatopoulos, Kostas, and Rosenquist, Richard

Published
2023
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21. Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.

Author

Burger, Jan A, Landau, Dan A, Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M, Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J, Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R, Abruzzo, Lynne V, Carter, Scott L, Keating, Michael J, Davids, Matthew S, Wierda, William G, Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Dal Cin, Paola, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O'Brien, Susan, Letai, Anthony, Weitz, David A, Nowak, Martin A, Getz, Gad, and Wu, Catherine J

Subjects
Humans, Neoplasm Recurrence, Local, Pyrazoles, Pyrimidines, Apoptosis, Drug Resistance, Neoplasm, Mutation, Adult, Aged, 80 and over, Middle Aged, Female, Male, Protein-Tyrosine Kinases, Leukemia, Lymphocytic, Chronic, B-Cell, Cell Transdifferentiation, Histiocytic Sarcoma, Selection, Genetic, Clonal Evolution, Agammaglobulinaemia Tyrosine Kinase, Aged, and over, Drug Resistance, Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Neoplasm Recurrence, Local, Selection, Genetic
Abstract

Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ibrutinib resistance in serial samples from five chronic lymphocytic leukaemia patients. In two patients, we detect BTK-C481S mutation or multiple PLCG2 mutations. The other three patients exhibit an expansion of clones harbouring del(8p) with additional driver mutations (EP300, MLL2 and EIF2A), with one patient developing trans-differentiation into CD19-negative histiocytic sarcoma. Using droplet-microfluidic technology and growth kinetic analyses, we demonstrate the presence of ibrutinib-resistant subclones and estimate subclone size before treatment initiation. Haploinsufficiency of TRAIL-R, a consequence of del(8p), results in TRAIL insensitivity, which may contribute to ibrutinib resistance. These findings demonstrate that the ibrutinib therapy favours selection and expansion of rare subclones already present before ibrutinib treatment, and provide insight into the heterogeneity of genetic changes associated with ibrutinib resistance.

Published
2016

22. Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Author

Fowler, Nathan H, Cheah, Chan Yoon, Gascoyne, Randy D, Gribben, John, Neelapu, Sattva S, Ghia, Paolo, Bollard, Catherine, Ansell, Stephen, Curran, Michael, Wilson, Wyndham H, O'Brien, Susan, Grant, Cliona, Little, Richard, Zenz, Thorsten, Nastoupil, Loretta J, and Dunleavy, Kieron

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Hematology, Rare Diseases, Cancer, Lymphoma, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, B-Lymphocytes, Biomarkers, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Humans, Immunotherapy, Leukemia, B-Cell, Lymphoma, B-Cell, Molecular Targeted Therapy, Neoplasm Grading, Neoplasm Staging, Signal Transduction, Tumor Escape, Tumor Microenvironment, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.

Published
2016

23. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

Author

Oakes, Christopher C, Seifert, Marc, Assenov, Yassen, Gu, Lei, Przekopowitz, Martina, Ruppert, Amy S, Wang, Qi, Imbusch, Charles D, Serva, Andrius, Koser, Sandra D, Brocks, David, Lipka, Daniel B, Bogatyrova, Olga, Weichenhan, Dieter, Brors, Benedikt, Rassenti, Laura, Kipps, Thomas J, Mertens, Daniel, Zapatka, Marc, Lichter, Peter, Döhner, Hartmut, Küppers, Ralf, Zenz, Thorsten, Stilgenbauer, Stephan, Byrd, John C, and Plass, Christoph

Subjects
Hematology, Genetics, Human Genome, Rare Diseases, Cancer, Lymphoma, Adult, Aged, Aged, 80 and over, B-Lymphocytes, Binding Sites, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Leukemic, Gene Expression Regulation, Neoplastic, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Neoplasm Proteins, Phenotype, Promoter Regions, Genetic, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B cell subsets, we observed broad epigenetic programming of selective transcription factor binding sites coincident with the degree of B cell maturation. By comparing normal B cells to malignant B cells from 268 patients with chronic lymphocytic leukemia (CLL), we showed that tumors derive largely from a continuum of maturation states reflected in normal developmental stages. Epigenetic maturation in CLL was associated with an indolent gene expression pattern and increasingly favorable clinical outcomes. We further uncovered that most previously reported tumor-specific methylation events are normally present in non-malignant B cells. Instead, we identified a potential pathogenic role for transcription factor dysregulation in CLL, where excess programming by EGR and NFAT with reduced EBF and AP-1 programming imbalances the normal B cell epigenetic program.

Published
2016

24. IGLV3-21R110 mutation has prognostic value in patients with treatment-naive chronic lymphocytic leukemia

Author

Syrykh, Charlotte, primary, Pons-Brun, Berta, additional, Russiñol, Núria, additional, Playa-Albinyana, Heribert, additional, Baumann, Tycho, additional, Duran-Ferrer, Martí, additional, Kulis, Marta, additional, Carbó-Meix, Anna, additional, Mozas, Pablo, additional, Alcoceba, Miguel, additional, González, Marcos, additional, Navarro-Bailón, Almudena, additional, Colado, Enrique, additional, Payer, Ángel R., additional, Aymerich, Marta, additional, Terol, María J., additional, Lu, Junyan, additional, Knisbacher, Binyamin A., additional, Hahn, Cynthia K., additional, Ruiz-Gaspà, Sílvia, additional, Enjuanes, Anna, additional, Wu, Catherine J., additional, Getz, Gad, additional, Zenz, Thorsten, additional, López-Guillermo, Armando, additional, Martín-Subero, José I., additional, Colomer, Dolors, additional, Delgado, Julio, additional, Campo, Elías, additional, and Nadeu, Ferran, additional

Published
2023
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25. Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome

Author

Gabbutt, Calum, primary, Duran-Ferrer, Marti, additional, Grant, Heather, additional, Mallo, Diego, additional, Nadeu, Ferran, additional, Househam, Jacob, additional, Villamor, Neus, additional, Krali, Olga, additional, Nordlund, Jessica, additional, Zenz, Thorsten, additional, Campo, Elias, additional, Lopez-Guillermo, Armando, additional, Fitzgibbon, Jude, additional, Barnes, Chris P, additional, Shibata, Darryl, additional, Martin-Subero, Jose I, additional, and Graham, Trevor A, additional

Published
2023
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27. The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

Author

Duran-Ferrer, Martí, Clot, Guillem, Nadeu, Ferran, Beekman, Renée, Baumann, Tycho, Nordlund, Jessica, Marincevic-Zuniga, Yanara, Lönnerholm, Gudmar, Rivas-Delgado, Alfredo, Martín, Silvia, Ordoñez, Raquel, Castellano, Giancarlo, Kulis, Marta, Queirós, Ana C., Lee, Seung-Tae, Wiemels, Joseph, Royo, Romina, Puiggrós, Montserrat, Lu, Junyan, Giné, Eva, Beà, Sílvia, Jares, Pedro, Agirre, Xabier, Prosper, Felipe, López-Otín, Carlos, Puente, Xosé S., Oakes, Christopher C., Zenz, Thorsten, Delgado, Julio, López-Guillermo, Armando, Campo, Elías, and Martín-Subero, José Ignacio

Published
2020
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30. Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Author

Chapiro, Elise, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim, Settegrana, Catherine, Baseggio, Lucile, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frédéric, Le Garff-Tavernier, Magali, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Véronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stéphanie, Collonge-Rame, Marie-Agnès, Quilichini, Benoit, Fert-Ferrer, Sandra, Auger, Nathalie, Radford-Weiss, Isabelle, Wagner, Lena, Scheinost, Sebastian, Zenz, Thorsten, Susin, Santos A., Bernard, Olivier A., and Nguyen-Khac, Florence

Published
2019
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32. Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels

Author

Roider, Tobias, Seufert, Julian, Uvarovskii, Alexey, Frauhammer, Felix, Bordas, Marie, Abedpour, Nima, Stolarczyk, Marta, Mallm, Jan-Philipp, Herbst, Sophie A., Bruch, Peter-Martin, Balke-Want, Hyatt, Hundemer, Michael, Rippe, Karsten, Goeppert, Benjamin, Seiffert, Martina, Brors, Benedikt, Mechtersheimer, Gunhild, Zenz, Thorsten, Peifer, Martin, Chapuy, Björn, Schlesner, Matthias, Müller-Tidow, Carsten, Fröhling, Stefan, Huber, Wolfgang, Anders, Simon, and Dietrich, Sascha

Published
2020
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35. Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia

Author

Giacopelli, Brian, Zhao, Qiuhong, Ruppert, Amy S., Agyeman, Akwasi, Weigel, Christoph, Wu, Yue-Zhong, Gerber, Madelyn M., Rabe, Kari G., Larson, Melissa C., Lu, Junyan, Blachly, James S., Rogers, Kerry A., Wierda, William G., Brown, Jennifer R., Rai, Kanti R., Keating, Michael, Rassenti, Laura Z., Kipps, Thomas J., Zenz, Thorsten, Shanafelt, Tait D., Kay, Neil E., Abruzzo, Lynne V., Coombes, Kevin R., Woyach, Jennifer A., Byrd, John C., and Oakes, Christopher C.

Published
2019
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37. Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia

Author

Oakes, Christopher C, Claus, Rainer, Gu, Lei, Assenov, Yassen, Hüllein, Jennifer, Zucknick, Manuela, Bieg, Matthias, Brocks, David, Bogatyrova, Olga, Schmidt, Christopher R, Rassenti, Laura, Kipps, Thomas J, Mertens, Daniel, Lichter, Peter, Döhner, Hartmut, Stilgenbauer, Stephan, Byrd, John C, Zenz, Thorsten, and Plass, Christoph

Subjects
Rare Diseases, Genetic Testing, Genetics, Cancer, Lymphoma, Human Genome, Hematology, Good Health and Well Being, Aged, Chromosomes, Human, CpG Islands, DNA Methylation, Disease Progression, Epigenesis, Genetic, Female, Gene Expression Regulation, Leukemic, Genetic Heterogeneity, Genome, Human, Genomic Instability, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Oncology and Carcinogenesis
Abstract

Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation heterogeneity and up to 10% of total CpGs in a monoallelically methylated state. Increasing methylation heterogeneity correlates with advanced genetic subclonal complexity. Selection of novel DNA methylation patterns is observed only in cases that undergo genetic evolution, and independent genetic evolution is uncommon and is restricted to low-risk alterations. These results reveal that although evolution of DNA methylation occurs in high-risk, clinically progressive cases, positive selection of novel methylation patterns entails coevolution of genetic alteration(s) in CLL.

Published
2014

38. How to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B‐cell lymphoma?

Author

de Ramon Ortiz, Carmen, Wang, Sisi, Stathis, Anastasios, Bertoni, Francesco, Zenz, Thorsten, Novak, Urban, and Simonetta, Federico

Subjects
DIFFUSE large B-cell lymphomas, CHIMERIC antigen receptors, CD19 antigen, BISPECIFIC antibodies, ANTIBODY-drug conjugates
Abstract

About one third of patients with diffuse large B‐cell lymphoma (DLBCL) have a relapsing/refractory (R/R) disease after first line chemo‐immunotherapy, with particularly poor outcomes observed in patients with primary refractory disease and early relapse. CD19 specific chimeric antigen receptor (CAR) T cell therapy is a game changer that results in durable and complete response rates in almost half of the patients with R/R DLBCL. Other emerging CD19‐targeting therapies include monoclonal antibodies, bispecific antibodies and targeting antibody‐drug conjugates, which also show encouraging results. However, the timing and sequencing of different anti‐CD19‐targeting agents and how they might interfere with subsequent CAR T cell treatment is still unclear. In this review, we summarize the results of the pivotal clinical trials as well as evidence from real‐world series of the use of different CD19‐targeting approved agents. We discuss the effect of various therapies on CD19 expression and its implications for treatment sequencing. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Jüngste Entwicklungen in der Hämatologie, Teil 2

Author

Duchosal, Michel A., primary, Alberio, Lorenzo, additional, Angelillo-Scherrer, Anne, additional, Arber, Caroline, additional, Balabanov, Stefan, additional, Blum, Sabine, additional, Bttcher, Steffen, additional, Buser, Andreas, additional, Cairoli, Anne, additional, Chalandon, Yves, additional, Driessen, Christoph, additional, Fontana, Stefano, additional, Grandoni, Francesco, additional, Gregor, Michael, additional, Infanti, Laura, additional, Lambert, Jean-Franois, additional, Meyer, Sara Christina, additional, Passweg, Jakob, additional, Azur Porret, Naomi, additional, Rossi, Davide, additional, Schoumans, Jacqueline, additional, Schwotzer, Rahel, additional, Stssi, Georg, additional, Studte, Jan-Dirk, additional, Theocharides, Alexandre, additional, Tichelli, Andr, additional, Widmer, Corinne, additional, and Zenz, Thorsten, additional

Published
2023
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40. Développements récents en hématologie, Partie 2

Author

Duchosal, Michel A., primary, Alberio, Lorenzo, additional, Angelillo-Scherrer, Anne, additional, Arber, Caroline, additional, Balabanov, Stefan, additional, Blum, Sabine, additional, Bttcher, Steffen, additional, Buser, Andreas, additional, Cairoli, Anne, additional, Chalandon, Yves, additional, Driessen, Christoph, additional, Fontana, Stefano, additional, Grandoni, Francesco, additional, Gregor, Michael, additional, Infanti, Laura, additional, Lambert, Jean-Franois, additional, Meyer, Sara Christina, additional, Passweg, Jakob, additional, Azur Porret, Naomi, additional, Rossi, Davide, additional, Schoumans, Jacqueline, additional, Schwotzer, Rahel, additional, Stssi, Georg, additional, Studte, Jan-Dirk, additional, Theocharides, Alexandre, additional, Tichelli, Andr, additional, Widmer, Corinne, additional, and Zenz, Thorsten, additional

Published
2023
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41. Développements récents en hématologie, Teil 1

Author

Duchosal, Michel A., primary, Alberio, Lorenzo, additional, Angelillo-Scherrer, Anne, additional, Arber, Caroline, additional, Balabanov, Stefan, additional, Blum, Sabine, additional, Bttcher, Steffen, additional, Buser, Andreas, additional, Cairoli, Anne, additional, Chalandon, Yves, additional, Driessen, Christoph, additional, Fontana, Stefano, additional, Grandoni, Francesco, additional, Gregor, Michael, additional, Infanti, Laura, additional, Lambert, Jean-Franois, additional, Meyer, Sara Christina, additional, Passweg, Jakob, additional, Azur Porret, Naomi, additional, Rossi, Davide, additional, Schoumans, Jacqueline, additional, Schwotzer, Rahel, additional, Studt, Jan-Dirk, additional, Stssi, Georg, additional, Theocharides, Alexandre, additional, Tichelli, Andr, additional, Widmer, Corinne, additional, and Zenz, Thorsten, additional

Published
2023
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42. Jüngste Entwicklungen in der Hämatologie, Teil 1

Author

Duchosal, Michel A., primary, Alberio, Lorenzo, additional, Angelillo-Scherrer, Anne, additional, Arber, Caroline, additional, Balabanov, Stefan, additional, Blum, Sabine, additional, Bttcher, Steffen, additional, Buser, Andreas, additional, Cairoli, Anne, additional, Chalandon, Yves, additional, Driessen, Christoph, additional, Fontana, Stefano, additional, Grandoni, Francesco, additional, Gregor, Michael, additional, Infanti, Laura, additional, Lambert, Jean-Franois, additional, Meyer, Sara Christina, additional, Passweg, Jakob, additional, Azur Porret, Naomi, additional, Rossi, Davide, additional, Schoumans, Jacqueline, additional, Schwotzer, Rahel, additional, Studt, Jan-Dirk, additional, Stssi, Georg, additional, Theocharides, Alexandre, additional, Tichelli, Andr, additional, Widmer, Corinne, additional, and Zenz, Thorsten, additional

Published
2023
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43. BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases

Author

Carbo-Meix, Anna, primary, Guijarro, Francesca, additional, Wang, Luojun, additional, Grau, Marta, additional, Royo, Romina, additional, Frigola, Gerard, additional, Playa-Albinyana, Heribert, additional, Buhler, Marco M., additional, Clot, Guillem, additional, Duran-Ferrer, Marti, additional, Lu, Junyan, additional, Granada, Isabel, additional, Baptista, Maria-Joao, additional, Navarro, Jose-Tomas, additional, Espinet, Blanca, additional, Puiggros, Anna, additional, Tapia, Gustavo, additional, Bandiera, Laura, additional, De Canal, Gabriella, additional, Bonoldi, Emanuela, additional, Climent, Fina, additional, Ribera-Cortada, Inmaculada, additional, Fernandez-Caballero, Mariana, additional, De la Banda, Esmeralda, additional, Do Nascimento, Janilson, additional, Pineda, Alberto, additional, Vela, Dolors, additional, Rozman, Maria, additional, Aymerich, Marta, additional, Syrykh, Charlotte, additional, Brousset, Pierre, additional, Perera, Miguel, additional, Yanez, Lucrecia, additional, Ortin, Jesus Xavier, additional, Tuset, Esperanza, additional, Zenz, Thorsten, additional, Cook, James R., additional, Swerdlow, Steven H., additional, Martin-Subero, Jose I., additional, Colomer, Dolors, additional, Matutes, Estella, additional, Bea, Silvia, additional, Costa, Dolors, additional, Nadeu, Ferran, additional, and Campo, Elias, additional

Published
2023
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44. S257: CAR T CELLS AND THEIR IMMUNE ENVIRONMENT SHAPE DISTINCT IMMUNE PROFILES IN RESPONSE AND TOXICITY IN B CELL LYMPHOMA PATIENTS

Author

Kreutmair, Stefanie, primary, Schaefer, Maximilian, additional, Stolz, Sebastian, additional, Merten, Carla, additional, Ulutekin, Can, additional, Wertheimer, Tobias, additional, Ingelfinger, Florian, additional, Unger, Susanne, additional, Alberti, Chiara, additional, Sethi, Aakriti, additional, Manz, Markus, additional, Zenz, Thorsten, additional, Müller, Antonia, additional, Widmer, Corinne, additional, and Becher, Burkhard, additional

Published
2023
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45. P600: DNA METHYLATION ANALYSIS OF B-CELL PROLYMPHOCYTIC LEUKEMIA REVEALS TWO EPIGENETIC SUBTYPES WITH DISTINCT BIOLOGICAL AND CLINICAL FEATURES

Author

Charalampopoulou, Stella, primary, Chapiro, Elise, additional, Nadeu, Ferran, additional, Zenz, Thorsten, additional, Beà, Silvia, additional, Roos-Weil, Damien, additional, Bernard, Olivier, additional, Susin, Santos A, additional, Matutes, Estella, additional, Campo, Elias, additional, Duran-Ferrer, Martí, additional, Nguyen-Khac, Florence, additional, and Ignacio Martín-Subero, José, additional

Published
2023
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46. S147: EFFICACY AND SAFETY RESULTS OF MOLTO, A MULTICENTER, OPEN LABEL, PHASE II CLINICAL TRIAL EVALUATING VENETOCLAX, ATEZOLIZUMAB AND OBINUTUZUMAB COMBINATION IN RICHTER SYNDROME

Author

Frustaci, Anna Maria, primary, Montillo, Marco, additional, Rossi, Davide, additional, Zinzani, Pier Luigi, additional, Motta, Marina, additional, Gaidano, Gianluca, additional, Quaresmini, Giulia, additional, Scarfò, Lydia, additional, Pietrasanta, Daniela, additional, Coscia, Marta, additional, Deodato, Marina, additional, Zamprogna, Giulia, additional, Cairoli, Roberto, additional, Stüssi, Georg, additional, Zucca, Emanuele, additional, Pileri, Stefano, additional, Zenz, Thorsten, additional, and Tedeschi, Alessandra, additional

Published
2023
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47. Hairy cell leukemia variant and WHO classification correspondence Re: 5thedition WHO classification haematolymphoid tumors: lymphoid neoplasms

Author

Grever, Michael, Andritsos, Leslie, Anghelina, Mirela, Arons, Evgeny, Banerji, Versha, Barrientos, Jacqueline, Bhat, Seema A., Blachly, James, Broccoli, Alessandro, Call, Timothy, Dearden, Claire, Dietrich, Sascha, Else, Monica, Epperla, Narendranath, Fagarasanu, Andrei, Falini, Brunangelo, Forconi, Francesco, Gozzetti, Alessandro, Hampel, Paul, Hermel, David J., Iyengar, Sunil, Johnston, James B., Juliusson, Gunnar, Kreitman, Robert J., Lauria, Francesco, Lozanski, Gerard, Oakes, Christopher C., Parikh, Sameer A., Park, Jae, Quest, Graeme, Rai, Kanti, Ravandi, Farhad, Robak, Tadeusz, Rogers, Kerry A., Saven, Alan, Seymour, John F., Tadmor, Tamar, Tallman, Martin S., Tam, Constantine S., Tiacci, Enrico, Troussard, Xavier, Wörmann, Bernhard, Zent, Clive S., Zenz, Thorsten, and Zinzani, Pier Luigi

Published
2024
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49. Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia

Author

Jebaraj, Billy Michael Chelliah, Tausch, Eugen, Landau, Dan A., Bahlo, Jasmin, Robrecht, Sandra, Taylor-Weiner, Amaro N., Bloehdorn, Johannes, Scheffold, Annika, Mertens, Daniel, Böttcher, Sebastian, Kneba, Michael, Jäger, Ulrich, Zenz, Thorsten, Wenger, Michael K., Fingerle-Rowson, Guenter, Wendtner, Clemens, Fink, Anna-Maria, Wu, Catherine J., Eichhorst, Barbara, Fischer, Kirsten, Hallek, Michael, Döhner, Hartmut, and Stilgenbauer, Stephan

Published
2019
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50. HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Author

Bobrowicz, Malgorzata, Dwojak, Michal, Pyrzynska, Beata, Stachura, Joanna, Muchowicz, Angelika, Berthel, Elise, Dalla-Venezia, Nicole, Kozikowski, Mieszko, Siernicka, Marta, Miazek, Nina, Zapala, Piotr, Domagala, Antoni, Bojarczuk, Kamil, Malenda, Agata, Barankiewicz, Joanna, Graczyk-Jarzynka, Agnieszka, Zagozdzon, Agnieszka, Gabrysiak, Magdalena, Diaz, Jean-Jacques, Karp, Marta, Lech-Maranda, Ewa, Firczuk, Malgorzata, Giannopoulos, Krzysztof, Efremov, Dimitar G., Laurenti, Luca, Baatout, Dunja, Frenzel, Lukas, Malinowska, Agata, Slabicki, Mikolaj, Zenz, Thorsten, Zerrouqi, Abdessamad, Golab, Jakub, and Winiarska, Magdalena

Published
2017
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