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2. Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories

Author

Razavi-Shearer, D., Child, H., Razavi-Shearer, K., Voeller, A., Razavi, H., Buti, M., Tacke, F., Terrault, N., Zeuzem, S., Abbas, Z., Aghemo, A., Akarca, U.S., Al Masri, N., Alalwan, A., Blomé, M. Alanko, Jerkeman, A., Aleman, S., Kamal, H., Alghamdi, A., Alghamdi, M., Alghamdi, S., Al-Hamoudi, W., Ali, E., Aljumah, A., Altraif, I., Amarsanaa, J., Asselah, T., Baatarkhuu, O., Babameto, A., Ben-Ari, Z., Berg, T., Biondi, M., Braga, W., Brandão-Mello, C., Brown, R., Brunetto, M., Cabezas, J., Cardoso, M., Martins, A., Chan, H.L.Y., Cheinquer, H., Chen, C.-J., Yang, H.-I., Chen, P.-J., Chien, C.-H., Chuang, W.-L., Garza, L. Cisneros, Coco, B., Coffin, C., Coppola, N., Cornberg, M., Craxi, A., Crespo, J., Cuko, L., De Ledinghen, V., Duberg, A.-S., Etzion, O., Ferraz, M.L., Ferreira, P., Forns, X., Foster, G., Fung, J., Gaeta, G., García-Samaniego, J., Genov, J., Gheorghe, L., Gholam, P., Gish, R., Glenn, J., Hamid, S., Hercun, J., Hsu, Y.-C., Hu, C.-C., Huang, J.-F., Idilman, R., Jafri, W., Janjua, N., Jelev, D., Jia, J., Kåberg, M., Kaita, K., Kao, J.-H., Khan, A., Kim, D.Y., Kondili, L., Lagging, M., Lampertico, P., Lázaro, P., Lazarus, J.V., Lee, M.-H., Lim, Y.-S., Lobato, C., Macedo, G., Marinho, R., Marotta, P., Mendes-Correa, M.C., Méndez-Sánchez, N., Navas, M.-C., Ning, Q., Örmeci, N., Orrego, M., Osiowy, C., Pan, C., Pessoa, M., Piracha, Z., Pop, C., Qureshi, H., Raimondo, G., Ramji, A., Ribeiro, S., Ríos-Hincapié, C., Rodríguez, M., Rosenberg, W., Roulot, D., Ryder, S., Saeed, U., Safadi, R., Shouval, D., Sanai, F., Sanchez-Avila, J.F., Santantonio, T., Sarrazin, C., Seto, W.-K., Simonova, M., Tanaka, J., Tergast, T., Tsendsuren, O., Valente, C., Villalobos-Salcedo, J.M., Waheed, Y., Wong, G., Wong, V., Yip, T., Wu, J.-C., Yu, M.-L., Yuen, M.-F., Yurdaydin, C., and Zuckerman, E.

Published
2024
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7. The adjusted prevalence of hepatitis delta virus (HDV) in 25 countries and territories

Author

Razavi-Shearer, D., primary, Child, H., additional, Razavi-Shearer, K., additional, Voeller, A., additional, Razavi, H., additional, Buti, M., additional, Tacke, F., additional, Terrault, N., additional, Zeuzem, S., additional, Abbas, Z., additional, Aghemo, A., additional, Akarca, U.S., additional, Al Masri, N., additional, Alalwan, A., additional, Blomé, M Alanko, additional, Jerkeman, A., additional, Aleman, S., additional, Kamal, H., additional, Alghamdi, A., additional, Alghamdi, M., additional, Alghamdi, S., additional, Al-Hamoudi, W., additional, Ali, E., additional, Aljumah, A., additional, Altraif, I., additional, Amarsanaa, J., additional, Asselah, T., additional, Baatarkhuu, O., additional, Babameto, A., additional, Ben-Ari, Z., additional, Berg, T., additional, Biondi, M., additional, Braga, W., additional, Brandão-Mello, C., additional, Brown, R., additional, Brunetto, M., additional, Cabezas, J., additional, Cardoso, M., additional, Martins, A., additional, Chan, H.L.Y., additional, Cheinquer, H., additional, Chen, C.-J., additional, Yang, H.-I., additional, Chen, P.-J., additional, Chien, C.-H., additional, Chuang, W.-L., additional, Garza, L Cisneros, additional, Coco, B., additional, Coffin, C., additional, Coppola, N., additional, Cornberg, M., additional, Craxi, A., additional, Crespo, J., additional, Cuko, L., additional, De Ledinghen, V., additional, Duberg, A.-S., additional, Etzion, O., additional, Ferraz, M.L., additional, Ferreira, P., additional, Forns, X., additional, Foster, G., additional, Fung, J., additional, Gaeta, G., additional, García-Samaniego, J., additional, Genov, J., additional, Gheorghe, L., additional, Gholam, P., additional, Gish, R., additional, Glenn, J., additional, Hamid, S., additional, Hercun, J., additional, Hsu, Y.-C., additional, Hu, C.-C., additional, Huang, J.-F., additional, Idilman, R., additional, Jafri, W., additional, Janjua, N., additional, Jelev, D., additional, Jia, J., additional, Kåberg, M., additional, Kaita, K., additional, Kao, J.-H., additional, Khan, A., additional, Kim, D.Y., additional, Kondili, L., additional, Lagging, M., additional, Lampertico, P., additional, Lázaro, P., additional, Lazarus, J.V., additional, Lee, M.-H., additional, Lim, Y.-S., additional, Lobato, C., additional, Macedo, G., additional, Marinho, R., additional, Marotta, P., additional, Mendes-Correa, M.C., additional, Méndez-Sánchez, N., additional, Navas, M.-C., additional, Ning, Q., additional, Örmeci, N., additional, Orrego, M., additional, Osiowy, C., additional, Pan, C., additional, Pessoa, M., additional, Piracha, Z., additional, Pop, C., additional, Qureshi, H., additional, Raimondo, G., additional, Ramji, A., additional, Ribeiro, S., additional, Ríos-Hincapié, C., additional, Rodríguez, M., additional, Rosenberg, W., additional, Roulot, D., additional, Ryder, S., additional, Saeed, U., additional, Safadi, R., additional, Shouval, D., additional, Sanai, F., additional, Sanchez-Avila, J.F., additional, Santantonio, T., additional, Sarrazin, C., additional, Seto, W.-K., additional, Simonova, M., additional, Tanaka, J., additional, Tergast, T., additional, Tsendsuren, O., additional, Valente, C., additional, Villalobos-Salcedo, J.M., additional, Waheed, Y., additional, Wong, G., additional, Wong, V., additional, Yip, T., additional, Wu, J.-C., additional, Yu, M.-L., additional, Yuen, M.-F., additional, Yurdaydin, C., additional, and Zuckerman, E., additional

Published
2023
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8. Colonization with multidrug-resistant organisms is associated with impaired survival of patients with surgically resected cholangiocarcinoma

Author

Kinzler, M. N., additional, Stehle, A., additional, Schulze, F., additional, Hogardt, M., additional, Wichelhaus, T. A., additional, Kempf, V. A., additional, Finkelmeier, F., additional, Trojan, J., additional, Zeuzem, S., additional, Schnitzbauer, A. A., additional, Bechstein, W. O., additional, Wild, P. J., additional, and Walter, D., additional

Published
2023
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11. Nicht-alkoholische Fettlebererkrankung (NAFLD) in Deutschland: Baseline-Charakteristika von Patienten aus dem Deutschen NAFLD-Register

Author

Geier, A., additional, Rau, M., additional, Pathil-Warth, A., additional, von der Ohe, M., additional, Schattenberg, J., additional, Dikopoulos, N., additional, Stein, K., additional, Griemsmann, M., additional, Serfert, Y., additional, Wiebner, B., additional, Berg, T., additional, Buggisch, P., additional, Demir, M., additional, Roeb, E., additional, Wedemeyer, H., additional, Zeuzem, S., additional, and Hofmann, W. P., additional

Published
2023
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12. Impact of IDH1 mutation on clinical course of patients with intrahepatic cholangiocarcinoma: a retrospective analysis from a German tertiary center

Author

Kinzler, M. N., additional, Jeroch, J., additional, Klasen, C., additional, Himmelsbach, V., additional, Koch, C., additional, Finkelmeier, F., additional, Trojan, J., additional, Zeuzem, S., additional, Pession, U., additional, Reis, H., additional, Demes, M. C., additional, Wild, P. J., additional, and Walter, D., additional

Published
2023
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13. The new paradigm of hepatitis C therapy: integration of oral therapies into best practices

Author

Afdhal, NH, Zeuzem, S, Schooley, RT, Thomas, DL, Ward, JW, Litwin, AH, Razavi, H, Castera, L, Poynard, T, Muir, A, Mehta, SH, Dee, L, Graham, C, Church, DR, Talal, AH, Sulkowski, MS, Jacobson, IM, and Participants, for the New Paradigm of HCV Therapy Meeting

Subjects
Emerging Infectious Diseases, Liver Disease, Hepatitis, Health Services, Prevention, Orphan Drug, Digestive Diseases, Infectious Diseases, Rare Diseases, Clinical Research, Hepatitis - C, Chronic Liver Disease and Cirrhosis, Infection, Good Health and Well Being, Administration, Oral, Antiviral Agents, Centers for Disease Control and Prevention, U.S., Hepatitis C, Chronic, Humans, Liver, Mass Screening, Practice Guidelines as Topic, United States, diagnosis, directly acting antiviral agents, health services, hepatitis C, pharmacoeconomics, New Paradigm of HCV Therapy Meeting Participants, Microbiology, Clinical Sciences, Medical Microbiology, Gastroenterology & Hepatology
Abstract

Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C virus (HCV) will become a reality in the near future. In replacing interferon-based therapies, all-oral regimens are expected to be more tolerable, more effective, shorter in duration and simpler to administer. Coinciding with new treatment options are novel methodologies for disease screening and staging, which create the possibility of more timely care and treatment. Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive assessments of histologic damage have become the norm in some European countries and are becoming more widespread in the United States. Also in place are new Centers for Disease Control and Prevention (CDC) initiatives to simplify testing, improve provider and patient awareness and expand recommendations for HCV screening beyond risk-based strategies. Issued in 2012, the CDC recommendations aim to increase HCV testing among those with the greatest HCV burden in the United States by recommending one-time testing for all persons born during 1945-1965. In 2013, the United States Preventive Services Task Force adopted similar recommendations for risk-based and birth-cohort-based testing. Taken together, the developments in screening, diagnosis and treatment will likely increase demand for therapy and stimulate a shift in delivery of care related to chronic HCV, with increased involvement of primary care and infectious disease specialists. Yet even in this new era of therapy, barriers to curing patients of HCV will exist. Overcoming such barriers will require novel, integrative strategies and investment of resources at local, regional and national levels.

Published
2013

14. Noninvasive screening identifies patients at risk for spontaneous bacterial peritonitis caused by multidrug-resistant organisms

Author

Ferstl PG, Müller M, Filmann N, Hogardt M, Kempf VAJ, Wichelhaus TA, Lange CM, Vermehren J, Zeuzem S, Reinheimer C, and Waidmann O

Subjects
Multidrug resistance, spontaneous bacterial peritonitis, screening routine, antibiotic therapy, Infectious and parasitic diseases, RC109-216
Abstract

Philip G Ferstl,1,2 Mona Müller,1 Natalie Filmann,3 Michael Hogardt,2,4,5 Volkhard AJ Kempf,2,4,5 Thomas A Wichelhaus,2,4,5 Christian M Lange,1,2 Johannes Vermehren,1,2 Stefan Zeuzem,1,2 Claudia Reinheimer,2,4,5 Oliver Waidmann1,2 1Department for Internal Medicine I/Gastroenterology and Hepatology, University Hospital Frankfurt, Frankfurt am Main, Germany; 2University Center for Infectious Diseases (UCI), University Hospital Frankfurt, Frankfurt am Main, Germany; 3Institute of Biostatistics and Mathematical Modeling, University Hospital Frankfurt, Frankfurt am Main, Germany; 4Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany; 5University Center of Competence for Infection Control at the Universities Frankfurt, Giessen, and Marburg, Frankfurt am Main, State of Hesse, Germany Background and aims: Spontaneous bacterial peritonitis (SBP) is a severe complication of decompensated cirrhosis. The prevalence of multidrug-resistant organisms (MDROs) in patients with cirrhosis is increasing. Identification of patients at risk for SBP due to MDROs (ie, SBP with the evidence of MDROs or Stenotrophomonas maltophilia in ascitic culture, MDRO-SBP) is crucial to the early adaptation of antibiotic treatment in such patients. We therefore investigated whether MDROs found in ascitic cultures can also be found in specimens determined by noninvasive screening procedures.Patients and methods: This retrospective study was conducted at the liver center of the University Hospital Frankfurt, Germany. Between 2011 and 2016, patients with cirrhosis were included upon diagnosis of SBP and sample collection of aerobic/anaerobic ascitic cultures. Furthermore, the performance of at least one complete MDRO screening was mandatory for study inclusion.Results: Of 133 patients diagnosed with SBP, 75 (56.4%) had culture-positive SBP and 22 (16.5%) had MDRO-SBP. Multidrug-resistant Escherichia coli (10/22; 45.5%) and vancomycin-resistant enterococci (7/22; 36.4%) resembled the major causatives of MDRO-SBP. Rectal swabs identified MDROs in 17 of 22 patients (77.3%) who developed MDRO-SBP with a time-dependent sensitivity of 77% and 87% after 30 and 90 days upon testing, while negative predictive value was 83% and 76%, respectively. The majority of patients were included from intensive care unit or intermediate care unit.Conclusion: MDRO screening may serve as a noninvasive diagnostic tool to identify patients at risk for MDRO-SBP. Patients with decompensated cirrhosis should be screened for MDROs from the first day of inpatient treatment onward. Keywords: multidrug resistance, liver cirrhosis, ascites, screening routine, antibiotic therapy

Published
2018

34. Polyposissyndrome

Author

Trojan, J., Rädle, J., Zeuzem, S., Caspary, Wolfgang F., editor, Mössner, Joachim, editor, and Stein, Jürgen, editor

Published
2005
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35. Bulevirtide monotherapy at low and high dose in patients with chronic hepatitis delta: 24 weeks interim data of the phase 3 MYR301 study

Author

Wedemeyer, H., primary, Aleman, S., additional, Andreone, P., additional, Blank, A., additional, Brunetto, M., additional, Bogomolov, P., additional, Chulanov, V., additional, Geyvandova, N., additional, Hilgard, G., additional, Mamonova, N., additional, Merle, U., additional, Viacheslav, M., additional, Sagalova, O., additional, Stepanova, T., additional, zur Wiesch, J. Schulze, additional, Zotov, S., additional, Zeuzem, S., additional, and Lampertico, P., additional

Published
2022
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45. Lebertransplantation

Author

Encke, A., Wenisch, H. J. C., Markus, B. H., Allers, C., Teuber, G., Karich, H. J., Zeuzem, S., Caspary, Wolfgang F., editor, Leuschner, Ulrich, editor, and Zeuzem, Stefan, editor

Published
1997
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47. Krankheiten der Leber

Author

Zeuzem, S., Lembcke, B., Leuschner, U., Teuber, G., Caspary, W. F., Kaltwasser, J. P., Bargon, J., Dietrich, C. F., Sahm, S. W., Güldütuna, S., Danzygier, H., Buhl, R., Caspary, Wolfgang F., editor, Leuschner, Ulrich, editor, and Zeuzem, Stefan, editor

Published
1997
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